
Seth Kahan on Grand Challenges
Grand Challenges represent the wicked problems that society faces—complex, persistent, and difficult to solve due to incomplete, contradictory, and ever-changing demands. Yet, addressing them is essential for humanity and life on Earth to survive and thrive. My work is dedicated to confronting these monumental issues.
These challenges are too vast for any single mind to fully comprehend or solve. They are multi-dimensional, with deep systemic roots that are reflected in legislation, policies, social behavior, and even individual thoughts and mindsets. These factors limit our ability to effectively address them.
However, there are models and frameworks I’ve developed to help organizations and activists collaborate in making tangible progress. These stem from my experience at the World Bank, where I’ve witnessed both the successes and failures of multinational efforts, and from my work with Grand Challenges in sectors that include maternal health in Kenya, earth science, finance, nursing, and mental health.
Seth Kahan on Grand Challenges
Grand Challenge with the American Association of Physicists in Medicine and Dr. Ehsan Samei
I'm thrilled to share insights from a recent conversation with Dr. Ehsan Samei, Reed and Martha Rice Distinguished Professor of Radiology at Duke University. We discussed an exciting Grand Challenge I’m leading with the American Association of Physicists in Medicine—focused on identifying bold, breakthrough challenges that could shape the future of medical physics.
But what is medical physics? Its applications are vast—spanning MRI, lasers, ultrasound, AI, and nuclear medicine. As I’ve spoken with physicists dedicated to this field, I’ve been inspired by the incredible advancements on the horizon. From AI models to digital twins, the future of medical physics is unfolding in powerful ways.
During our conversation, Dr. Samei shared his perspective on developing AI models for medical applications. He echoed the famous phrase, “All models are wrong, but some are useful,” emphasizing that the goal is to find models that are truly impactful in advancing patient care.
Scientific breakthroughs don’t just improve technologies—they open doors to new research, innovative techniques, and deeper understanding. They prevent suffering, save lives, and reshape our world. It's a privilege to contribute to this transformative work.
Dr. Samei’s leadership has been pivotal in integrating physics principles into clinical practice, pushing the boundaries of what’s possible in patient care. Listen in to learn more about this groundbreaking work!
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