Curing Alzheimer's w/ Anna Shelander

Read, Brush, Floss, Repeat... one way to mitigate the chances of Alzheimer's Disease. In a science and syllable heavy episode, we learn a bit about the role that oral health can play in preventing Alzheimer's Disease and the lab at the University of Minnesota researching this issue. A lab funded by the CAD (Curing Alzheimer's Disease) Foundation.

Transcript

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Welcome to the Kindness Chronicles, where we hope to inject the world with a dose of the Minnesota kindness that it desperately needs. We've got Steve Brown in the studio. Yeah. Yeah. Hey, and then we've got Jeff Hoffman is, on the road on assignment. Are you there Jeff? Hi Jeff. I'm, how are you? We have a special guest in Studio Anna. She Lander, and we're gonna get to her in just a moment. KG is at the, uh, the track, the, this is a bad night for kg, but it's been chaos for me, so. This is what you're getting. You got the three of us, and then Dempsey's down in, Texas. He's in Texas. He's, uh, he's on a, on assignment in Texas. He is the, the, everybody's on assignment. I would just like to start with, we lost a legend of music this past, Couple of days. he left some lovely gifts for the community that I just wanted to talk about. Uh, Ozzy Osborne died. Yeah. Now Ozzy was an interesting character. He's definitely a, a character. What do you think would hap, he falls in that, what do you think happened when he showed up at the pearly gates? Do you think He said, you know, God, all that devil stuff. I was kidding. I was just kidding about that. He loved that moniker, the Prince of Darkness, that he was just silly. He's being, he's a, he's a silly guy. Did you happen to see the tribute concert that Tom Morello organized? I only saw some of it. I saw it. It was kind of sad. And it was only like two weeks ago. Yeah. July 5th or something. And at the very end, uh, Ozzy appears out of the, uh, yes. The stage in a chair in a black, it's more of a throne. Yeah. In this black throne. Throne. Yeah. And, uh, you know, sings a couple of his, uh, his greatest hits, he. His second to last song was, mama I'm Coming Home. Yeah. Which was pretty interesting. And then he did, uh. Did a couple of Black Sabbath songs with, uh, with the whole original lineup from Black Sabbath. Think how many hits and how much time he spent on the radio. How many, how many times we've heard Ozzy songs. Black between Black Sabbath and, oh God, seventies, all the way through. He's, and I mean, for being such a crazy character and so many problems he's endured for a long time. But, and then he became really famous when he had that, uh, the show, the show with his family, what was it called? Uh, Oz Osborn. Os it was from oh two to oh five and uh, he had a very loving family. And that's where I started to kind of realize, this guy's actually pretty cool. You know, I was a Catholic school kid, so Oh yeah. When I saw, like, he was scary stuff that the Diary of a madman, I mean, that stuff freaked me out when I was in, in high school or uh, junior high. I realized, oh, it was all marketing. It was an all an act because he loved his family. Yeah. He was a, a, a very smart business person. this tribute concert that was done, apparently it made like$180 million. Is that possible? Well, it was a charity event too. No one, no one accepted any money for, for performing. I know that. It's just unbelievable. Yeah. So all the money apparently was being donated to a, a variety of different charities. Ozzy had Parkinson's Disease. Which is a brain disorder. But what a, a, a neat guy. Speaking of brain disorders, we're gonna pivot right away Wow. To our, uh, to our guests. See how I did that? Yeah. Um, we have with us. That was impressive. Uh, a a a friend of mine from, uh, long ago, many years ago, uh, her son Weston, and my son Jack, played football and baseball together. And Weston, uh, very, very bright young man. Uh, I just a couple quick Weston stories. Weston was. I would say Weston is a guy that kind of marches to the beat of his own drum. Okay. He, he was this, he was like the biggest, strongest guy, freshman year in high school, and he decided I don't want to be the biggest guy in high school. And how much weight did Weston lose? I mean. You gotta give me close to the mic. Yeah. Okay. Sorry. This is my first shot at this. Yeah, that's fine. This is big fun. Okay. Um, actually we never weighed him once. Yeah. He just got completely cut. He went real and he went from being the starting left tackle to a, a guy that played with the rest of the regular sized human beings, but