The Just MS (Multiple Sclerosis) Show
A podcast about multiple sclerosis hosted by Justin Loizos. Each episode will explore the world of MS. This will either be done through interviews with MS stakeholders or with Justin providing information about the illness. Thank you for listening.
The Just MS (Multiple Sclerosis) Show
Hidden MS Progression, NAC, Exercise & Christina Applegate Update | Just MS News 04/08 - 10 /08 2026
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This week on Just MS News, we take a closer look at three important stories from the multiple sclerosis community.
First, new research in JAMA Neurology strengthens the evidence around GFAP, a blood biomarker that may help researchers track progression independent of relapse activity, or PIRA. The study included more than 2,300 people with MS and over 18,000 blood measurements.
That story also connects with a small randomized study of high-dose N-acetyl cysteine, or NAC, in progressive MS. Participants received 1,250 mg three times daily for four weeks, and researchers observed a significant difference in GFAP levels compared with placebo. The study was very small and does not show that NAC slows MS progression, but a larger trial is already underway.
Next, we review a systematic review of exercise in people with severe MS disability. What can exercise still improve when walking is limited or disability has progressed, and why are nonambulatory people still so underrepresented in exercise research?
Finally, Christina Applegate is reportedly back home and doing very well following a months-long hospitalization. Applegate has been living publicly with MS since announcing her diagnosis in 2021.
Just MS News looks beyond the headline to explain what the research actually found, what remains uncertain, and why it may matter to people living with MS.
Sources include JAMA Neurology, Multiple Sclerosis Journal, Multiple Sclerosis and Related Disorders, University of Basel, UCSF, Neurology Advisor, and PEOPLE.
Learn more and follow the latest MS news at:
www.justmultiplesclerosis.com
This content is for news and educational purposes and is not medical advice.
The Just MS (Multiple Sclerosis) Show, w host Justin Loizos, is a podcast that connects, educates and tries to uplift others living with multiple sclerosis. It provides real-life stories, interviews, and information about DMTs (disease modification therapies) and updates on research developments.
www.justmultiplesclerosis.com
