Let's Talk ID hosts, Buddy Creech, MD, MPH, FPIDS, Mati Hlatshwayo Davis, MD, MPH, FIDSA and Paul Sax, MD, FIDSA reunite live at IDWeek 2025 to share their hottest takes on infectious diseases and public health. They discuss the controversial dismantling of CDC, exciting breakthroughs in treating staph aureus bacteremia, and shifts that could shape the future of the field.