The Dr. Francavilla Show

Carolynn Francavilla, MD is Board Certified in Family Medicine and a Diplomate of the American Board of Obesity Medicine. She owns and operates Green Mountain Partners for Health and Colorado Weight Care. Dr. Francavilla is a nationally recognized obesity expert, lecturing on the topic obesity as well as through her own platform HelpYourPatientsLoseWeight.com. She serves on the Obesity Medicine Association Board of Trustees. She is an Assistant Professor at Rocky Vista University and Volunteer Faculty at the University of Colorado School of Medicine. She is passionate about helping people lose weight to treat and prevent medical problems. Dr. Francavilla has learned that losing weight and keeping it off is complex and not a matter of will power, but biology, and seeks to help others finds healthy longterm solutions to their weight.

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The Dr. Francavilla Show

Weird Weight Loss Side Effects

May 26, 2025 • Dr. Francavilla

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Ever lost a lot of weight like 40, 50 pounds or more and noticed some unexpected changes in your body?

In today’s episode, we’re talking about the surprising (and sometimes downright weird) side effects that don’t get mentioned much when it comes to major weight loss—whether it’s from lifestyle changes or medications like Zepbound or Wegovy.

For example, some people develop Eustachian tube dysfunction, which can make your ears feel blocked or pop unexpectedly. Sitting might even feel uncomfortable now that the fat cushioning your tailbone is gone.

Then there’s “slimmer’s paralysis”—a temporary nerve irritation that can pop up when the fat around certain nerves disappears. You might also spot new lumps or bumps, or find yourself feeling colder than usual since fat helps keep you warm.

Other changes can include lower blood pressure and shifts in your menstrual cycle as your body adjusts.

Want to hear more about these lesser-known effects and how to deal with them? Tune in to the full episode!

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