{"version":"1.0.0","segments":[{"speaker":"John Simboli","startTime":0.0,"endTime":3.9,"body":"Today I'm speaking"},{"speaker":"John Simboli","startTime":0.0,"endTime":3.9,"body":"with Iain Kilty, CEO of Sitryx"},{"speaker":"John Simboli","startTime":3.9,"endTime":8.7,"body":"therapeutics, headquartered in"},{"speaker":"John Simboli","startTime":3.9,"endTime":8.7,"body":"Oxford, UK. Welcome to BioBoss,"},{"speaker":"John Simboli","startTime":8.7,"endTime":9.09,"body":"Iain."},{"speaker":"Iain Kilty","startTime":9.06,"endTime":10.38,"body":"Thanks, John. I'm"},{"speaker":"Iain Kilty","startTime":9.06,"endTime":10.38,"body":"looking forward to the"},{"speaker":"Iain Kilty","startTime":10.38,"endTime":11.16,"body":"conversation."},{"speaker":"John Simboli","startTime":12.6,"endTime":15.51,"body":"Iain, what led to"},{"speaker":"John Simboli","startTime":12.6,"endTime":15.51,"body":"your role as CEO at Sitryx?"},{"speaker":"Iain Kilty","startTime":15.48,"endTime":18.12,"body":"So I took on the"},{"speaker":"Iain Kilty","startTime":15.48,"endTime":18.12,"body":"role relatively recently,"},{"speaker":"Iain Kilty","startTime":18.12,"endTime":20.76,"body":"actually just a couple of months"},{"speaker":"Iain Kilty","startTime":18.12,"endTime":20.76,"body":"ago, but I've been working with"},{"speaker":"Iain Kilty","startTime":20.79,"endTime":23.76,"body":"Sitryx for just over the last"},{"speaker":"Iain Kilty","startTime":20.79,"endTime":23.76,"body":"three years. I was the CSO"},{"speaker":"Iain Kilty","startTime":23.76,"endTime":28.77,"body":"before transitioning into the"},{"speaker":"Iain Kilty","startTime":23.76,"endTime":28.77,"body":"CEO role, and it was a great"},{"speaker":"Iain Kilty","startTime":28.77,"endTime":31.41,"body":"opportunity for me to lead a"},{"speaker":"Iain Kilty","startTime":28.77,"endTime":31.41,"body":"company that I'm passionate"},{"speaker":"Iain Kilty","startTime":31.41,"endTime":34.35,"body":"about and really believe that we"},{"speaker":"Iain Kilty","startTime":31.41,"endTime":34.35,"body":"have a chance to have a huge"},{"speaker":"Iain Kilty","startTime":34.35,"endTime":38.4,"body":"impact on patients who suffer"},{"speaker":"Iain Kilty","startTime":34.35,"endTime":38.4,"body":"from autoimmune diseases. And"},{"speaker":"Iain Kilty","startTime":38.4,"endTime":41.73,"body":"that's really been the area I've"},{"speaker":"Iain Kilty","startTime":38.4,"endTime":41.73,"body":"spent my whole career in"},{"speaker":"Iain Kilty","startTime":41.73,"endTime":45.63,"body":"different guises. So prior to"},{"speaker":"Iain Kilty","startTime":41.73,"endTime":45.63,"body":"Sitryx, I was working in"},{"speaker":"Iain Kilty","startTime":45.66,"endTime":49.11,"body":"Cambridge Mass actually, with"},{"speaker":"Iain Kilty","startTime":45.66,"endTime":49.11,"body":"Atlas venture, as a CSO for one"},{"speaker":"Iain Kilty","startTime":49.11,"endTime":52.05,"body":"of their immunology companies,"},{"speaker":"Iain Kilty","startTime":49.11,"endTime":52.05,"body":"but also as an entrepreneur in"},{"speaker":"Iain Kilty","startTime":52.05,"endTime":56.4,"body":"residence, helping them seed new"},{"speaker":"Iain Kilty","startTime":52.05,"endTime":56.4,"body":"companies in that space. But"},{"speaker":"Iain Kilty","startTime":56.4,"endTime":58.95,"body":"spent the bulk of my career"},{"speaker":"Iain Kilty","startTime":56.4,"endTime":58.95,"body":"actually at Pfizer. I was at"},{"speaker":"Iain Kilty","startTime":58.95,"endTime":63.75,"body":"Pfizer over 20 years, both US"},{"speaker":"Iain Kilty","startTime":58.95,"endTime":63.75,"body":"and UK, always in the immunology"},{"speaker":"Iain Kilty","startTime":63.75,"endTime":66.78,"body":"space, but a variety of roles,"},{"speaker":"Iain Kilty","startTime":63.75,"endTime":66.78,"body":"from leading early target"},{"speaker":"Iain Kilty","startTime":66.78,"endTime":69.15,"body":"discovery teams through to"},{"speaker":"Iain Kilty","startTime":66.78,"endTime":69.15,"body":"leading clinical clusters in"},{"speaker":"Iain Kilty","startTime":69.15,"endTime":72.39,"body":"rheumatology and dermatology,"},{"speaker":"Iain Kilty","startTime":69.15,"endTime":72.39,"body":"before ultimately being"},{"speaker":"Iain Kilty","startTime":72.39,"endTime":77.01,"body":"responsible for their"},{"speaker":"Iain Kilty","startTime":72.39,"endTime":77.01,"body":"preclinical portfolio in INI."},{"speaker":"Iain Kilty","startTime":77.34,"endTime":79.17,"body":"And as part of that role,"},{"speaker":"Iain Kilty","startTime":77.34,"endTime":79.17,"body":"actually, I was doing a lot of"},{"speaker":"Iain Kilty","startTime":79.17,"endTime":83.19,"body":"work, working with biotech, and"},{"speaker":"Iain Kilty","startTime":79.17,"endTime":83.19,"body":"whilst, I guess lots of"},{"speaker":"Iain Kilty","startTime":83.19,"endTime":85.71,"body":"fantastic things about Big"},{"speaker":"Iain Kilty","startTime":83.19,"endTime":85.71,"body":"Pharma and Pfizer and had an"},{"speaker":"Iain Kilty","startTime":85.71,"endTime":88.59,"body":"amazing time there, learnt a"},{"speaker":"Iain Kilty","startTime":85.71,"endTime":88.59,"body":"huge amount, had the opportunity"},{"speaker":"Iain Kilty","startTime":88.59,"endTime":93.96,"body":"to contribute to marketed"},{"speaker":"Iain Kilty","startTime":88.59,"endTime":93.96,"body":"therapies now, but the dynamism,"},{"speaker":"Iain Kilty","startTime":93.96,"endTime":98.43,"body":"the opportunity to impact"},{"speaker":"Iain Kilty","startTime":93.96,"endTime":98.43,"body":"things, to really drive programs"},{"speaker":"Iain Kilty","startTime":98.43,"endTime":103.02,"body":"at speed and take risks was was"},{"speaker":"Iain Kilty","startTime":98.43,"endTime":103.02,"body":"more available to me in the"},{"speaker":"Iain Kilty","startTime":103.02,"endTime":106.5,"body":"biotech world, and I've really"},{"speaker":"Iain Kilty","startTime":103.02,"endTime":106.5,"body":"enjoyed making that transition."},{"speaker":"John Simboli","startTime":108.68,"endTime":111.68,"body":"What's it like to"},{"speaker":"John Simboli","startTime":108.68,"endTime":111.68,"body":"be a CSO and then become a CEO?"},{"speaker":"John Simboli","startTime":111.68,"endTime":115.28,"body":"What sorts of understandings do"},{"speaker":"John Simboli","startTime":111.68,"endTime":115.28,"body":"you have now? I know you're in"},{"speaker":"John Simboli","startTime":115.28,"endTime":118.4,"body":"the job relatively a short time,"},{"speaker":"John Simboli","startTime":115.28,"endTime":118.4,"body":"but what's it like to be a CSO"},{"speaker":"John Simboli","startTime":118.4,"endTime":119.87,"body":"versus what's like to be CEO?"},{"speaker":"Iain Kilty","startTime":121.0,"endTime":124.0,"body":"Yeah, so it's, as"},{"speaker":"Iain Kilty","startTime":121.0,"endTime":124.0,"body":"you say, relatively early in my"},{"speaker":"Iain Kilty","startTime":124.0,"endTime":128.38,"body":"CEO experience, but the previous"},{"speaker":"Iain Kilty","startTime":124.0,"endTime":128.38,"body":"CEO actually is chap called Neil"},{"speaker":"Iain Kilty","startTime":128.38,"endTime":131.74,"body":"Weir. He was the CEO from the"},{"speaker":"Iain Kilty","startTime":128.38,"endTime":131.74,"body":"start of Sitryx, and when the"},{"speaker":"Iain Kilty","startTime":131.74,"endTime":134.83,"body":"company was founded, and he's"},{"speaker":"Iain Kilty","startTime":131.74,"endTime":134.83,"body":"still within the company, he's"},{"speaker":"Iain Kilty","startTime":134.83,"endTime":137.5,"body":"now president of the company."},{"speaker":"Iain Kilty","startTime":134.83,"endTime":137.5,"body":"Which is great for me, because"},{"speaker":"Iain Kilty","startTime":137.5,"endTime":141.82,"body":"Neil's been a mentor all the way"},{"speaker":"Iain Kilty","startTime":137.5,"endTime":141.82,"body":"for me since I joined Sitryx,"},{"speaker":"Iain Kilty","startTime":142.03,"endTime":144.73,"body":"and this was part of a"},{"speaker":"Iain Kilty","startTime":142.03,"endTime":144.73,"body":"succession planning it was even"},{"speaker":"Iain Kilty","startTime":144.73,"endTime":148.63,"body":"discussed as I very first joined"},{"speaker":"Iain Kilty","startTime":144.73,"endTime":148.63,"body":"as the CSO. And obviously, as a"},{"speaker":"Iain Kilty","startTime":148.63,"endTime":151.81,"body":"CSO, you're primarily focused on"},{"speaker":"Iain Kilty","startTime":148.63,"endTime":151.81,"body":"driving that scientific"},{"speaker":"Iain Kilty","startTime":151.81,"endTime":155.29,"body":"portfolio. And I joined at a"},{"speaker":"Iain Kilty","startTime":151.81,"endTime":155.29,"body":"time the company was really"},{"speaker":"Iain Kilty","startTime":155.29,"endTime":159.79,"body":"evolving from having some early"},{"speaker":"Iain Kilty","startTime":155.29,"endTime":159.79,"body":"targets to driving those targets"},{"speaker":"Iain Kilty","startTime":159.79,"endTime":163.24,"body":"towards development candidates"},{"speaker":"Iain Kilty","startTime":159.79,"endTime":163.24,"body":"and needing to become more of a"},{"speaker":"Iain Kilty","startTime":163.24,"endTime":167.53,"body":"professional drug discovery or"},{"speaker":"Iain Kilty","startTime":163.24,"endTime":167.53,"body":"drug development organization,"},{"speaker":"Iain Kilty","startTime":167.86,"endTime":170.8,"body":"which was a huge amount of fun,"},{"speaker":"Iain Kilty","startTime":167.86,"endTime":170.8,"body":"and we've now been able to"},{"speaker":"Iain Kilty","startTime":170.8,"endTime":174.61,"body":"deliver multiple programs"},{"speaker":"Iain Kilty","startTime":170.8,"endTime":174.61,"body":"through those stage gates. So"},{"speaker":"Iain Kilty","startTime":174.64,"endTime":177.94,"body":"with respect to the transition"},{"speaker":"Iain Kilty","startTime":174.64,"endTime":177.94,"body":"of role over this time, Neil's"},{"speaker":"Iain Kilty","startTime":177.94,"endTime":180.7,"body":"given me opportunities to be"},{"speaker":"Iain Kilty","startTime":177.94,"endTime":180.7,"body":"heavily involved in the investor"},{"speaker":"Iain Kilty","startTime":180.7,"endTime":184.12,"body":"discussions, the pitches, the"},{"speaker":"Iain Kilty","startTime":180.7,"endTime":184.12,"body":"strategic thinking of the"},{"speaker":"Iain Kilty","startTime":184.12,"endTime":187.78,"body":"company and so on. So it's less"},{"speaker":"Iain Kilty","startTime":184.12,"endTime":187.78,"body":"of an abrupt you're the"},{"speaker":"Iain Kilty","startTime":187.78,"endTime":190.63,"body":"scientist. Oh, now I want you to"},{"speaker":"Iain Kilty","startTime":187.78,"endTime":190.63,"body":"be involved in all of these"},{"speaker":"Iain Kilty","startTime":190.63,"endTime":193.96,"body":"other things than a transition"},{"speaker":"Iain Kilty","startTime":190.63,"endTime":193.96,"body":"over time, which has been great"},{"speaker":"Iain Kilty","startTime":193.96,"endTime":196.87,"body":"because, obviously I know the"},{"speaker":"Iain Kilty","startTime":193.96,"endTime":196.87,"body":"company very well. It's not like"},{"speaker":"Iain Kilty","startTime":196.87,"endTime":200.11,"body":"coming in as a CEO and trying"},{"speaker":"Iain Kilty","startTime":196.87,"endTime":200.11,"body":"and learning the science,"},{"speaker":"Iain Kilty","startTime":200.11,"endTime":203.35,"body":"learning the strategy and so on."