The Egg Factor

Understanding DOR, POA, and POI

Center For Human Reproduction

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0:00 | 7:30

What do Diminished Ovarian Reserve (DOR), Premature Ovarian Aging (POA), and Primary Ovarian Insufficiency (POI) really mean—and how are they different?

In this episode of The Egg Factor, Dr. Sonia Gayete-Lafuente breaks down these often-confused diagnoses, explaining how they're identified, what they mean for fertility, and the treatment options available. Whether you're navigating your own fertility journey or simply looking to better understand ovarian health, this conversation offers clear, evidence-based insights to help you make informed decisions.

Brought to you by the Center for Human Reproduction (CHR) on the Upper East Side of New York City. With over 40 years of experience and a history of innovation, CHR has been at the forefront of fertility care since the beginning. 

Our founder, Dr. Norbert Gleicher, reported the first successful transvaginal egg retrieval in human history, helping to shape the future of IVF as we know it today. CHR is known for tackling some of the most challenging fertility cases—especially women over 40 and those with diminished ovarian reserve—by offering highly individualized, evidence-based care when others often turn patients away.

Our team has published more than 450 peer-reviewed research papers advancing reproductive medicine, reflecting our deep commitment not only to patient care but to the science that drives better outcomes. At CHR, you're never just a number. You're part of a community focused on giving you the personalized support, science, and hope you deserve.

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