{"version":"1.0.0","segments":[{"speaker":"John Simboli","startTime":0.0,"endTime":3.6,"body":"Today I'm speaking"},{"speaker":"John Simboli","startTime":0.0,"endTime":3.6,"body":"with Hartmut Ehrlich, CEO of"},{"speaker":"John Simboli","startTime":3.63,"endTime":8.19,"body":"Abivax, headquartered in Paris."},{"speaker":"John Simboli","startTime":3.63,"endTime":8.19,"body":"Welcome to BioBoss, Hartmut."},{"speaker":"Hartmut Ehrlich","startTime":8.34,"endTime":10.65,"body":"Thank you very"},{"speaker":"Hartmut Ehrlich","startTime":8.34,"endTime":10.65,"body":"much, John. It's a pleasure."},{"speaker":"John Simboli","startTime":10.98,"endTime":14.43,"body":"What led you to"},{"speaker":"John Simboli","startTime":10.98,"endTime":14.43,"body":"your role as CEO at Abivax?"},{"speaker":"Hartmut Ehrlich","startTime":14.97,"endTime":18.48,"body":"Well, maybe I"},{"speaker":"Hartmut Ehrlich","startTime":14.97,"endTime":18.48,"body":"should start by saying that I"},{"speaker":"Hartmut Ehrlich","startTime":18.48,"endTime":22.98,"body":"spent most of my professional"},{"speaker":"Hartmut Ehrlich","startTime":18.48,"endTime":22.98,"body":"career and that means over 35"},{"speaker":"Hartmut Ehrlich","startTime":23.01,"endTime":29.01,"body":"years, actually in large"},{"speaker":"Hartmut Ehrlich","startTime":23.01,"endTime":29.01,"body":"pharmaceutical companies, and"},{"speaker":"Hartmut Ehrlich","startTime":29.01,"endTime":34.11,"body":"before Abivax I was head of"},{"speaker":"Hartmut Ehrlich","startTime":29.01,"endTime":34.11,"body":"Global Research and Development"},{"speaker":"Hartmut Ehrlich","startTime":34.11,"endTime":39.87,"body":"at Baxter Bioscience for almost"},{"speaker":"Hartmut Ehrlich","startTime":34.11,"endTime":39.87,"body":"20 years, where I managed a"},{"speaker":"Hartmut Ehrlich","startTime":39.87,"endTime":46.38,"body":"portfolio of over 50 programs in"},{"speaker":"Hartmut Ehrlich","startTime":39.87,"endTime":46.38,"body":"non-clinical and clinical"},{"speaker":"Hartmut Ehrlich","startTime":46.38,"endTime":53.31,"body":"development, which then, after"},{"speaker":"Hartmut Ehrlich","startTime":46.38,"endTime":53.31,"body":"my departure from Baxter was"},{"speaker":"Hartmut Ehrlich","startTime":53.31,"endTime":59.19,"body":"sold to Shire. And another year"},{"speaker":"Hartmut Ehrlich","startTime":53.31,"endTime":59.19,"body":"later, as you probably know,"},{"speaker":"Hartmut Ehrlich","startTime":59.43,"endTime":65.16,"body":"Shire was sold to Takeda. And"},{"speaker":"Hartmut Ehrlich","startTime":59.43,"endTime":65.16,"body":"after such a long time in big"},{"speaker":"Hartmut Ehrlich","startTime":65.16,"endTime":69.27,"body":"pharma, and I had been with"},{"speaker":"Hartmut Ehrlich","startTime":65.16,"endTime":69.27,"body":"Novartis before I had"},{"speaker":"Hartmut Ehrlich","startTime":69.87,"endTime":76.86,"body":"been—actually before Novartis,"},{"speaker":"Hartmut Ehrlich","startTime":69.87,"endTime":76.86,"body":"so it was the old Sandoz. And"},{"speaker":"Hartmut Ehrlich","startTime":76.86,"endTime":81.9,"body":"then I also have been with Eli"},{"speaker":"Hartmut Ehrlich","startTime":76.86,"endTime":81.9,"body":"Lilly, before, so I was really"},{"speaker":"Hartmut Ehrlich","startTime":81.9,"endTime":88.71,"body":"looking for a new challenge in a"},{"speaker":"Hartmut Ehrlich","startTime":81.9,"endTime":88.71,"body":"smaller company where decision"},{"speaker":"Hartmut Ehrlich","startTime":88.71,"endTime":95.31,"body":"making process processes are"},{"speaker":"Hartmut Ehrlich","startTime":88.71,"endTime":95.31,"body":"much less complex and shorter"},{"speaker":"Hartmut Ehrlich","startTime":95.37,"endTime":101.22,"body":"compared to large pharma. And"},{"speaker":"Hartmut Ehrlich","startTime":95.37,"endTime":101.22,"body":"also, of course, having"},{"speaker":"Hartmut Ehrlich","startTime":101.22,"endTime":106.74,"body":"responsibility for all functions"},{"speaker":"Hartmut Ehrlich","startTime":101.22,"endTime":106.74,"body":"within the company, if you want."},{"speaker":"Hartmut Ehrlich","startTime":107.04,"endTime":111.84,"body":"So Abivax was the right"},{"speaker":"Hartmut Ehrlich","startTime":107.04,"endTime":111.84,"body":"opportunity at the right time"},{"speaker":"Hartmut Ehrlich","startTime":111.87,"endTime":117.3,"body":"and exactly what I was looking"},{"speaker":"Hartmut Ehrlich","startTime":111.87,"endTime":117.3,"body":"for. And the only regret I have"},{"speaker":"Hartmut Ehrlich","startTime":118.02,"endTime":122.97,"body":"is that I did not take this"},{"speaker":"Hartmut Ehrlich","startTime":118.02,"endTime":122.97,"body":"decision to go to small earlier,"},{"speaker":"John Simboli","startTime":123.72,"endTime":127.86,"body":"When you had made"},{"speaker":"John Simboli","startTime":123.72,"endTime":127.86,"body":"that decision that you were at"},{"speaker":"John Simboli","startTime":127.86,"endTime":130.8,"body":"least going to consider moving"},{"speaker":"John Simboli","startTime":127.86,"endTime":130.8,"body":"to a smaller company but hadn't"},{"speaker":"John Simboli","startTime":130.8,"endTime":136.38,"body":"yet decided which one, what was"},{"speaker":"John Simboli","startTime":130.8,"endTime":136.38,"body":"that process like? Or did the"},{"speaker":"John Simboli","startTime":136.38,"endTime":139.74,"body":"process suddenly present itself"},{"speaker":"John Simboli","startTime":136.38,"endTime":139.74,"body":"in the form of a call from the"},{"speaker":"John Simboli","startTime":139.74,"endTime":142.65,"body":"founder? How did that play out?"},{"speaker":"Hartmut Ehrlich","startTime":143.49,"endTime":147.81,"body":"I was ready to"},{"speaker":"Hartmut Ehrlich","startTime":143.49,"endTime":147.81,"body":"move. But the real move came"},{"speaker":"Hartmut Ehrlich","startTime":147.81,"endTime":155.04,"body":"about when I was approached by"},{"speaker":"Hartmut Ehrlich","startTime":147.81,"endTime":155.04,"body":"the founder of Abivax. I got the"},{"speaker":"Hartmut Ehrlich","startTime":155.43,"endTime":162.21,"body":"call from Paris to explore"},{"speaker":"Hartmut Ehrlich","startTime":155.43,"endTime":162.21,"body":"whether I would be interested in"},{"speaker":"Hartmut Ehrlich","startTime":162.21,"endTime":168.51,"body":"leading the company. And the"},{"speaker":"Hartmut Ehrlich","startTime":162.21,"endTime":168.51,"body":"answer, after looking into this"},{"speaker":"Hartmut Ehrlich","startTime":168.54,"endTime":173.19,"body":"with a lot of due diligence, was"},{"speaker":"Hartmut Ehrlich","startTime":168.54,"endTime":173.19,"body":"clearly a yes, for me."},{"speaker":"John Simboli","startTime":173.82,"endTime":176.52,"body":"So the picture you"},{"speaker":"John Simboli","startTime":173.82,"endTime":176.52,"body":"had formed of what it might be"},{"speaker":"John Simboli","startTime":176.52,"endTime":181.35,"body":"like to lead a smaller biopharma"},{"speaker":"John Simboli","startTime":176.52,"endTime":181.35,"body":"company, a growing biopharma"},{"speaker":"John Simboli","startTime":181.35,"endTime":185.19,"body":"company versus what you'd"},{"speaker":"John Simboli","startTime":181.35,"endTime":185.19,"body":"experienced at Baxter, that"},{"speaker":"John Simboli","startTime":185.19,"endTime":189.03,"body":"picture that you had, how"},{"speaker":"John Simboli","startTime":185.19,"endTime":189.03,"body":"accurate was that compared to"},{"speaker":"John Simboli","startTime":189.03,"endTime":191.16,"body":"what you experienced after you"},{"speaker":"John Simboli","startTime":189.03,"endTime":191.16,"body":"became CEO?"},{"speaker":"Hartmut Ehrlich","startTime":191.76,"endTime":196.59,"body":"I think I was"},{"speaker":"Hartmut Ehrlich","startTime":191.76,"endTime":196.59,"body":"pretty much prepared for most of"},{"speaker":"Hartmut Ehrlich","startTime":196.59,"endTime":203.91,"body":"the elements that are an"},{"speaker":"Hartmut Ehrlich","startTime":196.59,"endTime":203.91,"body":"intrinsic part of the job. Of"},{"speaker":"Hartmut Ehrlich","startTime":203.91,"endTime":207.84,"body":"course, when you're working in a"},{"speaker":"Hartmut Ehrlich","startTime":203.91,"endTime":207.84,"body":"large company, you very often"},{"speaker":"Hartmut Ehrlich","startTime":207.84,"endTime":215.64,"body":"meet with biotech CEOs, etc. And"},{"speaker":"Hartmut Ehrlich","startTime":207.84,"endTime":215.64,"body":"from these discussions, you get"},{"speaker":"Hartmut Ehrlich","startTime":215.64,"endTime":225.48,"body":"a pretty good picture about what"},{"speaker":"Hartmut Ehrlich","startTime":215.64,"endTime":225.48,"body":"is important, how are the"},{"speaker":"Hartmut Ehrlich","startTime":225.48,"endTime":230.88,"body":"different views between large"},{"speaker":"Hartmut Ehrlich","startTime":225.48,"endTime":230.88,"body":"pharma and biotech on some of"},{"speaker":"Hartmut Ehrlich","startTime":230.88,"endTime":236.55,"body":"the activities. And actually the"},{"speaker":"Hartmut Ehrlich","startTime":230.88,"endTime":236.55,"body":"biggest difference between the"},{"speaker":"Hartmut Ehrlich","startTime":236.64,"endTime":243.99,"body":"two jobs, that I did not realize"},{"speaker":"Hartmut Ehrlich","startTime":236.64,"endTime":243.99,"body":"when I took the decision, was"},{"speaker":"Hartmut Ehrlich","startTime":244.02,"endTime":252.99,"body":"the constant need to be engaged"},{"speaker":"Hartmut Ehrlich","startTime":244.02,"endTime":252.99,"body":"with investors, which, however,"},{"speaker":"Hartmut Ehrlich","startTime":252.99,"endTime":258.63,"body":"is something that I must say I"},{"speaker":"Hartmut Ehrlich","startTime":252.99,"endTime":258.63,"body":"really enjoy because it gives me"},{"speaker":"Hartmut Ehrlich","startTime":258.66,"endTime":263.25,"body":"and the team members that that"},{"speaker":"Hartmut Ehrlich","startTime":258.66,"endTime":263.25,"body":"are participating in these"},{"speaker":"Hartmut Ehrlich","startTime":263.25,"endTime":271.47,"body":"meetings, a fresh perspective on"},{"speaker":"Hartmut Ehrlich","startTime":263.25,"endTime":271.47,"body":"the company and what the view"},{"speaker":"Hartmut Ehrlich","startTime":271.47,"endTime":277.98,"body":"from the outside in, through the"},{"speaker":"Hartmut Ehrlich","startTime":271.47,"endTime":277.98,"body":"through the investors, what is"},{"speaker":"Hartmut Ehrlich","startTime":277.98,"endTime":283.29,"body":"really important. And that was a"},{"speaker":"Hartmut Ehrlich","startTime":277.98,"endTime":283.29,"body":"learning that I really"},{"speaker":"Hartmut Ehrlich","startTime":283.29,"endTime":289.71,"body":"appreciated and that I still"},{"speaker":"Hartmut Ehrlich","startTime":283.29,"endTime":289.71,"body":"value, and you can imagine,"},{"speaker":"Hartmut Ehrlich","startTime":289.74,"endTime":297.9,"body":"after our successful 130 million"},{"speaker":"Hartmut Ehrlich","startTime":289.74,"endTime":297.9,"body":"euro capital raise. I think this"},{"speaker":"Hartmut Ehrlich","startTime":297.9,"endTime":303.72,"body":"is an example of the kinds of"},{"speaker":"Hartmut Ehrlich","startTime":297.9,"endTime":303.72,"body":"activities that are very"},{"speaker":"Hartmut Ehrlich","startTime":303.72,"endTime":309.21,"body":"specific for biotech companies,"},{"speaker":"Hartmut Ehrlich","startTime":303.72,"endTime":309.21,"body":"and are an activity that I"},{"speaker":"Hartmut Ehrlich","startTime":309.21,"endTime":315.03,"body":"really enjoy. The decision"},{"speaker":"Hartmut Ehrlich","startTime":309.21,"endTime":315.03,"body":"making process or processes,"},{"speaker":"Hartmut Ehrlich","startTime":315.72,"endTime":322.95,"body":"especially in a smaller company,"},{"speaker":"Hartmut Ehrlich","startTime":315.72,"endTime":322.95,"body":"that was something that I was"},{"speaker":"Hartmut Ehrlich","startTime":322.95,"endTime":332.13,"body":"really looking forward to. And"},{"speaker":"Hartmut Ehrlich","startTime":322.95,"endTime":332.13,"body":"it didn't catch me by surprise,"},{"speaker":"Hartmut Ehrlich","startTime":332.52,"endTime":337.86,"body":"because I came to the job with"},{"speaker":"Hartmut Ehrlich","startTime":332.52,"endTime":337.86,"body":"the expectation that one of my"},{"speaker":"Hartmut Ehrlich","startTime":337.86,"endTime":342.69,"body":"key tasks is to find a"},{"speaker":"Hartmut Ehrlich","startTime":337.86,"endTime":342.69,"body":"resolution between different"},{"speaker":"Hartmut Ehrlich","startTime":342.69,"endTime":348.99,"body":"opinions in a management team,"},{"speaker":"Hartmut Ehrlich","startTime":342.69,"endTime":348.99,"body":"and to work with the management"},{"speaker":"Hartmut Ehrlich","startTime":348.99,"endTime":355.05,"body":"team to sort out these"},{"speaker":"Hartmut Ehrlich","startTime":348.99,"endTime":355.05,"body":"differences and find the best"},{"speaker":"Hartmut Ehrlich","startTime":355.05,"endTime":359.28,"body":"way forward to the company."