Cure Bacterial Infections

 Tuberculosis — Mycobacterium tuberculosis. This is the obvious one for your story. WHO estimates about 10.7 million people developed TB and 1.23 million died from it in 2024. It remains the world's leading cause of death from a single infectious agent. Drug-resistant TB makes it especially interesting for your proposed bacteriophage research. 

 Bacterial pneumonia — especially Streptococcus pneumoniae, but also Klebsiella pneumoniae, Staphylococcus aureus, etc. Rather than one bacterium, pneumonia is a syndrome caused by several organisms. Bacterial lower-respiratory infections are enormous killers. S. pneumoniae alone was associated with roughly 829,000 deaths in the major Global Burden of Disease analysis, most through lower-respiratory infection. 
 
 Staphylococcal infections — Staphylococcus aureus, including MRSA. This one is surprisingly important. The large Lancet analysis estimated S. aureus was associated with about 1.1 million deaths in 2019, making it the deadliest of the 33 bacterial pathogens examined. It causes bloodstream infections, pneumonia, wound infections, surgical infections and sepsis. MRSA adds the antibiotic-resistance problem. 

 Serious E. coli infections. Most E. coli living in our intestines are harmless, but pathogenic strains can cause diarrheal disease, urinary infections, kidney infections, abdominal infections and bloodstream infections. The Lancet analysis associated E. coli with about 950,000 deaths worldwide in 2019. 

 Klebsiella infections — Klebsiella pneumoniae. This is particularly attractive for your storyline because some strains have become extremely resistant to antibiotics. It causes pneumonia, bloodstream infections, urinary infections and serious hospital-acquired infections. The same global analysis associated it with about 790,000 deaths in 2019.

 An important sixth candidate is Pseudomonas aeruginosa, particularly for hospital patients, burns, wounds, ventilators and people with weakened immune systems. It was associated with roughly 559,000 deaths in that analysis. 
Hello people, this is the Mad Scientist Green, talking today about bacterial infections. Now, we all get infected by bacteria, but some bacteria is more deadly than others. Tuberculosis, very deadly, and becoming antibiotic resistant. Pneumonia, Staphylococcus, strep throat, E. coli, and Klebsiella,
 Well, we need to get away from antibiotics. And one way to do that is using the Tree of Life Project. Now, the Tree of Life Project, they are researching all life and genetically analyzing it to see what it's closest related to. And we also have viruses, which are not technically alive, but they're analyzing them too. And certain viruses affect certain animals. There are certain types of virus that only affect bats. And every time it replicates, a few of those viruses are mutating. And they have a chance, a very, very small chance, but a chance that they have mutated so they will affect a human or a mouse or a cow. Bird flu, same way. Affects birds, only a certain type of birds. But then as birds, you know, meet other birds and it spreads, there's a very small chance it'll go to a new species. So something that only affects crows might jump over to affect geese. Well, if you grow a bunch of bacteria, let's say tuberculosis bacteria in a bat, and you can't find any virus that attacks that, but you find a virus that attacks a bacteria that's similar to or very closely related to tuberculosis. Grow tuberculosis and that other bacteria in one bat. So they're co-mingling. And then infect it with that virus. That virus will attack the one it's supposed to attack, and tuberculosis will be unaffected, most of the time. But you keep doing this generation after generation. And eventually, the virus will mutate so it will attack tuberculosis. And you breed it again and again and get the ones that attack it the best. Make it extremely virulent against tuberculosis. And then simply spray that in the air around somebody with tuberculosis. They breathe that in, it affects their tuberculosis, and they're cured. And we can go around curing the world of tuberculosis. Well, strep throat, if you don't have the antibiotics to kill that, it can kill you. Well, we do the same thing again. Find the virus that attacks bacteria that's closest to that. Brew those two or three or four bacterias together. And eventually, the virus will change to attack strep throat and attack the other things. All those other bacteria that kill us. We can kill them by breeding the correct viruses that will only affect those bacteria. Now, it's a hit or miss thing. I realize that. Now, they specifically alter a virus to attack us that only affected bats. Well, if we don't specifically alter this, it's going to take a lot longer for it to happen. You're going to have to have a much larger sample size, etc. But it will be natural. And I don't want to affect viruses or change viruses to affect us. I want it to affect the things that affect us. We can, your bacteria on your teeth that cause cavities. We might be able to get a virus that kills bacteria that causes tooth decay. So, we end up with no tooth decay without having to go through other steps. We end up with not having to floss or brush your teeth as often. Yes, for fresh minty breath and fresh breath, it would be a good idea to floss and brush your teeth. But to prevent cavities, that won't be a problem anymore if we can invent, or if we can breed bacteria and breed the viruses that attack those bacteria. The viruses will naturally change given the right environments. We don't have to go in there with a set of tweezers, change the viruses. And if you intentionally genetically modify an organism, you've got to get government approval for that. But if you're just growing bacteria in a bat, and it happens to be affected by a virus, that's legal. So, let's do things that are legal and make viruses attack those things that attack us. All right, that's my little speech for today, and I encourage people to go out there and actually do this, get the money together to do this. Thank you very much for listening. This is the Mad Scientist Green, signing out.
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