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In this episode, Dr. Jaclyn Smeaton and DUTCH Founder Mark Newman discuss a case study published in Integrative Medicine: A Clinician’s Journal in which Mark himself was the patient. The case covers the step-by-step hormonal and metabolic effects of using HCG to boost endogenous testosterone, revealing how increasing testosterone can cascade into elevated estrogen, impaired estrogen clearance, and strained methylation capacity. 

Their conversation also highlights: 

• The benefits of combining serum testing and DUTCH testing to monitor dosing as well as metabolism, clearance, and methylation 
• How methylation is affected by raising testosterone 
• The value of tracking step-by-step supplementation plans with repeated testing 
• The importance of baseline testing before beginning testosterone therapy 
• An upcoming research publication that compares hormone testing methods for testosterone monitoring 

Read the DUTCH article and access the full IMCJ case report. 

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