},{"speaker":"John Simboli","startTime":359.97,"endTime":361.86,"body":"When you first"},{"speaker":"John Simboli","startTime":359.97,"endTime":361.86,"body":"made that decision, you wanted"},{"speaker":"John Simboli","startTime":361.86,"endTime":366.72,"body":"to lead Abivax, were you"},{"speaker":"John Simboli","startTime":361.86,"endTime":366.72,"body":"thinking to yourself anything"},{"speaker":"John Simboli","startTime":366.72,"endTime":370.14,"body":"like maybe I can accomplish"},{"speaker":"John Simboli","startTime":366.72,"endTime":370.14,"body":"something here that I can't"},{"speaker":"John Simboli","startTime":370.14,"endTime":372.99,"body":"accomplish someplace else? Was"},{"speaker":"John Simboli","startTime":370.14,"endTime":372.99,"body":"there something in particular"},{"speaker":"John Simboli","startTime":372.99,"endTime":376.38,"body":"about Abivax that spoke to you"},{"speaker":"John Simboli","startTime":372.99,"endTime":376.38,"body":"and said, this is an unusually"},{"speaker":"John Simboli","startTime":376.38,"endTime":377.07,"body":"good fit?"},{"speaker":"Hartmut Ehrlich","startTime":378.12,"endTime":382.383,"body":"Abivax caters"},{"speaker":"Hartmut Ehrlich","startTime":378.12,"endTime":382.383,"body":"to my preferences. We are a very"},{"speaker":"Hartmut Ehrlich","startTime":382.476,"endTime":388.037,"body":"small company. I mean, between"},{"speaker":"Hartmut Ehrlich","startTime":382.476,"endTime":388.037,"body":"employees and contractors, we"},{"speaker":"Hartmut Ehrlich","startTime":388.13,"endTime":393.783,"body":"are about 50 people. That also"},{"speaker":"Hartmut Ehrlich","startTime":388.13,"endTime":393.783,"body":"entails that there is a strong"},{"speaker":"Hartmut Ehrlich","startTime":393.876,"endTime":399.622,"body":"commitment from our employees."},{"speaker":"Hartmut Ehrlich","startTime":393.876,"endTime":399.622,"body":"And there's also strong support"},{"speaker":"Hartmut Ehrlich","startTime":399.715,"endTime":405.462,"body":"from our board and our investors"},{"speaker":"Hartmut Ehrlich","startTime":399.715,"endTime":405.462,"body":"who all believe, actually, in"},{"speaker":"Hartmut Ehrlich","startTime":405.554,"endTime":408.15,"body":"the potential of obefazimod."},{"speaker":"John Simboli","startTime":408.69,"endTime":410.79,"body":"When you're"},{"speaker":"John Simboli","startTime":408.69,"endTime":410.79,"body":"working for a big pharma"},{"speaker":"John Simboli","startTime":410.79,"endTime":413.58,"body":"company, and someone says,"},{"speaker":"John Simboli","startTime":410.79,"endTime":413.58,"body":"someone you've met, perhaps"},{"speaker":"John Simboli","startTime":413.58,"endTime":417.54,"body":"socially, says, Oh, I think I"},{"speaker":"John Simboli","startTime":413.58,"endTime":417.54,"body":"understand what Hartmut does, he"},{"speaker":"John Simboli","startTime":417.54,"endTime":420.06,"body":"works,  for and everybody knows"},{"speaker":"John Simboli","startTime":417.54,"endTime":420.06,"body":"the name of the company. When"},{"speaker":"John Simboli","startTime":420.06,"endTime":423.42,"body":"they don't know the name of the"},{"speaker":"John Simboli","startTime":420.06,"endTime":423.42,"body":"company and you say, This is"},{"speaker":"John Simboli","startTime":423.42,"endTime":426.84,"body":"what I do. How do you explain"},{"speaker":"John Simboli","startTime":423.42,"endTime":426.84,"body":"what it is that you do each day"},{"speaker":"John Simboli","startTime":426.84,"endTime":428.52,"body":"to someone who says what have"},{"speaker":"John Simboli","startTime":426.84,"endTime":428.52,"body":"you been up to?"},{"speaker":"Hartmut Ehrlich","startTime":429.09,"endTime":432.72,"body":"I am the CEO of"},{"speaker":"Hartmut Ehrlich","startTime":429.09,"endTime":432.72,"body":"a small Paris-based biotech"},{"speaker":"Hartmut Ehrlich","startTime":432.72,"endTime":438.75,"body":"company with a very promising"},{"speaker":"Hartmut Ehrlich","startTime":432.72,"endTime":438.75,"body":"drug candidate in phase 3"},{"speaker":"Hartmut Ehrlich","startTime":438.75,"endTime":443.88,"body":"clinical trials for the"},{"speaker":"Hartmut Ehrlich","startTime":438.75,"endTime":443.88,"body":"treatment of patients with"},{"speaker":"Hartmut Ehrlich","startTime":443.91,"endTime":449.07,"body":"ulcerative colitis. So that's"},{"speaker":"Hartmut Ehrlich","startTime":443.91,"endTime":449.07,"body":"essentially the bare minimum."},{"speaker":"Hartmut Ehrlich","startTime":449.52,"endTime":453.12,"body":"But then of course, you"},{"speaker":"Hartmut Ehrlich","startTime":449.52,"endTime":453.12,"body":"typically have more time than"},{"speaker":"Hartmut Ehrlich","startTime":453.12,"endTime":460.23,"body":"you would normally have in an"},{"speaker":"Hartmut Ehrlich","startTime":453.12,"endTime":460.23,"body":"elevator speech. So as many"},{"speaker":"Hartmut Ehrlich","startTime":460.23,"endTime":464.43,"body":"people do not know what"},{"speaker":"Hartmut Ehrlich","startTime":460.23,"endTime":464.43,"body":"ulcerative colitis is, I can"},{"speaker":"Hartmut Ehrlich","startTime":464.43,"endTime":472.11,"body":"seize the opportunity to"},{"speaker":"Hartmut Ehrlich","startTime":464.43,"endTime":472.11,"body":"sensibilize them for this very,"},{"speaker":"Hartmut Ehrlich","startTime":472.11,"endTime":477.75,"body":"very debilitating disease. So I"},{"speaker":"Hartmut Ehrlich","startTime":472.11,"endTime":477.75,"body":"tell them that I'm sure that"},{"speaker":"Hartmut Ehrlich","startTime":477.75,"endTime":481.11,"body":"they know at least one or two"},{"speaker":"Hartmut Ehrlich","startTime":477.75,"endTime":481.11,"body":"people who suffer from this"},{"speaker":"Hartmut Ehrlich","startTime":481.11,"endTime":486.66,"body":"chronic inflammatory bowel"},{"speaker":"Hartmut Ehrlich","startTime":481.11,"endTime":486.66,"body":"disease, but that patients do"},{"speaker":"Hartmut Ehrlich","startTime":486.66,"endTime":492.9,"body":"not talk about it. As we all"},{"speaker":"Hartmut Ehrlich","startTime":486.66,"endTime":492.9,"body":"know, the symptoms are very"},{"speaker":"Hartmut Ehrlich","startTime":494.88,"endTime":501.99,"body":"cumbersome for the patient. But"},{"speaker":"Hartmut Ehrlich","startTime":494.88,"endTime":501.99,"body":"interestingly, once people know"},{"speaker":"Hartmut Ehrlich","startTime":502.02,"endTime":507.15,"body":"about ulcerative colitis or the"},{"speaker":"Hartmut Ehrlich","startTime":502.02,"endTime":507.15,"body":"sister disease, which is Crohn's"},{"speaker":"Hartmut Ehrlich","startTime":507.15,"endTime":511.77,"body":"Disease, or we can also say the"},{"speaker":"Hartmut Ehrlich","startTime":507.15,"endTime":511.77,"body":"other side of the coin of"},{"speaker":"Hartmut Ehrlich","startTime":511.77,"endTime":518.22,"body":"inflammatory bowel disease,"},{"speaker":"Hartmut Ehrlich","startTime":511.77,"endTime":518.22,"body":"people often find out that they"},{"speaker":"Hartmut Ehrlich","startTime":518.22,"endTime":525.12,"body":"have acquaintances, friends,"},{"speaker":"Hartmut Ehrlich","startTime":518.22,"endTime":525.12,"body":"colleagues, relatives, suffering"},{"speaker":"Hartmut Ehrlich","startTime":525.12,"endTime":534.12,"body":"from it, without them initially"},{"speaker":"Hartmut Ehrlich","startTime":525.12,"endTime":534.12,"body":"being aware that the other"},{"speaker":"Hartmut Ehrlich","startTime":534.12,"endTime":540.54,"body":"person indeed has this disease."},{"speaker":"Hartmut Ehrlich","startTime":534.12,"endTime":540.54,"body":"So this is all part of an"},{"speaker":"Hartmut Ehrlich","startTime":540.54,"endTime":548.07,"body":"ongoing education about the"},{"speaker":"Hartmut Ehrlich","startTime":540.54,"endTime":548.07,"body":"disease and creating an"},{"speaker":"Hartmut Ehrlich","startTime":548.07,"endTime":554.61,"body":"understanding for the problems"},{"speaker":"Hartmut Ehrlich","startTime":548.07,"endTime":554.61,"body":"that people who are suffering"},{"speaker":"Hartmut Ehrlich","startTime":554.61,"endTime":556.65,"body":"from this disease are having."},{"speaker":"John Simboli","startTime":557.31,"endTime":559.83,"body":"After that"},{"speaker":"John Simboli","startTime":557.31,"endTime":559.83,"body":"description, do you think that,"},{"speaker":"John Simboli","startTime":560.67,"endTime":563.28,"body":"I know it varies according to"},{"speaker":"John Simboli","startTime":560.67,"endTime":563.28,"body":"the person to whom you're"},{"speaker":"John Simboli","startTime":563.28,"endTime":567.78,"body":"speaking, but do you think"},{"speaker":"John Simboli","startTime":563.28,"endTime":567.78,"body":"people picture you in a lab? Do"},{"speaker":"John Simboli","startTime":567.78,"endTime":571.14,"body":"you think they picture you in a"},{"speaker":"John Simboli","startTime":567.78,"endTime":571.14,"body":"conference room giving orders"},{"speaker":"John Simboli","startTime":571.14,"endTime":579.09,"body":"and when they try to locate you"},{"speaker":"John Simboli","startTime":571.14,"endTime":579.09,"body":"as the CEO of a biopharma"},{"speaker":"John Simboli","startTime":579.09,"endTime":582.33,"body":"company? How do you get across"},{"speaker":"John Simboli","startTime":579.09,"endTime":582.33,"body":"what it is you do each day?"},{"speaker":"Hartmut Ehrlich","startTime":582.93,"endTime":586.83,"body":"The people that"},{"speaker":"Hartmut Ehrlich","startTime":582.93,"endTime":586.83,"body":"I'm typically talking to are"},{"speaker":"Hartmut Ehrlich","startTime":586.83,"endTime":595.08,"body":"usually realizing what the job"},{"speaker":"Hartmut Ehrlich","startTime":586.83,"endTime":595.08,"body":"of the CEO is about. And this is"},{"speaker":"Hartmut Ehrlich","startTime":595.08,"endTime":600.51,"body":"about bringing all the talent in"},{"speaker":"Hartmut Ehrlich","startTime":595.08,"endTime":600.51,"body":"the company together to"},{"speaker":"Hartmut Ehrlich","startTime":600.51,"endTime":608.97,"body":"strategically, essentially align"},{"speaker":"Hartmut Ehrlich","startTime":600.51,"endTime":608.97,"body":"the forces that we have within"},{"speaker":"Hartmut Ehrlich","startTime":608.97,"endTime":614.1,"body":"the company. And so they realize"},{"speaker":"Hartmut Ehrlich","startTime":608.97,"endTime":614.1,"body":"that this is nothing that you"},{"speaker":"Hartmut Ehrlich","startTime":614.1,"endTime":619.89,"body":"can do on the side, this is a"},{"speaker":"Hartmut Ehrlich","startTime":614.1,"endTime":619.89,"body":"full-time job, working with the"},{"speaker":"Hartmut Ehrlich","startTime":619.89,"endTime":626.52,"body":"team, but also working with the"},{"speaker":"Hartmut Ehrlich","startTime":619.89,"endTime":626.52,"body":"board, working with investors,"},{"speaker":"Hartmut Ehrlich","startTime":626.94,"endTime":634.17,"body":"etc, which is clearly the"},{"speaker":"Hartmut Ehrlich","startTime":626.94,"endTime":634.17,"body":"essential part of my job."},{"speaker":"John Simboli","startTime":634.83,"endTime":638.31,"body":"I've heard that"},{"speaker":"John Simboli","startTime":634.83,"endTime":638.31,"body":"described as storytelling, that"},{"speaker":"John Simboli","startTime":638.31,"endTime":641.67,"body":"the main job of a CEO is"},{"speaker":"John Simboli","startTime":638.31,"endTime":641.67,"body":"aligning forces, as you just"},{"speaker":"John Simboli","startTime":641.67,"endTime":644.91,"body":"described, but there's also this"},{"speaker":"John Simboli","startTime":641.67,"endTime":644.91,"body":"other component of telling the"},{"speaker":"John Simboli","startTime":644.91,"endTime":647.7,"body":"story. And I don't mean that in"},{"speaker":"John Simboli","startTime":644.91,"endTime":647.7,"body":"a fictional sense, of course,"},{"speaker":"John Simboli","startTime":647.7,"endTime":650.52,"body":"but it sounds like from what you"},{"speaker":"John Simboli","startTime":647.7,"endTime":650.52,"body":"said at the beginning, that you"},{"speaker":"John Simboli","startTime":650.52,"endTime":654.03,"body":"enjoy talking with investors and"},{"speaker":"John Simboli","startTime":650.52,"endTime":654.03,"body":"telling them that story."},{"speaker":"Hartmut Ehrlich","startTime":654.9,"endTime":657.78,"body":"Absolutely. And"},{"speaker":"Hartmut Ehrlich","startTime":654.9,"endTime":657.78,"body":"I think wouldn't be good in my"},{"speaker":"Hartmut Ehrlich","startTime":657.78,"endTime":662.64,"body":"job, if I wouldn't enjoy this."