Speed to market is a common driver in manufacturing and life sciences projects, requiring some facilities to be completed before the product and manufacturing process have been well defined. Some facilities may need to be reconfigured for multiple uses during their operational lives. This podcast explores the research that provides guidance on which common core building components are dependent upon the manufacturing process, and which can easily be decoupled. It identifies innovative methods that contribute to the development of a flexible facility. Please enjoy our conversation with Keith Molenaar, K. Stanton Lewis Professor of Construction Engineering and Management, Interim Dean, College of Engineering & Applied Science, University of Colorado, Boulder, and Samar “Summer” Adranly, Senior Vice President, Eichleay. This was recorded at the CII Annual Conference in August of 2019.