The Dr. Francavilla Show

Micro-Dosing GLPs Like Wegovy and Zepbound — Do We Even Need To???

Dr. Francavilla

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What If the Lowest Dose Isn't Actually the Safest Dose?

If you've spent any time in weight loss or wellness spaces online, you've probably come across the term microdosing — and chances are, it was framed as the smarter, gentler, more mindful way to use GLP-1 medications. But is that actually true? That's exactly what we're digging into today.

In this episode, we cover:

  • Is "Microdosing" GLP-1s Actually a Thing? — Where the term came from, why it took off, and whether it holds up clinically.
  • The Right Dose Is the One That's Actually Working for You — What therapeutic dosing actually means and how to know if yours is doing its job.
  • Weight Loss Is a Side Effect, Not Always the Goal — Why the scale isn't the only thing worth tracking — and what to measure instead.
  • There Is No Prize for the Lowest Dose — The real cost of staying subtherapeutic and why "less is more" doesn't always apply here.

There is no prize for taking the lowest dose. The goal isn't to stay as low as possible, and it isn't to push as high as possible either. The goal is to find the dose that actually works for you — for your body, your health conditions, and your specific outcomes. Check out the full episode and give it a listen — it's worth your time.

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