On this week's episode we investigate the molecule amylin, a hormone that also affects the body and brain. Amylin is released in response to eating, and helps us know when we're full. We look at what amylin is, how it works, and how investigational versions of the hormone may help with obesity and weight loss.

References:

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• Billings LK, Hsia S, Bays H, Tidemann-Miller B, O’Hagan J, San Tham L, Butler A, Kazda C, Mather KJ, Coskun T. Eloralintide, a selective amylin receptor agonist for the treatment of obesity: a 48-week phase 2, multicentre, double-blind, randomised, placebo-controlled trial. The Lancet. 2025 Dec 6;406(10520):2631-43. https://doi.org/10.1016/S0140-6736(25)02155-5
• Volčanšek Š, Koceva A, Jensterle M, Janež A, Muzurović E. Amylin: From mode of action to future clinical potential in diabetes and obesity. Diabetes Therapy. 2025 May 7:1-21. https://link.springer.com/article/10.1007/s13300-025-01733-8
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• Koren MJ, Schramm E. Beyond blood sugar: How science tackles obesity and diabetes. MedEvidence! Articles. February 11, 2026. Accessed February 11, 2026. https://medevidence.com/beyond-blood-sugar-how-science-tackles-obesity-and-diabetes
• NIDDK. Overweight & Obesity Statistics. U.S. Department of Health and Human Services. https://www.niddk.nih.gov/health-information/health-statistics/overweight-obesity Accessed December 22, 2025.
• UConn Rudd Center for Food Policy and Health. Food marketing. University of Connecticut. Accessed February 11, 2026. https://uconnruddcenter.org/research/food-marketing/
• Center for Drug Evaluation and Research. Application number 21-332: Approval package. US Food and Drug Administration. Published February 9, 2005. Accessed Feburary 11, 2026. https://www.accessdata.fda.gov/drugsatf

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