The Jenes Pod
I'm Damien Hsieh, a Year 10 student from Hong Kong who loves genetics and molecular biology. These molecules and proteins are practically invisible to the naked eye, but when closely examined, can reveal the inner complexities of thousands of millions of processes that make you. With this science now being harnessed for good, this genetic technology of the future (and practically now!) is what I will be discussing in Jenes, and I hope you will enjoy the breakdowns and explanations of the complex human genome.
The Jenes Pod
Episode 1 - CRISPR-Cas9: The Good, The Bad, and The Unethical
Hello everyone, welcome to the first ACTUAL episode of The Jenes Podcast where we will be highlighting one of the most exciting genetic discoveries in modern science, CRISPR-Cas9 gene editing!
This piece of technology was what first made me interested in looking into genetics in the first place when I was back in primary school, so I hope I am able to show you the awesomeness of CRISPR-Cas9 today while offering you some other perspectives regarding the possible drawbacks of it.
Enjoy the episode! Citations below:
Ayanoglu, Fatma Betul, et al. “Bioethical Issues in Genome Editing by the CRISPR/Cas9 Technology.” Turkish Journal of Biology, vol. 44, no. 2, Apr. 2020, pp. 110–20, https://doi.org/10.3906/biy-1912-52. Accessed 29 July 2024.
Casgevy. “How CASGEVYTM Works | CASGEVYTM (Exagamglogene Autotemcel).” Www.casgevy.com, www.casgevy.com/sickle-cell-disease/how-casgevy-works. Accessed 29 July 2024.
Klug, William S. Concepts of Genetics : William S. Klug ... [et Al.]. 2024. Pearson, Cop, 2016.
Liu, Qier, et al. “Application of CRISPR/Cas9 in Crop Quality Improvement.” International Journal of Molecular Sciences, vol. 22, no. 8, Apr. 2021, p. 4206, https://doi.org/10.3390/ijms22084206. Accessed 29 July 2024.
Park, Jae-Ryoung, et al. “Applications of CRISPR/Cas9 as New Strategies for Short Breeding to Drought Gene in Rice.” Frontiers in Plant Science, vol. 13, Feb. 2022, https://doi.org/10.3389/fpls.2022.850441.
Philadelphia, The Children’s Hospital of. “FDA Approves Two Gene Therapies for Sickle Cell Disease.” Www.chop.edu, 5 Dec. 2023, www.chop.edu/news/fda-approves-two-gene-therapies-sickle-cell-disease. Accessed 29 July 2024.
Powerhouse of the Cell. “But What Is CRISPR-Cas9? An Animated Introduction to Gene Editing. #Some2.” YouTube, 12 July 2022, www.youtube.com/watch?v=ANehpGhbuF4&t=320s. Accessed 29 July 2024.
Quinton, Amy. “CRISPR Genome Editing Strategy Could Improve Rice, Other Crops.” College of Agricultural and Environmental Sciences, 16 Mar. 2020, caes.ucdavis.edu/news/crispr-genome-editing-strategy-could-improve-rice-other-crops. Accessed 29 July 2024.
U.S. Food & Drug Administration. “CASGEVY.” FDA, Dec. 2023, www.fda.gov/vaccines-blood-biologics/casgevy. Accessed 29 July 2024.