🦠 Hunting HIV: How Cytotoxic CD4+ T Cells Could Crack the Viral Hideout 🦠

Keywords

HIV, immunology, virology, immunological niches, Cytotoxic CD4 T cells, , CD137, HIV reservoirs

Summary

In this episode of the Young Immunologist Podcast ImmunoChat, Pia Leipe engages with Dr. Anna Malyshkina to explore the complexities of HIV, its interaction with the immune system, and the innovative research being conducted to combat this virus. They discuss the roles of various immune cells, the challenges of antiretroviral therapy, and the significance of immunological niches where HIV can hide. Dr. Malyshkina shares insights into her research on cytotoxic CD4 T follicular helper cells and the potential of CD137 as a target for immunotherapy. 

Takeaways

• HIV primarily targets CD4 T cells, disrupting the immune system's coordination.
• Antiretroviral therapy suppresses HIV but does not eliminate it.
• Immunological niches provide safe harbors for HIV, complicating treatment.
• CD4 T follicular helper cells can be armed to target HIV.
• CD137 is a promising target for enhancing T cell responses.

Please find here links to publications referred to in this Episode:  

https://pubmed.ncbi.nlm.nih.gov/37965314/ 

https://pubmed.ncbi.nlm.nih.gov/37883584/

https://pubmed.ncbi.nlm.nih.gov/30635687/

https://pubmed.ncbi.nlm.nih.gov/30782653/ 

https://pubmed.ncbi.nlm.nih.gov/28798348/ 

https://pubmed.ncbi.nlm.nih.gov/26608920/

https://pubmed.ncbi.nlm.nih.gov/37910505/

Contact details

·      Dr. Anna Malyshkina 

·      LinkedIn: https://www.linkedin.com/in/anna-malyshkina-776324178/

·      Institute of Physiology Essen: https://www.uni-due.de/physiologie/

·      Institute for Virology Essen: https://www.uni-due.de/virologie/

·    ELAN Proposal UDE: https://www.unidue.de/med/promotionskolleg/evaluierte_projekte.php