},{"speaker":"Iain Kilty","startTime":200.11,"endTime":203.35,"body":"I've been involved in building"},{"speaker":"Iain Kilty","startTime":203.35,"endTime":206.2,"body":"the company to this point, and"},{"speaker":"Iain Kilty","startTime":203.35,"endTime":206.2,"body":"that was one of the reasons this"},{"speaker":"Iain Kilty","startTime":206.2,"endTime":209.59,"body":"was a really exciting"},{"speaker":"Iain Kilty","startTime":206.2,"endTime":209.59,"body":"opportunity for me. Because I"},{"speaker":"Iain Kilty","startTime":209.59,"endTime":211.99,"body":"said earlier, I think I have"},{"speaker":"Iain Kilty","startTime":209.59,"endTime":211.99,"body":"great belief that we have a"},{"speaker":"Iain Kilty","startTime":211.99,"endTime":214.3,"body":"chance to really make a"},{"speaker":"Iain Kilty","startTime":211.99,"endTime":214.3,"body":"difference for patients in what"},{"speaker":"Iain Kilty","startTime":214.3,"endTime":217.63,"body":"we're doing. I really like the"},{"speaker":"Iain Kilty","startTime":214.3,"endTime":217.63,"body":"team, and I think we have some"},{"speaker":"Iain Kilty","startTime":217.66,"endTime":221.92,"body":"really quite exciting assets to"},{"speaker":"Iain Kilty","startTime":217.66,"endTime":221.92,"body":"take forward to the clinic now."},{"speaker":"Iain Kilty","startTime":222.37,"endTime":225.37,"body":"The key thing even in these"},{"speaker":"Iain Kilty","startTime":222.37,"endTime":225.37,"body":"early days, is my focus is"},{"speaker":"Iain Kilty","startTime":225.37,"endTime":228.76,"body":"moving away from that management"},{"speaker":"Iain Kilty","startTime":225.37,"endTime":228.76,"body":"of that scientific portfolio on"},{"speaker":"Iain Kilty","startTime":228.76,"endTime":232.39,"body":"a day to day basis to all the"},{"speaker":"Iain Kilty","startTime":228.76,"endTime":232.39,"body":"other pieces, thinking about the"},{"speaker":"Iain Kilty","startTime":232.39,"endTime":235.57,"body":"discussions with the bankers,"},{"speaker":"Iain Kilty","startTime":232.39,"endTime":235.57,"body":"the discussions with lawyers"},{"speaker":"Iain Kilty","startTime":235.6,"endTime":238.87,"body":"working with the board, and"},{"speaker":"Iain Kilty","startTime":235.6,"endTime":238.87,"body":"that's an interesting reporting"},{"speaker":"Iain Kilty","startTime":238.87,"endTime":242.38,"body":"relationship that's new for me,"},{"speaker":"Iain Kilty","startTime":238.87,"endTime":242.38,"body":"I've always had a direct boss,"},{"speaker":"Iain Kilty","startTime":242.38,"endTime":245.05,"body":"and whilst I report into the"},{"speaker":"Iain Kilty","startTime":242.38,"endTime":245.05,"body":"chair of the board, Pierre"},{"speaker":"Iain Kilty","startTime":245.05,"endTime":249.13,"body":"Legault, and he's been also a"},{"speaker":"Iain Kilty","startTime":245.05,"endTime":249.13,"body":"great mentor for me, you have"},{"speaker":"Iain Kilty","startTime":249.16,"endTime":251.89,"body":"lots of other players on the"},{"speaker":"Iain Kilty","startTime":249.16,"endTime":251.89,"body":"board as well who are from"},{"speaker":"Iain Kilty","startTime":251.89,"endTime":253.87,"body":"different institutions,"},{"speaker":"Iain Kilty","startTime":251.89,"endTime":253.87,"body":"different organizations that"},{"speaker":"Iain Kilty","startTime":253.87,"endTime":257.95,"body":"you're working with. So huge"},{"speaker":"Iain Kilty","startTime":253.87,"endTime":257.95,"body":"amounts for me to learn on that"},{"speaker":"Iain Kilty","startTime":257.95,"endTime":262.39,"body":"front, lots of connections, lots"},{"speaker":"Iain Kilty","startTime":257.95,"endTime":262.39,"body":"of talking to people and a lso"},{"speaker":"Iain Kilty","startTime":262.39,"endTime":266.17,"body":"important for me within the"},{"speaker":"Iain Kilty","startTime":262.39,"endTime":266.17,"body":"Sitryx organization, that it's"},{"speaker":"Iain Kilty","startTime":266.17,"endTime":268.57,"body":"not just the science part of the"},{"speaker":"Iain Kilty","startTime":266.17,"endTime":268.57,"body":"organization that feels they"},{"speaker":"Iain Kilty","startTime":268.57,"endTime":272.08,"body":"know Iain. Now we're small"},{"speaker":"Iain Kilty","startTime":268.57,"endTime":272.08,"body":"enough for 45 people that I knew"},{"speaker":"Iain Kilty","startTime":272.11,"endTime":276.07,"body":"everyone anyway, but it's a"},{"speaker":"Iain Kilty","startTime":272.11,"endTime":276.07,"body":"different relationship now to"},{"speaker":"Iain Kilty","startTime":276.1,"endTime":279.04,"body":"make sure I'm interacting with"},{"speaker":"Iain Kilty","startTime":276.1,"endTime":279.04,"body":"the finance team and in a"},{"speaker":"Iain Kilty","startTime":279.04,"endTime":283.33,"body":"different way, the operations"},{"speaker":"Iain Kilty","startTime":279.04,"endTime":283.33,"body":"team and so on and so forth. So"},{"speaker":"Iain Kilty","startTime":283.84,"endTime":287.5,"body":"yeah, lost lots to learn, but"},{"speaker":"Iain Kilty","startTime":283.84,"endTime":287.5,"body":"it's a transition more than any"},{"speaker":"Iain Kilty","startTime":287.5,"endTime":289.84,"body":"sort of revolution in the way"},{"speaker":"Iain Kilty","startTime":287.5,"endTime":289.84,"body":"I'm doing things"},{"speaker":"John Simboli","startTime":289.9,"endTime":293.14,"body":"From early on in"},{"speaker":"John Simboli","startTime":289.9,"endTime":293.14,"body":"your in your career, your 25"},{"speaker":"John Simboli","startTime":293.14,"endTime":295.75,"body":"years with Pfizer, did you"},{"speaker":"John Simboli","startTime":293.14,"endTime":295.75,"body":"picture at some point being a"},{"speaker":"John Simboli","startTime":295.75,"endTime":298.57,"body":"CEO? Or is this something that"},{"speaker":"John Simboli","startTime":295.75,"endTime":298.57,"body":"sort of evolves as time goes"},{"speaker":"John Simboli","startTime":298.57,"endTime":298.84,"body":"along?"},{"speaker":"Iain Kilty","startTime":300.11,"endTime":302.27,"body":"Yeah, so when I was"},{"speaker":"Iain Kilty","startTime":300.11,"endTime":302.27,"body":"at Pfizer, I don't think I"},{"speaker":"Iain Kilty","startTime":302.27,"endTime":306.44,"body":"necessarily pictured myself as"},{"speaker":"Iain Kilty","startTime":302.27,"endTime":306.44,"body":"being a CEO. I think actually,"},{"speaker":"Iain Kilty","startTime":306.44,"endTime":310.07,"body":"as I developed in my career at"},{"speaker":"Iain Kilty","startTime":306.44,"endTime":310.07,"body":"Pfizer, I would take on new"},{"speaker":"Iain Kilty","startTime":310.07,"endTime":312.86,"body":"levels of responsibility and"},{"speaker":"Iain Kilty","startTime":310.07,"endTime":312.86,"body":"always enjoy it, and once you"},{"speaker":"Iain Kilty","startTime":312.86,"endTime":314.87,"body":"got comfortable with that, you'd"},{"speaker":"Iain Kilty","startTime":312.86,"endTime":314.87,"body":"look at the next role and think,"},{"speaker":"Iain Kilty","startTime":314.87,"endTime":318.11,"body":"well, I could have more impact"},{"speaker":"Iain Kilty","startTime":314.87,"endTime":318.11,"body":"in that next role. And then look"},{"speaker":"Iain Kilty","startTime":318.11,"endTime":321.26,"body":"for those opportunities to build"},{"speaker":"Iain Kilty","startTime":318.11,"endTime":321.26,"body":"out my toolkit, build out my"},{"speaker":"Iain Kilty","startTime":321.26,"endTime":325.43,"body":"experiences to be in a position"},{"speaker":"Iain Kilty","startTime":321.26,"endTime":325.43,"body":"to take on those next roles. And"},{"speaker":"Iain Kilty","startTime":325.76,"endTime":328.88,"body":"as I mentioned earlier, actually"},{"speaker":"Iain Kilty","startTime":325.76,"endTime":328.88,"body":"I spent a bit of time in the"},{"speaker":"Iain Kilty","startTime":328.88,"endTime":333.56,"body":"clinical phase of drug discovery"},{"speaker":"Iain Kilty","startTime":328.88,"endTime":333.56,"body":"while I was at Pfizer, which was"},{"speaker":"Iain Kilty","startTime":333.98,"endTime":338.81,"body":"not my initial background. I was"},{"speaker":"Iain Kilty","startTime":333.98,"endTime":338.81,"body":"PhD scientist, very much lab"},{"speaker":"Iain Kilty","startTime":338.81,"endTime":342.38,"body":"based early on in my career, but"},{"speaker":"Iain Kilty","startTime":338.81,"endTime":342.38,"body":"really research focused. But"},{"speaker":"Iain Kilty","startTime":342.38,"endTime":345.32,"body":"that experience for those few"},{"speaker":"Iain Kilty","startTime":342.38,"endTime":345.32,"body":"years was hugely impactful in"},{"speaker":"Iain Kilty","startTime":345.32,"endTime":349.13,"body":"how I then did my job leading a"},{"speaker":"Iain Kilty","startTime":345.32,"endTime":349.13,"body":"portfolio through to"},{"speaker":"Iain Kilty","startTime":349.31,"endTime":351.65,"body":"development, candidate,"},{"speaker":"Iain Kilty","startTime":349.31,"endTime":351.65,"body":"nomination and early, early"},{"speaker":"Iain Kilty","startTime":351.65,"endTime":357.62,"body":"development, So phase one, 1b"},{"speaker":"Iain Kilty","startTime":351.65,"endTime":357.62,"body":"type work. So in a similar guise"},{"speaker":"Iain Kilty","startTime":357.65,"endTime":360.17,"body":"as I talked about, I was"},{"speaker":"Iain Kilty","startTime":357.65,"endTime":360.17,"body":"interacting quite a bit with"},{"speaker":"Iain Kilty","startTime":360.17,"endTime":362.9,"body":"biotech companies when I was at"},{"speaker":"Iain Kilty","startTime":360.17,"endTime":362.9,"body":"Pfizer, and that's what really"},{"speaker":"Iain Kilty","startTime":362.9,"endTime":366.14,"body":"fired my interest, that a"},{"speaker":"Iain Kilty","startTime":362.9,"endTime":366.14,"body":"dynamic place to work. I could"},{"speaker":"Iain Kilty","startTime":366.14,"endTime":369.65,"body":"really try and influence things."},{"speaker":"Iain Kilty","startTime":366.14,"endTime":369.65,"body":"I felt I could bring experience"},{"speaker":"Iain Kilty","startTime":369.65,"endTime":372.83,"body":"from big pharma into that"},{"speaker":"Iain Kilty","startTime":369.65,"endTime":372.83,"body":"biotech setting and add value."},{"speaker":"Iain Kilty","startTime":372.95,"endTime":375.44,"body":"And to me, that's one of the"},{"speaker":"Iain Kilty","startTime":372.95,"endTime":375.44,"body":"most important things. Am I able"},{"speaker":"Iain Kilty","startTime":375.44,"endTime":379.64,"body":"to add value here and really"},{"speaker":"Iain Kilty","startTime":375.44,"endTime":379.64,"body":"progress towards making drugs?"},{"speaker":"Iain Kilty","startTime":379.64,"endTime":381.59,"body":"Because fundamentally, that's"},{"speaker":"Iain Kilty","startTime":379.64,"endTime":381.59,"body":"what I want to do. I want to"},{"speaker":"Iain Kilty","startTime":381.59,"endTime":384.62,"body":"make drugs that change people's"},{"speaker":"Iain Kilty","startTime":381.59,"endTime":384.62,"body":"lives. And there's no feeling"},{"speaker":"Iain Kilty","startTime":384.62,"endTime":387.38,"body":"quite like being involved in a"},{"speaker":"Iain Kilty","startTime":384.62,"endTime":387.38,"body":"program that you get the first"},{"speaker":"Iain Kilty","startTime":387.38,"endTime":390.5,"body":"clinical data and you see it's"},{"speaker":"Iain Kilty","startTime":387.38,"endTime":390.5,"body":"working, and you think I was"},{"speaker":"Iain Kilty","startTime":390.5,"endTime":392.96,"body":"involved in that. That was an"},{"speaker":"Iain Kilty","startTime":390.5,"endTime":392.96,"body":"idea that we had on a PowerPoint"},{"speaker":"Iain Kilty","startTime":392.96,"endTime":397.64,"body":"slide and so on. So that drove"},{"speaker":"Iain Kilty","startTime":392.96,"endTime":397.64,"body":"my transition into a biotech and"},{"speaker":"Iain Kilty","startTime":397.64,"endTime":401.39,"body":"CSO was the obvious area for"},{"speaker":"Iain Kilty","startTime":397.64,"endTime":401.39,"body":"even my scientific background."