Neuroscience and Beyond
We are a team of PhD students located in Göttingen, Germany, who share a passion about neuroscience and science communication. On a monthly basis we talk with experts in neuroscience and discuss their research, career path, struggles along the way and current problems in the field. Supported by the International Max Planck Research School for Neurosciences as well as the Cluster of Excellence "Multiscale Bioimaging" in Göttingen. The content of the podcast represents our personal opinions and is separate from the institutions we are working at. Ideas are our own!
Neuroscience and Beyond
Super-resolution microscopy reveals the secret of neuronal architecture | Dr. Christophe Leterrier
In this episode, we speak with Christophe Letterrier, PhD, the leader of the NeuroCyto research group at the Institute of Neurophysiopathology, Aix-Marseille University. We dive deep inside neurons, discussing the structural support and trafficking system in the cells - the cytoskeleton. Visualising molecules comprising this structure requires super-resolution microscopy, hence, we explore cutting-edge techniques from the world of imaging. Dr. Leterrier emphasises the importance of the community and open science principles in research and tool development. Finally, we address challenges in the publishing system and the mindset required for an academic career. Our channel is supported by International Max Planck Research School (IMPRS) for Neurosciences as well as Cluster of Excellence Multiscale Bioimaging (MBExC) in Göttingen, Germany. The views presented on this channel are not representative of IMPRS or MBExC.
Timestamps:
00:00:00 Intro
00:03:00 Early career and motivation for doing science
00:09:17 Establishing own research group in Marseille, France
00:11:47 Cell architecture, trafficking, cytoskeleton and the molecules involved 00:17:54 Origin of action potentials - electric pulses in the neurons.
00:21:23 Relevance of basic research
00:24:25 Neuronal cultures: studying neurons in a dish
00:29:42 Super-resolution microscopy
00:34:27 Single molecule localisation microscopy: STORM, SIM and imaging living cells 00:45:57 Open science algorithms for image analysis (SRRF)
00:51:19 Combining different techniques: platinum replica electron microscopy and STORM
00:55:39 Social media as a way of fostering scientific community
01:02:47 Failures in academia
01:07:07 Problems in academia: publishing and reviewing system
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Neuroscience and Beyond team:
Svilen Georgiev
Kristina Jevdokimenko
Sabina Nowakowska
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