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Brother and sister, originally from Alabama who are now both Nashvillians, break down anything and everything. Trying our best to find the humor wherever we can. Hosted by Marty Booth and Amy Goodgame.
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Dire Wolves
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Scientists Bring Back Dire Wolves
Speaker 1Hey , welcome to hey Real Quick . Well , I try not to read the news .
Speaker 2Oh yeah , I don't like it .
Speaker 1We don't need to say it , but there is one thing that has come out in the last . I guess it was the last week . It's mid-April right now .
Speaker 2Right .
Speaker 1About scientists . I'm hoping it's scientists bringing back the dire wolf .
Speaker 2Yeah , like in Game of Thrones , right the really big one , yeah , like the super size .
Speaker 1So you know I mean .
Speaker 2That's what we need right now is dire wolves .
Speaker 1I guess Let them loose . I don't know , but Can't hurt ?
Speaker 2Yeah , it can .
Speaker 1Yeah , well , you know , I was in college when Jurassic Park came out , the first one .
Speaker 2Yeah , I feel like we know where this is going .
Speaker 1Yeah , we already saw it .
Speaker 2That's why we have zoos .
Speaker 1Yeah .
Speaker 2If you want to see an animal go .
Speaker 1Right Go to the zoo and we don't need to bring back any more . There's already lions in there .
Speaker 2There's already you know Bengal tigers , yeah , well , yeah , the company that did this , I don't know , was Colossal Biosciences , which sounds like maybe the evil corporation that did it in Jurassic Park .
Speaker 1I don't know . I know Colossal .
Speaker 2Yeah , it does Sorry Sounds like a colossal mistake to mess with Mother Nature .
Speaker 1Yeah , and I don't know . There's a lot going on . Did this project need to be , you know , april 2025 ? I don't think so .
Speaker 2And there's no telling how long they've been working on it .
Speaker 1Oh my goodness , Can you imagine yeah ?
Speaker 2It says there . Well , the first thing from the article is the dire wolves were born by colossal biosciences . Are super cute and growing into stately animals ? I don't think super cute no I mean they are when you look at the picture but isn't everything .
Speaker 1Isn't a puppy cute ? Isn't everything ? A baby lion is cute , but then it's gonna eat your head off when it's full grown . Yeah , that's what they said . And that's what they said in Jurassic Park , like oh , when the little things were hatching , you know , and all them people on the island .
Speaker 2Yeah .
Speaker 1No , uh-uh , laura Dern and all the people this is pre-Chris Pratt , uh-uh .
Speaker 2Yeah , but yeah , it says . The company seeking to bring back the woolly mammoth revealed it had produced three live dire wolf wolves puppies I didn't sound right . Remus , romulus and Khaleesi Is one of them named after Game of Thrones , I guess . So Whatever , we all know how that turned out if you watched it . I didn't watch it , but yeah , didn't turn out good Resurrecting a species that died out as many as 13,000 years ago , according to their calculations .
Speaker 1Yeah .
Speaker 2I don't know where that pops up . It was a really long time ago .
Speaker 1So the main goal is the woolly mammoth . Are we going for Ice Age here with Ray Romano ? That's what we're headed for .
Speaker 2I feel like it's not a good time to bring back an animal that thrived in the Ice Age .
Speaker 1Yeah , just spitballing . Yeah , I'm just saying they're probably going to be terribly hot and uncomfortable .
Speaker 2That woolly mammoth is going to have a crew cut .
Speaker 1How did you lose all that weight ? Well , I just started sweating it . How did you lose all that weight ? Well , I just started sweating . It was like a sweat box in there . Oh my gosh , you look fantastic Wooly . Yeah , I know , I sweated all off .
Understanding the Science Behind Extinction
Speaker 1You know sweating to the oldies . Yeah , and so they have these pictures If you go online . Well , this is USA Today , but they have these cute little pictures . They're cute . Oh , they're super cute yeah .
Speaker 2Until they grow into stately adults and take over the world .
Speaker 1Right , yeah , how many are there ? Three ?