he also was a baseball player and everybody else used a, uh, an aluminum bat. And wore gloves. Weston was from the 1910s and he used a wood bat and no gloves. Weston was an interesting cat, but a very good dude. Wow. Very interest. Great guy. Interesting. And when you listen to his mother, you'll understand where some of that, uh, attitude, so to speak comes from. But Anna Sealander is the executive director of an organization that is trying to take on, Alzheimer's disease and you know, I mentioned Ozzy with his, uh, his brain disorder. Mm-hmm. Uh, Anna has a very interesting story. For starters, why don't you tell us a little bit about. where the motivation for this, foundation that you created came from? Sure. Wait, Anna? Yes. Welcome to the Kindness Chronicle. Oh, sorry about that. He welcome down to, we have her here in studio too, which is fantastic. So it's good to, good to have you down here. It's a pretty nice spot. Oh, it's so, it's, yeah, right. I'm impressed. Surrounded by Legos. Yeah. And t-shirts, it's real. It's got a mood. Yes. We, it's got a mood. Mm-hmm. Alright, so, and thank you John for bringing me on, Steve. Yeah. Appreciate it. Yeah. Um, so first of all, we're called the curing Alzheimer's Disease Foundation. And, um, that is an interesting story in that it wasn't our initial plan. I'm, I'm a marketer. I'm a journalist. Um, my dad was a dentist. Uh, I helped him build up his practice, getting it ready to transition a dentist in White Bear Lake right in White Bear Lake here in Minnesota. Right. And, and my dad, um, ended up suddenly, or not suddenly to him, but to those of us outside because Alzheimer's is a very interesting disease. It slowly happens and in the very early time, the person that has it can actually do a lot of things to protect against. Other people understanding that that might be the course that they're on. So, and my dad with lots of cognitive reserve, which is a, is a critical part of, um, one of the reasons why. It can take longer to be detected from an outside source. Um, people with a lot of cognitive reserves, such as lots of education is generally, or reading, and by the way, these are the things you wanna do. Yeah. So everybody start reading more and get more educ education. Oh God. Because that's really important for your brain. But anyway, so my dad was recognizing that there was something going on probably before any of us did. Um, but he had a, a A a C, A circumstance where he ended up having, um, uh, a something called PMR, which is an autoimmune disease, and that brought us over to Mayo. And during the Mayo Run they said, um, you know, there's something going on with your cognition too, Dave. His name is David Crandall. And so we did a little bit of testing and they said, yeah, you could be really early on that MCI. This could be Alzheimer's. Let's watch this. So anyway, this particular disease is addressed through steroid. So my dad went on steroid and all of the cognition issues went away. Hmm. Now, what we know now is Alzheimer's is a disease of inflammation. Back at the time that was. That was under, um, research and that hadn't been determined quite yet. But here, my dad was having no issues with cognition after he is taking steroids. So it goes back to Mayo and they say you can't possibly have. Alzheimer's, which was our very first turnaround on a diagnosis for Alzheimer's. There were probably 15 beyond that. Never once did anybody stay stay with that diagnosis because my dad kept reversing a symptom. That symptom being cognitive issues. So the neurologist gave him a clear bill of health. He went away thinking, well, that was, they thought it was pain. That's why he was having issues with cognition. And when he finally was on the taper. He had issues with cognition. Again, that's when he went out into the research world and started asking questions, looking for research papers. What is there that that would say that cognition could be steroid responsive? And that's where he starts to find all these researchers around the world. Who are fascinated with his case. So, go ahead. Just a quick question. What era are we talking about? What, what year is this? This is 2013 to 2015. Okay. Okay. So this is not that long ago really. Okay. Nope. And so during that time, um, of course you'd be talking the medical community I, I put on my website, which is curing alzheimer's disease.com. I put together, put together a really, you know, a silly little, not silly, but just because I'm not professional, a video and it's called. In between. So caught in between, and this really identifies what happens to a patient, I think in