#301 - 📑 Journal Club - The Complete Episode from April 20th 2025

In this Journal Club episode, Ben and Daphna review several impactful studies shaping neonatal care. They begin with a secondary analysis of the ETTNO trial, which examined whether liberal transfusion thresholds reduce intermittent hypoxemia or improve neurodevelopmental outcomes in extremely low birth weight infants. Despite prior concerns, the study found no benefit to liberal thresholds, supporting current restrictive practices. A JAMA Network Open study follows, revealing that late preterm infants are least likely to receive mother’s own milk at 12 weeks, underscoring an overlooked group in breastfeeding support efforts. Dr. David Rube joins the show to discuss a two-year follow-up of the IN-RECSURE trial, which investigated whether lung recruitment before surfactant administration leads to improved long-term outcomes—ultimately showing no difference in death or disability. The hosts also explore a meta-analysis on umbilical cord blood therapy for children with cerebral palsy, highlighting benefits in motor function for younger children with milder CP when treated at higher doses. Additional topics include the association between funisitis and cerebral palsy in extremely preterm infants and the AZTEC trial’s conclusion that azithromycin does not reduce BPD. The episode concludes with a review of best practices for discussing autopsy with families in the NICU setting.

As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

Enjoy!