The Diagnostic Minute

Synopsis: Yolk Sac Tumor of the Ovary (00:02:30)

EssentialPathology, NNMI Season 2026 Episode 13

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0:00 | 2:30

Key Feature Summary of Yolk Sac Tumor

  1. Second most common malignant germ cell tumor
  2. Elevated serum alpha-fetoprotein (AFP)
  3. Friable, hemorrhagic, solid and cystic mass
  4. Reticular or microcystic pattern is most common
  5. Schiller-Duval bodies are pathognomonic but variable
  6. IHC: positive for SALL4 and glypican-3; negative for CD30
  7. Main differential diagnosis: clear cell carcinoma and embryonal carcinoma

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