},{"speaker":"Iain Kilty","startTime":401.57,"endTime":404.81,"body":"But in a similar guise, my first"},{"speaker":"Iain Kilty","startTime":401.57,"endTime":404.81,"body":"CEO, I worked with a lady called"},{"speaker":"Iain Kilty","startTime":404.81,"endTime":410.15,"body":"Sam Truex at Quench Bio, who's a"},{"speaker":"Iain Kilty","startTime":404.81,"endTime":410.15,"body":"good friend, and again, another"},{"speaker":"Iain Kilty","startTime":410.15,"endTime":412.37,"body":"great mentor. I've been really"},{"speaker":"Iain Kilty","startTime":410.15,"endTime":412.37,"body":"lucky with the people I've"},{"speaker":"Iain Kilty","startTime":412.37,"endTime":415.4,"body":"interacted and worked with"},{"speaker":"Iain Kilty","startTime":412.37,"endTime":415.4,"body":"through the years. And there"},{"speaker":"Iain Kilty","startTime":415.4,"endTime":418.19,"body":"were lots of elements of what"},{"speaker":"Iain Kilty","startTime":415.4,"endTime":418.19,"body":"Sam was doing that she gave me"},{"speaker":"Iain Kilty","startTime":418.19,"endTime":421.88,"body":"the opportunity to learn about."},{"speaker":"Iain Kilty","startTime":418.19,"endTime":421.88,"body":"And I thought, well, there's"},{"speaker":"Iain Kilty","startTime":421.88,"endTime":424.67,"body":"areas here that I think I could"},{"speaker":"Iain Kilty","startTime":421.88,"endTime":424.67,"body":"really help too, because I bring"},{"speaker":"Iain Kilty","startTime":424.67,"endTime":427.79,"body":"a different style, I bring a"},{"speaker":"Iain Kilty","startTime":424.67,"endTime":427.79,"body":"different way of thinking. And"},{"speaker":"Iain Kilty","startTime":427.79,"endTime":431.24,"body":"even then, I wouldn't say I was"},{"speaker":"Iain Kilty","startTime":427.79,"endTime":431.24,"body":"100% sure that my next goal is"},{"speaker":"Iain Kilty","startTime":431.24,"endTime":436.52,"body":"to be CEO, but I certainly felt"},{"speaker":"Iain Kilty","startTime":431.24,"endTime":436.52,"body":"there were areas where I thought"},{"speaker":"Iain Kilty","startTime":436.52,"endTime":439.52,"body":"I could bring value again as a"},{"speaker":"Iain Kilty","startTime":436.52,"endTime":439.52,"body":"CEO with a slightly different"},{"speaker":"Iain Kilty","startTime":439.52,"endTime":442.25,"body":"background. Sam's background was"},{"speaker":"Iain Kilty","startTime":439.52,"endTime":442.25,"body":"more business development than a"},{"speaker":"Iain Kilty","startTime":442.55,"endTime":447.05,"body":"core science and so on. So"},{"speaker":"Iain Kilty","startTime":442.55,"endTime":447.05,"body":"joining Sitryx was similar and"},{"speaker":"Iain Kilty","startTime":447.05,"endTime":450.74,"body":"coming in as CSO, not"},{"speaker":"Iain Kilty","startTime":447.05,"endTime":450.74,"body":"necessarily absolutely setting"},{"speaker":"Iain Kilty","startTime":450.74,"endTime":454.58,"body":"my heart on CEO at all, but, but"},{"speaker":"Iain Kilty","startTime":450.74,"endTime":454.58,"body":"it really felt like there was an"},{"speaker":"Iain Kilty","startTime":454.58,"endTime":458.12,"body":"opportunity here, given what"},{"speaker":"Iain Kilty","startTime":454.58,"endTime":458.12,"body":"I've already described through"},{"speaker":"Iain Kilty","startTime":458.12,"endTime":463.28,"body":"the transition with Neil moving"},{"speaker":"Iain Kilty","startTime":458.12,"endTime":463.28,"body":"into a role as president and so"},{"speaker":"Iain Kilty","startTime":463.28,"endTime":467.87,"body":"on for me to take that next"},{"speaker":"Iain Kilty","startTime":463.28,"endTime":467.87,"body":"step. And I really do enjoy the"},{"speaker":"Iain Kilty","startTime":467.87,"endTime":471.89,"body":"business side of biotech as well"},{"speaker":"Iain Kilty","startTime":467.87,"endTime":471.89,"body":"as the scientific side. And I"},{"speaker":"Iain Kilty","startTime":471.89,"endTime":475.28,"body":"think it's you bringing those"},{"speaker":"Iain Kilty","startTime":471.89,"endTime":475.28,"body":"two pieces together that give"},{"speaker":"Iain Kilty","startTime":475.28,"endTime":478.61,"body":"you the best opportunity to"},{"speaker":"Iain Kilty","startTime":475.28,"endTime":478.61,"body":"deliver those new drugs for"},{"speaker":"Iain Kilty","startTime":478.61,"endTime":482.6,"body":"patients. And another quick"},{"speaker":"Iain Kilty","startTime":478.61,"endTime":482.6,"body":"comment, some of the exposure"},{"speaker":"Iain Kilty","startTime":482.6,"endTime":485.3,"body":"that I've had on that business"},{"speaker":"Iain Kilty","startTime":482.6,"endTime":485.3,"body":"side has also come through my"},{"speaker":"Iain Kilty","startTime":485.66,"endTime":489.11,"body":"entrepreneur in residence role"},{"speaker":"Iain Kilty","startTime":485.66,"endTime":489.11,"body":"at Atlas, and I'm a venture"},{"speaker":"Iain Kilty","startTime":489.11,"endTime":492.41,"body":"partner with SV health investors"},{"speaker":"Iain Kilty","startTime":489.11,"endTime":492.41,"body":"right now in London, and those"},{"speaker":"Iain Kilty","startTime":492.41,"endTime":497.27,"body":"things, you start to see those"},{"speaker":"Iain Kilty","startTime":492.41,"endTime":497.27,"body":"elements of the job. And again,"},{"speaker":"Iain Kilty","startTime":497.27,"endTime":500.6,"body":"felt, well, I think there's"},{"speaker":"Iain Kilty","startTime":497.27,"endTime":500.6,"body":"value I can add. I've got"},{"speaker":"Iain Kilty","startTime":500.6,"endTime":503.09,"body":"experience pre clinically, and"},{"speaker":"Iain Kilty","startTime":500.6,"endTime":503.09,"body":"clinically, the company's moving"},{"speaker":"Iain Kilty","startTime":503.09,"endTime":506.48,"body":"to more of a clinical phase now,"},{"speaker":"Iain Kilty","startTime":503.09,"endTime":506.48,"body":"and it's the next step in"},{"speaker":"Iain Kilty","startTime":506.48,"endTime":508.97,"body":"development for me, and"},{"speaker":"Iain Kilty","startTime":506.48,"endTime":508.97,"body":"hopefully I will be able to add"},{"speaker":"Iain Kilty","startTime":508.97,"endTime":510.35,"body":"real value to Sitryx."},{"speaker":"John Simboli","startTime":510.0,"endTime":513.18,"body":"I want to ask you"},{"speaker":"John Simboli","startTime":510.0,"endTime":513.18,"body":"about the leap of faith part of"},{"speaker":"John Simboli","startTime":513.18,"endTime":516.39,"body":"this. You were well prepared, as"},{"speaker":"John Simboli","startTime":513.18,"endTime":516.39,"body":"I've understood what you just"},{"speaker":"John Simboli","startTime":516.39,"endTime":520.47,"body":"told me, and it's quite logical"},{"speaker":"John Simboli","startTime":516.39,"endTime":520.47,"body":"in some ways, in most ways, to"},{"speaker":"John Simboli","startTime":520.86,"endTime":523.5,"body":"follow that path that you"},{"speaker":"John Simboli","startTime":520.86,"endTime":523.5,"body":"follow. On the other hand, there"},{"speaker":"John Simboli","startTime":523.5,"endTime":526.14,"body":"is, I would say, probably, for"},{"speaker":"John Simboli","startTime":523.5,"endTime":526.14,"body":"most people I've spoken with,"},{"speaker":"John Simboli","startTime":526.41,"endTime":529.86,"body":"there is a leap of faith about"},{"speaker":"John Simboli","startTime":526.41,"endTime":529.86,"body":"going from something that's very"},{"speaker":"John Simboli","startTime":529.86,"endTime":533.37,"body":"big, like Pfizer or BMS or"},{"speaker":"John Simboli","startTime":529.86,"endTime":533.37,"body":"wherever it might be, to"},{"speaker":"John Simboli","startTime":533.37,"endTime":535.56,"body":"something that's new and getting"},{"speaker":"John Simboli","startTime":533.37,"endTime":535.56,"body":"started. And I remember a"},{"speaker":"John Simboli","startTime":535.56,"endTime":540.3,"body":"conversation with two founders"},{"speaker":"John Simboli","startTime":535.56,"endTime":540.3,"body":"who, one co founder spoke to the"},{"speaker":"John Simboli","startTime":540.3,"endTime":541.83,"body":"other and said, I'm thinking"},{"speaker":"John Simboli","startTime":540.3,"endTime":541.83,"body":"about starting this company,"},{"speaker":"John Simboli","startTime":541.83,"endTime":543.63,"body":"would you like to join me? The"},{"speaker":"John Simboli","startTime":541.83,"endTime":543.63,"body":"other guy said yeah, and they"},{"speaker":"John Simboli","startTime":543.63,"endTime":546.06,"body":"were both really excited as they"},{"speaker":"John Simboli","startTime":543.63,"endTime":546.06,"body":"told me the story, and then they"},{"speaker":"John Simboli","startTime":546.06,"endTime":549.75,"body":"said, then we went home and told"},{"speaker":"John Simboli","startTime":546.06,"endTime":549.75,"body":"our wives. So that's the part of"},{"speaker":"John Simboli","startTime":549.75,"endTime":552.12,"body":"the question I want to ask you"},{"speaker":"John Simboli","startTime":549.75,"endTime":552.12,"body":"about when you come to grips"},{"speaker":"John Simboli","startTime":552.12,"endTime":556.02,"body":"with that, this is exciting, but"},{"speaker":"John Simboli","startTime":552.12,"endTime":556.02,"body":"this is an unknown. How does one"},{"speaker":"John Simboli","startTime":556.02,"endTime":557.01,"body":"negotiate that?"},{"speaker":"Iain Kilty","startTime":557.57,"endTime":559.79,"body":"Well, you're"},{"speaker":"Iain Kilty","startTime":557.57,"endTime":559.79,"body":"absolutely right, and you've"},{"speaker":"Iain Kilty","startTime":559.79,"endTime":562.4,"body":"been in the environment, in Big"},{"speaker":"Iain Kilty","startTime":559.79,"endTime":562.4,"body":"Pharma, but you've been"},{"speaker":"Iain Kilty","startTime":562.4,"endTime":565.19,"body":"reasonably successful. It's"},{"speaker":"Iain Kilty","startTime":562.4,"endTime":565.19,"body":"reasonably comfortable. You're"},{"speaker":"Iain Kilty","startTime":565.19,"endTime":569.27,"body":"well compensated, and you've"},{"speaker":"Iain Kilty","startTime":565.19,"endTime":569.27,"body":"also, you've got teams you"},{"speaker":"Iain Kilty","startTime":569.27,"endTime":572.27,"body":"really like, generally, I did"},{"speaker":"Iain Kilty","startTime":569.27,"endTime":572.27,"body":"anyway, that's the hardest"},{"speaker":"Iain Kilty","startTime":572.27,"endTime":574.4,"body":"piece, in many respects, was"},{"speaker":"Iain Kilty","startTime":572.27,"endTime":574.4,"body":"leaving some of the people."},{"speaker":"Iain Kilty","startTime":574.43,"endTime":577.19,"body":"You're also leaving value on the"},{"speaker":"Iain Kilty","startTime":574.43,"endTime":577.19,"body":"table, because you have various"},{"speaker":"Iain Kilty","startTime":577.19,"endTime":580.52,"body":"options and all the rest of it."