The Diagnostic Minute
The Diagnostic Minute delivers concise and pragmatic diagnostic insights in a scholarly format. Each episode features a specific diagnostic topic in a succinct and clear manner in just a few minutes. Our team of experts draws from their extensive clinical experience and the latest evidence-based research to provide you with the most up-to-date information. (www.essentialpathology.info).
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The content of "The Diagnostic Minute" is intended for educational and training purposes only. The information provided in this podcast is not intended to diagnose, treat, cure, or prevent any disease or medical condition. The podcast is not a substitute for professional medical advice, diagnosis, or treatment. EssentialPathology, NNMI, LLC, and its affiliates do not endorse any specific treatment, drug, test, or medical procedure discussed in the podcast.
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The Diagnostic Minute
Synopsis: Gli-1-Altered Tumors, an emerging diagnostic entity (Gli-1) (0:30:51)
Feature Summary of Gli-1-altered Tumors
1. A distinct group of mesenchymal neoplasms with low malignant behavior.
2. Found in a wide variety of organ sites.
3. Multinodular or plexiform growth patterns, and monomorphic round to spindle epithelioid tumor cells.
4. Positive for CD56 and S100, but highly variable immunohistochemical stain profile.
5. Gli-1 gene fusion involving ACTB, MALAT1, and PTCHI gene partners is characteristic.
6. Gli-1 gene amplification accompanied by co-amplification of other genes mapped to the chromosome 12q13 to q15 region.
7. Main differential diagnosis include solitary fibrous tumor, glomus tumor, clear cell sarcoma, and follicular dendritic cell sarcoma.
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Disclaimer The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates, from any and all claims, damages, and expenses arising from the use or misuse of the information provided in the podcast.