People with Down syndrome face a high risk of developing Alzheimer’s disease, which is the leading cause of death in this population over the age of 35.

In this episode, Morgane Boillot (Senior Editor) is joined by Professor Michael Rafii to explore the intersection of Down syndrome and Alzheimer’s disease. They discuss the latest research into disease pathology, biomarkers, and clinical trials, and examine the key challenges and future opportunities in understanding and treating Alzheimer’s disease in individuals with Down syndrome.

Read the Rapid Review:

https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(25)00237-6/fulltext?dgcid=buzzsprout_icw_podcast_August_25_laneur

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In this episode, host Laura Hart chats with Professor Amit Bar-Or (University of Pennsylvania) about the potential of the BTK inhibitor fenebrutinib in treating relapsing multiple sclerosis, highlighting future challenges in MS research.

Read the full article:

https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(25)00174-7/fulltext?dgcid=buzzsprout_icw_podcast_July_25_laneur

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Sarah Passey is joined by Dr Marte-Helene Bjørk (Haukeland University Hospital, Norway) to discuss the latest evidence and practical guidance on managing reproductive risks in people with epilepsy, including medication safety, pregnancy planning, and global challenges in care.

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https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(25)00130-9/fulltext?dgcid=buzzsprout_icw_podcast_June_25_laneur

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Assistant Editor Sam Griffiths is joined by Professor Geoff Manley (UCSF, CA, USA) to discuss his new NIH-NINDS classification of acute TBI, the limitations of traditional classifications, how the new framework was developed, and what it means for the future of TBI research and patient care.

Read the full article:

https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(25)00154-1/fulltext?dgcid=buzzsprout_icw_podcast_May_25_laneur

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Increasing numbers of people are surviving stroke but with motor impairments that can contribute substantially to long-term disability. 

Transcranial direct current stimulation has shown promise in reducing motor impairment when combined with rehabilitation therapy. Sarah Passey talks to Wayne Feng (Duke University School of Medicine, Durham, NC, USA) about his latest trial, TRANSPORT2, which assesses transcranial direct current stimulation in combination with modified constraint-induced movement therapy.

Read the full article:

https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(25)00044-4/fulltext?dgcid=buzzsprout_icw_podcast_16-04-25_laneur

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In this podcast, linked to the April 2025 issue of The Lancet Neurology, Laura Hart (Deputy Editor) chats to Marialuisa Gandolfi (University of Verona in Italy) about advances in the classification and management of pain in Parkinson’s disease.

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Sarah Passey (The Lancet Neurology) is joined by Michael Tymianski (University Health Network, Toronto, Canada) to discuss an Article in the March issue reporting a meta-analysis looking at neuroprotection in stroke and what can be learnt for future research.

Read the full article:

https://www.thelancet.com/journals/laneur/article/PiiS1474-4422(24)00515-5/fulltext?dgcid=buzzsprout_icw_podcast_generic_laneur

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In this podcast, linked to the February 2025 issue of The Lancet Neurology, Elena Becker-Barroso (Editor-in-Chief) chats to Elizabeth Finger (Western University, London, ON, Canada) about the FOXY trial of oxytocin for apathy in people with frontotemporal dementia.

Read the full article:
https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(24)00456-3/fulltext?dgcid=buzzsprout_icw_podcast_generic_laneur

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The Lancet Neurology Editors take a look back at advances in neurology in 2024, as highlighted by experts in a series of Round-ups published in the January issue.

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Florian Krismer (Innsbruck Medical University) and Elizabeth Coon (Mayo Clinic) join Sarah Passey (The Lancet Neurology) to discuss their Review paper on multiple system atrophy, which is published in the December issue of The Lancet Neurology.

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Professor Suvankar Pal (University of Edinburgh) joins Sarah Passey (Senior Editor at The Lancet Neurology) to discuss the first findings from the MND-SMART trial of treatments for motor neuron disease. The Article is published in the November issue of The Lancet Neurology.

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Prof Jorge Correale and Dr Lilyana Amezcua talk to The Lancet Neurology about their Personal View papers, published in the October 2024 issue, on the differential diagnosis of multiple sclerosis in regions outside North America and Western Europe and in people from minority ethnic or racial backgrounds in North America, northern Europe, and Australasia.