Speaker 2Three . It said they spent more than a year to decode the dire wolf's evolutionary history . Well , it used to be history .
Speaker 1Now it's just current events Said . We generated high quality ancient genomes from dire wolves that lived 13,000 and 72,000 years ago .
Speaker 2Which one is it ? Yeah , high quality .
Speaker 1Yeah , what does that mean ? No store brand 72,000 years ago .
Speaker 2Okay , if you say so . Yeah , but it says that dire wolves and gray wolves are much more closely related than previously thought . Well , they both have the word wolf in it . So I would assume they're kind of related . Yeah , yeah , I don't . I don't know how I feel about it .
Speaker 1I'm a little bit like okay , I'll give him this , ok , spectacular , you did that . You made that . It wasn't there for a long , long time . It had gone extinct and now it's back in existence . I will give you the . That's kind of amazing . And also quit messing , quit messing with it . Don't mess with that . Do you know how much we've already messed up , already , trying to do stuff with just stuff that already exists , uh-uh .
Speaker 2Yeah , well , it's like , and it says here , their findings also suggest the dire wolf goes back about 4.5 million years ago . Well , first of all , you said 13,000 . You said 72,000 .
Speaker 1Yeah .
Speaker 2And then four and a half million . Y'all don't know .
Speaker 1No , I don't know that . They did do the research .
Speaker 2This sounds like a fifth grader giving a report and he didn't go back and double check it .
Speaker 1Let's just clone eggs or like chicken eggs to eat , or iPhones so I don't have to buy another one .
Speaker 2Yeah , but so all right . So a gray wolf , like nowadays .
Speaker 1Yeah .
Speaker 2A gray wolf all right . Labrador retriever Right , 21 to 26 inches , 55 to 80 pounds . Okay and height 21 , 26, . Okay , A gray wolf is 26 to 33 inches , about 50 to 150 pounds , and a dire wolf is 31 inches to 42 inches tall , 75 to 150 pounds . So it's almost . I mean , it's three and a half feet tall , 150 pounds , and it's a wolf . It's a wolf and we don't . I don't understand spending this much money and time . And energy On something we don't need .
Speaker 1No .
Speaker 2And or want . I don't think .
Speaker 1No , mm-mm , it is the houseboat of extinct animals . Nobody needs it , nobody .
Speaker 2Yeah , it says they had a vision of restoring the woolly mammoth . That would not only prove that a massive extinct animal can be brought back , but that the mammoth , if reinserted into the Arctic region , would improve the ecosystem and help combat global warming . Not sure if the woolly mammoth is going to recycle or I don't know .
Speaker 1I think it's going to die of being dehydrated .
Speaker 2Yeah , where are they going to put ?
Speaker 1it , everything's melting anyway . Do they have a big like freezer ?
Speaker 2Is there a zoo in the ? Yeah , where are we ?
Speaker 1Yeah , that's a good question . Is he doing an ice plunge every hour ? What's happening ? I don't know .
Speaker 2Yeah , I don happening , I don't know . Yeah , I don't get the whole yeah , so there's .
Speaker 1Where are these wolves ? Where are they right now ?
Speaker 2oh , does it say that is a good question . Oh , it says also , what about the unintended consequences ?
Speaker 1yeah , what about ? Oh , that's a section , isn't that nice ? Somebody did do a little bit of somebody put .
Speaker 2We're messing with nature . I think you're doing more than messing with it . You've made wolves . Yeah , um , we're messing with nature . I think you're doing more than messing with it . You've made wolves yeah . We're genetically engineering these wolves , we know .
Speaker 1Yeah , you just told us .
Speaker 2Yeah , if we start tinkering with genes , there may be unexpected problems . Did that ever occur ? No , I don't know . Maybe in like the first phase of research .
Speaker 1Yeah , like , what are the moral implications ? Like , should we even be doing this ? Um , yeah , so was it in the U S .
Speaker 2I'm going to have to .
Speaker 1I'm going to feel . I feel like it says yeah , I think it's in the U S , yeah , Um , I feel like it's this .
