Rutgers Learn and Go

Relative and Absolute Configurations (Stereoisomers Part 3)

Rutgers Learn and Go Podcast Organization Season 1 Episode 11

Subject: Organic Chemistry

This deep dive explains relative and absolute configurations in stereochemistry, focusing on how to determine them. Relative configuration compares a molecule to a reference molecule, while absolute configuration describes a molecule's exact 3D structure using the Cahn-Ingold-Prelog (CIP) priority rules to assign R or S descriptors. The deep dive also covers E/Z nomenclature for alkenes, which uses CIP rules to describe double bond geometry. Finally, it describes Fischer projections, a 2D representation of molecules simplifying visualization of chiral centers.

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