Jesus says "See that you do not despise one of these little ones." To despise is to look down on them, or think little of them, and then treat them like they are insignificant or detestable. I. Don't despise them because of their guardian angels, v10. II. Don't despise them because of their Good Shepherd, vv12-13. III. Don't despise them because of the will of God the Father, v14.