In one of her most personal episodes, Functional Nutrition Practitioner Kristie Calise dives deep into Mast Cell Activation Syndrome (MCAS)—a complex mast cell activation disorder that played a major role in her chronic illness journey long before it became widely recognized.

MCAS is considered one of several mast cell disorders, where mast cells—an important type of immune cell and part of your immune system—release excessive chemical mediators such as histamine. This process, known as mast cell degranulation, can affect multiple body systems and contribute to a wide range of symptoms including brain fog, stomach pain, flushing, heart rate changes, low blood pressure, allergy-like symptoms, histamine intolerance, and severe reactions.

In this episode, Kristie discusses:

• The history and diagnosis of MCAS and how it differs from systemic mastocytosis
 • Common MCAS symptoms and why many patients have normal blood tests and serum tryptase levels
 • Current diagnostic criteria, blood samples, urine tests, and genetic testing options
 • The connection between MCAS, mold exposure, chronic infections, long COVID, autoimmune diseases, Ehlers-Danlos Syndrome, and Postural Orthostatic Tachycardia Syndrome (POTS)
 • Common triggers including environmental triggers, temperature changes, high-histamine foods, stress, and infections
 • Pharmaceutical treatment options such as mast cell stabilizers and cromolyn sodium
 • Natural approaches including a low-histamine diet, lifestyle changes, nervous system support, and symptom management strategies

Kristie also shares why she believes MCAS is often a symptom of deeper dysfunction rather than a known cause itself. Whether you're dealing with MCAS flare-ups, severe symptoms, or trying to understand the root causes behind mast cell activity, this episode offers both scientific insight and personal perspective.

If you've been told your labs are normal but you're still experiencing wide-ranging symptoms, this episode may provide the validation, education, and next steps you've been searching for. 🖤

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Disclaimer: The information shared in this podcast is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. This content is not medical advice and should not be used as a substitute for professional medical guidance, diagnosis, or treatment. Always consult with your qualified healthcare provider before making changes to your health, medications, supplements, or lifestyle.