Speaker 2Yeah , I think it's in the US . Yeah , A lot of scientists have disagreed , which I'm . Yeah , I get it . Colossal used a gray wolf genome . Wait a minute . Okay , they used a gray wolf genome , which is 99.5% identical to the dire wolf genomes .
Speaker 1Hmm .
Speaker 2That don't even make no sense . So 0.5% is the different part .
Speaker 1I guess , and then is that what they made up ?
Speaker 2And edited it to make it even more similar to the extinct dire wolf , altering their size . Y'all just yeah , uh-uh , y'all just willy-nilly .
Speaker 1That's .
Speaker 2You're just like going on a website to create a car .
Speaker 1Yeah .
Speaker 2And like can I do a custom color ? You know , let's change it .
Speaker 1Yeah , let's do that .
Speaker 2That's what it is . It's like Jurassic Park , mm-hmm . Let's take a little bit of T-Rex A little bit . Mix it up with a little Velociraptor , the Endoraptor , or whatever .
Speaker 1Yeah , oh gosh , uh-uh . No , thank you ,
The Ethics of De-extinction
Speaker 1I don't know what I think .
Speaker 2I don't like it , but .
Speaker 1I don't like it .
Speaker 2I feel like it's a lot of wasted . Colossal Chief Sciences Officer Beth Shapiro . Wow , wait a minute . They're here with the image of the dodo bird , an extinct bird that Colossal has announced it hopes to bring back with its biotech and genetic technology .
Speaker 1They are the company from Jurassic Park .
Speaker 2These people need to be stopped immediately . You're going to bring back the dodo bird , which maybe it's just because I watched Ice Age or different movies or something . Isn't it like the dumbest bird in ?
Speaker 1the world . It's called dodo .
Speaker 2It's extinct . It's called dodo and it's ugly as sin . It's not a pretty bird , you know . It looks like a fluffy flamingo put on a mask to go in and rob a bank . That's what it looks like looking at this picture .
Speaker 1Oh , my gosh man I the dodo bird . Oh y'all , both dodos , y'all need to stop making animals I just think oh , you know , I can just hear the music now from the movie , you know and like looking at the picture of these two scientists in front of the image of the dodo bird and suddenly like a t-Rex is running toward them , or velociraptors , and I'll say this the dodo bird in the picture that are standing in front of it doesn't look too happy that they're cloning . No , it's going to peck their eyes out . Yeah .
Speaker 2We're going to dodo this again . Yeah , things go extinct for a reason .
Speaker 1Yeah , come on , quit it .
Speaker 2Whether it be plastic straws in the ocean , whatever , I don't know , but yeah , yeah when something's gone , it's gone . It's gone . Yeah , you're not bringing back stuff .
Speaker 1No , that's weird . That's weird . It's already weird enough .
Speaker 2It . It's weird . It's already weird enough . It's weird . It's gross and y'all wasting money . Yeah , stop it . Stop making up jobs .
Speaker 1Yeah .
Speaker 2Stop making yourself feel good .
Speaker 1No .
Speaker 2You got some genomes from 75,000 years or whatever you want to say .
Speaker 1Yeah , sell them and put that money into schools . What you doing .
Speaker 2Yeah .
Speaker 1Buy some people food . It's like evil science .
Speaker 2It's just like some scientists that got too much money , yeah , and they're kind of bored .
Speaker 1Well , you know , at the beginning of Jurassic Park you'd like that little old man with the cane , with the ember and the amber .
Speaker 2That's all it is .
Speaker 1Yeah , and then by the end you wanted to just wring his neck Because you're like , you know what you did . Yeah .
Speaker 2Yeah .
Speaker 1Yeah , don't do it .
Speaker 2Well , I guess I'm glad they started with dire wolves instead of just jumping straight to woolly mammoth . I have a question , and this is more than a question . So when they clone , I guess they're cloning it , right ? I'm going to feel dumb saying this out loud . So when they clone something so you're just coming it's just from thin air , right ? So you've got to get all the genomes and all this stuff .