},{"speaker":"Iain Kilty","startTime":577.19,"endTime":580.52,"body":"So it is an element of leap of"},{"speaker":"Iain Kilty","startTime":580.52,"endTime":582.95,"body":"faith. It was interesting. I"},{"speaker":"Iain Kilty","startTime":580.52,"endTime":582.95,"body":"didn't need to go back to my"},{"speaker":"Iain Kilty","startTime":582.95,"endTime":586.46,"body":"wife and sell this. She knew"},{"speaker":"Iain Kilty","startTime":582.95,"endTime":586.46,"body":"that I was really ready to go,"},{"speaker":"Iain Kilty","startTime":586.46,"endTime":590.09,"body":"probably before I did, in some"},{"speaker":"Iain Kilty","startTime":586.46,"endTime":590.09,"body":"respects, because she could see"},{"speaker":"Iain Kilty","startTime":590.09,"endTime":594.41,"body":"how energized I was when I was"},{"speaker":"Iain Kilty","startTime":590.09,"endTime":594.41,"body":"working with those biotech"},{"speaker":"Iain Kilty","startTime":594.5,"endTime":596.69,"body":"teams, through some of the work"},{"speaker":"Iain Kilty","startTime":594.5,"endTime":596.69,"body":"I was doing for Pfizer at the"},{"speaker":"Iain Kilty","startTime":596.69,"endTime":599.57,"body":"time, and how I'd come back and"},{"speaker":"Iain Kilty","startTime":596.69,"endTime":599.57,"body":"talk about it and the receptions"},{"speaker":"Iain Kilty","startTime":599.57,"endTime":603.2,"body":"I'd been. And chatting to those"},{"speaker":"Iain Kilty","startTime":599.57,"endTime":603.2,"body":"guys, and I obviously discussed,"},{"speaker":"Iain Kilty","startTime":603.2,"endTime":606.11,"body":"I think I could, I could have an"},{"speaker":"Iain Kilty","startTime":603.2,"endTime":606.11,"body":"impact, that I could, I could do"},{"speaker":"Iain Kilty","startTime":606.11,"endTime":609.77,"body":"something that's valuable. And"},{"speaker":"Iain Kilty","startTime":606.11,"endTime":609.77,"body":"she, she was very encouraging,"},{"speaker":"Iain Kilty","startTime":609.77,"endTime":611.99,"body":"actually, well, if you believe"},{"speaker":"Iain Kilty","startTime":609.77,"endTime":611.99,"body":"it, just go, you should do it,"},{"speaker":"Iain Kilty","startTime":612.2,"endTime":614.69,"body":"which was fantastic. It's"},{"speaker":"Iain Kilty","startTime":612.2,"endTime":614.69,"body":"fantastic to have that sort of"},{"speaker":"Iain Kilty","startTime":614.69,"endTime":617.54,"body":"support at home, because yeah"},{"speaker":"Iain Kilty","startTime":614.69,"endTime":617.54,"body":"there's definitely a"},{"speaker":"Iain Kilty","startTime":617.54,"endTime":619.43,"body":"nervousness, and it's really"},{"speaker":"Iain Kilty","startTime":617.54,"endTime":619.43,"body":"interesting because one of the"},{"speaker":"Iain Kilty","startTime":619.43,"endTime":622.4,"body":"things I was most nervous about,"},{"speaker":"Iain Kilty","startTime":619.43,"endTime":622.4,"body":"actually, was job security"},{"speaker":"Iain Kilty","startTime":622.76,"endTime":626.09,"body":"moving into a small company. I"},{"speaker":"Iain Kilty","startTime":622.76,"endTime":626.09,"body":"was the fourth employee at"},{"speaker":"Iain Kilty","startTime":626.45,"endTime":628.85,"body":"Quench Bio when I moved there,"},{"speaker":"Iain Kilty","startTime":626.45,"endTime":628.85,"body":"so it was a small company at the"},{"speaker":"Iain Kilty","startTime":628.85,"endTime":631.7,"body":"time. But I'm not sure that"},{"speaker":"Iain Kilty","startTime":628.85,"endTime":631.7,"body":"actually, now I've been in that"},{"speaker":"Iain Kilty","startTime":631.7,"endTime":633.71,"body":"world for a number of years, I"},{"speaker":"Iain Kilty","startTime":631.7,"endTime":633.71,"body":"don't think that's really the"},{"speaker":"Iain Kilty","startTime":633.71,"endTime":637.61,"body":"right thing to be concerned"},{"speaker":"Iain Kilty","startTime":633.71,"endTime":637.61,"body":"about, because the reality is"},{"speaker":"Iain Kilty","startTime":637.61,"endTime":641.51,"body":"that with any of these, with any"},{"speaker":"Iain Kilty","startTime":637.61,"endTime":641.51,"body":"of these investor ecosystems, if"},{"speaker":"Iain Kilty","startTime":641.51,"endTime":646.1,"body":"you do a good job within that"},{"speaker":"Iain Kilty","startTime":641.51,"endTime":646.1,"body":"ecosystem, there's always need"},{"speaker":"Iain Kilty","startTime":646.1,"endTime":650.84,"body":"for people with experience and"},{"speaker":"Iain Kilty","startTime":646.1,"endTime":650.84,"body":"drive to join other startup"},{"speaker":"Iain Kilty","startTime":650.84,"endTime":654.26,"body":"companies or establish biotechs."},{"speaker":"Iain Kilty","startTime":650.84,"endTime":654.26,"body":"There's no shortage of roles."},{"speaker":"Iain Kilty","startTime":654.26,"endTime":657.47,"body":"Now, your company name may"},{"speaker":"Iain Kilty","startTime":654.26,"endTime":657.47,"body":"change more than it would at a"},{"speaker":"Iain Kilty","startTime":657.47,"endTime":660.38,"body":"Pfizer and so on, but, but I"},{"speaker":"Iain Kilty","startTime":657.47,"endTime":660.38,"body":"just don't think actually"},{"speaker":"Iain Kilty","startTime":660.38,"endTime":662.84,"body":"there's that there's such a big"},{"speaker":"Iain Kilty","startTime":660.38,"endTime":662.84,"body":"difference in job security. It's"},{"speaker":"Iain Kilty","startTime":662.84,"endTime":665.06,"body":"just a different type of"},{"speaker":"Iain Kilty","startTime":662.84,"endTime":665.06,"body":"security, as long as you could"},{"speaker":"Iain Kilty","startTime":665.06,"endTime":667.37,"body":"deliver. And I guess then the"},{"speaker":"Iain Kilty","startTime":665.06,"endTime":667.37,"body":"other piece that you always"},{"speaker":"Iain Kilty","startTime":667.37,"endTime":670.7,"body":"have, and you have as you step,"},{"speaker":"Iain Kilty","startTime":667.37,"endTime":670.7,"body":"well, I have as you step, from a"},{"speaker":"Iain Kilty","startTime":670.73,"endTime":674.3,"body":"CSO into a CEO role, is there's"},{"speaker":"Iain Kilty","startTime":670.73,"endTime":674.3,"body":"always an element of, you know,"},{"speaker":"Iain Kilty","startTime":674.36,"endTime":677.15,"body":"can I, can I do this"},{"speaker":"Iain Kilty","startTime":674.36,"endTime":677.15,"body":"effectively? You know, there's"},{"speaker":"Iain Kilty","startTime":677.15,"endTime":679.79,"body":"always a bit of imposter"},{"speaker":"Iain Kilty","startTime":677.15,"endTime":679.79,"body":"syndrome. And mind you, those"},{"speaker":"Iain Kilty","startTime":679.79,"endTime":682.31,"body":"sort of things, you know that"},{"speaker":"Iain Kilty","startTime":679.79,"endTime":682.31,"body":"those things keep you sharp,"},{"speaker":"Iain Kilty","startTime":682.31,"endTime":686.21,"body":"keep you focused, make you work"},{"speaker":"Iain Kilty","startTime":682.31,"endTime":686.21,"body":"hard, so I think that's just all"},{"speaker":"Iain Kilty","startTime":686.21,"endTime":687.44,"body":"part of the process."},{"speaker":"John Simboli","startTime":687.0,"endTime":690.42,"body":"So here's a"},{"speaker":"John Simboli","startTime":687.0,"endTime":690.42,"body":"related question about how"},{"speaker":"John Simboli","startTime":690.42,"endTime":695.82,"body":"people think of a CEO as"},{"speaker":"John Simboli","startTime":690.42,"endTime":695.82,"body":"compared to another C suite job."},{"speaker":"John Simboli","startTime":695.82,"endTime":701.25,"body":"So I spoke with a person who was"},{"speaker":"John Simboli","startTime":695.82,"endTime":701.25,"body":"the Chief Business Officer at a"},{"speaker":"John Simboli","startTime":702.03,"endTime":705.0,"body":"biopharma company. And he told"},{"speaker":"John Simboli","startTime":702.03,"endTime":705.0,"body":"me that he was accustomed to"},{"speaker":"John Simboli","startTime":705.0,"endTime":707.25,"body":"going into the meetings with CEO"},{"speaker":"John Simboli","startTime":705.0,"endTime":707.25,"body":"and the other members of the"},{"speaker":"John Simboli","startTime":707.25,"endTime":710.73,"body":"team and posing options, you"},{"speaker":"John Simboli","startTime":707.25,"endTime":710.73,"body":"know, we could do this. We could"},{"speaker":"John Simboli","startTime":710.73,"endTime":715.17,"body":"do this. And then he said, when"},{"speaker":"John Simboli","startTime":710.73,"endTime":715.17,"body":"he became CEO, he just without"},{"speaker":"John Simboli","startTime":715.2,"endTime":719.4,"body":"even understanding that he was"},{"speaker":"John Simboli","startTime":715.2,"endTime":719.4,"body":"he was doing that, he was"},{"speaker":"John Simboli","startTime":719.4,"endTime":721.62,"body":"explaining to his team we could"},{"speaker":"John Simboli","startTime":719.4,"endTime":721.62,"body":"do this and this. And he said"},{"speaker":"John Simboli","startTime":721.62,"endTime":724.98,"body":"frequently, suddenly they would"},{"speaker":"John Simboli","startTime":721.62,"endTime":724.98,"body":"turn to him and surprise, he was"},{"speaker":"John Simboli","startTime":724.98,"endTime":727.71,"body":"surprised by this, and turn to"},{"speaker":"John Simboli","startTime":724.98,"endTime":727.71,"body":"him and say, yeah, but which one"},{"speaker":"John Simboli","startTime":727.71,"endTime":731.04,"body":"are we going to do? So there is"},{"speaker":"John Simboli","startTime":727.71,"endTime":731.04,"body":"a collaborative aspect, but"},{"speaker":"John Simboli","startTime":731.04,"endTime":734.82,"body":"there's also an expectation,"},{"speaker":"John Simboli","startTime":731.04,"endTime":734.82,"body":"right, that the CEO will be a"},{"speaker":"John Simboli","startTime":734.82,"endTime":738.75,"body":"final decider. So again,"},{"speaker":"John Simboli","startTime":734.82,"endTime":738.75,"body":"probably early in the cycle,"},{"speaker":"John Simboli","startTime":738.75,"endTime":741.09,"body":"maybe I should ask you this in"},{"speaker":"John Simboli","startTime":738.75,"endTime":741.09,"body":"six months, but do people look"},{"speaker":"John Simboli","startTime":741.09,"endTime":744.96,"body":"at you any differently as the"},{"speaker":"John Simboli","startTime":741.09,"endTime":744.96,"body":"CEO than they did as the CSO"},{"speaker":"John Simboli","startTime":745.47,"endTime":746.07,"body":"internally?"},{"speaker":"Iain Kilty","startTime":746.81,"endTime":749.69,"body":"I think so. I mean,"},{"speaker":"Iain Kilty","startTime":746.81,"endTime":749.69,"body":"my natural style is I do like to"},{"speaker":"Iain Kilty","startTime":749.69,"endTime":754.13,"body":"make decisions. And we've done"},{"speaker":"Iain Kilty","startTime":749.69,"endTime":754.13,"body":"various analyzes with our LT,"},{"speaker":"Iain Kilty","startTime":754.13,"endTime":756.83,"body":"you know, all the different"},{"speaker":"Iain Kilty","startTime":754.13,"endTime":756.83,"body":"Hogan type analyzes and things"},{"speaker":"Iain Kilty","startTime":756.83,"endTime":759.83,"body":"to look at our different styles"},{"speaker":"Iain Kilty","startTime":756.83,"endTime":759.83,"body":"and I'm probably the strongest"},{"speaker":"Iain Kilty","startTime":760.25,"endTime":763.94,"body":"decision maker style within the"},{"speaker":"Iain Kilty","startTime":760.25,"endTime":763.94,"body":"team. So that piece is quite"},{"speaker":"Iain Kilty","startTime":763.94,"endTime":768.05,"body":"natural for me, and I quite"},{"speaker":"Iain Kilty","startTime":763.94,"endTime":768.05,"body":"enjoy that, being able to make a"},{"speaker":"Iain Kilty","startTime":768.05,"endTime":770.42,"body":"decision and move on. I like to"},{"speaker":"Iain Kilty","startTime":768.05,"endTime":770.42,"body":"make a decision before we leave"},{"speaker":"Iain Kilty","startTime":770.42,"endTime":775.52,"body":"the room. But yeah, obviously I"},{"speaker":"Iain Kilty","startTime":770.42,"endTime":775.52,"body":"like to listen to the team and"},{"speaker":"Iain Kilty","startTime":775.52,"endTime":780.14,"body":"so on. Now, as a relatively"},{"speaker":"Iain Kilty","startTime":775.52,"endTime":780.14,"body":"early stage biotech just moving"},{"speaker":"Iain Kilty","startTime":780.14,"endTime":783.44,"body":"our first wholly owned program"},{"speaker":"Iain Kilty","startTime":780.14,"endTime":783.44,"body":"to the clinic now, a lot of what"},{"speaker":"Iain Kilty","startTime":783.44,"endTime":785.93,"body":"we're talking about is in my"},{"speaker":"Iain