Ready for a quick dive into the connection between diet and cognitive health? In this Doctor Journal Club Podcast episode, Dr. Joshua Goldenberg swiftly unpacks the Mind Diet Trial for dementia, a major study from 2023. Discover why a Mediterranean and Dash-inspired diet in high-risk elderly adults didn't show significant cognitive differences. Dr. Goldenberg's rapid analysis gives you a speedy overview of Alzheimer's prevention. Plus, catch tips on evaluating medical literature and a glimpse into our EBM Boot Camp for clinicians. Get set for a fast-paced journey into medical research and eye-opening insights!
Ready for a quick dive into the connection between diet and cognitive health? In this Doctor Journal Club Podcast episode, Dr. Joshua Goldenberg swiftly unpacks the Mind Diet Trial for dementia, a major study from 2023. Discover why a Mediterranean and Dash-inspired diet in high-risk elderly adults didn't show significant cognitive differences. Dr. Goldenberg's rapid analysis gives you a speedy overview of Alzheimer's prevention. Plus, catch tips on evaluating medical literature and a glimpse into our EBM Boot Camp for clinicians. Get set for a fast-paced journey into medical research and eye-opening insights!
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Introducer:
Welcome to the Doctor Journal Club podcast, the show that goes on to the hood of evidence-based integrative medicine. We review recent research articles, interview evidence-based medicine thought leaders and discuss the challenges and opportunities of integrating evidence-based and integrative medicine. Continue your learning after the show at www. doctorjournalclub. com.
Josh:
We have all these observational studies and some suggestive data. That diet may be associated that people that have a quote unquote better diet or a more Mediterranean-like diet or a dash-like diet, which is the diet for originally developed for hypertension. They may have improved cognition compared to those that don't follow these types of diets. What happened was with the Mind Diet. They designed a diet that's primarily based around the Mediterranean diet and the dash diet with a few other things that have been found in the literature to perhaps be protective against cognitive decline et cetera, and they package it together in a diet. Then they have this massive randomized controlled trial over many years. Over 600 patients were randomized or participants were randomized. They were looking at elderly adults, so over 65, they had to have a suboptimal diet and had to be overweight so that a diet would be useful to them and to have a family history of dementia. They themselves did not have cognitive issues nor dementia, but they were at higher risk because of family history. That was the population we're looking at prevention in this type of population. They gave them the Mind Diet plus mild caloric restriction over a three-year period compared to similar strength of intervention for the same amount of caloric restriction over three years. And they looked at cognition scores as well as MRIs between groups and what they found was that the Mind Diet trial improved in their cognition by.2 standardized cognition units and the control group increased as well by somewhat similar. The difference was essentially minuscule. The confidence interval there and the p-value being over 0.05 tells you, of course, that difference is not statistically significant and I would highly doubt it would be clinically significant as well. They also looked at MRIs, which were also similar between two groups. So guidance for this large randomized, controlled trial, very well conducted Guidance for a sort of Alzheimer's prevention specific diet. This Mind Diet did not seem to lead to difference in cognition or MRI brain imaging, at least over a three-year period, when following this diet, compared to following a similar recommendation scheduled for general caloric restriction.
Josh:
Dr Adam Sadowski goes into great detail in the basic and in-depth level of this video, so go ahead and check those out . If you have any questions, of course, reach out to us. We'll see you next time. If you enjoy this podcast, chances are that one of your colleagues and friends probably would as well. Please do us a favor and let them know about the podcast. And if you have a little bit of extra time, even just a few seconds, if you could rate us and review us on Apple Podcast or any other distributor, it would be greatly appreciated. It would mean a lot to us and help get the word out to other people that would really enjoy our content. Thank you.
Introducer:
Thank you for listening to the Dr Journal Club Podcast, the show that goes under the hood of evidence-based integrative medicine. We review recent research articles, interview evidence-based medicine thought leaders and discuss the challenges and opportunities of integrating evidence-based and integrative medicine. Be sure to visit www. drjournalclub. com to learn more.