},{"speaker":"Hartmut Ehrlich","startTime":657.78,"endTime":662.64,"body":"And also, as this is such a"},{"speaker":"Hartmut Ehrlich","startTime":662.64,"endTime":667.83,"body":"necessity for me, I think I will"},{"speaker":"Hartmut Ehrlich","startTime":662.64,"endTime":667.83,"body":"take this a step forward and"},{"speaker":"Hartmut Ehrlich","startTime":667.83,"endTime":676.89,"body":"say, if I wouldn't enjoy this, I"},{"speaker":"Hartmut Ehrlich","startTime":667.83,"endTime":676.89,"body":"really wouldn't be suitable to"},{"speaker":"Hartmut Ehrlich","startTime":676.98,"endTime":688.83,"body":"function in my role of CEO. When"},{"speaker":"Hartmut Ehrlich","startTime":676.98,"endTime":688.83,"body":"you are faced with bringing this"},{"speaker":"Hartmut Ehrlich","startTime":688.86,"endTime":694.89,"body":"story of the company, the story"},{"speaker":"Hartmut Ehrlich","startTime":688.86,"endTime":694.89,"body":"of the product, the story of the"},{"speaker":"Hartmut Ehrlich","startTime":694.89,"endTime":700.56,"body":"patients across to any kind of"},{"speaker":"Hartmut Ehrlich","startTime":694.89,"endTime":700.56,"body":"audience, whether these are"},{"speaker":"Hartmut Ehrlich","startTime":700.56,"endTime":704.49,"body":"investors, whether these"},{"speaker":"Hartmut Ehrlich","startTime":700.56,"endTime":704.49,"body":"physicians that are interested"},{"speaker":"Hartmut Ehrlich","startTime":704.49,"endTime":711.54,"body":"in participating in a clinical"},{"speaker":"Hartmut Ehrlich","startTime":704.49,"endTime":711.54,"body":"trial, whether this is your own"},{"speaker":"Hartmut Ehrlich","startTime":711.54,"endTime":718.68,"body":"team, storytelling is really"},{"speaker":"Hartmut Ehrlich","startTime":711.54,"endTime":718.68,"body":"critical, from my point of view,"},{"speaker":"Hartmut Ehrlich","startTime":719.01,"endTime":725.16,"body":"so that your audience is getting"},{"speaker":"Hartmut Ehrlich","startTime":719.01,"endTime":725.16,"body":"the real essentials about what"},{"speaker":"Hartmut Ehrlich","startTime":725.16,"endTime":731.16,"body":"you do. And this is far better"},{"speaker":"Hartmut Ehrlich","startTime":725.16,"endTime":731.16,"body":"accomplished, by providing"},{"speaker":"Hartmut Ehrlich","startTime":731.16,"endTime":737.37,"body":"examples by providing stories"},{"speaker":"Hartmut Ehrlich","startTime":731.16,"endTime":737.37,"body":"than just presenting the facts."},{"speaker":"Hartmut Ehrlich","startTime":737.58,"endTime":746.22,"body":"For example, the mechanism of"},{"speaker":"Hartmut Ehrlich","startTime":737.58,"endTime":746.22,"body":"action of of ABX464, which goes"},{"speaker":"Hartmut Ehrlich","startTime":746.25,"endTime":753.3,"body":"into a lot of biology and"},{"speaker":"Hartmut Ehrlich","startTime":746.25,"endTime":753.3,"body":"biochemistry. And if you can"},{"speaker":"Hartmut Ehrlich","startTime":753.39,"endTime":760.62,"body":"bring this across in a way that"},{"speaker":"Hartmut Ehrlich","startTime":753.39,"endTime":760.62,"body":"even complex mechanisms can be"},{"speaker":"Hartmut Ehrlich","startTime":760.62,"endTime":765.51,"body":"understood, especially from the"},{"speaker":"Hartmut Ehrlich","startTime":760.62,"endTime":765.51,"body":"way of where do they lead to?"},{"speaker":"Hartmut Ehrlich","startTime":765.54,"endTime":772.77,"body":"What does it mean to the"},{"speaker":"Hartmut Ehrlich","startTime":765.54,"endTime":772.77,"body":"patients, for example? That is"},{"speaker":"Hartmut Ehrlich","startTime":772.77,"endTime":778.44,"body":"something from my point of view"},{"speaker":"Hartmut Ehrlich","startTime":772.77,"endTime":778.44,"body":"that is essential in bringing a"},{"speaker":"Hartmut Ehrlich","startTime":778.44,"endTime":779.67,"body":"message across."},{"speaker":"John Simboli","startTime":780.78,"endTime":783.54,"body":"In my experience,"},{"speaker":"John Simboli","startTime":780.78,"endTime":783.54,"body":"the people that I've met who"},{"speaker":"John Simboli","startTime":783.54,"endTime":788.67,"body":"have become biopharma CEOs often"},{"speaker":"John Simboli","startTime":783.54,"endTime":788.67,"body":"come from big pharma, or other"},{"speaker":"John Simboli","startTime":789.75,"endTime":795.99,"body":"places where they were in a more"},{"speaker":"John Simboli","startTime":789.75,"endTime":795.99,"body":"secure environment. And you can"},{"speaker":"John Simboli","startTime":795.99,"endTime":799.68,"body":"define secure in lots of"},{"speaker":"John Simboli","startTime":795.99,"endTime":799.68,"body":"different ways. And it occurs to"},{"speaker":"John Simboli","startTime":799.68,"endTime":803.94,"body":"me, working alongside some of"},{"speaker":"John Simboli","startTime":799.68,"endTime":803.94,"body":"these folks, that this is a very"},{"speaker":"John Simboli","startTime":803.94,"endTime":807.69,"body":"hard way to make a living,"},{"speaker":"John Simboli","startTime":803.94,"endTime":807.69,"body":"because the chances of success"},{"speaker":"John Simboli","startTime":807.69,"endTime":812.43,"body":"are not high. There's so many"},{"speaker":"John Simboli","startTime":807.69,"endTime":812.43,"body":"people trying new ideas. It's"},{"speaker":"John Simboli","startTime":812.43,"endTime":816.15,"body":"almost by definition, it's an"},{"speaker":"John Simboli","startTime":812.43,"endTime":816.15,"body":"extremely difficult task. So my"},{"speaker":"John Simboli","startTime":816.15,"endTime":820.59,"body":"question is, why? Why does one"},{"speaker":"John Simboli","startTime":816.15,"endTime":820.59,"body":"choose to do something so hard?"},{"speaker":"Hartmut Ehrlich","startTime":821.07,"endTime":823.95,"body":"That's a very"},{"speaker":"Hartmut Ehrlich","startTime":821.07,"endTime":823.95,"body":"interesting question that I must"},{"speaker":"Hartmut Ehrlich","startTime":823.95,"endTime":831.87,"body":"admit, I never asked myself. For"},{"speaker":"Hartmut Ehrlich","startTime":823.95,"endTime":831.87,"body":"me. It has a lot to do with"},{"speaker":"Hartmut Ehrlich","startTime":832.56,"endTime":842.67,"body":"leadership. And I really enjoy"},{"speaker":"Hartmut Ehrlich","startTime":832.56,"endTime":842.67,"body":"leading a very competent group"},{"speaker":"Hartmut Ehrlich","startTime":842.67,"endTime":849.87,"body":"of people, experts in the field."},{"speaker":"Hartmut Ehrlich","startTime":842.67,"endTime":849.87,"body":"And by the way, my mantra is"},{"speaker":"Hartmut Ehrlich","startTime":849.9,"endTime":858.81,"body":"that every single individual in"},{"speaker":"Hartmut Ehrlich","startTime":849.9,"endTime":858.81,"body":"my leadership team, for his"},{"speaker":"Hartmut Ehrlich","startTime":858.84,"endTime":867.03,"body":"specific area of expertise, has"},{"speaker":"Hartmut Ehrlich","startTime":858.84,"endTime":867.03,"body":"to be better than I am in this"},{"speaker":"Hartmut Ehrlich","startTime":867.78,"endTime":876.51,"body":"particular area, to play the"},{"speaker":"Hartmut Ehrlich","startTime":867.78,"endTime":876.51,"body":"role that I'm expecting from"},{"speaker":"Hartmut Ehrlich","startTime":876.51,"endTime":883.14,"body":"these individuals. So I think,"},{"speaker":"Hartmut Ehrlich","startTime":876.51,"endTime":883.14,"body":"for me, it's an interesting"},{"speaker":"Hartmut Ehrlich","startTime":883.44,"endTime":891.06,"body":"leadership challenge. It has to"},{"speaker":"Hartmut Ehrlich","startTime":883.44,"endTime":891.06,"body":"do with not being afraid of"},{"speaker":"Hartmut Ehrlich","startTime":892.02,"endTime":899.67,"body":"having to deal with complexity."},{"speaker":"Hartmut Ehrlich","startTime":892.02,"endTime":899.67,"body":"And around the leadership, then"},{"speaker":"Hartmut Ehrlich","startTime":899.67,"endTime":909.03,"body":"again, having a personality that"},{"speaker":"Hartmut Ehrlich","startTime":899.67,"endTime":909.03,"body":"is actually characterized by"},{"speaker":"Hartmut Ehrlich","startTime":909.18,"endTime":917.1,"body":"deriving transparency in the"},{"speaker":"Hartmut Ehrlich","startTime":909.18,"endTime":917.1,"body":"team, and as a consequence, open"},{"speaker":"Hartmut Ehrlich","startTime":917.1,"endTime":924.39,"body":"discussion in order to get the"},{"speaker":"Hartmut Ehrlich","startTime":917.1,"endTime":924.39,"body":"best outcome for the"},{"speaker":"Hartmut Ehrlich","startTime":924.39,"endTime":928.68,"body":"organization. And that also"},{"speaker":"Hartmut Ehrlich","startTime":924.39,"endTime":928.68,"body":"means that there is an"},{"speaker":"Hartmut Ehrlich","startTime":928.71,"endTime":936.03,"body":"overriding principle to me that"},{"speaker":"Hartmut Ehrlich","startTime":928.71,"endTime":936.03,"body":"communication is absolutely"},{"speaker":"Hartmut Ehrlich","startTime":936.03,"endTime":942.06,"body":"critical for the success of the"},{"speaker":"Hartmut Ehrlich","startTime":936.03,"endTime":942.06,"body":"organization. And that means,"},{"speaker":"Hartmut Ehrlich","startTime":942.48,"endTime":952.17,"body":"for my own personal success. I"},{"speaker":"Hartmut Ehrlich","startTime":942.48,"endTime":952.17,"body":"believe, and this is something"},{"speaker":"Hartmut Ehrlich","startTime":952.2,"endTime":960.6,"body":"that is also important when you"},{"speaker":"Hartmut Ehrlich","startTime":952.2,"endTime":960.6,"body":"ask, what really counts, leading"},{"speaker":"Hartmut Ehrlich","startTime":960.6,"endTime":969.6,"body":"by example and being authentic"},{"speaker":"Hartmut Ehrlich","startTime":960.6,"endTime":969.6,"body":"is absolutely important. Because"},{"speaker":"Hartmut Ehrlich","startTime":969.66,"endTime":977.07,"body":"I see, the team and myself"},{"speaker":"Hartmut Ehrlich","startTime":969.66,"endTime":977.07,"body":"together, trying to, as I"},{"speaker":"Hartmut Ehrlich","startTime":977.07,"endTime":979.95,"body":"mentioned, to get to the best"},{"speaker":"Hartmut Ehrlich","startTime":977.07,"endTime":979.95,"body":"outcome for the company, and"},{"speaker":"Hartmut Ehrlich","startTime":979.95,"endTime":986.85,"body":"that can only be accomplished if"},{"speaker":"Hartmut Ehrlich","startTime":979.95,"endTime":986.85,"body":"I trust my team. And if I'm not"},{"speaker":"Hartmut Ehrlich","startTime":986.85,"endTime":992.04,"body":"afraid of really being authentic"},{"speaker":"Hartmut Ehrlich","startTime":986.85,"endTime":992.04,"body":"when I interact with the team,"},{"speaker":"Hartmut Ehrlich","startTime":992.55,"endTime":1001.01,"body":"and really driving the team to"},{"speaker":"Hartmut Ehrlich","startTime":992.55,"endTime":1001.01,"body":"full transparency, I would add"},{"speaker":"Hartmut Ehrlich","startTime":1001.01,"endTime":1012.92,"body":"to this, I think, lack of fear."},{"speaker":"Hartmut Ehrlich","startTime":1001.01,"endTime":1012.92,"body":"I would say people who are not"},{"speaker":"Hartmut Ehrlich","startTime":1012.92,"endTime":1022.25,"body":"very optimistic, for them, there"},{"speaker":"Hartmut Ehrlich","startTime":1012.92,"endTime":1022.25,"body":"is really not much of a role in"},{"speaker":"Hartmut Ehrlich","startTime":1022.25,"endTime":1028.76,"body":"leading a company, as you said,"},{"speaker":"Hartmut Ehrlich","startTime":1022.25,"endTime":1028.76,"body":"in this space. Because if you"},{"speaker":"Hartmut Ehrlich","startTime":1028.76,"endTime":1032.06,"body":"look what the chances are for"},{"speaker":"Hartmut Ehrlich","startTime":1028.76,"endTime":1032.06,"body":"you to ever be able to"},{"speaker":"Hartmut Ehrlich","startTime":1032.06,"endTime":1038.51,"body":"participate in a successful"},{"speaker":"Hartmut Ehrlich","startTime":1032.06,"endTime":1038.51,"body":"development program, and you"},{"speaker":"Hartmut Ehrlich","startTime":1038.51,"endTime":1043.16,"body":"know that very well, I suppose,"},{"speaker":"Hartmut Ehrlich","startTime":1038.51,"endTime":1043.16,"body":"these chances are actually"},{"speaker":"Hartmut Ehrlich","startTime":1043.19,"endTime":1051.41,"body":"relatively slim. So even moreso"},{"speaker":"Hartmut Ehrlich","startTime":1043.19,"endTime":1051.41,"body":"that is a very rewarding factor"},{"speaker":"Hartmut Ehrlich","startTime":1052.04,"endTime":1058.97,"body":"in the team, driving a promising"},{"speaker":"Hartmut Ehrlich","startTime":1052.04,"endTime":1058.97,"body":"compound into the last stage of"},{"speaker":"Hartmut Ehrlich","startTime":1059.21,"endTime":1064.52,"body":"clinical development, phase 3,"},{"speaker":"Hartmut Ehrlich","startTime":1059.21,"endTime":1064.52,"body":"and then collecting the data and"},{"speaker":"Hartmut Ehrlich","startTime":1065.0,"endTime":1071.06,"body":"applying for registration. This"},{"speaker":"Hartmut Ehrlich","startTime":1065.0,"endTime":1071.06,"body":"is actually very, very"},{"speaker":"Hartmut Ehrlich","startTime":1071.09,"endTime":1076.4,"body":"motivating for the team. But if"},{"speaker":"Hartmut Ehrlich","startTime":1071.09,"endTime":1076.4,"body":"you are a person for whom the"},{"speaker":"Hartmut Ehrlich","startTime":1076.4,"endTime":1084.44,"body":"glass is half empty, that may"},{"speaker":"Hartmut Ehrlich","startTime":1076.4,"endTime":1084.44,"body":"pose a substantial hurdle in"},{"speaker":"Hartmut Ehrlich","startTime":1084.44,"endTime":1091.13,"body":"being successful in this role,"},{"speaker":"Hartmut Ehrlich","startTime":1084.44,"endTime":1091.13,"body":"because as we all know, positive"},{"speaker":"Hartmut Ehrlich","startTime":1092.06,"endTime":1099.92,"body":"energy, the ability to carry"},{"speaker":"Hartmut Ehrlich","startTime":1092.06,"endTime":1099.92,"body":"other people with you, to have"},{"speaker":"Hartmut Ehrlich","startTime":1099.92,"endTime":1104.24,"body":"them experience how can you"},{"speaker":"Hartmut Ehrlich","startTime":1099.92,"endTime":1104.24,"body":"remove obstacles, et cetera? I"},{"speaker":"Hartmut Ehrlich","startTime":1104.24,"endTime":1107.33,"body":"think this is so important in"},{"speaker":"Hartmut Ehrlich","startTime":1104.24,"endTime":1107.33,"body":"this role."