Neuroscience and Beyond
We are young researchers at the forefront of neuroscience in Göttingen, Germany, driven by a passion for discovery and communication. In our monthly conversations, we go beyond publications to discuss the real stories with leading experts: their revolutionary work, their personal paths, the struggles they've overcome, and the big questions driving the field forward.
Our mission is built on a simple, powerful idea: knowledge is the only resource that grows when shared. Through open dialogue, we aim to build a bridge between cutting-edge research and the curious minds eager to understand it.
Supported by the International Max Planck Research School for Neurosciences, the European Neuroscience Institute in Göttingen, the Cluster of Excellence "Multiscale Bioimaging" in Göttingen and SFB1286 Quantitative Synaptology in Göttingen.
This podcast reflects our personal views and is separate from our affiliated institutions.
Neuroscience and Beyond
Super-resolution microscopy reveals the secret of neuronal architecture | Dr. Christophe Leterrier
In this episode, we speak with Christophe Letterrier, PhD, the leader of the NeuroCyto research group at the Institute of Neurophysiopathology, Aix-Marseille University. We dive deep inside neurons, discussing the structural support and trafficking system in the cells - the cytoskeleton. Visualising molecules comprising this structure requires super-resolution microscopy, hence, we explore cutting-edge techniques from the world of imaging. Dr. Leterrier emphasises the importance of the community and open science principles in research and tool development. Finally, we address challenges in the publishing system and the mindset required for an academic career. Our channel is supported by International Max Planck Research School (IMPRS) for Neurosciences as well as Cluster of Excellence Multiscale Bioimaging (MBExC) in Göttingen, Germany. The views presented on this channel are not representative of IMPRS or MBExC.
Timestamps:
00:00:00 Intro
00:03:00 Early career and motivation for doing science
00:09:17 Establishing own research group in Marseille, France
00:11:47 Cell architecture, trafficking, cytoskeleton and the molecules involved 00:17:54 Origin of action potentials - electric pulses in the neurons.
00:21:23 Relevance of basic research
00:24:25 Neuronal cultures: studying neurons in a dish
00:29:42 Super-resolution microscopy
00:34:27 Single molecule localisation microscopy: STORM, SIM and imaging living cells 00:45:57 Open science algorithms for image analysis (SRRF)
00:51:19 Combining different techniques: platinum replica electron microscopy and STORM
00:55:39 Social media as a way of fostering scientific community
01:02:47 Failures in academia
01:07:07 Problems in academia: publishing and reviewing system
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Neuroscience and Beyond team:
Svilen Georgiev
Kristina Jevdokimenko
Sabina Nowakowska
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