Bench Boost by Inorganic Ventures
Join our host and Inorganic Ventures Technical Director, Mike Booth, as he sparks insightful conversations with our panel of experts in Bench Boost, your go-to podcast for analytical chemistry enthusiasts. Together, they explore the realm of ICP, sharing tips and tricks and diving deep into all things analytical chemistry.
Bench Boost by Inorganic Ventures
Common Tips for Analyzing Low Concentrations
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This week on Bench Boost Mike shares practical tips for analyzing pharmaceutical samples at low concentrations for USP 232 elemental impurities, emphasizing that high dilution makes small contamination or carryover issues critical. He advises minimizing contamination through careful container selection (avoiding glass and using acid-leached LDPE or leached polypropylene), and outlines a typical leaching process using dilute nitric acid for seven days. He also stresses using high-purity acids (ppb/ppt grade) and method blanks to monitor impurities. For trace measurements, he recommends tightening calibration ranges with more points near the LOD/LOQ, managing washout by running blanks before/after calibration and throughout batches, using appropriate internal standards to correct drift or suppression, recalibrating about every 20 samples, and understanding signal-to-noise requirements for LOD and LOQ.
