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Michael Rafii on Down syndrome-related Alzheimer’s disease

The Lancet Neurology in conversation with

The Lancet Neurology in conversation with
Michael Rafii on Down syndrome-related Alzheimer’s disease
Aug 13, 2025
The Lancet Group

People with Down syndrome face a high risk of developing Alzheimer’s disease, which is the leading cause of death in this population over the age of 35.

In this episode, Morgane Boillot (Senior Editor) is joined by Professor Michael Rafii to explore the intersection of Down syndrome and Alzheimer’s disease. They discuss the latest research into disease pathology, biomarkers, and clinical trials, and examine the key challenges and future opportunities in understanding and treating Alzheimer’s disease in individuals with Down syndrome.

Read the Rapid Review:

https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(25)00237-6/fulltext?dgcid=buzzsprout_icw_podcast_August_25_laneur

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