The Discovery of Viagra (aka Sildenafil) With a History of Erectile Dysfunction and Priapism Treatments

From the discovery of this well-known medication, to the science behind its function, and spanning all the way to treatments for the underlying condition of erectile dysfunction as well as a complication of said treatments called priapism, this episode covers a lot of ground.

As you might imagine, there will be discussions of male genitalia, the existence of sex, and sexual health in this one,  as written by Dr. Mike and presented in Poor Historians Podcast fashion.

Listener discretion is advised.

Sources:
-https://www.space.com/24983-auroras-1989-great-solar-storm.html

-https://pubmed.ncbi.nlm.nih.gov/26206161/

-https://en.wikipedia.org/wiki/Priapism

-https://www.mirror.co.uk/news/world-news/how-doctors-treat-impotence-before-7530711

-https://www.thedailybeast.com/the-strange-true-tale-of-the-old-timey-goat-testicle-implanting-governor

-Rezaee ME, Gross MS. Are We Overstating the Risk of Priapism With Oral Phosphodiesterase Type 5 Inhibitors? J Sex Med. 2020 Aug;17(8):1579-1582. doi: 10.1016/j.jsxm.2020.05.019. Epub 2020 Jul 2. PMID: 32622767.

-Ghofrani HA, Osterloh IH, Grimminger F. Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond. Nat Rev Drug Discov. 2006 Aug;5(8):689-702. doi: 10.1038/nrd2030. PMID: 16883306; PMCID: PMC7097805.

-https://en.wikipedia.org/wiki/Sildenafil

-https://en.wikipedia.org/wiki/Pulmonary_hypertension

-https://www.washingtonpost.com/news/retropolis/wp/2018/03/27/the-rise-of-viagra-a-history-of-the-little-blue-pill-at-20/

Goldstein I, Burnett AL, Rosen RC, Park PW, Stecher VJ. The Serendipitous Story of Sildenafil: An Unexpected Oral Therapy for Erectile Dysfunction. Sex Med Rev. 2019 Jan;7(1):115-128. doi: 10.1016/j.sxmr.2018.06.005. Epub 2018 Oct 6. PMID: 30301707.

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#medicine
#historyofpharmacy
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