The Metabolic Link

Journal Club: Prenatal Sugar Exposure & a Metabolic Therapy Framework for Brain Cancer | Ep.71

Dr. Dominic D'Agostino PhD, Dr. Angela Poff PhD, and Victoria Field Episode 71

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In this Journal Club edition of The Metabolic Link, hosts - Victoria Field, Dr. Dominic D’Agostino, and Dr. Angela Poff dissect two powerful papers reshaping our understanding of metabolic health. First up: a striking human study showing that exposure to sugar rationing during the first 1,000 days of life reduced the risk of type 2 diabetes and hypertension decades later—offering a rare glimpse into how early-life nutrition programs lifelong health. Then, the team dives into a landmark publication proposing a clinical research framework for ketogenic metabolic therapy in glioblastoma. With insights on developmental programming, public policy, and personalized metabolic approaches to cancer, this is a must-listen for anyone passionate about where science meets societal change.

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Read both papers here: 

  1. Exposure to sugar rationing in the first 1000 days of life protected against chronic disease
  2. Clinical research framework proposal for ketogenic metabolic therapy in glioblastoma

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