Why Statins Cause Muscle Pain (And What You Can Do About It) Artwork

The Pain and Performance Podcast

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The Pain and Performance Podcast

Why Statins Cause Muscle Pain (And What You Can Do About It)

April 04, 2026 • Derrick Hines

0:00 | 21:11

Statins are one of the most commonly prescribed medications for managing high cholesterol, but many people experience muscle pain, fatigue, and weakness while taking them. In this episode of the Pain and Performance Podcast, Dr. Derrick Hines explains the science behind statin-associated muscle symptoms (SAMS) and why these issues occur in some patients. He breaks down how statins can affect CoQ10 levels and mitochondrial energy production, leading to muscle dysfunction. The episode also explores evidence-based lifestyle strategies, metabolic interventions, and supplement options that may help support cardiovascular health for those who struggle to tolerate statins.

In This Episode

- What statin-associated muscle symptoms (SAMS) are and why they occur

- How statins can affect CoQ10, mitochondrial energy production, and muscle function

- Important tests that give a clearer picture of cardiovascular risk beyond a standard lipid panel

- Lifestyle strategies including nutrition, fasting protocols, and exercise to improve metabolic health

- Supplements and therapies that may support cholesterol balance and vascular health

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