any situation. But ours particularly, the caught in between is you've got medical at the base and that's who's treating you. And then you have science who's in a lofty spot, and these two groups don't talk. And so as my dad's learning these in this great information from scientists. The researcher or the, the medical doctors are saying it's not gold standard and therefore, uh, we're not going to pay any attention to that. Alright, so going further. My dad then is thinking, okay, this, there is something neurologically wrong and I'm seeing this in the dental office. That's another great interesting point. Medical and dental still are super separate. The mouth is not connected to the body. It doesn't make sense. But that's how it is right now. Huh? So what happens? What do you mean the mouth that's it is not, it is not covered by medical insurance. Oh, I see what you're saying. Your medical doctor doesn't care about it. Perspective. Yeah. Interesting. What? So, and yet, we know right now definitively a hundred diseases are caused from. The pathogens in our mouth. Wow. So how is this? And I think it'll change, but for right now, this is where we're at. Hmm. So anyway, my dad, as a dentist, as a profession professional caring for people would see this all the time. And that is people that had gum disease, gum diseases caused by bacteria. And so people would have gum disease, it would go untreated, either because they weren't following protocol or because it was not managed well enough. And then they eventually would develop dementia. And so if you talk to a hygienist, I invite anybody listening on this podcast, next time you go to the dentist, ask your hygienist, do you see a correlation between oral gum disease? And dementia. And they'll say, yes, we've been seeing it a long time. But again, this information just pay, it stays put super siloed. So, so far I've learned two things. Mm-hmm. I need to start reading more. Yes. Um, and I better start flossing every single day, every day, every day. Every day. Every single day. Um, one other question is watching YouTube videos qualify as cognitive? Uh, yes. Absolutely. You're doing all kinds of things, especially if they're subtitled, cogniti, serve. Yes, I think I have cognitive reverse. Re Yeah. Okay. Well we can just switching a couple of things, figure that out. I hate to, to make light of this. Oh, no, no. It's, but it is very fascinating to me. It's especially fascinating. Um, a while back, Minnesota Masonic Charities had made a big gift to the University of Minnesota to create what's called the Masonic Institute for the Biology of Aging and Metabolism. And something got posted on LinkedIn and I made a comment. And Weston Slander said, oh, Dr. Laura's terrific. You'll love working with her. And I'm like, how does Weston slander that little punk that went to high school with my son, know who Dr. Laura is and well enough to say what a great, you know how great she is. Turns out he was a, he worked in her lab. Yeah. He worked in in her lab. Yeah. And, uh, so all of these sealander, like everything is, is, is drawing you toward. The University of Minnesota. Oh, absolutely. Question. Tell us about the lab, because I think what's unique about, yeah, yeah. So I was, okay, so you're right. Thank you for scooting me along. I'm gonna get better at this at some point, but you, yes. Hopefully you won't hear me. Hit a button that says, is this a long No, that's great story. You gave us the basis your dad's finding and your dad's. Issue. So that's, we needed that job. Absolutely. Well, and you're not complaining about it. Oh my God. Okay. Okay. Okay guys, so we'll go on. So anyway, here's what happens. Like, let's jump forward. My dad is eventually experimenting on himself. He's using, um, protocols from the scientists that are around the world who are eagerly watching. They only work on animal model. They don't have a human example. And yet my dad is actually walking them through. Uh, a hypothesis. And that hypothesis is the infectious microbial hypothesis. Something from my mouth is broken through my blood brain barrier, and what are we gonna do about it? So they've given him protocols, he's taken those to d, different doctors fired a couple who said no, signed everything away, and said, there's no, I'm literally doing this with my full faculty, because at this point, he still does not have Alzheimer's, and he is in control of his faculties, but it is a progressive disease. So with that being said. We are taking both steroid. We. He and I, I mean, I'm, I'm like his, his, uh, you know, ace in the hall. I'm right there with