As we approach Thanksgiving and gather with family, it's the perfect time to ponder how our genetics, from eye color to cholesterol levels, shape our lives in unique and sometimes dangerous ways. This episode sheds explores how genetic disorders run in families and looks at lipoprotein (a), a very very very very bad kind of cholesterol. We also learn how to get a free cholesterol check that can identify high levels of this dangerous genetic cholesterol which affects up to 20% of the population through cholesterolconnect.com

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References:
https://www.cholesterolconnect.org/

Bhatia, H. S., Becker, R. C., Leibundgut, G., Patel, M., Lacaze, P., Tonkin, A., ... & Tsimikas, S. (2024). Lipoprotein (a), platelet function and cardiovascular disease. Nature Reviews Cardiology, 21(5), 299-311. https://www.nature.com/articles/s41569-023-00947-2

Boffa, M. B., & Koschinsky, M. L. (2019). Oxidized phospholipids as a unifying theory for lipoprotein (a) and cardiovascular disease. Nature Reviews Cardiology, 16(5), 305-318. https://www.nature.com/articles/s41569-018-0153-2

Centers for Disease Control. (n.d.). About cascade testing. Cascade Testing. [Website]. Accessed 14 November, 2024. https://www.cdc.gov/cascade-testing/about/index.html

Koren, M.J. & Helow, V. (Hosts). (2024).Cracking the lipid code. [Podcast Episode]. In MedEvidence! Truth Behind the Data. MedEvidence. https://medevidence.com/cracking-the-lipid-code

Kronenberg, F., & Utermann, G. (2013). Lipoprotein (a): resurrected by genetics. Journal of internal medicine, 273(1), 6-30. https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2796.2012.02592.x

Lee, C., Rivera-Valerio, M., Bangash, H., Prokop, L., & Kullo, I. J. (2019). New case detection by cascade testing in familial hypercholesterolemia: a systematic review of the literature. Circulation: Genomic and Precision Medicine, 12(11), e002723. https://www.ahajournals.org/doi/abs/10.1161/CIRCGEN.119.002723