Kilty","startTime":783.44,"endTime":785.93,"body":"area of expertise, because it's"},{"speaker":"Iain Kilty","startTime":785.93,"endTime":788.99,"body":"the drug discovery piece. So I"},{"speaker":"Iain Kilty","startTime":785.93,"endTime":788.99,"body":"feel comfortable around that"},{"speaker":"Iain Kilty","startTime":788.99,"endTime":791.96,"body":"drug discovery development. It"},{"speaker":"Iain Kilty","startTime":788.99,"endTime":791.96,"body":"gets a bit more tricky if you're"},{"speaker":"Iain Kilty","startTime":792.08,"endTime":796.85,"body":"talking about decisions you need"},{"speaker":"Iain Kilty","startTime":792.08,"endTime":796.85,"body":"to make around a legal decision"},{"speaker":"Iain Kilty","startTime":796.85,"endTime":799.67,"body":"or a decision about some things"},{"speaker":"Iain Kilty","startTime":796.85,"endTime":799.67,"body":"we've been talking about"},{"speaker":"Iain Kilty","startTime":799.67,"endTime":803.57,"body":"recently, the lease and lab"},{"speaker":"Iain Kilty","startTime":799.67,"endTime":803.57,"body":"space we might want versus not,"},{"speaker":"Iain Kilty","startTime":803.57,"endTime":806.81,"body":"and some of those things. So"},{"speaker":"Iain Kilty","startTime":803.57,"endTime":806.81,"body":"yes. So I think as you move more"},{"speaker":"Iain Kilty","startTime":806.81,"endTime":809.66,"body":"out of your comfort zone, those"},{"speaker":"Iain Kilty","startTime":806.81,"endTime":809.66,"body":"sort of decisions get harder,"},{"speaker":"Iain Kilty","startTime":809.66,"endTime":812.63,"body":"don't they? Now what's great is"},{"speaker":"Iain Kilty","startTime":809.66,"endTime":812.63,"body":"I have a really good leadership"},{"speaker":"Iain Kilty","startTime":812.63,"endTime":817.22,"body":"team who I can rely on to advise"},{"speaker":"Iain Kilty","startTime":812.63,"endTime":817.22,"body":"me and to be involved in that"},{"speaker":"Iain Kilty","startTime":817.22,"endTime":822.23,"body":"debate around any of those sorts"},{"speaker":"Iain Kilty","startTime":817.22,"endTime":822.23,"body":"of decisions that need to be"},{"speaker":"Iain Kilty","startTime":822.23,"endTime":825.59,"body":"made. But yeah, no doubt"},{"speaker":"Iain Kilty","startTime":822.23,"endTime":825.59,"body":"there'll be challenges in the"},{"speaker":"Iain Kilty","startTime":825.59,"endTime":829.73,"body":"future in that way. I think"},{"speaker":"Iain Kilty","startTime":825.59,"endTime":829.73,"body":"actually, one of the things I've"},{"speaker":"Iain Kilty","startTime":829.73,"endTime":831.83,"body":"already seen is just people"},{"speaker":"Iain Kilty","startTime":829.73,"endTime":831.83,"body":"treat you differently once"},{"speaker":"Iain Kilty","startTime":831.83,"endTime":834.92,"body":"you're the CEO, because you're"},{"speaker":"Iain Kilty","startTime":831.83,"endTime":834.92,"body":"not quite a peer anymore. And"},{"speaker":"Iain Kilty","startTime":834.92,"endTime":837.23,"body":"some of those, you know, much of"},{"speaker":"Iain Kilty","startTime":834.92,"endTime":837.23,"body":"the team, it's many of the team"},{"speaker":"Iain Kilty","startTime":837.23,"endTime":841.01,"body":"were my peers previously. And"},{"speaker":"Iain Kilty","startTime":837.23,"endTime":841.01,"body":"whilst you don't, I don't"},{"speaker":"Iain Kilty","startTime":841.13,"endTime":844.01,"body":"personally feel any different."},{"speaker":"Iain Kilty","startTime":841.13,"endTime":844.01,"body":"You do notice the style of"},{"speaker":"Iain Kilty","startTime":844.01,"endTime":846.47,"body":"people's interaction can be"},{"speaker":"Iain Kilty","startTime":844.01,"endTime":846.47,"body":"subtly different. And I think"},{"speaker":"Iain Kilty","startTime":846.47,"endTime":849.77,"body":"you just have to get used to"},{"speaker":"Iain Kilty","startTime":846.47,"endTime":849.77,"body":"that, that you know you're in a"},{"speaker":"Iain Kilty","startTime":849.77,"endTime":851.0,"body":"slightly different position."},{"speaker":"John Simboli","startTime":851.84,"endTime":853.64,"body":"When you first"},{"speaker":"John Simboli","startTime":851.84,"endTime":853.64,"body":"came to Sitryx, do you recall"},{"speaker":"John Simboli","startTime":853.64,"endTime":857.06,"body":"what it was in particular about"},{"speaker":"John Simboli","startTime":853.64,"endTime":857.06,"body":"the science that grabbed hold"},{"speaker":"John Simboli","startTime":857.06,"endTime":859.61,"body":"you? I'm sure you looked at"},{"speaker":"John Simboli","startTime":857.06,"endTime":859.61,"body":"hundreds of other options and"},{"speaker":"John Simboli","startTime":859.61,"endTime":862.64,"body":"possibilities at that time"},{"speaker":"John Simboli","startTime":859.61,"endTime":862.64,"body":"coming from Atlas, you saw many"},{"speaker":"John Simboli","startTime":862.64,"endTime":866.87,"body":"different things, I'm certain."},{"speaker":"John Simboli","startTime":862.64,"endTime":866.87,"body":"So my question is, do you recall"},{"speaker":"John Simboli","startTime":866.87,"endTime":869.27,"body":"what it was specifically about"},{"speaker":"John Simboli","startTime":866.87,"endTime":869.27,"body":"Sitryx that made you say, I"},{"speaker":"John Simboli","startTime":869.27,"endTime":870.95,"body":"really want to investigate this?"},{"speaker":"Iain Kilty","startTime":871.56,"endTime":874.08,"body":"Yeah so there's,"},{"speaker":"Iain Kilty","startTime":871.56,"endTime":874.08,"body":"there's a few elements to it,"},{"speaker":"Iain Kilty","startTime":874.08,"endTime":877.2,"body":"actually. So I had the"},{"speaker":"Iain Kilty","startTime":874.08,"endTime":877.2,"body":"privilege, again, working at"},{"speaker":"Iain Kilty","startTime":877.2,"endTime":881.25,"body":"Pfizer, to work on particularly"},{"speaker":"Iain Kilty","startTime":877.2,"endTime":881.25,"body":"jak kinase inhibitors, which"},{"speaker":"Iain Kilty","startTime":881.25,"endTime":886.23,"body":"have become drugs and other"},{"speaker":"Iain Kilty","startTime":881.25,"endTime":886.23,"body":"programs which have really had"},{"speaker":"Iain Kilty","startTime":886.23,"endTime":888.87,"body":"an impact on patients, which is"},{"speaker":"Iain Kilty","startTime":886.23,"endTime":888.87,"body":"great. The way that those"},{"speaker":"Iain Kilty","startTime":888.87,"endTime":892.14,"body":"approaches work is that they're"},{"speaker":"Iain Kilty","startTime":888.87,"endTime":892.14,"body":"suppressing elements of the"},{"speaker":"Iain Kilty","startTime":892.14,"endTime":895.68,"body":"immune system, and from there"},{"speaker":"Iain Kilty","startTime":892.14,"endTime":895.68,"body":"you can drive a certain level of"},{"speaker":"Iain Kilty","startTime":895.68,"endTime":899.25,"body":"disease remission, but we kind"},{"speaker":"Iain Kilty","startTime":895.68,"endTime":899.25,"body":"of got stuck with the amount of"},{"speaker":"Iain Kilty","startTime":899.37,"endTime":902.82,"body":"disease remission we can achieve"},{"speaker":"Iain Kilty","startTime":899.37,"endTime":902.82,"body":"in rheumatoid arthritis, in"},{"speaker":"Iain Kilty","startTime":902.94,"endTime":906.06,"body":"inflammatory bowel disease and"},{"speaker":"Iain Kilty","startTime":902.94,"endTime":906.06,"body":"other indications. So we need to"},{"speaker":"Iain Kilty","startTime":906.06,"endTime":908.34,"body":"start thinking slightly"},{"speaker":"Iain Kilty","startTime":906.06,"endTime":908.34,"body":"differently about how can we"},{"speaker":"Iain Kilty","startTime":908.34,"endTime":913.17,"body":"really move that needle to drive"},{"speaker":"Iain Kilty","startTime":908.34,"endTime":913.17,"body":"greater therapeutic benefit for"},{"speaker":"Iain Kilty","startTime":913.17,"endTime":915.84,"body":"patients and drive more"},{"speaker":"Iain Kilty","startTime":913.17,"endTime":915.84,"body":"patients, as I say, into true"},{"speaker":"Iain Kilty","startTime":916.32,"endTime":921.63,"body":"remission and sustained"},{"speaker":"Iain Kilty","startTime":916.32,"endTime":921.63,"body":"remission at that. So actually,"},{"speaker":"Iain Kilty","startTime":921.63,"endTime":924.03,"body":"when I was at Pfizer, we were"},{"speaker":"Iain Kilty","startTime":921.63,"endTime":924.03,"body":"looking at different areas we"},{"speaker":"Iain Kilty","startTime":924.03,"endTime":927.36,"body":"could invest in to do that. And"},{"speaker":"Iain Kilty","startTime":924.03,"endTime":927.36,"body":"one of the areas we felt really"},{"speaker":"Iain Kilty","startTime":927.36,"endTime":930.63,"body":"had that potential was"},{"speaker":"Iain Kilty","startTime":927.36,"endTime":930.63,"body":"immunometabolism. So we actually"},{"speaker":"Iain Kilty","startTime":930.63,"endTime":934.08,"body":"had a group there, when I was at"},{"speaker":"Iain Kilty","startTime":930.63,"endTime":934.08,"body":"Pfizer, focused in this space."},{"speaker":"Iain Kilty","startTime":934.08,"endTime":938.82,"body":"It was a space I knew pretty"},{"speaker":"Iain Kilty","startTime":934.08,"endTime":938.82,"body":"well. And the fundamental thesis"},{"speaker":"Iain Kilty","startTime":938.82,"endTime":942.72,"body":"for immunometabolism is that by"},{"speaker":"Iain Kilty","startTime":938.82,"endTime":942.72,"body":"modulating the metabolic pathway"},{"speaker":"Iain Kilty","startTime":942.72,"endTime":946.26,"body":"cells are depending upon, you"},{"speaker":"Iain Kilty","startTime":942.72,"endTime":946.26,"body":"can modulate the phenotype of"},{"speaker":"Iain Kilty","startTime":946.26,"endTime":949.26,"body":"those cells. So you can move a"},{"speaker":"Iain Kilty","startTime":946.26,"endTime":949.26,"body":"cell from in effect, a pro"},{"speaker":"Iain Kilty","startTime":949.26,"endTime":953.16,"body":"inflammatory cell, to more of a"},{"speaker":"Iain Kilty","startTime":949.26,"endTime":953.16,"body":"regulatory or homeostatic sort"},{"speaker":"Iain Kilty","startTime":953.16,"endTime":957.33,"body":"of type cell, and that has the"},{"speaker":"Iain Kilty","startTime":953.16,"endTime":957.33,"body":"potential to really drive much"},{"speaker":"Iain Kilty","startTime":957.33,"endTime":961.2,"body":"greater efficacy for patients."},{"speaker":"Iain Kilty","startTime":957.33,"endTime":961.2,"body":"So the disease area was"},{"speaker":"Iain Kilty","startTime":961.2,"endTime":964.47,"body":"interesting to me. I think the"},{"speaker":"Iain Kilty","startTime":961.2,"endTime":964.47,"body":"other elements were, it's a"},{"speaker":"Iain Kilty","startTime":964.47,"endTime":967.08,"body":"small molecule company. I've got"},{"speaker":"Iain Kilty","startTime":964.47,"endTime":967.08,"body":"a lot of experience in that"},{"speaker":"Iain Kilty","startTime":967.08,"endTime":970.17,"body":"space. And going back to the"},{"speaker":"Iain Kilty","startTime":967.08,"endTime":970.17,"body":"point I made about, do I think I"},{"speaker":"Iain Kilty","startTime":970.17,"endTime":973.2,"body":"can make a difference in that"},{"speaker":"Iain Kilty","startTime":970.17,"endTime":973.2,"body":"organization and really add"},{"speaker":"Iain Kilty","startTime":973.2,"endTime":977.7,"body":"benefit? And then,"},{"speaker":"Iain Kilty","startTime":973.2,"endTime":977.7,"body":"fundamentally, it's super"},{"speaker":"Iain Kilty","startTime":977.7,"endTime":981.33,"body":"important it's the right team."