him. Yeah. Anyway, and so he's taking steroid and then eventually we add antibiotic onto on top of it. So this nice little cocktail is great, except for we don't know how to feed the brain any kind of medication without running into issues like, um, uh, res resistance. We don't know how long how to give it. We're actually, at this point, he's just taking it orally. You can't give high levels of anything orally. Mm-hmm. And so as a result, my dad does die. And that is he dies of something. We actually are, the autopsy says of DI dementia of unknown origin. Remember 17 different doctors said you cannot have Alzheimer's.'cause nobody has ever reversed the symptoms. And when I speak about that, this is what's so amazing. My dad would go from. In a wheelchair, literally unable to move his legs because his parietal lobe is not catching the right registering. Yep. Yep. And within, uh, a change of regimen. He's up walking no cane, and he would be able to go from recognizing names, first names, last names to being almost moot, sometimes not being able to eat. And then being able to, to completely do his daily, daily, you know, DOLs, whatever they're called, um, tasks of daily living. And, and it was all because of these medications and it was clinically supported. We have the records. That show that, show this. Okay. So, so who's prescribing these medications to him? If he's good? Yeah. Yeah, doctors, medical doctors. So he would get MDs that would, that would buy in and, and, okay. And they would have to be somebody who's seen this before. So urology sees this all the time. Oh yeah. So they see these patients come in with a UTI, you know, you get one and they go nuts as a kid. Yeah. But if you get one as a kid, it hurts. But now our blood brainin barrier as we age, is actually loosening bigger and bigger things can get through, such as virus. I believe a lot of that, that, uh, brain fog that people have from COVID is probably, um, going along this line, uh, and bacteria and fungus. So now we have a UTI and an elderly person and they go batshit crazy, just like you said. You talk about the challenges of homelessness. People that are unhoused or homeless or whatever we're calling it these days, there, there appears to be a lot of mental illness among those people, and it makes you wonder, is it because they're just not taking care of their mouths? I've been reading a whole bunch since we had breakfast, the, uh, on Monday. Good, good. I find it completely fascinating. Um, there's a lot there, there, there's a lot, real lot there. A lot and, and mm-hmm. It, it has become kind of a mainstream. Like there's a lot of people now that are looking at this, but you have, you fund a laugh, so let's go there. So this is what's so cool. So my daddy dies. What year did you done? I said that twice. 2019 at the end of the year. Just before COVID. Thank goodness. Because this would've been really, yeah, maybe not the same outcome. He orders his own autopsy. Unprecedented. Wow. And so, yeah. Right. Wow. And so we go in and, and we've got the university they're ready to, to, to tell us what's going on. So the first thing they tell us is, what I see is bad news. Now, first, just let's step back. You talk about this as the Kindness Chronicles. My dad, kindest guy in the world. Mm-hmm. And what he was hoping, because we didn't have Alzheimer's, that's so that we were told he was gonna help 5% of the people that were also misdiagnosed. This was gonna be called the Crandall Disease. And he was going to start a foundation and, and, and funnel money that we would get some way maybe from the sale of the dental office. Mm-hmm. And we would, we would fund a lab and they would come to this conclusion and carve it out. Of the Alzheimer's bucket and, and it would be solvable, and he was really convinced of that. So when I go in and the university pathology team sits me down and says, your dad had the worst Alzheimer's we've ever. Ever seen really, like people die long before this. Hmm. So there's so much. So Alzheimer's is diagnosed by pathology, meaning the protein deposition that's on in the brain and in my dad's brain, in his case, it was everywhere in his brain. There was not a place, they was not protein. Now, the theory right now that's being funded most generally is that this protein kills neurons. But I can tell you most recently, research is now coming to find. It does not, you can actually put those protein, uh, the put protein like amyloid beta on top of a neuron and nothing happens. You know what kills the neuron inflammation? Hmm. So now we have this bad news. I'm thinking, I'm thinking it's good that dad's