The Estrogen Myth: Rethinking Hormone Therapy & Breast Cancer Risk

The DUTCH Podcast

The DUTCH Podcast
The Estrogen Myth: Rethinking Hormone Therapy & Breast Cancer Risk
May 12, 2026 Episode 153
DUTCH Test

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Join us for this episode with Dr. Jenn Simmons, an integrative breast surgeon and oncologist, alongside host Dr. Jaclyn Smeaton and DUTCH founder Mark Newman. This conversation deepens the discussion from a previous episode on hormones and breast cancer risk, challenging widely held clinical assumptions rooted in the Women's Health Initiative (WHI) study. 

This episode also explores: 

  • The critical distinction between progestins and progesterone 
  • The role of metabolic dysfunction in cancer development 
  • Breast cancer as a disease of hormone deficiency, particularly progesterone deficiency, rather than hormone excess 
  • The impact of estrogen metabolism, especially the 4-hydroxy pathway, and how the DUTCH Test can provide insight into these pathways 
  • Individualized hormone therapy for breast cancer survivors 

Show Notes 

Listen to our previous episode with Dr. Jenn Simmons

Check out the aging human breast study, the study on menopausal hormone therapy after breast cancer, and the transdermal testosterone study mentioned in this episode. 

Learn more about Dr. Jenn Simmons and follow her on Instagram @drjennsimmons

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