},{"speaker":"Iain Kilty","startTime":977.7,"endTime":981.33,"body":"And when I met previous CEO,"},{"speaker":"Iain Kilty","startTime":981.33,"endTime":984.87,"body":"Neil, Neil Weir, and some of the"},{"speaker":"Iain Kilty","startTime":981.33,"endTime":984.87,"body":"other leadership team at the"},{"speaker":"Iain Kilty","startTime":984.87,"endTime":989.1,"body":"time, I really felt that this is"},{"speaker":"Iain Kilty","startTime":984.87,"endTime":989.1,"body":"a team that would be fun to work"},{"speaker":"Iain Kilty","startTime":989.1,"endTime":991.98,"body":"with, but know what they're"},{"speaker":"Iain Kilty","startTime":989.1,"endTime":991.98,"body":"doing and have a clear vision of"},{"speaker":"Iain Kilty","startTime":991.98,"endTime":994.92,"body":"where they want to go. And"},{"speaker":"Iain Kilty","startTime":991.98,"endTime":994.92,"body":"equally, we have a great"},{"speaker":"Iain Kilty","startTime":994.92,"endTime":997.83,"body":"investor base, and that's also"},{"speaker":"Iain Kilty","startTime":994.92,"endTime":997.83,"body":"incredibly important, as you"},{"speaker":"Iain Kilty","startTime":997.83,"endTime":1000.95,"body":"know, in the biotech world,"},{"speaker":"Iain Kilty","startTime":997.83,"endTime":1000.95,"body":"seasoned investors who really"},{"speaker":"Iain Kilty","startTime":1000.95,"endTime":1006.17,"body":"understand drug discovery and"},{"speaker":"Iain Kilty","startTime":1000.95,"endTime":1006.17,"body":"development and I had the"},{"speaker":"Iain Kilty","startTime":1006.17,"endTime":1008.63,"body":"opportunity to meet with a"},{"speaker":"Iain Kilty","startTime":1006.17,"endTime":1008.63,"body":"number of the investors as well"},{"speaker":"Iain Kilty","startTime":1008.63,"endTime":1011.54,"body":"before I took the role and and"},{"speaker":"Iain Kilty","startTime":1008.63,"endTime":1011.54,"body":"again, was really encouraged"},{"speaker":"Iain Kilty","startTime":1011.54,"endTime":1014.3,"body":"that they would be great people"},{"speaker":"Iain Kilty","startTime":1011.54,"endTime":1014.3,"body":"to work with. So it was a"},{"speaker":"Iain Kilty","startTime":1014.3,"endTime":1017.15,"body":"mixture of the science made"},{"speaker":"Iain Kilty","startTime":1014.3,"endTime":1017.15,"body":"sense to me, I already knew some"},{"speaker":"Iain Kilty","startTime":1017.15,"endTime":1020.33,"body":"elements of it, the team were"},{"speaker":"Iain Kilty","startTime":1017.15,"endTime":1020.33,"body":"great and the investor base was"},{"speaker":"Iain Kilty","startTime":1020.33,"endTime":1020.63,"body":"good."},{"speaker":"John Simboli","startTime":1022.04,"endTime":1024.35,"body":"When you tell"},{"speaker":"John Simboli","startTime":1022.04,"endTime":1024.35,"body":"someone who's from outside the"},{"speaker":"John Simboli","startTime":1024.35,"endTime":1029.06,"body":"industry that you're the CEO of"},{"speaker":"John Simboli","startTime":1024.35,"endTime":1029.06,"body":"Sitryx therapeutics, what do you"},{"speaker":"John Simboli","startTime":1029.06,"endTime":1033.08,"body":"think they picture you doing all"},{"speaker":"John Simboli","startTime":1029.06,"endTime":1033.08,"body":"day, and what do you do all day"},{"speaker":"John Simboli","startTime":1033.08,"endTime":1035.15,"body":"when you try to explain to them,"},{"speaker":"John Simboli","startTime":1033.08,"endTime":1035.15,"body":"no, I do this."},{"speaker":"Iain Kilty","startTime":1035.96,"endTime":1037.94,"body":"So usually, if I'm"},{"speaker":"Iain Kilty","startTime":1035.96,"endTime":1037.94,"body":"asked, what do I do for a"},{"speaker":"Iain Kilty","startTime":1037.94,"endTime":1040.61,"body":"living? I would say, well, I"},{"speaker":"Iain Kilty","startTime":1037.94,"endTime":1040.61,"body":"work in a company where we're"},{"speaker":"Iain Kilty","startTime":1040.64,"endTime":1043.94,"body":"trying to make new drugs to help"},{"speaker":"Iain Kilty","startTime":1040.64,"endTime":1043.94,"body":"people with autoimmune diseases,"},{"speaker":"Iain Kilty","startTime":1043.94,"endTime":1046.7,"body":"diseases like arthritis and"},{"speaker":"Iain Kilty","startTime":1043.94,"endTime":1046.7,"body":"inflammatory bowel disease,"},{"speaker":"Iain Kilty","startTime":1046.7,"endTime":1050.03,"body":"eczema and so on. And then"},{"speaker":"Iain Kilty","startTime":1046.7,"endTime":1050.03,"body":"people have usually got a"},{"speaker":"Iain Kilty","startTime":1050.03,"endTime":1053.3,"body":"reference point there that they"},{"speaker":"Iain Kilty","startTime":1050.03,"endTime":1053.3,"body":"know somebody who who struggles"},{"speaker":"Iain Kilty","startTime":1053.66,"endTime":1057.41,"body":"with one of those diseases. And"},{"speaker":"Iain Kilty","startTime":1053.66,"endTime":1057.41,"body":"then perhaps, if that piece is"},{"speaker":"Iain Kilty","startTime":1057.41,"endTime":1060.02,"body":"clear, and they say, oh no, I"},{"speaker":"Iain Kilty","startTime":1057.41,"endTime":1060.02,"body":"understand that. But, is it"},{"speaker":"Iain Kilty","startTime":1060.02,"endTime":1063.65,"body":"pharma biotech, then I would"},{"speaker":"Iain Kilty","startTime":1060.02,"endTime":1063.65,"body":"jump in and say, well, I built a"},{"speaker":"Iain Kilty","startTime":1063.65,"endTime":1067.37,"body":"lot of my experience and skill"},{"speaker":"Iain Kilty","startTime":1063.65,"endTime":1067.37,"body":"set working in Big Pharma, but"},{"speaker":"Iain Kilty","startTime":1067.37,"endTime":1072.11,"body":"now I work in biotech and enjoy"},{"speaker":"Iain Kilty","startTime":1067.37,"endTime":1072.11,"body":"working there because of the"},{"speaker":"Iain Kilty","startTime":1072.11,"endTime":1076.73,"body":"dynamic nature of that business."},{"speaker":"Iain Kilty","startTime":1072.11,"endTime":1076.73,"body":"But it's an ecosystem. Big"},{"speaker":"Iain Kilty","startTime":1076.73,"endTime":1079.76,"body":"biotech needs Big Pharma. Big"},{"speaker":"Iain Kilty","startTime":1076.73,"endTime":1079.76,"body":"Pharma needs biotech, so we"},{"speaker":"Iain Kilty","startTime":1079.76,"endTime":1082.43,"body":"still work closely with pharma"},{"speaker":"Iain Kilty","startTime":1079.76,"endTime":1082.43,"body":"and spends a lot of time with"},{"speaker":"Iain Kilty","startTime":1082.43,"endTime":1087.26,"body":"those teams. And then to what do"},{"speaker":"Iain Kilty","startTime":1082.43,"endTime":1087.26,"body":"I specifically do there? Well,"},{"speaker":"Iain Kilty","startTime":1088.04,"endTime":1091.52,"body":"I'm a scientist at heart. I'm"},{"speaker":"Iain Kilty","startTime":1088.04,"endTime":1091.52,"body":"focused on developing drugs"},{"speaker":"Iain Kilty","startTime":1091.82,"endTime":1096.17,"body":"that'll change people's lives,"},{"speaker":"Iain Kilty","startTime":1091.82,"endTime":1096.17,"body":"and perhaps tell them a bit"},{"speaker":"Iain Kilty","startTime":1096.17,"endTime":1098.54,"body":"about our lead programs in"},{"speaker":"Iain Kilty","startTime":1096.17,"endTime":1098.54,"body":"eczema. A lot of people know"},{"speaker":"Iain Kilty","startTime":1098.54,"endTime":1101.15,"body":"eczema, and so you know this,"},{"speaker":"Iain Kilty","startTime":1098.54,"endTime":1101.15,"body":"this, it's a small molecule,"},{"speaker":"Iain Kilty","startTime":1101.15,"endTime":1104.03,"body":"it'll be it's a pill. If it"},{"speaker":"Iain Kilty","startTime":1101.15,"endTime":1104.03,"body":"works people, it'll really help"},{"speaker":"Iain Kilty","startTime":1104.03,"endTime":1107.42,"body":"those people with more severe"},{"speaker":"Iain Kilty","startTime":1104.03,"endTime":1107.42,"body":"disease. So, so trying to find"},{"speaker":"Iain Kilty","startTime":1107.42,"endTime":1110.09,"body":"those reference points that make"},{"speaker":"Iain Kilty","startTime":1107.42,"endTime":1110.09,"body":"sense to people."},{"speaker":"John Simboli","startTime":1110.6,"endTime":1112.16,"body":"Can you recall"},{"speaker":"John Simboli","startTime":1110.6,"endTime":1112.16,"body":"when you were eight or nine or"},{"speaker":"John Simboli","startTime":1112.19,"endTime":1115.16,"body":"10 or some formative stage and"},{"speaker":"John Simboli","startTime":1112.19,"endTime":1115.16,"body":"you were thinking, my parents,"},{"speaker":"John Simboli","startTime":1115.28,"endTime":1118.07,"body":"this is as a kid, of course, my"},{"speaker":"John Simboli","startTime":1115.28,"endTime":1118.07,"body":"parents think I should become a"},{"speaker":"John Simboli","startTime":1118.64,"endTime":1122.48,"body":"kind of connected to, gee, I'm"},{"speaker":"John Simboli","startTime":1118.64,"endTime":1122.48,"body":"interested in this. Does any of"},{"speaker":"John Simboli","startTime":1122.48,"endTime":1125.27,"body":"that have anything to do with"},{"speaker":"John Simboli","startTime":1122.48,"endTime":1125.27,"body":"how your professional life"},{"speaker":"John Simboli","startTime":1125.27,"endTime":1125.84,"body":"played out?"},{"speaker":"Iain Kilty","startTime":1126.44,"endTime":1129.44,"body":"It certainly does,"},{"speaker":"Iain Kilty","startTime":1126.44,"endTime":1129.44,"body":"to a degree. I think my parents"},{"speaker":"Iain Kilty","startTime":1129.44,"endTime":1132.11,"body":"and probably even I as a child,"},{"speaker":"Iain Kilty","startTime":1129.44,"endTime":1132.11,"body":"always knew I'd be involved in"},{"speaker":"Iain Kilty","startTime":1132.11,"endTime":1136.01,"body":"the sciences somewhere. I was a"},{"speaker":"Iain Kilty","startTime":1132.11,"endTime":1136.01,"body":"sort of kid who asked the why"},{"speaker":"Iain Kilty","startTime":1136.01,"endTime":1139.25,"body":"question all the time. I wanted"},{"speaker":"Iain Kilty","startTime":1136.01,"endTime":1139.25,"body":"to take things apart, understand"},{"speaker":"Iain Kilty","startTime":1139.25,"endTime":1143.03,"body":"how they worked. I used to love"},{"speaker":"Iain Kilty","startTime":1139.25,"endTime":1143.03,"body":"all the sciences, actually, so I"},{"speaker":"Iain Kilty","startTime":1143.03,"endTime":1145.85,"body":"didn't know which path I would"},{"speaker":"Iain Kilty","startTime":1143.03,"endTime":1145.85,"body":"follow. Would it be physics,"},{"speaker":"Iain Kilty","startTime":1145.85,"endTime":1150.05,"body":"chemistry, biology? It always"},{"speaker":"Iain Kilty","startTime":1145.85,"endTime":1150.05,"body":"felt like it was going to be"},{"speaker":"Iain Kilty","startTime":1150.05,"endTime":1152.24,"body":"something in one of the in one"},{"speaker":"Iain Kilty","startTime":1150.05,"endTime":1152.24,"body":"of those directions, because"},{"speaker":"Iain Kilty","startTime":1152.24,"endTime":1155.87,"body":"that was what fired me up as a"},{"speaker":"Iain Kilty","startTime":1152.24,"endTime":1155.87,"body":"child, reading about nature,"},{"speaker":"Iain Kilty","startTime":1155.9,"endTime":1158.99,"body":"being out in nature. I grew up"},{"speaker":"Iain Kilty","startTime":1155.9,"endTime":1158.99,"body":"in Cumbria in the northwest of"},{"speaker":"Iain Kilty","startTime":1158.99,"endTime":1161.81,"body":"the UK, and it's a stunning"},{"speaker":"Iain Kilty","startTime":1158.99,"endTime":1161.81,"body":"area. It's right by the net Lake"},{"speaker":"Iain Kilty","startTime":1161.81,"endTime":1165.35,"body":"District National Park. So used"},{"speaker":"Iain Kilty","startTime":1161.81,"endTime":1165.35,"body":"to spend lots of time out in the"},{"speaker":"Iain Kilty","startTime":1165.35,"endTime":1169.61,"body":"Fells and so on there and that"},{"speaker":"Iain Kilty","startTime":1165.35,"endTime":1169.61,"body":"used to really inspire me, that"},{"speaker":"Iain Kilty","startTime":1169.61,"endTime":1173.3,"body":"the again, just being in nature"},{"speaker":"Iain Kilty","startTime":1169.61,"endTime":1173.3,"body":"and trying to understand it,"},{"speaker":"Iain Kilty","startTime":1173.45,"endTime":1178.43,"body":"geography also. So did I know"},{"speaker":"Iain Kilty","startTime":1173.45,"endTime":1178.43,"body":"I'd be in a biotech company? I"},{"speaker":"Iain Kilty","startTime":1178.43,"endTime":1181.55,"body":"probably wouldn't have known"},{"speaker":"Iain Kilty","startTime":1178.43,"endTime":1181.55,"body":"what a biotech company was at"},{"speaker":"Iain Kilty","startTime":1181.55,"endTime":1184.37,"body":"that time. But did I think I'd"},{"speaker":"Iain Kilty","startTime":1181.55,"endTime":1184.37,"body":"be doing something scientific?"