Speaker 2And then do you just inject that into a gray wolf and then , when that wolf has the baby , it's now the dire wolf , because you , is that how they do it .
Speaker 1So here's what A1 , I mean ai says sorry I do like a1 steak sauce . I love it , sorry um . Cloning involves creating a genetically identical , identical copy of an organism . This is achieved through a process called somatic cell nuclear transfer , where the nucleus of a cell is transferred into an egg cell that has its own nucleus removed , the resulting egg now containing the donor's DNA is then stimulated to develop in an embryo which is then implanted to a surrogate mother . So maybe the gray wolf ?
Speaker 2So they do all this Jurassic Park stuff , pop that into the gray wolf , and then that gray wolf gives birth to a dire wolf .
Speaker 1I don't know . I wish they had explained it . So I feel so dumb , so wish they had explained it .
Speaker 2So I feel so dumb so they're going to do this .
Speaker 1So if they do this , you're not the scientist .
Speaker 2Yeah , I'm not the one wasting my time on this , making up a job . So if they do all this , do they implant that into a regular elephant and then that elephant mom gives birth to a woolly mammoth . Mmm that elephant mom is going to be like what is going on .
Speaker 1Ow , I don't know . So colossal biosciences , these people . The de-extinction of the dire wolf involved the process of gene editing , not cloning in the traditional sense . I'm reading this , by the way , can you tell ? They extracted DNA from the ancient dire wolf fossils . They compared it to the genome of the closest living relative , which is the gray wolf , found about 20 genes that contribute to the dire wolf's traits . Then these genes were edited into the cells of the gray wolves .
Speaker 2Okay .
Speaker 1And then the edited cells were used to create embryos which were then implanted into the surrogate domestic dog mothers . That's
Dodo Birds: Next on the List
Speaker 1what it says .
Speaker 2Wow .
Speaker 1The resulting pups are essentially genetically modified gray wolves with some dire wolf treats .
Speaker 2Okay .
Speaker 1So maybe it's not exactly like the true dire wolf .
Speaker 2Yeah , maybe it's just like , when you say it like that , it sounds like they're still alive , like naturally .
Speaker 1Yeah , you know what I'm saying . Yeah , yeah , yeah .
Speaker 2Well , I was reading that about the woolly mammoth . So it says the goal is to create an elephant mammoth hybrid .
Speaker 1Okay , yeah .
Speaker 2Like a golf club . That's easier to hit .
Speaker 1I guess Not a true clone . As the mammoth's .
Speaker 2DNA is too degraded for full cloning .
Speaker 1But they did clone sheep .
Speaker 2Remember that ? Yeah , when was that ? Somewhere , that was like 10 years ago or something . They cloned a sheep , which is that like 3d printing , I don't even know how that works . You just hit the button and leave the room and come back I don't know this is getting too severance .
Speaker 1But , um , yeah , the birth of the dire wolves da , da , da , da-da-da-da , romulus , remus and Khaleesi , whatever are not cloned dire wolves , but rather genetically modified gray wolves that resemble dire wolves , okay , okay , so maybe it would be like an elephant with Snuffleupagus , and not Woolly Mammoth Snuffleup , you know what I mean ? Like a little bit of a . It's a hybrid , it's a remix .
Speaker 2Well , romulus and Remus I know that sounded familiar were named after legendary founders of Rome , and Khaleesi is a reference to the Game of Thrones character .
Speaker 1Darnarius Targaryen . Okay , yeah , yeah , I didn't watch man , but I'm gonna put money on yeah anyway , I don't , yeah , I don't think there's to do it , but whatever I don't either if it makes you feel better yeah where does it stop , though , if they call ?
Speaker 2if they start doing t-rexes , I'm out can't we solve the microplastics ?
Speaker 1you can't , they said . Now you chew some gum , you're gonna get microplastics in your body . Can we get the plastic out of the extra first before we're doing this ? You know what I mean . Can y'all make some really fine mesh like nets for the ocean or I don't know ? Fix the ozone layer or something like that ? I don't know . There's more pressing problems .
