Neuroscience and Beyond
We are a team of PhD students located in Göttingen, Germany, who share a passion about neuroscience and science communication. On a monthly basis we talk with experts in neuroscience and discuss their research, career path, struggles along the way and current problems in the field. Supported by the International Max Planck Research School for Neurosciences as well as the Cluster of Excellence "Multiscale Bioimaging" in Göttingen. The content of the podcast represents our personal opinions and is separate from the institutions we are working at. Ideas are our own!
Neuroscience and Beyond
Beyond DNA: epigenetic mechanisms of inheritance and progress in research on Alzheimer’s disease
In this episode we talk to Prof. André Fischer, Director at the German Center for Neurodegenerative Diseases (DZNE) site Göttingen and Professor at the Department for Psychiatry and Psychotherapy, University Medical Center Göttingen. The focus of this interview is on understanding epigenetics - the mechanism of inheritance and determination of some traits outside the DNA code. You will learn how this mechanism can be linked to memory and neurodegenerative diseases. We talk extensively about the possible causes, treatment and prevention of Alzheimer's disease. We also touch on some problems in academia and comparison between the German and American approach to research.
Our channel is supported by International Max Planck Research School (IMPRS) for Neurosciences as well as Cluster of Excellence Multiscale Bioimaging (MBExC) in Göttingen, Germany. The views presented on this channel are not representative of IMPRS or MBExC.
Timestamps:
00:00:00 Intro
00:02:05 Motivation for doing science
00:04:30 Research and lifestyle in the US
00:14:47 Why Göttingen? Recruitment for academic positions in Germany
00:19:13 DZNE - German Centre for Neurodegenerative Diseases
00:27:54 Research interest: neurodegenerative diseases (e.g. Alzheimer’s)
00:32.37 What is epigenetics?
00:36:00 Link between epigenetics and neurodegenerative disease
00:51:50 Transgenerational epigenetics and an updated theory of evolution
00:56:50 Preventive strategies of living organisms against neurodegeneration: how to protect yourself from Alzheimer’s disease?
01:03:00 What causes AD and how is it treated?
01:18:06 Epigenetic biomarkers: ways of early identification of the disease
01:27:20 Problems in academia: funding
01:34:30 Problems in academia: reproducibility issues
References: All illustrations were created with BioRender.com unless stated otherwise: Fagan, M.B. (2011) ‘Waddington Redux: Models and explanation in Stem Cell and Systems Biology’, Biology & Philosophy, 27(2), pp. 179–213. doi:10.1007/s10539-011-9294-y https://www.tebubio.com/blog/writing-erasing-reading-epigenetics-targeting-erasers-in-drug-discovery/
Intro music by penguinmusic from Pixabay Following footage downloaded from videvo.net: Storage of samples in a hospital setting. Ungraded Prores file by MaartenLCF A scientist adjusting the magnification on a microscope by Videvo
Stock footage provided by Pressmaster Like and subscribe animation downloaded from SweetPhilMedia
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Neuroscience and Beyond team:
Svilen Georgiev
Kristina Jevdokimenko
Sabina Nowakowska
Lennart Schneider
#neuroscience #epigenetics #Alzheimer #AlzheimersDisease #AcademicChatter #SciComm #podcast #science #brain #göttingen #IMPRS #MBExC #evolution #inheritance