In this week's episode, we explore hypertriglyceridemia: high triglyceride levels in the blood. We look at what triglycerides are, why they might be elevated, and some of the risks and causes of hypertriglyceridemia. We also look at the pivotal role clinical research has and continues to play in controlling this dangerous condition, and give a powerful look at what's being investigated now in the research space.

References:

• Reeskamp LF, Tromp TR, Stroes ES. The next generation of triglyceride-lowering drugs: will reducing apolipoprotein C-III or angiopoietin like protein 3 reduce cardiovascular disease?. Current opinion in lipidology. 2020 Jun 1;31(3):140-6. https://doi.org/10.1097/MOL.0000000000000679
• Laufs U, Parhofer KG, Ginsberg HN, Hegele RA. Clinical review on triglycerides. European heart journal. 2020 Jan 1;41(1):99-109c. https://doi.org/10.1093/eurheartj/ehz785
• Mohamed F, Mansfield BS, Raal FJ. ANGPTL3 as a drug target in hyperlipidemia and atherosclerosis. Current Atherosclerosis Reports. 2022 Dec;24(12):959-67. https://doi.org/10.1007/s11883-022-01071-1
• Ward NC, Chan DC, Watts GF. A tale of two new targets for hypertriglyceridaemia: which choice of therapy?. BioDrugs. 2022 Mar 14;36(2):121. https://doi.org/10.1007/s40259-022-00520-2
• Robciuc MR, Maranghi M, Lahikainen A, Rader D, Bensadoun A, Öörni K, Metso J, Minicocci I, Ciociola E, Ceci F, Montali A. Angptl3 deficiency is associated with increased insulin sensitivity, lipoprotein lipase activity, and decreased serum free fatty acids. Arteriosclerosis, thrombosis, and vascular biology. 2013 Jul;33(7):1706-13. https://doi.org/10.1161/ATVBAHA.113.301397
• Reeskamp, L. F., Tromp, T. R., Huijgen, R., Stroes, E. S., Hovingh, G. K., & Grefhorst, A. (2020). Statin therapy reduces plasma angiopoietin-like 3 (ANGPTL3) concentrations in hypercholesterolemic patients via reduced liver X receptor (LXR) activation. Atherosclerosis, 315, 68-75. https://doi.org/10.1016/j.atherosclerosis.2020.11.013

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