Read the full article:
https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(24)00256-4/fulltext?dgcid=buzzsprout_icw_podcast_generic_laneur

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Dr Alex Iranzo joins The Lancet Neurology to discuss his recent Review on the association between sleep disorders and Parkinson's disease. The Review is published in the August issue of The Lancet Neurology.

Read the full article:
https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(24)00170-4?dgcid=buzzsprout_icw_podcast_generic_laneur

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Dr Adrian Owen joins Sarah Passey to chat about a his Personal View, published in the August 2024 issue of The Lancet Neurology, about detecting awareness after an acute brain injury.

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Dr Glenn Nielsen joins Lauren Southwell to discuss the Physio4FMD trial of specialist physiotherapy for people with functional motor disorder in England and Scotland. This Article is published in the July issue of The Lancet Neurology.

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Sanjay Sisodiya joins The Lancet Neurology to discuss the potential effects of climate change on brain health. The Personal View is published in the June issue of The Lancet Neurology.

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Jacqueline French and Jacob Pellinen join Senior Editor Sarah Passey to discuss recent progress made in the diagnosis of epilepsy and challenges that remain. Their Review on this topic is published in the May issue of The Lancet Neurology.

Read the full article:
https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(24)00079-6/fulltext?dgcid=buzzsprout_icw_podcast_generic_laneur

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Jaimie Steinmetz and Theo Vos from the Institute for Health Metrics and Evaluation, and Katrin Seeher and Tarun Dua from WHO, join Heather Brown and Lauren Southwell to discuss new data on the global, regional, and national burden of disorders affecting the nervous system. The Article is published in the April issue of The Lancet Neurology.

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Giovanni Frisoni joins The Lancet Neurology to discuss new European intersocietal recommendations for the biomarker-based diagnosis of neurocognitive disorders. The Personal View is published in the March issue of The Lancet Neurology.

Read the full article:
https://www.thelancet.com/journals/laneur/article/S1474-4422(23)00447-7/fulltext?dgcid=buzzsprout_icw_podcast_generic_laneur

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Marianne Chapleau and Gil Rabinovici join Senior Editor Sarah Passey to discuss their research on posterior cortical atrophy. The Article is published in the February issue of The Lancet Neurology.

Read the full article:
https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(23)00414-3/fulltext?dgcid=buzzsprout_icw_podcast_generic_laneur

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Cecilia Åkerlund and David Nelson join The Lancet Neurology to discuss their research on clinical variables that might distinguish how the disease process progresses in people with traumatic brain injury. The Article is published in the January issue of The Lancet Neurology.

Read the full article:
https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(23)00358-7/fulltext?dgcid=buzzsprout_icw_podcast_generic_laneur

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Rustam Al-Shahi Salman joins Senior Editor Sarah Passey to discuss the COCROACH meta-analysis findings, published in the December issue of The Lancet Neurology, of the effects of oral anticoagulation in people with atrial fibrillation after spontaneous intracranial haemorrhage.

Read the full article:
https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(23)00315-0/fulltext?dgcid=buzzsprout_icw_podcast_generic_laneur

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Njideka Okubadejo and Mie Rizig join The Lancet Neurology to discuss their comprehensive genome-wide assessment in African and African admixed individuals with the aim of developing a better understanding of the genetic architecture of Parkinson's disease in these underserved populations.

Read the full article:
https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(23)00283-1/fulltext?dgcid=buzzsprout_icw_podcast_generic_laneur

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Anthony Feinstein (University of Toronto and Sunnybrook Health Sciences Centre, Toronto, Canada) discusses CogEx, a randomised trial of cognitive rehabilitation and aerobic exercise for cognitive impairment in people with progressive multiple sclerosis. The Article is published in the October issue of The Lancet Neurology.

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William Jagust (University of California in Berkeley, CA, USA) talks to Senior Editor Sarah Passey about the complex pathway between amyloid β and cognition, and implications for therapy for people with Alzheimer’s disease. His Personal View on this topic is published in the September issue of The Lancet Neurology.

Read the full article:
https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(23)00128-X/fulltext?dgcid=buzzsprout_icw_podcast_generic_laneur

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