The Diagnostic Minute

MiniReview: Intrahepatic cholangiocarcinoma (iCCA) (0:06:10)

EssentialPathology, NNMI

Feature Summary of iCCA in Keywords:

  1. Small duct iCCA: Mass forming. mucin-poor. CRP positive. BAP1, IDH1/2 mutation, and FGFR2 fusion.
  2. Large duct iCCA:  geographic infiltrative. mucin-producing columnar epithelium. S100P-positive. Mutations in K -ras and SMAD4.
  3. Cholangioblastic cholangiocarcinoma: Women. young age. neuroendocrine-like cytology. inhinbin-positive. and NIPBL-NACC1 gene fusion.