In this week's episode, we explore the most common type of degenerative joint disease, osteoarthritis. We look at the risks of getting the disease, complications and symptoms, and what can be done about it. We also look at what may be next on the horizon; clinical trials targeting degenerative joint disease in myriad ways.

References:

• Murphy L, Schwartz TA, Helmick CG, Renner JB, Tudor G, Koch G, Dragomir A, Kalsbeek WD, Luta G, Jordan JM. Lifetime risk of symptomatic knee osteoarthritis. Arthritis Care & Research: Official Journal of the American College of Rheumatology. 2008 Sep 15;59(9):1207-13. https://doi.org/10.1002/art.24021
• Allen KD, Thoma LM, Golightly YM. Epidemiology of osteoarthritis. Osteoarthritis and cartilage. 2022 Feb 1;30(2):184-95. https://doi.org/10.1016/j.joca.2021.04.020
• Mobasheri A, Batt M. An update on the pathophysiology of osteoarthritis. Annals of physical and rehabilitation medicine. 2016 Dec 1;59(5-6):333-9. https://doi.org/10.1016/j.rehab.2016.07.004
• Fusco M, Skaper SD, Coaccioli S, Varrassi G, Paladini A. Degenerative joint diseases and neuroinflammation. Pain Practice. 2017 Apr;17(4):522-32. https://doi.org/10.1111/papr.12551
• Kolasinski SL, Neogi T, Hochberg MC, Oatis C, Guyatt G, Block J, Callahan L, Copenhaver C, Dodge C, Felson D, Gellar K. 2019 American College of Rheumatology/Arthritis Foundation guideline for the management of osteoarthritis of the hand, hip, and knee. Arthritis & rheumatology. 2020 Feb;72(2):220-33. https://doi.org/10.1002/acr.24131

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