Today we delve into the intricate relationship between diabetes and gastrointestinal health, focusing on a condition known as gastroparesis. Gastroparesis slows down the stomach's ability to empty food, a condition exacerbated by diabetes. The episode explores how diabetes disrupts the normal functioning of the enteric nervous system—our body's "second brain" that governs gut movements. This system, rich with neurons and interstitial cells of Cajal, orchestrates the rhythmic contractions of the gut's smooth muscles but is vulnerable to the high blood sugars characteristic of uncontrolled diabetes. The resultant neuronal damage and impaired muscle function slow stomach and intestinal transit, complicate nutrient absorption, and worsen diabetic symptoms. We also cover current treatments for gastroparesis, such as dietary modifications and medications that target dopamine receptors, offering hope and management strategies for those affected.

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References:
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