In this episode, we dive deep into the world of lipids and their crucial role in our bodies. Lipids, or fats, are essential for many bodily functions but pose a challenge when circulating in our watery bloodstream. We explore how the body packages these lipids with apolipoproteins to form lipoproteins, making them safe for transport. We discuss the differences between high-density lipoprotein (HDL), low-density lipoprotein (LDL), and the particularly harmful lipoprotein(a) or Lp(a). Discover the factors influencing Lp(a) levels and the dangers of high Lp(a), including plaque buildup, blood clots, and inflammation. Learn about current and emerging treatments, from PCSK9 inhibitors to promising new antisense oligonucleotides (ASOs) and small interfering RNA (siRNAs) that aim to tackle high Lp(a) at the genetic level. Tune in to understand the complexities of lipoproteins and the ongoing research that could revolutionize how we manage cardiovascular health.

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References:
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Koren, M.J. & Lopez, A. (Hosts). (2023). Two docs talk advanced lipids. [Podcast Episode]. In MedEvidence! Truth Behind the Data. MedEvidence.

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