},{"speaker":"John Simboli","startTime":1108.11,"endTime":1110.12,"body":"I know just from"},{"speaker":"John Simboli","startTime":1108.11,"endTime":1110.12,"body":"reading a little bit about your"},{"speaker":"John Simboli","startTime":1110.12,"endTime":1114.17,"body":"background, that you're a"},{"speaker":"John Simboli","startTime":1110.12,"endTime":1114.17,"body":"physician. Did you go through"},{"speaker":"John Simboli","startTime":1114.17,"endTime":1117.26,"body":"anything that was like that"},{"speaker":"John Simboli","startTime":1114.17,"endTime":1117.26,"body":"transition from helping an"},{"speaker":"John Simboli","startTime":1117.26,"endTime":1120.83,"body":"individual person in a"},{"speaker":"John Simboli","startTime":1117.26,"endTime":1120.83,"body":"remarkable way to potentially"},{"speaker":"John Simboli","startTime":1120.83,"endTime":1122.63,"body":"helping a lot of people in a"},{"speaker":"John Simboli","startTime":1120.83,"endTime":1122.63,"body":"remarkable way?"},{"speaker":"Hartmut Ehrlich","startTime":1123.2,"endTime":1127.31,"body":"The idea to"},{"speaker":"Hartmut Ehrlich","startTime":1123.2,"endTime":1127.31,"body":"provide new therapies for"},{"speaker":"Hartmut Ehrlich","startTime":1127.31,"endTime":1132.5,"body":"patients who currently are"},{"speaker":"Hartmut Ehrlich","startTime":1127.31,"endTime":1132.5,"body":"basically left alone with the"},{"speaker":"Hartmut Ehrlich","startTime":1132.5,"endTime":1140.3,"body":"disease is so rewarding. And of"},{"speaker":"Hartmut Ehrlich","startTime":1132.5,"endTime":1140.3,"body":"course, I had this previously in"},{"speaker":"Hartmut Ehrlich","startTime":1140.87,"endTime":1145.67,"body":"my life. For example, when at"},{"speaker":"Hartmut Ehrlich","startTime":1140.87,"endTime":1145.67,"body":"Baxter, we introduced the first"},{"speaker":"Hartmut Ehrlich","startTime":1145.67,"endTime":1149.72,"body":"recombinant and then the second"},{"speaker":"Hartmut Ehrlich","startTime":1145.67,"endTime":1149.72,"body":"recombinant factor VIII product"},{"speaker":"Hartmut Ehrlich","startTime":1149.72,"endTime":1154.82,"body":"for patients with hemophilia."},{"speaker":"Hartmut Ehrlich","startTime":1149.72,"endTime":1154.82,"body":"And, of course, these were"},{"speaker":"Hartmut Ehrlich","startTime":1154.82,"endTime":1164.06,"body":"products, because they were not"},{"speaker":"Hartmut Ehrlich","startTime":1154.82,"endTime":1164.06,"body":"made with any kind of human"},{"speaker":"Hartmut Ehrlich","startTime":1164.45,"endTime":1171.59,"body":"ingredients, that presented a"},{"speaker":"Hartmut Ehrlich","startTime":1164.45,"endTime":1171.59,"body":"very different level of safety"},{"speaker":"Hartmut Ehrlich","startTime":1172.58,"endTime":1178.67,"body":"for the patients. This is"},{"speaker":"Hartmut Ehrlich","startTime":1172.58,"endTime":1178.67,"body":"something that from my point of"},{"speaker":"Hartmut Ehrlich","startTime":1178.67,"endTime":1184.28,"body":"view, attracts me more than"},{"speaker":"Hartmut Ehrlich","startTime":1178.67,"endTime":1184.28,"body":"treating individual patients,"},{"speaker":"Hartmut Ehrlich","startTime":1184.31,"endTime":1191.54,"body":"providing new or improved, and"},{"speaker":"Hartmut Ehrlich","startTime":1184.31,"endTime":1191.54,"body":"improved can mean efficacy,"},{"speaker":"Hartmut Ehrlich","startTime":1191.54,"endTime":1196.79,"body":"improved can mean safety, as I"},{"speaker":"Hartmut Ehrlich","startTime":1191.54,"endTime":1196.79,"body":"as I mentioned, or improve the"},{"speaker":"Hartmut Ehrlich","startTime":1196.79,"endTime":1205.1,"body":"products to the patients. that"},{"speaker":"Hartmut Ehrlich","startTime":1196.79,"endTime":1205.1,"body":"actually take away their major"},{"speaker":"Hartmut Ehrlich","startTime":1205.1,"endTime":1210.59,"body":"fears. In the case that I just"},{"speaker":"Hartmut Ehrlich","startTime":1205.1,"endTime":1210.59,"body":"mentioned, it was clearly the"},{"speaker":"Hartmut Ehrlich","startTime":1210.59,"endTime":1220.85,"body":"fear of being infected with"},{"speaker":"Hartmut Ehrlich","startTime":1210.59,"endTime":1220.85,"body":"viral diseases. When patients"},{"speaker":"Hartmut Ehrlich","startTime":1220.85,"endTime":1226.64,"body":"were treated with plasma-derived"},{"speaker":"Hartmut Ehrlich","startTime":1220.85,"endTime":1226.64,"body":"products, as we know from the"},{"speaker":"Hartmut Ehrlich","startTime":1226.82,"endTime":1236.09,"body":"80s, so that this evolution to"},{"speaker":"Hartmut Ehrlich","startTime":1226.82,"endTime":1236.09,"body":"then recombinant products was"},{"speaker":"Hartmut Ehrlich","startTime":1236.09,"endTime":1240.59,"body":"really beautiful to see from the"},{"speaker":"Hartmut Ehrlich","startTime":1236.09,"endTime":1240.59,"body":"point of view what it did for"},{"speaker":"Hartmut Ehrlich","startTime":1240.59,"endTime":1241.4,"body":"patients."},{"speaker":"John Simboli","startTime":1242.84,"endTime":1245.0,"body":"Can you recall"},{"speaker":"John Simboli","startTime":1242.84,"endTime":1245.0,"body":"when you were eight or nine or"},{"speaker":"John Simboli","startTime":1245.06,"endTime":1248.3,"body":"10, did you have any kind of"},{"speaker":"John Simboli","startTime":1245.06,"endTime":1248.3,"body":"self image that you can remember"},{"speaker":"John Simboli","startTime":1248.3,"endTime":1253.58,"body":"now about what you wanted to be"},{"speaker":"John Simboli","startTime":1248.3,"endTime":1253.58,"body":"as an adult? Perhaps what you"},{"speaker":"John Simboli","startTime":1253.58,"endTime":1256.28,"body":"thought your parents thought you"},{"speaker":"John Simboli","startTime":1253.58,"endTime":1256.28,"body":"should do? And does that have"},{"speaker":"John Simboli","startTime":1256.28,"endTime":1259.07,"body":"anything to do with what you're"},{"speaker":"John Simboli","startTime":1256.28,"endTime":1259.07,"body":"doing now professionally?"},{"speaker":"Hartmut Ehrlich","startTime":1259.49,"endTime":1266.09,"body":"I was not"},{"speaker":"Hartmut Ehrlich","startTime":1259.49,"endTime":1266.09,"body":"really following a peculiar lead"},{"speaker":"Hartmut Ehrlich","startTime":1266.12,"endTime":1274.4,"body":"at this particular age. So I can"},{"speaker":"Hartmut Ehrlich","startTime":1266.12,"endTime":1274.4,"body":"remember then, when I was 15, or"},{"speaker":"Hartmut Ehrlich","startTime":1274.4,"endTime":1284.18,"body":"16, and in the last years of"},{"speaker":"Hartmut Ehrlich","startTime":1274.4,"endTime":1284.18,"body":"high school, that was the time"},{"speaker":"Hartmut Ehrlich","startTime":1284.21,"endTime":1290.84,"body":"when I started to seriously"},{"speaker":"Hartmut Ehrlich","startTime":1284.21,"endTime":1290.84,"body":"consider becoming a physician."},{"speaker":"Hartmut Ehrlich","startTime":1291.32,"endTime":1297.86,"body":"This was then what I wanted to"},{"speaker":"Hartmut Ehrlich","startTime":1291.32,"endTime":1297.86,"body":"accomplish. If you allow me,"},{"speaker":"Hartmut Ehrlich","startTime":1297.86,"endTime":1302.87,"body":"I'll give you a very personal"},{"speaker":"Hartmut Ehrlich","startTime":1297.86,"endTime":1302.87,"body":"vignette here. I was always a"},{"speaker":"Hartmut Ehrlich","startTime":1302.87,"endTime":1310.07,"body":"good student in school. But I"},{"speaker":"Hartmut Ehrlich","startTime":1302.87,"endTime":1310.07,"body":"wasn't sort of the the absolute"},{"speaker":"Hartmut Ehrlich","startTime":1310.58,"endTime":1316.31,"body":"top. And so my grade point"},{"speaker":"Hartmut Ehrlich","startTime":1310.58,"endTime":1316.31,"body":"average at the time was"},{"speaker":"Hartmut Ehrlich","startTime":1316.31,"endTime":1325.88,"body":"certainly not sufficient to go"},{"speaker":"Hartmut Ehrlich","startTime":1316.31,"endTime":1325.88,"body":"directly to medical school after"},{"speaker":"Hartmut Ehrlich","startTime":1326.42,"endTime":1333.32,"body":"I received my high school"},{"speaker":"Hartmut Ehrlich","startTime":1326.42,"endTime":1333.32,"body":"diploma, therefore, I decided in"},{"speaker":"Hartmut Ehrlich","startTime":1333.32,"endTime":1339.8,"body":"the last year of high school to"},{"speaker":"Hartmut Ehrlich","startTime":1333.32,"endTime":1339.8,"body":"actually not go for the final"},{"speaker":"Hartmut Ehrlich","startTime":1339.8,"endTime":1348.77,"body":"exams, but ask to be put a year"},{"speaker":"Hartmut Ehrlich","startTime":1339.8,"endTime":1348.77,"body":"back in school. So I had another"},{"speaker":"Hartmut Ehrlich","startTime":1348.77,"endTime":1359.09,"body":"shot at my grades. And so, as it"},{"speaker":"Hartmut Ehrlich","startTime":1348.77,"endTime":1359.09,"body":"happened, I was very lucky"},{"speaker":"Hartmut Ehrlich","startTime":1359.09,"endTime":1363.5,"body":"because there was a lot of"},{"speaker":"Hartmut Ehrlich","startTime":1359.09,"endTime":1363.5,"body":"appreciation for this from my"},{"speaker":"Hartmut Ehrlich","startTime":1363.5,"endTime":1366.68,"body":"teachers. In the end, I got the"},{"speaker":"Hartmut Ehrlich","startTime":1363.5,"endTime":1366.68,"body":"great point average that I"},{"speaker":"Hartmut Ehrlich","startTime":1366.68,"endTime":1371.87,"body":"needed, and was able to go"},{"speaker":"Hartmut Ehrlich","startTime":1366.68,"endTime":1371.87,"body":"straight to medical school after"},{"speaker":"Hartmut Ehrlich","startTime":1371.9,"endTime":1375.08,"body":"my my high school diploma."},{"speaker":"John Simboli","startTime":1375.83,"endTime":1378.71,"body":"That squares with"},{"speaker":"John Simboli","startTime":1375.83,"endTime":1378.71,"body":"my image of what it takes to be"},{"speaker":"John Simboli","startTime":1378.71,"endTime":1383.15,"body":"a successful CEO, in some ways,"},{"speaker":"John Simboli","startTime":1378.71,"endTime":1383.15,"body":"in biopharma, I would call it,"},{"speaker":"John Simboli","startTime":1383.18,"endTime":1388.46,"body":"not intentionally referring to a"},{"speaker":"John Simboli","startTime":1383.18,"endTime":1388.46,"body":"religious idea, but a messianic"},{"speaker":"John Simboli","startTime":1388.46,"endTime":1392.66,"body":"principle, you have to believe"},{"speaker":"John Simboli","startTime":1388.46,"endTime":1392.66,"body":"in a long term possibility."},{"speaker":"Hartmut Ehrlich","startTime":1392.87,"endTime":1397.1,"body":"I fully agree"},{"speaker":"Hartmut Ehrlich","startTime":1392.87,"endTime":1397.1,"body":"with you. And I think it is also"},{"speaker":"Hartmut Ehrlich","startTime":1397.13,"endTime":1401.24,"body":"really critical at certain"},{"speaker":"Hartmut Ehrlich","startTime":1397.13,"endTime":1401.24,"body":"stages of your life to take"},{"speaker":"Hartmut Ehrlich","startTime":1401.24,"endTime":1405.44,"body":"certain risks. Nobody could"},{"speaker":"Hartmut Ehrlich","startTime":1401.24,"endTime":1405.44,"body":"guarantee to me that this would"},{"speaker":"Hartmut Ehrlich","startTime":1407.06,"endTime":1412.28,"body":"be successful, this approach to"},{"speaker":"Hartmut Ehrlich","startTime":1407.06,"endTime":1412.28,"body":"step back one year in high"},{"speaker":"Hartmut Ehrlich","startTime":1412.28,"endTime":1417.59,"body":"school. And actually, there were"},{"speaker":"Hartmut Ehrlich","startTime":1412.28,"endTime":1417.59,"body":"several people that told me why"},{"speaker":"Hartmut Ehrlich","startTime":1417.59,"endTime":1423.11,"body":"did you do it? Why did you not"},{"speaker":"Hartmut Ehrlich","startTime":1417.59,"endTime":1423.11,"body":"do what most of the people did"},{"speaker":"Hartmut Ehrlich","startTime":1423.11,"endTime":1427.91,"body":"who were in a similar situation?"