In this episode, we delve into the fascinating world of kidneys, those incredible organs that tirelessly filter our blood and regulate our body’s fluids. We’ll explore the complexities of autosomal dominant polycystic kidney disease (ADPKD), a genetic condition that affects a small percentage of the population but can lead to severe outcomes like kidney failure. Join us as we uncover the latest research, including how animal studies and genetic analysis are helping scientists understand the mechanisms behind this disease. We’ll also discuss the ongoing efforts to find effective treatments and the crucial role of clinical research in advancing our knowledge of ADPKD.

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References:
Bennett, W. M. (2009). Autosomal dominant polycystic kidney disease: 2009 update for internists. The Korean journal of internal medicine, 24(3), 165.

Bergmann, C., Guay-Woodford, L. M., Harris, P. C., Horie, S., Peters, D. J., & Torres, V. E. (2018). Polycystic kidney disease. Nature reviews Disease primers, 4(1), 50. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592047/

Chapman, A. B. (2008). Approaches to testing new treatments in autosomal dominant polycystic kidney disease: insights from the CRISP and HALT-PKD studies. Clinical Journal of the American Society of Nephrology, 3(4), 1197-1204.

Halvorson, C. R., Bremmer, M. S., & Jacobs, S. C. (2010). Polycystic kidney disease: inheritance, pathophysiology, prognosis, and treatment. International journal of nephrology and renovascular disease, 69-83. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108786/

Patel, V., Chowdhury, R., & Igarashi, P. (2009). Advances in the pathogenesis and treatment of polycystic kidney disease. Current opinion in nephrology and hypertension, 18(2), 99-106. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820272/