dead because he would be really di disappointed. And then they said, wait a minute, it's not that bad because we're gonna go structure by structure. Let's look at his brain. So we're looking at like deposition of protein, but let's look at see, should his, his brain should be completely devastated. It should be dead by this point. Necrotic, like the cauliflower head that you would see. Mm-hmm. But it's not, it's actually vibrant. So they're going into the structures like, let's talk the hippocampus. That should be a completely gone, that's where your memories are started and that's where that short term memory right there consolidates and goes elsewhere in your brain. It's fine. It's a little atrophied as they write. It's age appropriate. Mm-hmm. Meaning it's completely capable of function. So now they went system by system or structure by structure, and then turned to me and said, this is the closest we've ever come to Alzheimer curing Alzheimer's. Let's start a. And I was like, yeah, let's just do it. Wow. You know what? I didn't even have to think about that. And then to, you start writing checks and then No, actually not. And so to this point, this is why this is kind of a heroic story, right? So I wait two years thinking that we're gonna get. A, I don't know anything about science. I mean, I've had to learn it backwards, obviously. No, not a lot now been, I was gonna say, I know's. Been it's been a gas son. Son. My son has been, that's Weston Weston has been phenomenal in helping me understand the baseball bat Kid physiology. Yes. Oh his. He's so smart's ridiculous. No gloves. So anyway, that being said, they come back to us and they said, we went to the NIH. This is one of the reasons why there might be some substance to what's happening. I'm not saying they're the bad guy by any means, but in our situation they were. They said they don't like the, this particular hypothesis, they like amyloid cascade. They like that one, so they're not gonna fund us. So we went two years and with nothing. So you can have your dad's brain back, and here's me. So my middle name is Tenacity times 10. A lot of people know that if you don't know that, now you do. Oh no, I hear that Anna Tenacity. So Anna tenacity times 10. So it takes me, I get myself that pity party. So I go one day, and then the next day I just pulled up my girl pants and I said, you know what? We're gonna start a foundation. I don't have the money. But I'm gonna get that money. Yep. So I, that's when I started, I and I and we, or incorporated in 2022. It took a bit of time. It's costly to start that. And, and then we, we developed this beautiful contract with the university, so it's sponsored. So I'm sponsoring a lab. That means we're the only funder to. And, you know, we're reliant on donations. Tell us about, so anybody hears this podcast if they donate, help us. Yeah. You've got Dr. Chen, Dr. Liam Chen. He's amazing. This guy has published, I don't know, 67 75. Some, you know, it, it falls off of his, his resume anytime you wanna look at it. But he is, Johns Hopkins, Harvard. He's here at the U. He's actually involved in Parkinson's. And he just published a breakthrough PLA paper that that has absolutely pointed to bacteria in our body causing that disease as well. You don't know the impact that just you message could have on curing. Alzheimer's just so I understand. Yeah. The belief is, is that 5% of the people that have Alzheimer's have it as a result of oral health matters. Did I understand that right? Inflammation? No. And thanks for that clarification. Okay. So, so, um, we believe, uh, going into this, that all a vast majority of late onset,'cause there's a dnce. Yep. Okay. Of late onset is going to be, um, at basis microbial. And the only way that the microbial challenges can present is through oral health. It's gonna come from a vast majority is gonna come from the mouth because if you look at the overlap between gum disease and, and. Um, Alzheimer's. It's really, really high. In fact, there was a meta-analysis that we did in advance of this. Um, uh, or actually we found this, it was published on my birthday, and I love these serendipitous, serendipitous types of things, but it was a, a, a 20 year re uh, retrospective of all research looking at periodontal disease, Alzheimer's disease, and where the overlap is. And then they ran it through AI and it, and by the way, it was. Beautifully done. They're all very broad, very representative studies, so they aren't, you know, five people and they're all white, right? White. So this is, so yeah. The conclusion that has has come from this is that oral health. Is