},{"speaker":"Iain Kilty","startTime":1184.4,"endTime":1187.52,"body":"Probably, that's probably what I"},{"speaker":"Iain Kilty","startTime":1184.4,"endTime":1187.52,"body":"would have told you. I want to"},{"speaker":"Iain Kilty","startTime":1187.52,"endTime":1191.96,"body":"be a scientist or a doctor or"},{"speaker":"Iain Kilty","startTime":1187.52,"endTime":1191.96,"body":"something that has a link to"},{"speaker":"Iain Kilty","startTime":1191.96,"endTime":1193.13,"body":"science. But yeah."},{"speaker":"John Simboli","startTime":1194.0,"endTime":1198.35,"body":"Do you recall at a"},{"speaker":"John Simboli","startTime":1194.0,"endTime":1198.35,"body":"later stage, when you were in at"},{"speaker":"John Simboli","startTime":1198.35,"endTime":1200.99,"body":"university or in medical"},{"speaker":"John Simboli","startTime":1198.35,"endTime":1200.99,"body":"training, whatever's the"},{"speaker":"John Simboli","startTime":1200.99,"endTime":1203.15,"body":"appropriate part for this"},{"speaker":"John Simboli","startTime":1200.99,"endTime":1203.15,"body":"question, can you remember,"},{"speaker":"John Simboli","startTime":1203.84,"endTime":1207.53,"body":"yeah, that's exactly the part of"},{"speaker":"John Simboli","startTime":1203.84,"endTime":1207.53,"body":"it that I want to investigate."},{"speaker":"John Simboli","startTime":1207.56,"endTime":1210.56,"body":"Maybe, as a professor, maybe it"},{"speaker":"John Simboli","startTime":1207.56,"endTime":1210.56,"body":"was an idea that, yeah."},{"speaker":"Iain Kilty","startTime":1211.1,"endTime":1214.01,"body":"Yeah, so I actually,"},{"speaker":"Iain Kilty","startTime":1211.1,"endTime":1214.01,"body":"I did my first degree in"},{"speaker":"Iain Kilty","startTime":1214.01,"endTime":1219.74,"body":"Cambridge in the UK. And the"},{"speaker":"Iain Kilty","startTime":1214.01,"endTime":1219.74,"body":"scientific degree you enter"},{"speaker":"Iain Kilty","startTime":1219.74,"endTime":1222.23,"body":"Cambridge in is called natural"},{"speaker":"Iain Kilty","startTime":1219.74,"endTime":1222.23,"body":"sciences. So it starts quite"},{"speaker":"Iain Kilty","startTime":1222.23,"endTime":1227.03,"body":"broad, and I actually entered"},{"speaker":"Iain Kilty","startTime":1222.23,"endTime":1227.03,"body":"thinking I'd be a chemist. So my"},{"speaker":"Iain Kilty","startTime":1227.03,"endTime":1231.38,"body":"first year, I was third"},{"speaker":"Iain Kilty","startTime":1227.03,"endTime":1231.38,"body":"chemistry, third molecular work,"},{"speaker":"Iain Kilty","startTime":1231.47,"endTime":1234.17,"body":"molecular biology, and then a"},{"speaker":"Iain Kilty","startTime":1231.47,"endTime":1234.17,"body":"third sort of zoology type work."},{"speaker":"Iain Kilty","startTime":1234.17,"endTime":1237.74,"body":"But it was really with a view to"},{"speaker":"Iain Kilty","startTime":1234.17,"endTime":1237.74,"body":"chemistry and moving forward."},{"speaker":"Iain Kilty","startTime":1237.74,"endTime":1240.29,"body":"But actually, once I got there,"},{"speaker":"Iain Kilty","startTime":1237.74,"endTime":1240.29,"body":"I got really inspired at an"},{"speaker":"Iain Kilty","startTime":1240.29,"endTime":1244.88,"body":"electrical Bruce Ponder, he was"},{"speaker":"Iain Kilty","startTime":1240.29,"endTime":1244.88,"body":"one of the guys who identified"},{"speaker":"Iain Kilty","startTime":1244.88,"endTime":1250.55,"body":"the BRCA gene mutation in breast"},{"speaker":"Iain Kilty","startTime":1244.88,"endTime":1250.55,"body":"cancer. And I remember he, I"},{"speaker":"Iain Kilty","startTime":1250.55,"endTime":1253.19,"body":"still remember when he gave a"},{"speaker":"Iain Kilty","startTime":1250.55,"endTime":1253.19,"body":"talk about this, and I thought,"},{"speaker":"Iain Kilty","startTime":1253.19,"endTime":1255.86,"body":"this is amazing. This is"},{"speaker":"Iain Kilty","startTime":1253.19,"endTime":1255.86,"body":"actually the world I want to go"},{"speaker":"Iain Kilty","startTime":1255.86,"endTime":1259.73,"body":"into at that point, because this"},{"speaker":"Iain Kilty","startTime":1255.86,"endTime":1259.73,"body":"is changing people's lives. He's"},{"speaker":"Iain Kilty","startTime":1259.73,"endTime":1262.76,"body":"worked out one of the causes of,"},{"speaker":"Iain Kilty","startTime":1259.73,"endTime":1262.76,"body":"you know, familial breast"},{"speaker":"Iain Kilty","startTime":1262.76,"endTime":1267.29,"body":"cancer. So it was fascinating."},{"speaker":"Iain Kilty","startTime":1262.76,"endTime":1267.29,"body":"And really it was the influence"},{"speaker":"Iain Kilty","startTime":1267.29,"endTime":1272.0,"body":"of people like him that that"},{"speaker":"Iain Kilty","startTime":1267.29,"endTime":1272.0,"body":"moved me from the chemistry"},{"speaker":"Iain Kilty","startTime":1272.12,"endTime":1275.36,"body":"focused more towards a molecular"},{"speaker":"Iain Kilty","startTime":1272.12,"endTime":1275.36,"body":"biology and biochemistry. And as"},{"speaker":"Iain Kilty","startTime":1275.36,"endTime":1279.35,"body":"part of that, I did pharmacology"},{"speaker":"Iain Kilty","startTime":1275.36,"endTime":1279.35,"body":"work and so on. I think the"},{"speaker":"Iain Kilty","startTime":1279.35,"endTime":1282.95,"body":"other thing that made me think"},{"speaker":"Iain Kilty","startTime":1279.35,"endTime":1282.95,"body":"is, I'm probably not a long term"},{"speaker":"Iain Kilty","startTime":1282.95,"endTime":1288.08,"body":"academic. I really want to think"},{"speaker":"Iain Kilty","startTime":1282.95,"endTime":1288.08,"body":"more about the applied nature of"},{"speaker":"Iain Kilty","startTime":1288.41,"endTime":1293.54,"body":"this medical research or"},{"speaker":"Iain Kilty","startTime":1288.41,"endTime":1293.54,"body":"scientific research, and then it"},{"speaker":"Iain Kilty","startTime":1293.54,"endTime":1297.5,"body":"just, it really just evolved"},{"speaker":"Iain Kilty","startTime":1293.54,"endTime":1297.5,"body":"from there, went on to a PhD and"},{"speaker":"Iain Kilty","startTime":1297.5,"endTime":1300.44,"body":"then into an industrial postdoc"},{"speaker":"Iain Kilty","startTime":1297.5,"endTime":1300.44,"body":"after that."},{"speaker":"John Simboli","startTime":1302.27,"endTime":1304.31,"body":"If someone says,"},{"speaker":"John Simboli","startTime":1302.27,"endTime":1304.31,"body":"who is Sitryx therapeutics, how"},{"speaker":"John Simboli","startTime":1304.31,"endTime":1305.3,"body":"do you like to answer that?"},{"speaker":"Iain Kilty","startTime":1305.66,"endTime":1307.91,"body":"Yes, Sitryx"},{"speaker":"Iain Kilty","startTime":1305.66,"endTime":1307.91,"body":"therapeutics are an immunology"},{"speaker":"Iain Kilty","startTime":1307.91,"endTime":1311.78,"body":"focused company, but within"},{"speaker":"Iain Kilty","startTime":1307.91,"endTime":1311.78,"body":"immunology, we're exploiting"},{"speaker":"Iain Kilty","startTime":1311.81,"endTime":1316.04,"body":"immunometabolism to drive a"},{"speaker":"Iain Kilty","startTime":1311.81,"endTime":1316.04,"body":"greater anti inflammatory"},{"speaker":"Iain Kilty","startTime":1316.04,"endTime":1320.84,"body":"response in chronic, autoimmune"},{"speaker":"Iain Kilty","startTime":1316.04,"endTime":1320.84,"body":"and auto inflammatory diseases."},{"speaker":"Iain Kilty","startTime":1321.38,"endTime":1324.35,"body":"The real potential here is this"},{"speaker":"Iain Kilty","startTime":1321.38,"endTime":1324.35,"body":"fundamental thesis around"},{"speaker":"Iain Kilty","startTime":1324.38,"endTime":1327.86,"body":"immunometabolism, that by"},{"speaker":"Iain Kilty","startTime":1324.38,"endTime":1327.86,"body":"modulating metabolic pathways,"},{"speaker":"Iain Kilty","startTime":1327.86,"endTime":1331.58,"body":"we can reset the phenotype of"},{"speaker":"Iain Kilty","startTime":1327.86,"endTime":1331.58,"body":"inflammatory cells, so we're not"},{"speaker":"Iain Kilty","startTime":1331.58,"endTime":1334.79,"body":"blocking a single pathway or a"},{"speaker":"Iain Kilty","startTime":1331.58,"endTime":1334.79,"body":"single cytokine. We're moving"},{"speaker":"Iain Kilty","startTime":1334.79,"endTime":1337.82,"body":"the cell to more of a non"},{"speaker":"Iain Kilty","startTime":1334.79,"endTime":1337.82,"body":"inflammatory cell type, so"},{"speaker":"Iain Kilty","startTime":1337.82,"endTime":1340.61,"body":"that's not immunosuppressive. So"},{"speaker":"Iain Kilty","startTime":1337.82,"endTime":1340.61,"body":"that's quite different to"},{"speaker":"Iain Kilty","startTime":1340.85,"endTime":1344.33,"body":"current anti inflammatory"},{"speaker":"Iain Kilty","startTime":1340.85,"endTime":1344.33,"body":"therapies, and we think offers"},{"speaker":"Iain Kilty","startTime":1344.33,"endTime":1348.89,"body":"that potential to drive much"},{"speaker":"Iain Kilty","startTime":1344.33,"endTime":1348.89,"body":"greater efficacy for patients."},{"speaker":"Iain Kilty","startTime":1349.19,"endTime":1351.83,"body":"It's a company that was founded"},{"speaker":"Iain Kilty","startTime":1349.19,"endTime":1351.83,"body":"by a number of the leaders in"},{"speaker":"Iain Kilty","startTime":1351.83,"endTime":1355.28,"body":"the immuno metabolism space. One"},{"speaker":"Iain Kilty","startTime":1351.83,"endTime":1355.28,"body":"of our founders, Luke O'Neill,"},{"speaker":"Iain Kilty","startTime":1355.28,"endTime":1358.88,"body":"has really driven a lot of the"},{"speaker":"Iain Kilty","startTime":1355.28,"endTime":1358.88,"body":"literature. Jeff Rathmell, Mike"},{"speaker":"Iain Kilty","startTime":1358.88,"endTime":1362.9,"body":"Rosenblum, Jonathan Powell, all"},{"speaker":"Iain Kilty","startTime":1358.88,"endTime":1362.9,"body":"great scientists working in the"},{"speaker":"Iain Kilty","startTime":1362.9,"endTime":1365.72,"body":"field, and that's given us a"},{"speaker":"Iain Kilty","startTime":1362.9,"endTime":1365.72,"body":"great basis in scientific"},{"speaker":"Iain Kilty","startTime":1365.72,"endTime":1368.96,"body":"knowledge. And then what we've"},{"speaker":"Iain Kilty","startTime":1365.72,"endTime":1368.96,"body":"done is combine that with a team"},{"speaker":"Iain Kilty","startTime":1368.96,"endTime":1372.47,"body":"who've got both big pharma and"},{"speaker":"Iain Kilty","startTime":1368.96,"endTime":1372.47,"body":"biotech experience, certainly"},{"speaker":"Iain Kilty","startTime":1372.47,"endTime":1374.96,"body":"within the leadership team, so"},{"speaker":"Iain Kilty","startTime":1372.47,"endTime":1374.96,"body":"they know what good looks like,"},{"speaker":"Iain Kilty","startTime":1375.02,"endTime":1378.38,"body":"but they can also work nimbly to"},{"speaker":"Iain Kilty","startTime":1375.02,"endTime":1378.38,"body":"then be able to exploit that"},{"speaker":"Iain Kilty","startTime":1378.38,"endTime":1381.53,"body":"science and deliver novel"},{"speaker":"Iain Kilty","startTime":1378.38,"endTime":1381.53,"body":"therapies to the clinic."