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DDI of the Month Podcast
Presented by Global DDI Solutions in collaboration with Academic Medical Education, the DDI of the Month podcast brings you the latest updates on drug-drug interactions.
Each month, a new paper will be selected and the author invited to discuss their findings and explore how this can optimize DDI management and patient care going forward.
Host: Dr. David Burger - Professor of Clinical Pharmacy at the Radboud University in Nijmegen, the Netherlands.
He is an Executive Editor of BJCP and serves on the editorial boards of TDM, JAIDS, JAC, and Antiviral Therapy. Since 1997 he has been leading a research group focussing on clinical pharmacology of antimicrobial agents with emphasis on HIV, TB, fungal infections, and hepatitis.
DDI of the Month Podcast
Episode 2: Colchicine | Daniel Malone & Ainhoa Gomez-Lumbreras
In the second episode of this podcast series, Dr. Malone, Dr. Gómez-Lumbreras, and Dr. Burger will discuss the drug-drug interaction potential of colchicine, which may be underestimated.
Dr. Malone’s research group did a study on real-world data on the interaction potential of colchicine. Colchicine concentration can be increased by CYP3A4 inhibitors, which may lead to toxicity and adverse events. Adverse events cases reported between 2004 and 2020 were studied for the involvement of colchicine in DDIs. In 66% of 787 studied reports, colchicine was identified as a concomitant drug. This indicates that the reporter did not think colchicine was the cause of the adverse events mentioned in the reports.
- Could colchicine possibly play a bigger role in DDIs than currently thought?
- Are there any safety concerns of colchicine use combined with strong CYP3A4 inhibitors?
- And what practical guidance is needed for the safe use of colchicine in combination with other medicines?
Listen to the second episode of DDI of the Month to find out!