MedLink Neurology Podcast is delighted to feature selected episodes from BrainWaves, courtesy of James E Siegler MD, its originator and host. BrainWaves is an academic audio podcast whose mission is to educate medical providers through clinical cases and topical reviews in neurology, medicine, and the humanities, and episodes originally aired from 2016 to 2021.
Originally released: July 18, 2017
The Landry-Guillain-Barre-Strohl Syndrome, aka Guillain-Barre Syndrome, is classically thought of as a painless ascending weakness with areflexia that typically follows an infectious prodrome. But there are a dozen variants with unusual clinical presentations, from back pain to pandysautonomia. And sometimes Guillain-Barre Syndrome follows a vaccination rather than a viral infection. In this BrainWaves episode, we discuss these and other unique facts regarding the history, clinical manifestations, and treatment of this polyneuropathy. BrainWaves podcasts and online content are intended for medical education only and should not be used to guide medical decision-making in routine clinical practice. Any cases discussed in this episode are fictional and do not contain any patient health-identifying information.
REFERENCES
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Asbury AK. Guillain-Barré syndrome: historical aspects. Ann Neurol 1990;27 Suppl:S2-6. PMID 2194421
Bril V, Katzberg HD. Acquired immune axonal neuropathies. Continuum (Minneap Minn) 2014;20(5 Peripheral Nervous System Disorders):1261-73. PMID 25299281
Dimachkie MM, Saperstein DS. Acquired immune demyelinating neuropathies. Continuum (Minneap Minn) 2014;20(5 Peripheral Nervous System Disorders):1241-60. PMID 25299280
Iodice V, Sandroni P. Autonomic neuropathies. Continuum (Minneap Minn) 2014;20(5 Peripheral Nervous System Disorders):1373-97. PMID 25299288
Lehmann HC, Hartung HP, Kieseier BC, Hughes RA. Guillain-Barré syndrome after exposure to influenza virus. Lancet Infect Dis 2010;10(9):643-51. PMID 20797646
Tam CC, O'Brien SJ, Petersen I, Islam A, Hayward A, Rodrigues LC. Guillain-Barré syndrome and preceding infection with campylobacter, influenza and Epstein-Barr virus in the general practice research database. PLoS One 2007;2(4):e344. PMID 17406668
We believe that the principles expressed or implied in the podcast remain valid, but certain details may be superseded by evolving knowledge since the episode’s original release date.