},{"speaker":"Hartmut Ehrlich","startTime":1423.11,"endTime":1427.91,"body":"They graduated and then had to"},{"speaker":"Hartmut Ehrlich","startTime":1427.91,"endTime":1433.64,"body":"deal with a waiting list for"},{"speaker":"Hartmut Ehrlich","startTime":1427.91,"endTime":1433.64,"body":"medical school for about five or"},{"speaker":"Hartmut Ehrlich","startTime":1433.64,"endTime":1438.38,"body":"six years. I saw the"},{"speaker":"Hartmut Ehrlich","startTime":1433.64,"endTime":1438.38,"body":"opportunity, I figured it's"},{"speaker":"Hartmut Ehrlich","startTime":1438.38,"endTime":1445.91,"body":"entirely upon me. And of course,"},{"speaker":"Hartmut Ehrlich","startTime":1438.38,"endTime":1445.91,"body":"on my teachers. I realized that"},{"speaker":"Hartmut Ehrlich","startTime":1446.27,"endTime":1453.56,"body":"risk taking is an essential part"},{"speaker":"Hartmut Ehrlich","startTime":1446.27,"endTime":1453.56,"body":"of life. And if you are a person"},{"speaker":"Hartmut Ehrlich","startTime":1453.56,"endTime":1458.54,"body":"who is not afraid of taking"},{"speaker":"Hartmut Ehrlich","startTime":1453.56,"endTime":1458.54,"body":"risks, then this is really the"},{"speaker":"Hartmut Ehrlich","startTime":1458.54,"endTime":1462.86,"body":"right path forward. And as you"},{"speaker":"Hartmut Ehrlich","startTime":1458.54,"endTime":1462.86,"body":"could see, I ended up as a CEO,"},{"speaker":"John Simboli","startTime":1463.79,"endTime":1467.45,"body":"When you're trying"},{"speaker":"John Simboli","startTime":1463.79,"endTime":1467.45,"body":"to give a very short defined,"},{"speaker":"John Simboli","startTime":1467.87,"endTime":1472.1,"body":"structured description of what"},{"speaker":"John Simboli","startTime":1467.87,"endTime":1472.1,"body":"Abivax is, how do you like to"},{"speaker":"John Simboli","startTime":1472.1,"endTime":1475.25,"body":"answer that when someone says,"},{"speaker":"John Simboli","startTime":1472.1,"endTime":1475.25,"body":"Who is Abivax? What do you say?"},{"speaker":"Hartmut Ehrlich","startTime":1475.97,"endTime":1482.3,"body":"We are a French"},{"speaker":"Hartmut Ehrlich","startTime":1475.97,"endTime":1482.3,"body":"biotech company, founded in 2013"},{"speaker":"Hartmut Ehrlich","startTime":1482.96,"endTime":1489.2,"body":"and listed at the Euronext Stock"},{"speaker":"Hartmut Ehrlich","startTime":1482.96,"endTime":1489.2,"body":"Exchange in Paris since 2015. We"},{"speaker":"Hartmut Ehrlich","startTime":1489.2,"endTime":1494.96,"body":"have a small but very dedicated"},{"speaker":"Hartmut Ehrlich","startTime":1489.2,"endTime":1494.96,"body":"team of roughly 50 employees and"},{"speaker":"Hartmut Ehrlich","startTime":1494.96,"endTime":1501.2,"body":"collaborators and are supported"},{"speaker":"Hartmut Ehrlich","startTime":1494.96,"endTime":1501.2,"body":"by top tier U.S. and European"},{"speaker":"Hartmut Ehrlich","startTime":1501.23,"endTime":1502.31,"body":"investors.``"},{"speaker":"John Simboli","startTime":1502.79,"endTime":1506.63,"body":"Why is it that"},{"speaker":"John Simboli","startTime":1502.79,"endTime":1506.63,"body":"patients need something that you"},{"speaker":"John Simboli","startTime":1506.63,"endTime":1510.38,"body":"hope to be able to deliver to"},{"speaker":"John Simboli","startTime":1506.63,"endTime":1510.38,"body":"them? What is the gap?"},{"speaker":"Hartmut Ehrlich","startTime":1511.01,"endTime":1517.97,"body":"The gap is"},{"speaker":"Hartmut Ehrlich","startTime":1511.01,"endTime":1517.97,"body":"based on the spectrum of current"},{"speaker":"Hartmut Ehrlich","startTime":1517.97,"endTime":1522.38,"body":"treatments. Inflammatory bowel"},{"speaker":"Hartmut Ehrlich","startTime":1517.97,"endTime":1522.38,"body":"disease, whether we talk about"},{"speaker":"Hartmut Ehrlich","startTime":1522.38,"endTime":1532.7,"body":"Crohn's or whether we talk about"},{"speaker":"Hartmut Ehrlich","startTime":1522.38,"endTime":1532.7,"body":"ulcerative colitis is a disease"},{"speaker":"Hartmut Ehrlich","startTime":1533.12,"endTime":1542.48,"body":"that massively impacts the"},{"speaker":"Hartmut Ehrlich","startTime":1533.12,"endTime":1542.48,"body":"patients. And whereas there were"},{"speaker":"Hartmut Ehrlich","startTime":1542.51,"endTime":1548.66,"body":"relatively few treatments that"},{"speaker":"Hartmut Ehrlich","startTime":1542.51,"endTime":1548.66,"body":"provided some kind of"},{"speaker":"Hartmut Ehrlich","startTime":1548.69,"endTime":1555.83,"body":"amelioration of symptoms before"},{"speaker":"Hartmut Ehrlich","startTime":1548.69,"endTime":1555.83,"body":"the advent of what we now call"},{"speaker":"Hartmut Ehrlich","startTime":1555.86,"endTime":1562.94,"body":"advanced therapies, monoclonal"},{"speaker":"Hartmut Ehrlich","startTime":1555.86,"endTime":1562.94,"body":"antibodies, JAK inhibitors, S1P"},{"speaker":"Hartmut Ehrlich","startTime":1562.94,"endTime":1568.67,"body":"inhibitors, etc. The fact is"},{"speaker":"Hartmut Ehrlich","startTime":1562.94,"endTime":1568.67,"body":"that patients with this disease,"},{"speaker":"Hartmut Ehrlich","startTime":1568.73,"endTime":1574.31,"body":"there is no cure. With what we"},{"speaker":"Hartmut Ehrlich","startTime":1568.73,"endTime":1574.31,"body":"know today, we simply cannot"},{"speaker":"Hartmut Ehrlich","startTime":1574.31,"endTime":1578.15,"body":"cure the disease. So then you"},{"speaker":"Hartmut Ehrlich","startTime":1574.31,"endTime":1578.15,"body":"ask yourself, what is the"},{"speaker":"Hartmut Ehrlich","startTime":1578.15,"endTime":1583.7,"body":"situation about the patients if"},{"speaker":"Hartmut Ehrlich","startTime":1578.15,"endTime":1583.7,"body":"they take state of the art"},{"speaker":"Hartmut Ehrlich","startTime":1584.03,"endTime":1589.55,"body":"therapies, and then you realize"},{"speaker":"Hartmut Ehrlich","startTime":1584.03,"endTime":1589.55,"body":"that treatments that have been"},{"speaker":"Hartmut Ehrlich","startTime":1589.55,"endTime":1596.18,"body":"introduced since the early"},{"speaker":"Hartmut Ehrlich","startTime":1589.55,"endTime":1596.18,"body":"2000s, with HUMIRA and Entyvio,"},{"speaker":"Hartmut Ehrlich","startTime":1596.33,"endTime":1602.87,"body":"Stelara and others, you realize"},{"speaker":"Hartmut Ehrlich","startTime":1596.33,"endTime":1602.87,"body":"that these treatments bring"},{"speaker":"Hartmut Ehrlich","startTime":1603.32,"endTime":1610.07,"body":"something between, I would say"},{"speaker":"Hartmut Ehrlich","startTime":1603.32,"endTime":1610.07,"body":"10 and 20% of the patients into"},{"speaker":"Hartmut Ehrlich","startTime":1610.1,"endTime":1617.0,"body":"a remission status within eight"},{"speaker":"Hartmut Ehrlich","startTime":1610.1,"endTime":1617.0,"body":"weeks of taking the product, but"},{"speaker":"Hartmut Ehrlich","startTime":1617.03,"endTime":1621.83,"body":"that only and that may be"},{"speaker":"Hartmut Ehrlich","startTime":1617.03,"endTime":1621.83,"body":"surprising that the percentages"},{"speaker":"Hartmut Ehrlich","startTime":1621.86,"endTime":1628.85,"body":"are relatively low. But this is"},{"speaker":"Hartmut Ehrlich","startTime":1621.86,"endTime":1628.85,"body":"basically sort of the initial"},{"speaker":"Hartmut Ehrlich","startTime":1629.12,"endTime":1633.29,"body":"phase of the treatment and you"},{"speaker":"Hartmut Ehrlich","startTime":1629.12,"endTime":1633.29,"body":"learn do patients respond to"},{"speaker":"Hartmut Ehrlich","startTime":1633.29,"endTime":1638.12,"body":"this treatment, even if they"},{"speaker":"Hartmut Ehrlich","startTime":1633.29,"endTime":1638.12,"body":"don't get to a remission. And"},{"speaker":"Hartmut Ehrlich","startTime":1638.6,"endTime":1644.57,"body":"therefore, the critical step is"},{"speaker":"Hartmut Ehrlich","startTime":1638.6,"endTime":1644.57,"body":"when you continue treatment,"},{"speaker":"Hartmut Ehrlich","startTime":1644.57,"endTime":1649.97,"body":"then to see that after one year,"},{"speaker":"Hartmut Ehrlich","startTime":1644.57,"endTime":1649.97,"body":"you will have as many patients"},{"speaker":"Hartmut Ehrlich","startTime":1650.0,"endTime":1654.23,"body":"in clinical remission, and"},{"speaker":"Hartmut Ehrlich","startTime":1650.0,"endTime":1654.23,"body":"clinical remission means almost"},{"speaker":"Hartmut Ehrlich","startTime":1654.23,"endTime":1661.19,"body":"complete absence of symptoms."},{"speaker":"Hartmut Ehrlich","startTime":1654.23,"endTime":1661.19,"body":"And also a clean endoscopy."},{"speaker":"Hartmut Ehrlich","startTime":1661.55,"endTime":1667.52,"body":"Really patients will tell you"},{"speaker":"Hartmut Ehrlich","startTime":1661.55,"endTime":1667.52,"body":"not only how well they tolerate"},{"speaker":"Hartmut Ehrlich","startTime":1667.52,"endTime":1673.25,"body":"the treatment, but also how they"},{"speaker":"Hartmut Ehrlich","startTime":1667.52,"endTime":1673.25,"body":"benefit from the efficacy,"},{"speaker":"Hartmut Ehrlich","startTime":1673.52,"endTime":1676.82,"body":"because this is something that"},{"speaker":"Hartmut Ehrlich","startTime":1673.52,"endTime":1676.82,"body":"is, of course, very important"},{"speaker":"Hartmut Ehrlich","startTime":1676.82,"endTime":1682.61,"body":"that the key symptoms. And the"},{"speaker":"Hartmut Ehrlich","startTime":1676.82,"endTime":1682.61,"body":"key symptoms are related to"},{"speaker":"Hartmut Ehrlich","startTime":1682.64,"endTime":1688.46,"body":"many, many stools that these"},{"speaker":"Hartmut Ehrlich","startTime":1682.64,"endTime":1688.46,"body":"patients have per day, and also"},{"speaker":"Hartmut Ehrlich","startTime":1688.46,"endTime":1694.73,"body":"to the blood that is often in"},{"speaker":"Hartmut Ehrlich","startTime":1688.46,"endTime":1694.73,"body":"the stools and the consequences"},{"speaker":"Hartmut Ehrlich","startTime":1694.73,"endTime":1702.44,"body":"from that. They typically get"},{"speaker":"Hartmut Ehrlich","startTime":1694.73,"endTime":1702.44,"body":"weaker and weaker. And patients"},{"speaker":"Hartmut Ehrlich","startTime":1702.44,"endTime":1708.32,"body":"that feel well on treatment,"},{"speaker":"Hartmut Ehrlich","startTime":1702.44,"endTime":1708.32,"body":"that is what we are trying to to"},{"speaker":"Hartmut Ehrlich","startTime":1708.32,"endTime":1713.09,"body":"accomplish. And so we have been"},{"speaker":"Hartmut Ehrlich","startTime":1708.32,"endTime":1713.09,"body":"seeing, and this is data that we"},{"speaker":"Hartmut Ehrlich","startTime":1713.09,"endTime":1720.44,"body":"were able to publish last year"},{"speaker":"Hartmut Ehrlich","startTime":1713.09,"endTime":1720.44,"body":"in September, in the in the"},{"speaker":"Hartmut Ehrlich","startTime":1720.44,"endTime":1725.03,"body":"Lancet, Gastroenterology and"},{"speaker":"Hartmut Ehrlich","startTime":1720.44,"endTime":1725.03,"body":"Hepatology, which is a very,"},{"speaker":"Hartmut Ehrlich","startTime":1725.03,"endTime":1731.99,"body":"very reputable journal, where we"},{"speaker":"Hartmut Ehrlich","startTime":1725.03,"endTime":1731.99,"body":"published our data that we bring"},{"speaker":"Hartmut Ehrlich","startTime":1732.02,"endTime":1738.89,"body":"essentially 66% of the patients"},{"speaker":"Hartmut Ehrlich","startTime":1732.02,"endTime":1738.89,"body":"that start long term treatment,"},{"speaker":"Hartmut Ehrlich","startTime":1738.89,"endTime":1744.08,"body":"or as we call it maintenance"},{"speaker":"Hartmut Ehrlich","startTime":1738.89,"endTime":1744.08,"body":"after eight weeks, at the end of"},{"speaker":"Hartmut Ehrlich","startTime":1744.08,"endTime":1750.95,"body":"the first year, roughly two"},{"speaker":"Hartmut Ehrlich","startTime":1744.08,"endTime":1750.95,"body":"thirds of the patients 65-66% of"},{"speaker":"Hartmut Ehrlich","startTime":1750.95,"endTime":1755.36,"body":"the patients are in clinical"},{"speaker":"Hartmut Ehrlich","startTime":1750.95,"endTime":1755.36,"body":"remission. This is not seen with"},{"speaker":"Hartmut Ehrlich","startTime":1755.36,"endTime":1760.22,"body":"most of the other drugs where"},{"speaker":"Hartmut Ehrlich","startTime":1755.36,"endTime":1760.22,"body":"you typically have remission"},{"speaker":"Hartmut Ehrlich","startTime":1760.22,"endTime":1768.35,"body":"rates after one year between 20"},{"speaker":"Hartmut