The Jenes Pod
I'm Damien Hsieh, a Year 10 student from Hong Kong who loves genetics and molecular biology. These molecules and proteins are practically invisible to the naked eye, but when closely examined, can reveal the inner complexities of thousands of millions of processes that make you. With this science now being harnessed for good, this genetic technology of the future (and practically now!) is what I will be discussing in Jenes, and I hope you will enjoy the breakdowns and explanations of the complex human genome.
The Jenes Pod
Episode 3 - The Guardian of the Genome, TP53
Sorry for the late upload, kind of got sick while this episode was in development and got swamped by work as I went back to school!
This episode is about TP53, a tumor suppressor gene critical when fighting one of the world's biggest medical evils, big C, cancer. I also recently wrote a review paper which investigated the different utilisations of TP53 in cancer treatment, which lead me to writing an entire podcast episode about it. When researching TP53, I also had the chance to read an article which showed how TP53's discovery as a tumor suppressor gene was actually pretty interesting, as at first it was found to be an oncogene, a direct opposite of its now widely accepted definition, really shows how the tables turn in science eh?! Anyways, I hope you enjoy this episode of The Jenes Pod and I'll see you in another. bye bye~
Works Cited
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Chen, Xiaohua, et al. “Mutant P53 in Cancer: From Molecular Mechanism to Therapeutic Modulation.” Cell Death & Disease, vol. 13, no. 11, Nov. 2022, https://doi.org/10.1038/s41419-022-05408-1. Accessed 12 Sept. 2024.
Chiang, Yen-Ting, et al. “The Function of the Mutant P53-R175H in Cancer.” Cancers, vol. 13, no. 16, Aug. 2021, p. 4088, https://doi.org/10.3390/cancers13164088. Accessed 12 Sept. 2024.
Hernández Borrero, Liz J., and Wafik S. El-Deiry. “Tumor Suppressor P53: Biology, Signaling Pathways, and Therapeutic Targeting.” Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, vol. 1876, no. 1, Aug. 2021, p. 188556, https://doi.org/10.1016/j.bbcan.2021.188556.
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Timmerman, Dennis M., et al. “Mechanisms of TP53 Pathway Inactivation in Embryonic and Somatic Cells—Relevance for Understanding (Germ Cell) Tumorigenesis.” International Journal of Molecular Sciences, vol. 22, no. 10, May 2021, p. 5377, https://doi.org/10.3390/ijms22105377. Accessed 12 Sept. 2024.
Wang, Haolan, et al. “Targeting P53 Pathways: Mechanisms, Structures, and Advances in Therapy.” Signal Transduction and Targeted Therapy, vol. 8, no. 1, Mar. 2023, pp. 1–35, https://doi.org/10.1038/s41392-023-01347-1. Accessed 27 Aug. 2024.