Speaker 2Yeah , do dodo birds eat plastic . Oh my gosh , you know , maybe clone that thing . Yeah , do dodo birds eat plastic .
Speaker 1Oh my gosh , you know , maybe clone that thing , yeah yeah , make some plastic-eating goats , I don't know . Just put them everywhere , put a little life preserver on them , just let them go to town .
Speaker 2Yeah .
Speaker 1I don't know .
Speaker 2Which I saw this on the news this morning .
Speaker 1Must be true . It's great news . It's great news .
Speaker 2It's great You've seen the thing about children's mattresses , which I don't know what a kid's mattress is , I mean is a mattress .
Speaker 1A mattress , what no ?
Speaker 2it's like so it's the stuff that makes them flame retardant .
Speaker 1Yes , yes .
Speaker 2Whatever ?
Speaker 1Causes cancer ? Well , of course it's like a chemical Carcinogens .
Speaker 2And then when your kid's sleeping , you know their body temperature and all that Like they're breathing in like harmful fumes . Yeah , which I have a question Is my mattress just going to burst into flames or am I breathing the same thing Like adults don't sweat at night . They're talking about , like , well , kids' body temperature you know it can do this . I'm like .
Speaker 1I'm pretty sure we all . Yeah , that's why you got to wash your sheets , because it's gross . Yeah , yeah , everybody gets hot .
Speaker 2Yeah , that's why you got to wash your sheets , because it's gross , yeah yeah , I think a dire wolf could sleep on this and still be smelling it . You know , I don't know why they're just going after . I'm going to go out on a limb and say let's give it six months . There's some other recall or warning . Maybe that's what's on the tag when they say don't remove this tag .
Speaker 1Yes on the tag when they say don't remove this tag yes , under any circumstances . We told you like ever even after I buy it even after .
Speaker 2Yeah , but yeah , that was this morning no , I've not heard that .
Speaker 1Yeah , but they make that . They make kids pajamas like that I guess . Well , I guess pajamas you're wearing it but it's right by your skin , not bad't that bad too , yeah , which I feel dumb about that .
Speaker 2Everything is a little bad . How close are we getting to fires ?
Speaker 1And how does the chemical stay in it after you wash it that many times ?
Speaker 2And don't call it that . That makes it sound like you could just walk through the fire .
Speaker 1Yeah , yeah , uh-uh what are firemen wearing ? Yeah , that's flame retardant .
Speaker 2They're going in burning buildings . Were people just bursting into flames 300 years ago , Like just everywhere .
Speaker 1Maybe they could use those mattresses to get people out of the buildings . Like you know , make one of those slides or ramp or something . Seriously .
Speaker 2Well , that's what they do when like grab a mattress .
Speaker 1Right , yeah , yeah , yeah and run through it . Well , maybe that's why you gotta jump out of the building .
Speaker 2Yeah , I ain't jumping on that thing . It's hot , there's fumes all over it . Go get that dire wolf . Come up here and get me . I'm going to hop on this dodo bird and fly down . Which now I'm thinking , could they fly ? I don't think they could .
Speaker 1I don't know . I know a woolly mammoth ain't probably moving very fast . Do you think they move fast Did ?
Speaker 2they ?
Environmental Concerns and Alternatives
Speaker 2I hope not .
Speaker 1Yeah , herds of woolly mammoths .
Speaker 2Well , now I feel dumb because a dodo bird is a flightless bird . That's an ugly bird number one .
Speaker 1You know what ? Okay , I thought that the image that the scientists were standing in front of we just looked this up on the Internet y'all Picture of a dodo . Look it up at your leisure . I thought it was just sort of an outline with no color .
Speaker 2Oh , okay . On it but that's how it looks . Yeah , there , that's terrifying .
Speaker 1That's a little scary looking , yeah , why you gotta If you go clone something .
Speaker 2It's pretty hummingbird or something .
Speaker 1I'm just saying Miss .
