Pomegranate Health
Pomegranate Health is a podcast about the culture of medicine. You'll hear insights from clinicians, researchers, and advocates as they tackle important questions — like how to make difficult clinical and ethical decisions without being influenced by bias, how to communicate better with patients and colleagues, and how to provide healthcare that’s both efficient and fair.
If you're a Fellow of the RACP, time spent listening can be counted toward your CPD hours. And if you're a Basic Physician Trainee, the [Case Report] series can help you prepare for your long case clinical exams.
This is also the home of [IMJ On-Air], featuring authors from the Internal Medicine Journal sharing their latest research. The [Journal Club] episodes give RACP researchers a space to talk through their work published in other academic journals. And for Basic Trainees, the [Case Report] series can help you prepare for your long case clinical exams.
Find out more at the website www.racp.edu.au/podcast and get in touch via the address podcast@racp.edu.au
Pomegranate Health
Ep102: Staying on script with semaglutide
Semaglutide, branded as Ozempic or Wegovy, is an analogue of glucagon-like peptide 1 which has glucose-dependent effects on insulin secretion. In this episode we discuss how semaglutide performs as an antihyperglycaemic agent compared to previous GLP-1 analogues and the soon-to-be launched tirzepatide. This dual agonist also binds receptors to glucose-dependent insulinotropic polypeptide, GIP.
GLP-1 and GIP are incretin hormones, secreted after food intake and involved in regulating gastric motility and appetite. The analogue therapies have resulted in weight loss of 10 to 20 percent in trials on patients with obesity or other weight-related comorbidities. For various reasons, however, they remain unsubsidised by the Pharmaceutical Benefits Scheme. This hasn’t stopped social media influencers driving up off-label demand from the wider public, creating a problem for regulators and the diabetic patients most in need.
Guests
Professor Chris Rayner MBBS PhD FRACP (Gwendolyn Michell Professor, Adelaide Medical School; Consultant Gastroenterologist, Royal Adelaide Hospital)
Professor Gary Wittert MBBch, MD, FRACP (Mortlock Professor, Adelaide Medical School; Senior Consultant Endocrinologist, Royal Adelaide Hospital)
Production
Produced by Mic Cavazzini DPhil. Music courtesy of Free Music Archive includes ‘Mister S’ by Tortue Super Sonic. Music licenced from Epidemic Sound includes ‘Multicolor’ and ‘Flower Fountain’ by Chill Cole, ‘Blacklight’ by John B Lund, and ‘Habitual’ by Ava Low. Image by Ketut Subiyanto courtesy of Pexels.
Editorial feedback kindly provided by RACP physicians Stephen Bacchi, Aidan Tan, David Arroyo, Joseph Lee, Jia-Wen Chong, Li-Zsa Tan, Fionnuala Fagan, Stella Sarlos and Marion Leighton.
Please visit the Pomegranate Health web page for a transcript and supporting references. Login to MyCPD to record listening and reading as a prefilled learning activity. Subscribe to new episode email alerts or search for ‘Pomegranate Health’ in Apple Podcasts, Spotify, Castbox or any podcasting app.