Ehrlich","startTime":1760.22,"endTime":1768.35,"body":"and 40%. And you see this with"},{"speaker":"Hartmut Ehrlich","startTime":1768.38,"endTime":1773.18,"body":"patients, if therapies don't"},{"speaker":"Hartmut Ehrlich","startTime":1768.38,"endTime":1773.18,"body":"work because then they get on"},{"speaker":"Hartmut Ehrlich","startTime":1773.18,"endTime":1779.09,"body":"the next version of advanced"},{"speaker":"Hartmut Ehrlich","startTime":1773.18,"endTime":1779.09,"body":"therapy and then maybe on a"},{"speaker":"Hartmut Ehrlich","startTime":1779.09,"endTime":1784.79,"body":"third version, but they are"},{"speaker":"Hartmut Ehrlich","startTime":1779.09,"endTime":1784.79,"body":"never really recovering from the"},{"speaker":"Hartmut Ehrlich","startTime":1784.79,"endTime":1789.98,"body":"symptoms of the disease and"},{"speaker":"Hartmut Ehrlich","startTime":1784.79,"endTime":1789.98,"body":"often the only option, treatment"},{"speaker":"Hartmut Ehrlich","startTime":1789.98,"endTime":1795.44,"body":"option, that is left for the"},{"speaker":"Hartmut Ehrlich","startTime":1789.98,"endTime":1795.44,"body":"treating physicians is actually"},{"speaker":"Hartmut Ehrlich","startTime":1795.44,"endTime":1801.5,"body":"to recommend collectomy, which"},{"speaker":"Hartmut Ehrlich","startTime":1795.44,"endTime":1801.5,"body":"as you know, then brings its own"},{"speaker":"Hartmut Ehrlich","startTime":1801.53,"endTime":1808.46,"body":"sequence of issues related to"},{"speaker":"Hartmut Ehrlich","startTime":1801.53,"endTime":1808.46,"body":"the stoma, etc etc. So, what we"},{"speaker":"Hartmut Ehrlich","startTime":1808.46,"endTime":1815.69,"body":"want to do is basically enable"},{"speaker":"Hartmut Ehrlich","startTime":1808.46,"endTime":1815.69,"body":"as many patients as possible to"},{"speaker":"Hartmut Ehrlich","startTime":1816.2,"endTime":1822.05,"body":"really enjoy their lives, having"},{"speaker":"Hartmut Ehrlich","startTime":1816.2,"endTime":1822.05,"body":"a high quality of life, because"},{"speaker":"Hartmut Ehrlich","startTime":1822.05,"endTime":1829.91,"body":"they are not basically impacted"},{"speaker":"Hartmut Ehrlich","startTime":1822.05,"endTime":1829.91,"body":"by the severe nature of the"},{"speaker":"Hartmut Ehrlich","startTime":1829.91,"endTime":1835.07,"body":"disease. The clinical data so"},{"speaker":"Hartmut Ehrlich","startTime":1829.91,"endTime":1835.07,"body":"far looks very promising. So,"},{"speaker":"Hartmut Ehrlich","startTime":1835.07,"endTime":1842.66,"body":"for us the job is now to"},{"speaker":"Hartmut Ehrlich","startTime":1835.07,"endTime":1842.66,"body":"complete the phase 3 program and"},{"speaker":"Hartmut Ehrlich","startTime":1842.66,"endTime":1846.86,"body":"see that we can get the product"},{"speaker":"Hartmut Ehrlich","startTime":1842.66,"endTime":1846.86,"body":"to the patients that need it as"},{"speaker":"Hartmut Ehrlich","startTime":1846.86,"endTime":1848.03,"body":"quickly as possible."},{"speaker":"John Simboli","startTime":1848.66,"endTime":1851.15,"body":"And what is it"},{"speaker":"John Simboli","startTime":1848.66,"endTime":1851.15,"body":"about the mechanism of action"},{"speaker":"John Simboli","startTime":1851.18,"endTime":1855.77,"body":"that gives you hope that you can"},{"speaker":"John Simboli","startTime":1851.18,"endTime":1855.77,"body":"bring this this relief?"},{"speaker":"Hartmut Ehrlich","startTime":1856.49,"endTime":1860.621,"body":"It is a new"},{"speaker":"Hartmut Ehrlich","startTime":1856.49,"endTime":1860.621,"body":"mechanism of action. Now, that"},{"speaker":"Hartmut Ehrlich","startTime":1860.719,"endTime":1866.917,"body":"of course, is not the only thing"},{"speaker":"Hartmut Ehrlich","startTime":1860.719,"endTime":1866.917,"body":"that counts, but when patients"},{"speaker":"Hartmut Ehrlich","startTime":1867.015,"endTime":1872.131,"body":"have been treated with"},{"speaker":"Hartmut Ehrlich","startTime":1867.015,"endTime":1872.131,"body":"antibodies against the let me"},{"speaker":"Hartmut Ehrlich","startTime":1872.229,"endTime":1877.639,"body":"say tumor necrosis factor alpha,"},{"speaker":"Hartmut Ehrlich","startTime":1872.229,"endTime":1877.639,"body":"like HUMIRA or the the"},{"speaker":"Hartmut Ehrlich","startTime":1877.738,"endTime":1883.443,"body":"anti-integrin antibody, etc,"},{"speaker":"Hartmut Ehrlich","startTime":1877.738,"endTime":1883.443,"body":"when you deal with monoclonal"},{"speaker":"Hartmut Ehrlich","startTime":1883.542,"endTime":1888.559,"body":"antibodies, you're always"},{"speaker":"Hartmut Ehrlich","startTime":1883.542,"endTime":1888.559,"body":"shutting down one pathway"},{"speaker":"Hartmut Ehrlich","startTime":1888.657,"endTime":1894.166,"body":"completely. And this is very,"},{"speaker":"Hartmut Ehrlich","startTime":1888.657,"endTime":1894.166,"body":"very different for ABX464."},{"speaker":"Hartmut Ehrlich","startTime":1894.264,"endTime":1899.379,"body":"Because, and this was not"},{"speaker":"Hartmut Ehrlich","startTime":1894.264,"endTime":1899.379,"body":"engineered by us, this was"},{"speaker":"Hartmut Ehrlich","startTime":1899.478,"endTime":1905.872,"body":"discovered while we were working"},{"speaker":"Hartmut Ehrlich","startTime":1899.478,"endTime":1905.872,"body":"through the mechanism of action."},{"speaker":"Hartmut Ehrlich","startTime":1905.97,"endTime":1911.676,"body":"What obefazimod actually does,"},{"speaker":"Hartmut Ehrlich","startTime":1905.97,"endTime":1911.676,"body":"it leads and I save you the"},{"speaker":"Hartmut Ehrlich","startTime":1911.774,"endTime":1917.578,"body":"biochemical and biological"},{"speaker":"Hartmut Ehrlich","startTime":1911.774,"endTime":1917.578,"body":"details, although this is a very"},{"speaker":"Hartmut Ehrlich","startTime":1917.676,"endTime":1923.677,"body":"very interesting process, but it"},{"speaker":"Hartmut Ehrlich","startTime":1917.676,"endTime":1923.677,"body":"leads to the generation of a"},{"speaker":"Hartmut Ehrlich","startTime":1923.776,"endTime":1929.678,"body":"small micro RNA that is called"},{"speaker":"Hartmut Ehrlich","startTime":1923.776,"endTime":1929.678,"body":"MiR-124. And I really want to"},{"speaker":"Hartmut Ehrlich","startTime":1929.776,"endTime":1935.482,"body":"use language as simple as"},{"speaker":"Hartmut Ehrlich","startTime":1929.776,"endTime":1935.482,"body":"possible. So, what do micro RNAs"},{"speaker":"Hartmut Ehrlich","startTime":1935.58,"endTime":1941.581,"body":"do in general? And just on the"},{"speaker":"Hartmut Ehrlich","startTime":1935.58,"endTime":1941.581,"body":"side, there are more than 1000"},{"speaker":"Hartmut Ehrlich","startTime":1941.679,"endTime":1947.68,"body":"micro RNAs known and they all"},{"speaker":"Hartmut Ehrlich","startTime":1941.679,"endTime":1947.68,"body":"have very specific function and"},{"speaker":"Hartmut Ehrlich","startTime":1947.778,"endTime":1952.795,"body":"this is determined by their"},{"speaker":"Hartmut Ehrlich","startTime":1947.778,"endTime":1952.795,"body":"structure and structure"},{"speaker":"Hartmut Ehrlich","startTime":1952.893,"endTime":1959.091,"body":"determines what molecules they"},{"speaker":"Hartmut Ehrlich","startTime":1952.893,"endTime":1959.091,"body":"are binding to. For MiR-124, for"},{"speaker":"Hartmut Ehrlich","startTime":1959.189,"endTime":1965.091,"body":"the micro RNA that is heavily"},{"speaker":"Hartmut Ehrlich","startTime":1959.189,"endTime":1965.091,"body":"upregulated in our case, micro"},{"speaker":"Hartmut Ehrlich","startTime":1965.19,"endTime":1971.486,"body":"RNAs actually bind to messenger"},{"speaker":"Hartmut Ehrlich","startTime":1965.19,"endTime":1971.486,"body":"RNAs and you know messenger RNAs"},{"speaker":"Hartmut Ehrlich","startTime":1971.584,"endTime":1977.093,"body":"are bringing the genetic"},{"speaker":"Hartmut Ehrlich","startTime":1971.584,"endTime":1977.093,"body":"information from the nucleus to"},{"speaker":"Hartmut Ehrlich","startTime":1977.191,"endTime":1983.093,"body":"the cytoplasm, where protein"},{"speaker":"Hartmut Ehrlich","startTime":1977.191,"endTime":1983.093,"body":"synthesis takes place. And this"},{"speaker":"Hartmut Ehrlich","startTime":1983.192,"endTime":1988.996,"body":"protein synthesis is impacted by"},{"speaker":"Hartmut Ehrlich","startTime":1983.192,"endTime":1988.996,"body":"micro RNAs in general. And"},{"speaker":"Hartmut Ehrlich","startTime":1989.094,"endTime":1995.291,"body":"specifically, the synthesis of a"},{"speaker":"Hartmut Ehrlich","startTime":1989.094,"endTime":1995.291,"body":"number of proteins involved in"},{"speaker":"Hartmut Ehrlich","startTime":1995.39,"endTime":2000.407,"body":"inflammatory reactions or"},{"speaker":"Hartmut Ehrlich","startTime":1995.39,"endTime":2000.407,"body":"processes is specifically"},{"speaker":"Hartmut Ehrlich","startTime":2000.505,"endTime":2006.703,"body":"inhibited by MiR-124. It binds"},{"speaker":"Hartmut Ehrlich","startTime":2000.505,"endTime":2006.703,"body":"to what we call the target gene,"},{"speaker":"Hartmut Ehrlich","startTime":2006.801,"endTime":2012.211,"body":"so, the target mRNAs, and"},{"speaker":"Hartmut Ehrlich","startTime":2006.801,"endTime":2012.211,"body":"prevents the translation from"},{"speaker":"Hartmut Ehrlich","startTime":2012.31,"endTime":2018.409,"body":"RNA into protein on the sides of"},{"speaker":"Hartmut Ehrlich","startTime":2012.31,"endTime":2018.409,"body":"the ribosomes. And this means"},{"speaker":"Hartmut Ehrlich","startTime":2018.507,"endTime":2024.213,"body":"that the effector molecules,"},{"speaker":"Hartmut Ehrlich","startTime":2018.507,"endTime":2024.213,"body":"which are responsible for the"},{"speaker":"Hartmut Ehrlich","startTime":2024.311,"endTime":2030.41,"body":"symptoms in these patients, are"},{"speaker":"Hartmut Ehrlich","startTime":2024.311,"endTime":2030.41,"body":"reduced from the point of view"},{"speaker":"Hartmut Ehrlich","startTime":2030.508,"endTime":2036.607,"body":"of them being generated. So we"},{"speaker":"Hartmut Ehrlich","startTime":2030.508,"endTime":2036.607,"body":"don't use a hammer to block one"},{"speaker":"Hartmut Ehrlich","startTime":2036.706,"endTime":2041.821,"body":"particular pathway or one"},{"speaker":"Hartmut Ehrlich","startTime":2036.706,"endTime":2041.821,"body":"molecule, we use a broader"},{"speaker":"Hartmut Ehrlich","startTime":2041.92,"endTime":2047.92,"body":"approach and we compare it with"},{"speaker":"Hartmut Ehrlich","startTime":2041.92,"endTime":2047.92,"body":"a car where actually when you"},{"speaker":"Hartmut Ehrlich","startTime":2048.019,"endTime":2053.921,"body":"break, you really better apply"},{"speaker":"Hartmut Ehrlich","startTime":2048.019,"endTime":2053.921,"body":"the brake to all four wheels,"},{"speaker":"Hartmut Ehrlich","startTime":2054.019,"endTime":2060.315,"body":"instead of just one, one or two,"},{"speaker":"Hartmut Ehrlich","startTime":2054.019,"endTime":2060.315,"body":"because the consequences can be"},{"speaker":"Hartmut Ehrlich","startTime":2060.413,"endTime":2066.414,"body":"very dangerous. So we are not"},{"speaker":"Hartmut Ehrlich","startTime":2060.413,"endTime":2066.414,"body":"reducing, like this is the case"},{"speaker":"Hartmut Ehrlich","startTime":2066.512,"endTime":2072.415,"body":"for monoclonal antibodies, we"},{"speaker":"Hartmut Ehrlich","startTime":2066.512,"endTime":2072.415,"body":"are not reducing the molecular"},{"speaker":"Hartmut Ehrlich","startTime":2072.513,"endTime":2078.514,"body":"targets by 100%. This you can"},{"speaker":"Hartmut Ehrlich","startTime":2072.513,"endTime":2078.514,"body":"accomplish with monoclonals. We"},{"speaker":"Hartmut Ehrlich","startTime":2078.612,"endTime":2084.219,"body":"are typically reducing them. And"},{"speaker":"Hartmut Ehrlich","startTime":2078.612,"endTime":2084.219,"body":"just to name a couple of"},{"speaker":"Hartmut Ehrlich","startTime":2084.318,"endTime":2090.22,"body":"examples. IL17, IL23, IL6, we"},{"speaker":"Hartmut Ehrlich","startTime":2084.318,"endTime":2090.22,"body":"are reducing them to the level"},{"speaker":"Hartmut Ehrlich","startTime":2090.318,"endTime":2095.827,"body":"that you find normally in"},{"speaker":"Hartmut Ehrlich","startTime":2090.318,"endTime":2095.827,"body":"patients, and we consider this"},{"speaker":"Hartmut Ehrlich","startTime":2095.925,"endTime":2101.631,"body":"is very, very important not only"},{"speaker":"Hartmut Ehrlich","startTime":2095.925,"endTime":2101.631,"body":"from the point of view of"},{"speaker":"Hartmut Ehrlich","startTime":2101.729,"endTime":2107.632,"body":"efficacy, but also from the"},{"speaker":"Hartmut Ehrlich","startTime":2101.729,"endTime":2107.632,"body":"point of view of safety. Because"},{"speaker":"Hartmut Ehrlich","startTime":2107.73,"endTime":2114.124,"body":"if you block a molecule to 100%,"},{"speaker":"Hartmut Ehrlich","startTime":2107.73,"endTime":2114.124,"body":"tumor necrosis factor IL6, these"},{"speaker":"Hartmut Ehrlich","startTime":2114.222,"endTime":2119.436,"body":"molecules don't only have bad"},{"speaker":"Hartmut Ehrlich","startTime":2114.222,"endTime":2119.436,"body":"consequences, these are"},{"speaker":"Hartmut Ehrlich","startTime":2119.535,"endTime":2125.142,"body":"molecules that were initially"},{"speaker":"Hartmut Ehrlich","startTime":2119.535,"endTime":2125.142,"body":"generated in the body to be"},{"speaker":"Hartmut Ehrlich","startTime":2125.24,"endTime":2131.044,"body":"helping with host defense and"},{"speaker":"Hartmut Ehrlich","startTime":2125.24,"endTime":2131.044,"body":"other processes. And we don't"},{"speaker":"Hartmut Ehrlich","startTime":2131.142,"endTime":2136.553,"body":"want to shut this down"},{"speaker":"Hartmut Ehrlich","startTime":2131.142,"endTime":2136.553,"body":"completely, because then you get"},{"speaker":"Hartmut Ehrlich","startTime":2136.651,"endTime":2142.652,"body":"to potential side effects like"},{"speaker":"Hartmut Ehrlich","startTime":2136.651,"endTime":2142.652,"body":"immuno-suppression, which then"},{"speaker":"Hartmut Ehrlich","startTime":2142.75,"endTime":2148.259,"body":"can lead to opportunistic"},{"speaker":"Hartmut Ehrlich","startTime":2142.75,"endTime":2148.259,"body":"viruses, for example, to grow."