Hydrazaline

• Trade – Apresoline
• Class – Vasodilator 
• MOA – Directly dilates peripheral blood vessels
• Indication – HTN associated with preeclampsia and eclampsia, HTN crisis 
• Contraindication – Patients taking diazoxide or MAOI’s, coronary artery disease, stroke, angina, dissecting aortic aneurism, mitral valve and rheumatic heart disease. 
• Side effects – Headache, angina, flushing, palpitations, reflex tachycardia, anorexia, N/V, diarrhea, hypotension, syncope, peripheral vasodilation, peripheral edema, fluid retention, pareshesias. 
• Dosing

Preeclampsia and eclampsia: 

        Adult : 5-10mg IV repeat every 20-30mins until Systolic pressure of 90-105mmhg

Acute HTN ( not associated with preeclampsia )

        Adult :10-20mg IV/IM

        Pedi : 1mo – 12yr  0.1-0.2 mg/kg IV/IM max 20mg per dose