one of the contributing factors. Yep. It could. So why aren't we talking to the folks at, Proctor and Gamble, you know, the people that do Crest and Colgate and Scope and Listerine and John? I can answer that. Okay. Caught in between because we're talking science still. We are not talking medicine. It hasn't been proven and it, by the way, but it, this is gonna re-engineer a lot of things, but, so it hasn't been proven. It sounds like that's what my lab's doing or the lab that I fund. Oh, by the way, it's called the Alzheimer's Legacy Lab. I got to name it. Okay. And I named it after my dad being a legacy. But I also wanna point, this is super cool. Like this is a fun cliff Claven moment. So, um, what we have here is the guy that, that came up with Alzheimer's, Eloise, Alzheimer. Mm-hmm. He had a contemporary, his name was. Oscar Fisher. Mm-hmm. They were both looking at these senile, diseased brains. This is like in the early 19 hundreds, AB a hundred years ago. Okay. And Alzheimer's. I knew that. I know he did. Thank you. Because he's been reading. Because I've been reading. Reading absolutely. Just started. This is interesting. So it, this is really great because Alzheimer's gets, he says it's the protein. So now we have this called Alzheimer's, and we're looking at it being mostly, most likely protein. Fisher says, wait a minute. Look at all that oral bacteria in every one of these brains. That doesn't exact, that doesn't, that's not supposed to be there. That's where it started. But wait, there's more. Yeah. I One of the reasons that back in the early 19 hundreds, it was hard for them To really study Alzheimer's is because life expectancy in these people Yep. Was so much shorter that they were dying of other natural causes before their brain would even have an opportunity to, get the bacteria as serious. How frustrating. Oh my God. I mean, but I just, I just find it just incredibly fascinating and I do think, you know, when you're raising money Yeah. One of the objectives is to dramatize the need. And I would think that, you know, if I am a guy who's working in a dental office, I would have articles. You know this Dr. Chen's articles about the influence that oral health can have on, your brain's health, right? Yes. Keeping it healthy. And that's, that's gonna come. So what I think is so exciting about what we're doing is, and we've privatized. Research funding at a time. This is all the groundwork was laid prior to the NIH pause. So the, the real exciting thing I think from a feeling of, of, of meaningfulness is we were able to keep that moving forward with no pause. And as a result, we're actually moving into animal model three years ahead of time. So that is going to mean what we're doing. Is, is going to yield the result. It unquestionably, it's gonna revolutionize our understanding of neurodegeneration with what we're doing. Um, unquestionably, uh, it's happening here in Minnesota, which is really, really exciting. Very cool. Yeah. And um, now as we're already in there, we're kind of like the first guy in, now we're starting to see more traction and more labs. We'll be starting and, and working on it. We've got a proprietary. Um, phase pro protocol on this, so I can't talk about that, but it's very well thought out this is fascinating. This is, I don't know how any of this works, um, it's super interesting, Steve, real quick before you get into that, you know when you go to the dentist and they take that little, that little sharp thing and they go 2, 2, 3, 2. Yeah, yeah, yeah. Two, four. They count all, or you hear those, the high numbers and it's like, okay, yeah, that's a problem. You wanna have all low numbers. Mm-hmm. Right? Mm-hmm. And, um, I'm gonna start paying closer attention to that.'cause they're Yeah. Checking out gum health, right? They're actually, yeah, they're actually telling you something without telling you something called. That would be a periodontist. Periodontist. So I think the periodontist should be on board. Absolutely. You were, you were good to point that out. We're gonna make some change. Yeah. I mean they're on my, my scientific committee, but as far as being on my, you need to be on your giving you money committee. Yeah. Right. Well, that, that's where my question lies. What is it? Obviously you're onto something great here. Mm-hmm. What does it take in this world where you have medical, dental. And, uh, what was that? Science Scientist science, all those things in our minds, John and I, like, we think that's, that's all one bucket. It's not what you're saying. What is it gonna take? Is it gonna take more labs that are doing