DDI of the Month Podcast
Presented by Global DDI Solutions in collaboration with Academic Medical Education, the DDI of the Month podcast brings you the latest updates on drug-drug interactions.
Each month, a new paper will be selected and the author invited to discuss their findings and explore how this can optimize DDI management and patient care going forward.
Host: Dr. David Burger - Professor of Clinical Pharmacy at the Radboud University in Nijmegen, the Netherlands.
He is an Executive Editor of BJCP and serves on the editorial boards of TDM, JAIDS, JAC, and Antiviral Therapy. Since 1997 he has been leading a research group focussing on clinical pharmacology of antimicrobial agents with emphasis on HIV, TB, fungal infections, and hepatitis.
DDI of the Month Podcast
Episode 7: Pharmacokinetics and Green Tea: The Catechin Connection
In the seventh episode, Prof. Dr. David Burger discusses with Nicki Kyriacou the review article: “Green tea catechins as perpetrators of drug pharmacokinetic interactions”.
You might think: “Green tea?– I drink it all the time! “But is it really that innocent?
Tune in now as we explore how catechins-compounds found in green tea, like (-)-epigallocatechin-3-gallate – can impact drug pharmacokinetics. These compounds can alter drug solubility, transporter activity, and metabolism, potentially affecting the concentration of therapeutic drugs such as atorvastatin, digoxin, and sildenafil.
The following key topics will be discussed in the podcast:
- The scope and intensity of green tea interaction studies;
- Different green tea formulations and their impact on drug interactions;
- Relevance for specific patient populations (especially cardiovascular medications);
- Why green tea reduces most drug concentrations – but increases sildenafil levels;
- The role of timing in green tea consumption vs. co-medication; and
- Practical guidance for clinicians and pharmacists to assess potential interaction.
Don’t miss this insightful discussion on the drug interaction potential of green tea and the practical takeaways for health professionals!