},{"speaker":"Hartmut Ehrlich","startTime":2148.357,"endTime":2154.358,"body":"So the mechanism of action, as"},{"speaker":"Hartmut Ehrlich","startTime":2148.357,"endTime":2154.358,"body":"we see it through, I would say"},{"speaker":"Hartmut Ehrlich","startTime":2154.456,"endTime":2160.26,"body":"the moderate downregulation of"},{"speaker":"Hartmut Ehrlich","startTime":2154.456,"endTime":2160.26,"body":"several of the key cytokines"},{"speaker":"Hartmut Ehrlich","startTime":2160.359,"endTime":2165.179,"body":"that trigger chronic"},{"speaker":"Hartmut Ehrlich","startTime":2160.359,"endTime":2165.179,"body":"inflammation. This really is"},{"speaker":"Hartmut Ehrlich","startTime":2165.277,"endTime":2170.983,"body":"important for us, and we believe"},{"speaker":"Hartmut Ehrlich","startTime":2165.277,"endTime":2170.983,"body":"has a major impact on the"},{"speaker":"Hartmut Ehrlich","startTime":2171.081,"endTime":2177.082,"body":"clinical picture that we are"},{"speaker":"Hartmut Ehrlich","startTime":2171.081,"endTime":2177.082,"body":"seeing in patients. And I'm glad"},{"speaker":"Hartmut Ehrlich","startTime":2177.18,"endTime":2183.181,"body":"to say that in all the patients"},{"speaker":"Hartmut Ehrlich","startTime":2177.18,"endTime":2183.181,"body":"that we have been treating so"},{"speaker":"Hartmut Ehrlich","startTime":2183.279,"endTime":2189.181,"body":"far, which is more than 1000,"},{"speaker":"Hartmut Ehrlich","startTime":2183.279,"endTime":2189.181,"body":"out of which more than 200 for"},{"speaker":"Hartmut Ehrlich","startTime":2189.28,"endTime":2195.28,"body":"longer than one year, we have"},{"speaker":"Hartmut Ehrlich","startTime":2189.28,"endTime":2195.28,"body":"not seen any imbalances between"},{"speaker":"Hartmut Ehrlich","startTime":2195.379,"endTime":2201.379,"body":"placebo group and active group"},{"speaker":"Hartmut Ehrlich","startTime":2195.379,"endTime":2201.379,"body":"when it comes to, for example,"},{"speaker":"Hartmut Ehrlich","startTime":2201.478,"endTime":2207.282,"body":"opportunistic infections. And"},{"speaker":"Hartmut Ehrlich","startTime":2201.478,"endTime":2207.282,"body":"actually we have not seen any"},{"speaker":"Hartmut Ehrlich","startTime":2207.38,"endTime":2213.282,"body":"kind of unlimited growth of"},{"speaker":"Hartmut Ehrlich","startTime":2207.38,"endTime":2213.282,"body":"viruses or bacteria as you would"},{"speaker":"Hartmut Ehrlich","startTime":2213.381,"endTime":2218.791,"body":"expect in sepsis. So that"},{"speaker":"Hartmut Ehrlich","startTime":2213.381,"endTime":2218.791,"body":"validates, the safety finding"},{"speaker":"Hartmut Ehrlich","startTime":2218.89,"endTime":2224.89,"body":"validates our conclusions from"},{"speaker":"Hartmut Ehrlich","startTime":2218.89,"endTime":2224.89,"body":"the mechanism of action on why"},{"speaker":"Hartmut Ehrlich","startTime":2224.989,"endTime":2231.58,"body":"obefazimod is such an effective,"},{"speaker":"Hartmut Ehrlich","startTime":2224.989,"endTime":2231.58,"body":"but also relatively safe molecule."},{"speaker":"John Simboli","startTime":2232.66,"endTime":2235.63,"body":"How does the"},{"speaker":"John Simboli","startTime":2232.66,"endTime":2235.63,"body":"pipeline express your vision for"},{"speaker":"John Simboli","startTime":2235.66,"endTime":2236.53,"body":"Abivax?"},{"speaker":"Hartmut Ehrlich","startTime":2237.07,"endTime":2241.409,"body":"The good news"},{"speaker":"Hartmut Ehrlich","startTime":2237.07,"endTime":2241.409,"body":"is that many of these products,"},{"speaker":"Hartmut Ehrlich","startTime":2241.505,"endTime":2247.58,"body":"and that goes for the monoclonal"},{"speaker":"Hartmut Ehrlich","startTime":2241.505,"endTime":2247.58,"body":"antibodies when they were used"},{"speaker":"Hartmut Ehrlich","startTime":2247.676,"endTime":2253.365,"body":"first in the early 2000s, but"},{"speaker":"Hartmut Ehrlich","startTime":2247.676,"endTime":2253.365,"body":"also other molecules like JAK"},{"speaker":"Hartmut Ehrlich","startTime":2253.461,"endTime":2259.15,"body":"inhibitors, and as many of the"},{"speaker":"Hartmut Ehrlich","startTime":2253.461,"endTime":2259.15,"body":"processes, the intracellular"},{"speaker":"Hartmut Ehrlich","startTime":2259.247,"endTime":2265.418,"body":"processes in patients that lead"},{"speaker":"Hartmut Ehrlich","startTime":2259.247,"endTime":2265.418,"body":"to chronic inflammation, as many"},{"speaker":"Hartmut Ehrlich","startTime":2265.514,"endTime":2271.01,"body":"of these are very similar"},{"speaker":"Hartmut Ehrlich","startTime":2265.514,"endTime":2271.01,"body":"between very different diseases"},{"speaker":"Hartmut Ehrlich","startTime":2271.107,"endTime":2276.796,"body":"like on one hand, inflammatory"},{"speaker":"Hartmut Ehrlich","startTime":2271.107,"endTime":2276.796,"body":"bowel, especially ulcerative"},{"speaker":"Hartmut Ehrlich","startTime":2276.892,"endTime":2282.292,"body":"colitis, almost exclusively"},{"speaker":"Hartmut Ehrlich","startTime":2276.892,"endTime":2282.292,"body":"impacting the bowel, whereas"},{"speaker":"Hartmut Ehrlich","startTime":2282.388,"endTime":2288.077,"body":"other chronic inflammatory"},{"speaker":"Hartmut Ehrlich","startTime":2282.388,"endTime":2288.077,"body":"processes like the ones that are"},{"speaker":"Hartmut Ehrlich","startTime":2288.174,"endTime":2294.248,"body":"taking place in the synovia in"},{"speaker":"Hartmut Ehrlich","startTime":2288.174,"endTime":2294.248,"body":"the lining of the joints leading"},{"speaker":"Hartmut Ehrlich","startTime":2294.345,"endTime":2300.13,"body":"to a number of different forms"},{"speaker":"Hartmut Ehrlich","startTime":2294.345,"endTime":2300.13,"body":"of arthritis or other chronic"},{"speaker":"Hartmut Ehrlich","startTime":2300.227,"endTime":2305.626,"body":"inflammatory diseases, they"},{"speaker":"Hartmut Ehrlich","startTime":2300.227,"endTime":2305.626,"body":"express themselves typically"},{"speaker":"Hartmut Ehrlich","startTime":2305.723,"endTime":2311.508,"body":"very differently. But because"},{"speaker":"Hartmut Ehrlich","startTime":2305.723,"endTime":2311.508,"body":"the underlying processes, as I"},{"speaker":"Hartmut Ehrlich","startTime":2311.605,"endTime":2316.522,"body":"mentioned, are very similar"},{"speaker":"Hartmut Ehrlich","startTime":2311.605,"endTime":2316.522,"body":"molecules in this space"},{"speaker":"Hartmut Ehrlich","startTime":2316.619,"endTime":2322.404,"body":"typically can treat a number of"},{"speaker":"Hartmut Ehrlich","startTime":2316.619,"endTime":2322.404,"body":"different diseases that also"},{"speaker":"Hartmut Ehrlich","startTime":2322.5,"endTime":2327.707,"body":"have different anatomic"},{"speaker":"Hartmut Ehrlich","startTime":2322.5,"endTime":2327.707,"body":"locations. I mean, if you have"},{"speaker":"Hartmut Ehrlich","startTime":2327.804,"endTime":2333.3,"body":"joint disease, that's, by"},{"speaker":"Hartmut Ehrlich","startTime":2327.804,"endTime":2333.3,"body":"definition very, very different"},{"speaker":"Hartmut Ehrlich","startTime":2333.396,"endTime":2339.664,"body":"from inflammatory bowel disease,"},{"speaker":"Hartmut Ehrlich","startTime":2333.396,"endTime":2339.664,"body":"for example. And this is exactly"},{"speaker":"Hartmut Ehrlich","startTime":2339.76,"endTime":2345.449,"body":"the interesting question around"},{"speaker":"Hartmut Ehrlich","startTime":2339.76,"endTime":2345.449,"body":"obefazimod now, because the"},{"speaker":"Hartmut Ehrlich","startTime":2345.546,"endTime":2351.524,"body":"first indication, and that was"},{"speaker":"Hartmut Ehrlich","startTime":2345.546,"endTime":2351.524,"body":"relatively clear to begin with,"},{"speaker":"Hartmut Ehrlich","startTime":2351.62,"endTime":2356.827,"body":"we explored was ulcerative"},{"speaker":"Hartmut Ehrlich","startTime":2351.62,"endTime":2356.827,"body":"colitis, it worked from the"},{"speaker":"Hartmut Ehrlich","startTime":2356.924,"endTime":2362.323,"body":"phase 2A study on. When we went"},{"speaker":"Hartmut Ehrlich","startTime":2356.924,"endTime":2362.323,"body":"into patients we saw the"},{"speaker":"Hartmut Ehrlich","startTime":2362.42,"endTime":2367.819,"body":"positive effects on the"},{"speaker":"Hartmut Ehrlich","startTime":2362.42,"endTime":2367.819,"body":"patients, but that then also led"},{"speaker":"Hartmut Ehrlich","startTime":2367.916,"endTime":2373.798,"body":"to us asking the question, of"},{"speaker":"Hartmut Ehrlich","startTime":2367.916,"endTime":2373.798,"body":"course, which other indications"},{"speaker":"Hartmut Ehrlich","startTime":2373.894,"endTime":2379.872,"body":"should we be tackling? So, of"},{"speaker":"Hartmut Ehrlich","startTime":2373.894,"endTime":2379.872,"body":"course most of the products that"},{"speaker":"Hartmut Ehrlich","startTime":2379.969,"endTime":2386.043,"body":"work in ulcerative colitis also"},{"speaker":"Hartmut Ehrlich","startTime":2379.969,"endTime":2386.043,"body":"work in Crohn's. We had planned"},{"speaker":"Hartmut Ehrlich","startTime":2386.14,"endTime":2392.118,"body":"a development plan for Crohn's"},{"speaker":"Hartmut Ehrlich","startTime":2386.14,"endTime":2392.118,"body":"that would start like we did it"},{"speaker":"Hartmut Ehrlich","startTime":2392.214,"endTime":2397.903,"body":"in ulcerative colitis with a"},{"speaker":"Hartmut Ehrlich","startTime":2392.214,"endTime":2397.903,"body":"small phase 2A study, look for"},{"speaker":"Hartmut Ehrlich","startTime":2398.0,"endTime":2403.014,"body":"some kind of evidence of"},{"speaker":"Hartmut Ehrlich","startTime":2398.0,"endTime":2403.014,"body":"efficacy and then go into a"},{"speaker":"Hartmut Ehrlich","startTime":2403.11,"endTime":2409.281,"body":"larger study. However, even the"},{"speaker":"Hartmut Ehrlich","startTime":2403.11,"endTime":2409.281,"body":"small study will cost us about a"},{"speaker":"Hartmut Ehrlich","startTime":2409.378,"endTime":2414.874,"body":"year and a half during the"},{"speaker":"Hartmut Ehrlich","startTime":2409.378,"endTime":2414.874,"body":"development. And so, our KOLs,"},{"speaker":"Hartmut Ehrlich","startTime":2414.97,"endTime":2420.081,"body":"and that's another very"},{"speaker":"Hartmut Ehrlich","startTime":2414.97,"endTime":2420.081,"body":"important point, that you are"},{"speaker":"Hartmut Ehrlich","startTime":2420.177,"endTime":2426.252,"body":"working with KOLs who are really"},{"speaker":"Hartmut Ehrlich","startTime":2420.177,"endTime":2426.252,"body":"interested in the product, and"},{"speaker":"Hartmut Ehrlich","startTime":2426.348,"endTime":2432.134,"body":"who want to help you develop"},{"speaker":"Hartmut Ehrlich","startTime":2426.348,"endTime":2432.134,"body":"this product because, as we all"},{"speaker":"Hartmut Ehrlich","startTime":2432.23,"endTime":2438.498,"body":"know, there are so many pitfalls"},{"speaker":"Hartmut Ehrlich","startTime":2432.23,"endTime":2438.498,"body":"potentially in idevelopment, but"},{"speaker":"Hartmut Ehrlich","startTime":2438.594,"endTime":2444.765,"body":"here clearly, they told us in no"},{"speaker":"Hartmut Ehrlich","startTime":2438.594,"endTime":2444.765,"body":"uncertain terms, that we should"},{"speaker":"Hartmut