similar work to you to kind of create this culmination, like smart people? That can see what your dad's put together. Have to start seeing that. Right? Like what does it take, what do you take to get that flag going? Is it you? You've started? Yeah. How does the Kindness Chronicles? I think that'll really put it on head. I think it's gonna blow apart. Yeah. It's gonna tell to send us out. You're on top of something so exciting. Yeah. Um, and that your dad has kind of discovered Yeah. What more Does it take more, more labs? You know what, I, I have an, I, I actually have an idea. Um, yeah, we forgot you were there. Go ahead, Jeff. It's okay. We need a, we need a, we need a Minnesota version of Aaron Brach, and I think we just found Herbert. Yeah. Oh God. Aaron Brockovich. Oh, that was a compliment, Anna. Yeah. I love it. Alzheimer's, Anna, for sure. Yeah. Alzheimer's, Anna. Well, and and I'm gonna go on record as to say, I think that, you know, legitimately. Gum disease could be your second highest risk factor for Alzheimer's. And, and that is a debatable, but we're gonna see everything else that's in there. Diabetics, that's a high risk. Mm-hmm. Any of the autoimmune, autoimmune diseases, women, that's a, that's actually gen. You know, being genetically female is a high risk factor. But if you look at all those risk factors, they all share in common periodontal disease or a propensity toward. Having periodontal disease. So if you really wanna switch the numbers around, I think number one is age. This is an age related disease, and number two is periodontal disease. And if that didn't, was it, if that wasn't a mic drop, I think that's a mic drop. Yeah. It's a wake up call That is a very wake up call. Uhhuh and I, so the lessons that we've learned here, yeah. So many. This is the kindness chronicles. Yeah. You know, be kind to your, to your choppers, you know, make sure that you're keeping your, teeth in decent shape. Yeah. Um. But yeah, start reading. Exercising, we can go all kinds of places. I quit eating so much ice cream. Oh no. That's a totally different problem. Yeah. Um, but hey Jeff, this, the fact that you went about 28 minutes without saying anything is really quite remarkable. For starters, I want to, uh, acknowledge that I am certain that you did all kinds of research on this. Uh, do you have any other questions? We had the mic drop, but we still have, you know, a couple minutes here. You know, in the spirit of just kind of, this is a pretty heady, uh, scientific conversation, so I'd like try to bring some pop references. Absolutely. My. Was my lifelong hygienist. So I'm very familiar with it. And I dunno if anybody remembers the brush, brush, brush song in Greece. Oh yeah. But he used to sing that to as little kids. So I think we could maybe bring that back in the spirit of, would you like to sing some of it for us? No, I don't. Let's not do that. I'll not, it's from the fifties. No. If I were, if I were live in the studio, maybe, but no. Hey, real quick while we have you, you were at a function today, honoring your brother, Chris. Chris Hoffman. Yep. It was a social hour. Athill Brewing Company. I'm actually sitting in the parking lot right now in Ed. Doesn't Edina always get the Oh, for you? Actually, when Anna said that, uh, that Dr. Chen went to Johns Hopkins and Harvard. Harvard, yeah. In my mind it went, oh, you missed the chance. Oh, good for you. Yeah. We like to make fun of the blue bloods. Okay. Tying it in with just the legacy lab, which I love that story and was great to be reading here and learning about your dad and, um, legacies in general. But yeah, my brother Chris passed away 10 years ago this, uh, this past May. And his employer Triple Tree put a nice little gathering together and so I went down with, uh, my niece, Chris' daughter. It was really fun to share stories. So maybe we'll talk about that on a future episode. Yeah. Very nice. So it's been pretty cool. Very nice. Very cool. Anna, you've given us a lot to think about. Again, the name of your website is Thank you, curing alzheimer's disease.com. Dot com because that's our intention. Yep. We're in it to win it. Yeah. And um, CAD, CAD Foundation. CAD Foundation. Mm-hmm. Um, the fact that you're supporting this lab is just, uh, remarkable. You seem to have the entire family involved in the process to honor your father. Dr. Crandall had the, uh, for those of you that are in the white Bear Lake area, he had the dental office that's just off of, was it Stewart? Yeah. N 96. So yeah, so right off of 96 and 61. That's kinda what I'd say. It's, it looks like it's recently renovated. Dr. Andrew