Speaker 2Yeah , I'm trying to see why they went extinct Primarily due to human activity . Oh , let's bring them back now . We ain't got none of that going on . And the introduction of invasive species I butchered that . Y'all know what I meant Like pigs , rats and cats . I'm going to go out on a limb and tell you something In 2025 , you know what we have ? We have pigs , we have rats and we have cats , mm-hmm .
Speaker 1Yeah .
Speaker 2And apparently direwolves and y'all going to bring back dodo birds .
Speaker 1Let's let these kind of roam around and not know what they're doing , so they can go extinct again .
Speaker 2Oh , we just brought them back and they're gone again and they're gone .
Speaker 1Yeah , no , that's silly .
Speaker 2I think , whatever it is I watched maybe it was like Madagascar or whatever the dodo birds like just were dodos and just ran off a cliff , which .
Speaker 1Oh yeah .
Speaker 2They kind of look like they would do that .
Speaker 1Yeah , they do . They are not the scientists of birds , for sure . Well , they didn't ask us . But I do . I don't believe in the bringing the extinct things back , I don't either .
Speaker 2I did just click on this , sorry . It says why was the dodo called a dumb bird ? They weren't dumb , that's what it says . Somebody had an affinity for dodo birds . They weren't dumb , they were trusting .
Speaker 1Aw Were they .
Speaker 2Did they ? Tell you that Because you're a dodo . It said they had no reason to fear man , as they'd never seen a human . Okay , okay , well , how would you ? Yeah , I don't know who wrote this did . The dodo said when humans began to hunt them . They had a . They had few defenses , being flightless , that didn't help a lot did it , and not especially fleet of foot . Oh my god I think I know why they went extinct yeah right there's like a walking target with feathers y'all want to go dodo bird hunting .
Speaker 1It's dodo season , you don't even need camouflage , you just walk right up . It's going to be over pretty quick , and then we'll just hit Wendy's on the way back . That's what I'm thinking .
Speaker 2Yeah .
Speaker 1There's no , you don't need a four-wheeler .
Speaker 2You don't need a dodo .
Speaker 1You probably don't need a cooler . You probably don't need a gun . You could just clock them in the head , sounds like .
Speaker 2Yeah , they're very trusting . You don't even need a Dodo call you , just go come here , Dodo .
Speaker 1Yeah .
Speaker 2And you hit them with a , put them in a bag . Hit them with a bat .
Speaker 1I don't know . The next one looks at you . This is violent . We just got dark , but yeah , it's okay . Good gracious
Final Thoughts on Playing God
Speaker 1Anyway , oh Dodo .
Speaker 2Well , I don't know , I don't think we should clone anything .
Speaker 1No , that's what museums are for , yeah what's going to happen to museums ?
Speaker 2You're going to bring back all this stuff and take down the woolly mammoth display outside .
Speaker 1Yeah , right what you're going to have a skeleton .
Speaker 2I didn't think about that , I'm offended .
Speaker 1You can't lay them to rest properly . Somebody's been working on a dodo bird display . Oh yeah , at Smithsonian they're like what ?
Speaker 2There's some place in Brazil . It's like we got a whole museum for dodo birds yeah . You know they're back right . What yeah ?
Speaker 1Take it all down . Take it all back down , shut it down .
Speaker 2Let's do dire wolves . I hate to tell you .
Speaker 1I saw them on the way here .
Speaker 2And before you get some new blueprints , they took the Willie Manless coming back . So just keep going . Just set up a museum for something we have now that is about to go extinct Polar bears .
Speaker 1Yeah , let's do something like that .
Speaker 2Because they ain't going to bring them back for a while . We've seen that Nobody wants to see the band that broke up three years ago come back on tour .
Speaker 1No , but 40 years ago . People are like , oh , I'm going , they're still buying tickets to that . They don't care how old they are .
Speaker 2Anyway , well .
Speaker 1Watch out for the wolves , I guess , I don't know .
Speaker 2Yeah , if you hear howling ? Yeah , yeah go in the house .
Speaker 1Go in the house .
Speaker 2Anyway , that's all I got .
Speaker 1All right .
Speaker 2Have a good one .
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