Ehrlich","startTime":2444.861,"endTime":2451.033,"body":"skip the 2A program for Crohn's"},{"speaker":"Hartmut Ehrlich","startTime":2444.861,"endTime":2451.033,"body":"because the mechanism of disease"},{"speaker":"Hartmut Ehrlich","startTime":2451.129,"endTime":2457.204,"body":"propagation in Crohn's is very"},{"speaker":"Hartmut Ehrlich","startTime":2451.129,"endTime":2457.204,"body":"similar to the one in ulcerative"},{"speaker":"Hartmut Ehrlich","startTime":2457.3,"endTime":2463.375,"body":"colitis. And also, because as I"},{"speaker":"Hartmut Ehrlich","startTime":2457.3,"endTime":2463.375,"body":"mentioned before, many products"},{"speaker":"Hartmut Ehrlich","startTime":2463.471,"endTime":2469.739,"body":"that work in one disease work in"},{"speaker":"Hartmut Ehrlich","startTime":2463.471,"endTime":2469.739,"body":"the other as well. But that also"},{"speaker":"Hartmut Ehrlich","startTime":2469.835,"endTime":2475.62,"body":"brings with it a certain crux,"},{"speaker":"Hartmut Ehrlich","startTime":2469.835,"endTime":2475.62,"body":"we have been doing this small"},{"speaker":"Hartmut Ehrlich","startTime":2475.717,"endTime":2480.924,"body":"study, because it was not a"},{"speaker":"Hartmut Ehrlich","startTime":2475.717,"endTime":2480.924,"body":"bowel disease study, but a"},{"speaker":"Hartmut Ehrlich","startTime":2481.02,"endTime":2486.902,"body":"rheumatoid arthritis phase 2A"},{"speaker":"Hartmut Ehrlich","startTime":2481.02,"endTime":2486.902,"body":"study, then  we saw ABX464 also"},{"speaker":"Hartmut Ehrlich","startTime":2486.998,"endTime":2492.398,"body":"working. So that now, we are"},{"speaker":"Hartmut Ehrlich","startTime":2486.998,"endTime":2492.398,"body":"dealing at least with three"},{"speaker":"Hartmut Ehrlich","startTime":2492.495,"endTime":2497.894,"body":"indications that are very"},{"speaker":"Hartmut Ehrlich","startTime":2492.495,"endTime":2497.894,"body":"interesting, from our point of"},{"speaker":"Hartmut Ehrlich","startTime":2497.991,"endTime":2503.101,"body":"view, to tackle. But here we"},{"speaker":"Hartmut Ehrlich","startTime":2497.991,"endTime":2503.101,"body":"have to now focus on the"},{"speaker":"Hartmut Ehrlich","startTime":2503.197,"endTime":2508.501,"body":"realities. And focus is"},{"speaker":"Hartmut Ehrlich","startTime":2503.197,"endTime":2508.501,"body":"absolutely important during the"},{"speaker":"Hartmut Ehrlich","startTime":2508.597,"endTime":2514.865,"body":"development process of any drug."},{"speaker":"Hartmut Ehrlich","startTime":2508.597,"endTime":2514.865,"body":"And for us, the need to focus is"},{"speaker":"Hartmut Ehrlich","startTime":2514.961,"endTime":2520.361,"body":"even more obvious, because"},{"speaker":"Hartmut Ehrlich","startTime":2514.961,"endTime":2520.361,"body":"programs. end-stage programs,"},{"speaker":"Hartmut Ehrlich","startTime":2520.457,"endTime":2526.725,"body":"so, phase 2b3  programs or phase"},{"speaker":"Hartmut Ehrlich","startTime":2520.457,"endTime":2526.725,"body":"3 programs in these indications,"},{"speaker":"Hartmut Ehrlich","startTime":2526.821,"endTime":2532.317,"body":"because you need to treat"},{"speaker":"Hartmut Ehrlich","startTime":2526.821,"endTime":2532.317,"body":"something between 1000 and 1500"},{"speaker":"Hartmut Ehrlich","startTime":2532.414,"endTime":2537.813,"body":"patients, they come with a"},{"speaker":"Hartmut Ehrlich","startTime":2532.414,"endTime":2537.813,"body":"substantial price tag. So, we"},{"speaker":"Hartmut Ehrlich","startTime":2537.91,"endTime":2543.888,"body":"just completed a capital raise"},{"speaker":"Hartmut Ehrlich","startTime":2537.91,"endTime":2543.888,"body":"that I mentioned. So, this will"},{"speaker":"Hartmut Ehrlich","startTime":2543.985,"endTime":2549.963,"body":"bring us much much closer to our"},{"speaker":"Hartmut Ehrlich","startTime":2543.985,"endTime":2549.963,"body":"goal. But in addition, we are"},{"speaker":"Hartmut Ehrlich","startTime":2550.059,"endTime":2555.652,"body":"also trying to acquire funds"},{"speaker":"Hartmut Ehrlich","startTime":2550.059,"endTime":2555.652,"body":"that help us looking into the"},{"speaker":"Hartmut Ehrlich","startTime":2555.748,"endTime":2561.823,"body":"other indications, not only into"},{"speaker":"Hartmut Ehrlich","startTime":2555.748,"endTime":2561.823,"body":"ulcerative colitis that we are"},{"speaker":"Hartmut Ehrlich","startTime":2561.919,"endTime":2567.897,"body":"focusing about. And so our main"},{"speaker":"Hartmut Ehrlich","startTime":2561.919,"endTime":2567.897,"body":"discussion and the main vision"},{"speaker":"Hartmut Ehrlich","startTime":2567.994,"endTime":2574.069,"body":"for the company is, by the fall,"},{"speaker":"Hartmut Ehrlich","startTime":2567.994,"endTime":2574.069,"body":"have ideas or even implemented"},{"speaker":"Hartmut Ehrlich","startTime":2574.165,"endTime":2579.758,"body":"other ideas to collect money"},{"speaker":"Hartmut Ehrlich","startTime":2574.165,"endTime":2579.758,"body":"whether this is licensing out"},{"speaker":"Hartmut Ehrlich","startTime":2579.854,"endTime":2585.157,"body":"the molecule in specific"},{"speaker":"Hartmut Ehrlich","startTime":2579.854,"endTime":2585.157,"body":"geographies for ABX464. We are"},{"speaker":"Hartmut Ehrlich","startTime":2585.254,"endTime":2590.557,"body":"thinking for example, about"},{"speaker":"Hartmut Ehrlich","startTime":2585.254,"endTime":2590.557,"body":"Japan, which would bring in"},{"speaker":"Hartmut Ehrlich","startTime":2590.653,"endTime":2596.824,"body":"revenues, but really to generate"},{"speaker":"Hartmut Ehrlich","startTime":2590.653,"endTime":2596.824,"body":"the money that we need in order"},{"speaker":"Hartmut Ehrlich","startTime":2596.921,"endTime":2602.417,"body":"not to only develop ulcerative"},{"speaker":"Hartmut Ehrlich","startTime":2596.921,"endTime":2602.417,"body":"colitis, but also at least"},{"speaker":"Hartmut Ehrlich","startTime":2602.513,"endTime":2608.299,"body":"Crohn's Disease alongside the"},{"speaker":"Hartmut Ehrlich","startTime":2602.513,"endTime":2608.299,"body":"ulcerative colitis development"},{"speaker":"Hartmut Ehrlich","startTime":2608.395,"endTime":2614.47,"body":"plan. And that's something that"},{"speaker":"Hartmut Ehrlich","startTime":2608.395,"endTime":2614.47,"body":"we want to clarify where we are"},{"speaker":"Hartmut Ehrlich","startTime":2614.566,"endTime":2620.062,"body":"and how far we can go before the"},{"speaker":"Hartmut Ehrlich","startTime":2614.566,"endTime":2620.062,"body":"year is over. What I see"},{"speaker":"Hartmut Ehrlich","startTime":2620.159,"endTime":2626.233,"body":"obefazimod can achieve is that"},{"speaker":"Hartmut Ehrlich","startTime":2620.159,"endTime":2626.233,"body":"it will put Abivax in a position"},{"speaker":"Hartmut Ehrlich","startTime":2626.33,"endTime":2632.308,"body":"where we can provide a safe and"},{"speaker":"Hartmut Ehrlich","startTime":2626.33,"endTime":2632.308,"body":"especially long-term efficient"},{"speaker":"Hartmut Ehrlich","startTime":2632.405,"endTime":2637.997,"body":"treatment to many ulcerative"},{"speaker":"Hartmut Ehrlich","startTime":2632.405,"endTime":2637.997,"body":"colitis patients in need. I'm"},{"speaker":"Hartmut Ehrlich","startTime":2638.094,"endTime":2643.879,"body":"not saying to everyone, but the"},{"speaker":"Hartmut Ehrlich","startTime":2638.094,"endTime":2643.879,"body":"numbers that I was providing"},{"speaker":"Hartmut Ehrlich","startTime":2643.975,"endTime":2649.761,"body":"before I think pretty much speak"},{"speaker":"Hartmut Ehrlich","startTime":2643.975,"endTime":2649.761,"body":"for themselves. And this is"},{"speaker":"Hartmut Ehrlich","startTime":2649.857,"endTime":2655.16,"body":"especially, in this situation,"},{"speaker":"Hartmut Ehrlich","startTime":2649.857,"endTime":2655.16,"body":"the current situation of"},{"speaker":"Hartmut Ehrlich","startTime":2655.257,"endTime":2661.139,"body":"patients is that many of them do"},{"speaker":"Hartmut Ehrlich","startTime":2655.257,"endTime":2661.139,"body":"not respond or actually stop"},{"speaker":"Hartmut Ehrlich","startTime":2661.235,"endTime":2666.442,"body":"responding after a certain"},{"speaker":"Hartmut Ehrlich","startTime":2661.235,"endTime":2666.442,"body":"amount of time to available"},{"speaker":"Hartmut Ehrlich","startTime":2666.538,"endTime":2672.324,"body":"therapies that are currently"},{"speaker":"Hartmut Ehrlich","startTime":2666.538,"endTime":2672.324,"body":"sort of part of the therapeutic"},{"speaker":"Hartmut Ehrlich","startTime":2672.42,"endTime":2677.434,"body":"armamentarium of the"},{"speaker":"Hartmut Ehrlich","startTime":2672.42,"endTime":2677.434,"body":"gastroenterologist. It is often"},{"speaker":"Hartmut Ehrlich","startTime":2677.531,"endTime":2683.605,"body":"very lengthy for these patients"},{"speaker":"Hartmut Ehrlich","startTime":2677.531,"endTime":2683.605,"body":"to find a treatment that works,"},{"speaker":"Hartmut Ehrlich","startTime":2683.702,"endTime":2689.294,"body":"if any. And this means pain,"},{"speaker":"Hartmut Ehrlich","startTime":2683.702,"endTime":2689.294,"body":"stool urgency, bloody stools,"},{"speaker":"Hartmut Ehrlich","startTime":2689.391,"endTime":2695.465,"body":"anemia, malaise, fatigue, upper"},{"speaker":"Hartmut Ehrlich","startTime":2689.391,"endTime":2695.465,"body":"gastrointestinal pain, what all"},{"speaker":"Hartmut Ehrlich","startTime":2695.562,"endTime":2701.251,"body":"goes with this. So therefore,"},{"speaker":"Hartmut Ehrlich","startTime":2695.562,"endTime":2701.251,"body":"for us to bring more patients"},{"speaker":"Hartmut Ehrlich","startTime":2701.347,"endTime":2706.65,"body":"into clinical remission,"},{"speaker":"Hartmut Ehrlich","startTime":2701.347,"endTime":2706.65,"body":"patients that then can bank on"},{"speaker":"Hartmut Ehrlich","startTime":2706.747,"endTime":2712.822,"body":"this remission to persist for a"},{"speaker":"Hartmut Ehrlich","startTime":2706.747,"endTime":2712.822,"body":"substantial amount of time. And"},{"speaker":"Hartmut Ehrlich","startTime":2712.918,"endTime":2718.896,"body":"for most of the patients that"},{"speaker":"Hartmut Ehrlich","startTime":2712.918,"endTime":2718.896,"body":"are in remission after one year,"},{"speaker":"Hartmut Ehrlich","startTime":2718.993,"endTime":2724.874,"body":"we now have data that is telling"},{"speaker":"Hartmut Ehrlich","startTime":2718.993,"endTime":2724.874,"body":"us that this outcome is very"},{"speaker":"Hartmut Ehrlich","startTime":2724.971,"endTime":2730.563,"body":"similar after two years of"},{"speaker":"Hartmut Ehrlich","startTime":2724.971,"endTime":2730.563,"body":"treatment. And then also as you"},{"speaker":"Hartmut Ehrlich","startTime":2730.66,"endTime":2736.831,"body":"go further from our 2A study, we"},{"speaker":"Hartmut Ehrlich","startTime":2730.66,"endTime":2736.831,"body":"have some very encouraging data"},{"speaker":"Hartmut Ehrlich","startTime":2736.927,"endTime":2743.195,"body":"on patients that are treated now"},{"speaker":"Hartmut Ehrlich","startTime":2736.927,"endTime":2743.195,"body":"for more than four years and who"},{"speaker":"Hartmut Ehrlich","startTime":2743.291,"endTime":2749.269,"body":"are still enjoying the benefit"},{"speaker":"Hartmut Ehrlich","startTime":2743.291,"endTime":2749.269,"body":"of Obefazimod. And this is what"},{"speaker":"Hartmut Ehrlich","startTime":2749.366,"endTime":2755.537,"body":"we want, to basically transform"},{"speaker":"Hartmut Ehrlich","startTime":2749.366,"endTime":2755.537,"body":"these patients who are suffering"},{"speaker":"Hartmut Ehrlich","startTime":2755.633,"endTime":2761.804,"body":"from a debilitating disease, by"},{"speaker":"Hartmut Ehrlich","startTime":2755.633,"endTime":2761.804,"body":"taking one pill a day, that they"},{"speaker":"Hartmut Ehrlich","startTime":2761.901,"endTime":2767.976,"body":"are relieved from the symptoms"},{"speaker":"Hartmut Ehrlich","startTime":2761.901,"endTime":2767.976,"body":"for a long, long period of time."},{"speaker":"Hartmut Ehrlich","startTime":2768.072,"endTime":2774.34,"body":"And, in the end, hopefully will"},{"speaker":"Hartmut Ehrlich","startTime":2768.072,"endTime":2774.34,"body":"not need to go through colectomy."},{"speaker":"John Simboli","startTime":2775.06,"endTime":2777.31,"body":"Hartmut, thank you"},{"speaker":"John Simboli","startTime":2775.06,"endTime":2777.31,"body":"for taking the time to speak"},{"speaker":"John Simboli","startTime":2777.31,"endTime":2778.15,"body":"with me today."},{"speaker":"Hartmut Ehrlich","startTime":2778.66,"endTime":2780.04,"body":"You're very"},{"speaker":"Hartmut Ehrlich","startTime":2778.66,"endTime":2780.04,"body":"welcome, John."}]}