Can a test tell me if Wegovy or Zepbound will work for me? With Dr. Andres Acosta of Phenomix Artwork

The Dr. Francavilla Show

Carolynn Francavilla, MD is Board Certified in Family Medicine and a Diplomate of the American Board of Obesity Medicine. She owns and operates Green Mountain Partners for Health and Colorado Weight Care. Dr. Francavilla is a nationally recognized obesity expert, lecturing on the topic obesity as well as through her own platform HelpYourPatientsLoseWeight.com. She serves on the Obesity Medicine Association Board of Trustees. She is an Assistant Professor at Rocky Vista University and Volunteer Faculty at the University of Colorado School of Medicine. She is passionate about helping people lose weight to treat and prevent medical problems. Dr. Francavilla has learned that losing weight and keeping it off is complex and not a matter of will power, but biology, and seeks to help others finds healthy longterm solutions to their weight.

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Can a test tell me if Wegovy or Zepbound will work for me? With Dr. Andres Acosta of Phenomix

September 08, 2025 • Dr. Francavilla

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Ever wonder why the same weight loss plan can work wonders for one person but barely move the needle for another?

Or why some people respond really well to medications like Wegovy, while others struggle with side effects or see minimal results? That’s exactly what precision obesity medicine aims to answer—and today, we’re diving into it with one of the world’s leading experts.

We’re joined by Dr. Andres Acosta, a true pioneer in obesity medicine and the creator of the obesity phenotypes concept. He’s board-certified in internal medicine, gastroenterology, hepatology, obesity medicine, and nutrition. At the Mayo Clinic, he co-directs the Nutrition and Obesity Research Program and leads the Precision Medicine for Obesity program, focusing on matching the right treatment to the right patient with fewer side effects.

Dr. Acosta’s research is supported by the National Institutes of Health, with more than 145 peer-reviewed papers in top journals. His work has been featured in The New York Times, TIME, CNN, and NPR, and he’s earned “40 Under 40” recognition and co-founded Genomic Sciences—just a glimpse of his many accomplishments.

If you’ve ever felt frustrated by trial-and-error weight loss or wondered if there’s a more scientific way to find what actually works for you, you’re going to want to hear what Dr. Acosta shares in this episode.

Connect with Dr. Acosta:

Mayo Clinic: mayu.edu
Phenomix Sciences: Website

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Facebook: Help Your Patients Lose Weight with Dr. Francavilla
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GLP Strong: glpstrong.com