Lund is knocking it down. It's beautiful. It, it's, it's lovely. Do you have something? So, okay, so. I, I'll just, I can add too, you know, as a dad of two daughters, uh, who are trying to get their in the world pretty inspirational too, how, uh, a dad inspired her daughter continue on his legacy. Pretty cool story and, um, very much appreciated and looking forward to learning more about this. Anna, thank you for coming down here, but I wanna ask you. Right now what is, what's, what's in the pipeline? What's the future? What tomorrow? Do you go to the You go to the lab. Oh, you're so sweet. I wanna know where you're going right now. He really is. Yeah. No, actually that's really exciting.'cause I'm getting on a plane tomorrow, as a matter of fact. Yep. I fly up to Toronto. Ooh. So I was just Toronto asked. Right. This is such a compliment. The Alzheimer's Association International Conference asked me to come up and speak. There'll be 10,000. Researchers at that convention and I'm going up and I'm gonna be putting it out there. And you do, you speak a lot. Have you done a lot of speaking stuff? No. You're very good at present. No presenting here actually. Thank you. Nope, but I, I'm, this is my zone. This, this is the guy to help you a little bit too. Oh yeah. Some obvious, obvious tips. John, what could you tell her as a, as, just as a presenter going in cold, bring a 10,000 people. That's one. Bring a towel if you start to sweat profusely.'cause that's always my number one thing. I have a perspiration situation. no, you're Anna, tenacity times 10. I don't think that you're gonna have any problem. Uh, yeah, you're gonna kill it. I just wonder after you get done speaking, if the local Walgreens and CVSs up in Toronto are gonna be, all of their dental floss will be, uh, you know, I'm serious. Like, I can't, can't wait to go upstairs and start working on my gums. I, I mean, so what is your goal? You're there to inspire doctors and, well, actually, scientists. Scientists, yeah. So, so. Okay. True. You know, true transparency. They want to know my secret sauce in funding labs. Okay. Because that makes sense. These labs are having issues with funding now. Oh yeah. So I'm crossing those barriers. They're picking my, they're picking my brain, and I'll be challenged to see where you're getting your money from. How are you doing it? What do you recommends? Very practical advice. And, and so that, and I'm, I'm co presenting with a pretty big deal over in another. University in Oregon. But anyway, super. It's not just me, but yeah, it's exciting. And then that's a, that's the con, that's the conference to be at everything. Cutting edge. A lot of times they take your phone, uh, wow. Stuff hasn't even been published. Oh, wow. Wow. So to be up there and have that opportunity is gonna be fantastic. All right. So we, we need to be the ones who hear from you after, or, you know, like, let's stay updated because. The exciting stuff. Let's ride this train, man. She's been to do some cool stuff. Yeah. We have to be a part of telling people about where this, uh, progress is going so we can be, you know, ahead of it. The idea of taking my phone away though, it makes me very uncomfortable. Have you ever gone like 15 minutes without your phone? It's liberating. Is it? Yes. I couldn't find my phone this morning. Do you know where it is? It's liberating. You, you know it's safe. Then it's like, ah, I don't, I'm, I'm untethered kind. Well, I was, I was afraid. So here, I'm gonna just open a vein as a hypochondriac. Mm-hmm. The idea of driving to work without my phone with me. What would happen if I've turned around? Yeah, I know it's weird. Terrible, right? What would happen? Terrible if something happened and I needed my phone. You know, pretend like it's 1980, you'd be lost navigationally and mentally. Oh God. Because you couldn't listen. You couldn't listen to the Kindness Chronicles. True. And you couldn't follow Google Map. That's true. There's nothing I love more than listening to our podcast all day long anyway. Well, thank you Anna for coming. Uh yes, thank you. It's very exciting to have me coming in studio. Jeff, thanks again for, uh, for all that you do and we'll, uh, we'll see you next week of course. And Steve, as always, great to see Johnny clueless himself. Yeah, you too. Something like that. Good luck. Thanks for coming down here, Anna. Good luck. Good luck. You'll knock him that and, uh, or break a leg, whatever the saying is, try and see if you can find Aaron Brockovich on the plane. Maybe that'll inspire you. And on that note, off we go. Oh, good for you. Is this a long story?