Albee Messing, Mel Feany, Florian Eichler, and Ming der Perng discuss the following recent publications:
[02:21] Wang L et al. (2022) Anastasis drives senescence and non-cell autonomous neurodegeneration in the astrogliopathy Alexander disease.
Journal of Neuroscience (in press)
[reports interesting new mechanisms of astrocyte dysfunction]
[18:42] Kang YR et al. (2022). A novel in-frame GFAP p.E138_L148del mutation in Type II Alexander disease with atypical phenotypes.
European Journal of Human Genetics (in press)
[case report describing unusual variant and symptoms, podcast includes commentary on head trauma and psychiatry]
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