DDI of the Month Podcast
Presented by Global DDI Solutions in collaboration with Academic Medical Education, the DDI of the Month podcast brings you the latest updates on drug-drug interactions.
Each month, a new paper will be selected and the author invited to discuss their findings and explore how this can optimize DDI management and patient care going forward.
Host: Dr. David Burger - Professor of Clinical Pharmacy at the Radboud University in Nijmegen, the Netherlands.
He is an Executive Editor of BJCP and serves on the editorial boards of TDM, JAIDS, JAC, and Antiviral Therapy. Since 1997 he has been leading a research group focussing on clinical pharmacology of antimicrobial agents with emphasis on HIV, TB, fungal infections, and hepatitis.
DDI of the Month Podcast
Episode 9: Decoding P-glycoprotein Interactions: Inhibitors, Inducers, and Clinical Relevance
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In this ninth edition of DDI of the Month, host Prof. dr. David Burger welcomes two leading experts from Switzerland, Dr Claire Coumau and Dr Chantal Csajka, for an in-depth discussion on P-glycoprotein (P-gp)–mediated drug–drug interactions.
The episode is centered around their recent publication in Clinical Pharmacokinetics: “A Systematic Review and Classification of the Effects of P-glycoprotein Inhibitors and Inducers in Humans, Using Digoxin, Fexofenadine, and Dabigatran as Probe Drugs.”
P-glycoprotein plays a key role in drug absorption and disposition, yet its interaction potential has long been less clearly defined than that of hepatic enzymes such as CYP3A. In this conversation, the authors explain why they set out to systematically review human data, propose a clinically meaningful classification of P-gp inhibitors and inducers, and highlight important similarities — and differences — between P-gp and CYP3A interactions.
Tune in to hear about:
- Why a human-only systematic review of P-gp interactions was needed
- How P-gp inhibitors and inducers can be classified using exposure-based criteria
- Which drugs qualify as moderate or potent P-gp inhibitors or inducers
- Why strong P-gp modulators are relatively rare compared to CYP3A modulators
- The concept of short-term inhibition followed by time-dependent induction
- The role of probe drugs such as digoxin, dabigatran, fexofenadine—and the potential of edoxaban
An insightful episode for clinicians, pharmacists, and researchers involved in managing and studying drug–drug interactions. Don’t miss it—listen now!