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In this episode, Dr. Mark Holthouse joins Dr. Jaclyn Smeaton and DUTCH founder Mark Newman to discuss a recent peer-reviewed publication from Precision Analytical, Inc. in Frontiers on hormone monitoring methods, including saliva testing, for testosterone hormone therapy. 

Their discussion also covers: 

• How saliva values spike when measuring transdermal testosterone or estradiol and the clinical impact 
• Dosing using saliva values and how it can cause overdosing or underdosing 
• The complexity of estradiol monitoring 
• The importance of relying on clinical evidence over established practice 
• Serum and urine testing’s clinical validity and how test values align with clinical outcomes 

Show Notes 

Read our DUTCH Article on the Frontiers study, Mark Newman’s commentary, and the full study here. 

Check out the resources mentioned in this episode: 

• The topical progesterone cream study in Fertility and Sterility 
• The transdermal progesterone study from Climacteric 
• Good Energy mentioned by Dr. Holthouse 
• The study on the cardiovascular safety of TRT in the New England Journal of Medicine 
• The study on testosterone threshold levels and skeletal muscle strength 

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