},{"speaker":"John Simboli","startTime":1382.64,"endTime":1384.44,"body":"Is there a way to"},{"speaker":"John Simboli","startTime":1382.64,"endTime":1384.44,"body":"talk about the mechanism of"},{"speaker":"John Simboli","startTime":1384.44,"endTime":1387.92,"body":"action for the lead candidate"},{"speaker":"John Simboli","startTime":1384.44,"endTime":1387.92,"body":"for the eczema candidate that"},{"speaker":"John Simboli","startTime":1387.92,"endTime":1389.0,"body":"you'd like to talk about?"},{"speaker":"Iain Kilty","startTime":1390.05,"endTime":1393.95,"body":"Yeah, so our LEAD"},{"speaker":"Iain Kilty","startTime":1390.05,"endTime":1393.95,"body":"program is a PKM2 activator"},{"speaker":"Iain Kilty","startTime":1393.95,"endTime":1397.46,"body":"program. So PKM2 is an enzyme"},{"speaker":"Iain Kilty","startTime":1393.95,"endTime":1397.46,"body":"that's involved in glycolysis."},{"speaker":"Iain Kilty","startTime":1397.58,"endTime":1401.45,"body":"It's been a well characterized"},{"speaker":"Iain Kilty","startTime":1397.58,"endTime":1401.45,"body":"enzyme for a number of years,"},{"speaker":"Iain Kilty","startTime":1401.72,"endTime":1404.69,"body":"but about a decade or so ago, it"},{"speaker":"Iain Kilty","startTime":1401.72,"endTime":1404.69,"body":"was shown that as well as this"},{"speaker":"Iain Kilty","startTime":1404.69,"endTime":1408.65,"body":"role in glycolysis, this enzyme"},{"speaker":"Iain Kilty","startTime":1404.69,"endTime":1408.65,"body":"has a moonlighting role"},{"speaker":"Iain Kilty","startTime":1408.68,"endTime":1413.24,"body":"regulating gene transcription"},{"speaker":"Iain Kilty","startTime":1408.68,"endTime":1413.24,"body":"within the nucleus of cells. And"},{"speaker":"Iain Kilty","startTime":1413.27,"endTime":1416.09,"body":"the way it regulates whether"},{"speaker":"Iain Kilty","startTime":1413.27,"endTime":1416.09,"body":"it's driving glycolysis or"},{"speaker":"Iain Kilty","startTime":1416.09,"endTime":1420.05,"body":"driving gene transcription is"},{"speaker":"Iain Kilty","startTime":1416.09,"endTime":1420.05,"body":"whether it exists as a dimer or"},{"speaker":"Iain Kilty","startTime":1420.05,"endTime":1422.87,"body":"a tetramer, so it says an"},{"speaker":"Iain Kilty","startTime":1420.05,"endTime":1422.87,"body":"equilibrium between the two in"},{"speaker":"Iain Kilty","startTime":1422.87,"endTime":1426.83,"body":"cells, and the dimer will drive"},{"speaker":"Iain Kilty","startTime":1422.87,"endTime":1426.83,"body":"the nuclear pro inflammatory"},{"speaker":"Iain Kilty","startTime":1426.83,"endTime":1431.12,"body":"gene transcription. The tetramer"},{"speaker":"Iain Kilty","startTime":1426.83,"endTime":1431.12,"body":"will drive glycolysis. So our"},{"speaker":"Iain Kilty","startTime":1431.12,"endTime":1435.2,"body":"small molecules induce formation"},{"speaker":"Iain Kilty","startTime":1431.12,"endTime":1435.2,"body":"of that tetramer, so skew you"},{"speaker":"Iain Kilty","startTime":1435.2,"endTime":1439.94,"body":"away from that nuclear activity"},{"speaker":"Iain Kilty","startTime":1435.2,"endTime":1439.94,"body":"and maintain that metabolic"},{"speaker":"Iain Kilty","startTime":1439.94,"endTime":1443.63,"body":"activity. And the net effect of"},{"speaker":"Iain Kilty","startTime":1439.94,"endTime":1443.63,"body":"that is you could, you reduce,"},{"speaker":"Iain Kilty","startTime":1443.66,"endTime":1447.44,"body":"particularly lymphocyte T and B,"},{"speaker":"Iain Kilty","startTime":1443.66,"endTime":1447.44,"body":"lymphocyte proliferation,"},{"speaker":"Iain Kilty","startTime":1447.62,"endTime":1450.11,"body":"cytokine production and antibody"},{"speaker":"Iain Kilty","startTime":1447.62,"endTime":1450.11,"body":"production."},{"speaker":"John Simboli","startTime":1451.31,"endTime":1454.82,"body":"How do you see the"},{"speaker":"John Simboli","startTime":1451.31,"endTime":1454.82,"body":"lead candidate in terms of your"},{"speaker":"John Simboli","startTime":1454.82,"endTime":1458.57,"body":"vision for the portfolio as a"},{"speaker":"John Simboli","startTime":1454.82,"endTime":1458.57,"body":"whole? Where does it fit in?"},{"speaker":"Iain Kilty","startTime":1459.35,"endTime":1461.93,"body":"So our lead"},{"speaker":"Iain Kilty","startTime":1459.35,"endTime":1461.93,"body":"candidate has helped us really"},{"speaker":"Iain Kilty","startTime":1461.93,"endTime":1465.38,"body":"build our understanding of how"},{"speaker":"Iain Kilty","startTime":1461.93,"endTime":1465.38,"body":"to prosecute immunometabolic"},{"speaker":"Iain Kilty","startTime":1465.38,"endTime":1468.41,"body":"targets. And one of the things I"},{"speaker":"Iain Kilty","startTime":1465.38,"endTime":1468.41,"body":"haven't really touched on yet,"},{"speaker":"Iain Kilty","startTime":1468.41,"endTime":1471.89,"body":"but is absolutely critical in"},{"speaker":"Iain Kilty","startTime":1468.41,"endTime":1471.89,"body":"prosecuting this target class,"},{"speaker":"Iain Kilty","startTime":1472.07,"endTime":1475.91,"body":"is looking at cells in the"},{"speaker":"Iain Kilty","startTime":1472.07,"endTime":1475.91,"body":"appropriate cellular context."},{"speaker":"Iain Kilty","startTime":1476.09,"endTime":1479.15,"body":"And what I mean by that is, if"},{"speaker":"Iain Kilty","startTime":1476.09,"endTime":1479.15,"body":"you're growing cells in media"},{"speaker":"Iain Kilty","startTime":1479.15,"endTime":1483.2,"body":"with lots of glucose, amino"},{"speaker":"Iain Kilty","startTime":1479.15,"endTime":1483.2,"body":"acids, oxygen and so on, that's"},{"speaker":"Iain Kilty","startTime":1483.2,"endTime":1485.57,"body":"designed to keep cells alive."},{"speaker":"Iain Kilty","startTime":1483.2,"endTime":1485.57,"body":"That's nothing like an"},{"speaker":"Iain Kilty","startTime":1485.57,"endTime":1487.91,"body":"inflammatory site where the"},{"speaker":"Iain Kilty","startTime":1485.57,"endTime":1487.91,"body":"cells are competing with each"},{"speaker":"Iain Kilty","startTime":1487.91,"endTime":1491.57,"body":"other for all of those things,"},{"speaker":"Iain Kilty","startTime":1487.91,"endTime":1491.57,"body":"amino acids, glucose, and it's"},{"speaker":"Iain Kilty","startTime":1491.57,"endTime":1495.62,"body":"often hypoxic and so on. So if"},{"speaker":"Iain Kilty","startTime":1491.57,"endTime":1495.62,"body":"you really want to reveal the"},{"speaker":"Iain Kilty","startTime":1495.62,"endTime":1499.91,"body":"pharmacology of modulating"},{"speaker":"Iain Kilty","startTime":1495.62,"endTime":1499.91,"body":"metabolic pathways, you need to"},{"speaker":"Iain Kilty","startTime":1500.06,"endTime":1504.92,"body":"modulate the environment the"},{"speaker":"Iain Kilty","startTime":1500.06,"endTime":1504.92,"body":"cell is in and build confidence"},{"speaker":"Iain Kilty","startTime":1504.92,"endTime":1508.4,"body":"that's relevant to the"},{"speaker":"Iain Kilty","startTime":1504.92,"endTime":1508.4,"body":"inflammatory state in disease to"},{"speaker":"Iain Kilty","startTime":1508.43,"endTime":1511.94,"body":"understand the pharmacology. Now"},{"speaker":"Iain Kilty","startTime":1508.43,"endTime":1511.94,"body":"our lead program is a great"},{"speaker":"Iain Kilty","startTime":1511.94,"endTime":1515.0,"body":"example of that where the"},{"speaker":"Iain Kilty","startTime":1511.94,"endTime":1515.0,"body":"pharmacology is only revealed"},{"speaker":"Iain Kilty","startTime":1515.0,"endTime":1518.51,"body":"under conditions where the cells"},{"speaker":"Iain Kilty","startTime":1515.0,"endTime":1518.51,"body":"have depleted extracellular"},{"speaker":"Iain Kilty","startTime":1518.51,"endTime":1522.08,"body":"serines, the amino acid serine,"},{"speaker":"Iain Kilty","startTime":1518.51,"endTime":1522.08,"body":"and then what happens is cells"},{"speaker":"Iain Kilty","startTime":1522.08,"endTime":1524.93,"body":"need to make their own serine."},{"speaker":"Iain Kilty","startTime":1522.08,"endTime":1524.93,"body":"Under those conditions, they up"},{"speaker":"Iain Kilty","startTime":1524.93,"endTime":1528.05,"body":"regulate this serine"},{"speaker":"Iain Kilty","startTime":1524.93,"endTime":1528.05,"body":"biosynthesis pathway. That's"},{"speaker":"Iain Kilty","startTime":1528.05,"endTime":1531.8,"body":"when you see the pharmacology of"},{"speaker":"Iain Kilty","startTime":1528.05,"endTime":1531.8,"body":"PKM2 activators in T lymphocytes"},{"speaker":"Iain Kilty","startTime":1531.8,"endTime":1535.76,"body":"and B lymphocytes. So there's a"},{"speaker":"Iain Kilty","startTime":1531.8,"endTime":1535.76,"body":"lot of reasons that's exciting,"},{"speaker":"Iain Kilty","startTime":1535.76,"endTime":1538.97,"body":"because that means you've got a"},{"speaker":"Iain Kilty","startTime":1535.76,"endTime":1538.97,"body":"very laser targeted approach to"},{"speaker":"Iain Kilty","startTime":1538.97,"endTime":1542.39,"body":"it sites where serine is being"},{"speaker":"Iain Kilty","startTime":1538.97,"endTime":1542.39,"body":"used up, not just in the blood,"},{"speaker":"Iain Kilty","startTime":1542.39,"endTime":1544.76,"body":"where you'll have high levels of"},{"speaker":"Iain Kilty","startTime":1542.39,"endTime":1544.76,"body":"serine, but at those"},{"speaker":"Iain Kilty","startTime":1544.76,"endTime":1548.27,"body":"inflammatory sites where you're"},{"speaker":"Iain Kilty","startTime":1544.76,"endTime":1548.27,"body":"getting competition. But it also"},{"speaker":"Iain Kilty","startTime":1548.27,"endTime":1552.23,"body":"provides, if you'd like, an"},{"speaker":"Iain Kilty","startTime":1548.27,"endTime":1552.23,"body":"initial way to think about any"},{"speaker":"Iain Kilty","startTime":1552.23,"endTime":1555.62,"body":"new target that we bring in. So"},{"speaker":"Iain Kilty","startTime":1552.23,"endTime":1555.62,"body":"not every target is going to be"},{"speaker":"Iain Kilty","startTime":1555.62,"endTime":1558.11,"body":"dependent on serine. Other"},{"speaker":"Iain Kilty","startTime":1555.62,"endTime":1558.11,"body":"targets are going to be"},{"speaker":"Iain Kilty","startTime":1558.11,"endTime":1560.57,"body":"dependent on other mediators,"},{"speaker":"Iain Kilty","startTime":1558.11,"endTime":1560.57,"body":"and they may be relevant to"},{"speaker":"Iain Kilty","startTime":1560.57,"endTime":1563.78,"body":"different situations. So those"},{"speaker":"Iain Kilty","startTime":1560.57,"endTime":1563.78,"body":"sort of insights have been"},{"speaker":"Iain Kilty","startTime":1563.78,"endTime":1567.62,"body":"important in how we've then"},{"speaker":"Iain Kilty","startTime":1563.78,"endTime":1567.62,"body":"prosecuted the future portfolio"},{"speaker":"Iain Kilty","startTime":1567.62,"endTime":1572.27,"body":"beyond PKM2. But I say we're"},{"speaker":"Iain Kilty","startTime":1567.62,"endTime":1572.27,"body":"very excited about PKM2. There's"},{"speaker":"Iain Kilty","startTime":1572.27,"endTime":1576.02,"body":"clear medical need in eczema,"},{"speaker":"Iain Kilty","startTime":1572.27,"endTime":1576.02,"body":"and a small molecule, once or"},{"speaker":"Iain Kilty","startTime":1576.02,"endTime":1579.47,"body":"twice a day pill that could"},{"speaker":"Iain Kilty","startTime":1576.02,"endTime":1579.47,"body":"really drive efficacy for those"},{"speaker":"Iain Kilty","startTime":1579.47,"endTime":1583.31,"body":"patients in a safe manner would"},{"speaker":"Iain Kilty","startTime":1579.47,"endTime":1583.31,"body":"be hugely beneficial."},{"speaker":"John Simboli","startTime":1583.94,"endTime":1587.99,"body":"Sometimes, when I"},{"speaker":"John Simboli","startTime":1583.94,"endTime":1587.99,"body":"talk with folks on BioBoss, I"},{"speaker":"John Simboli","startTime":1588.2,"endTime":1591.14,"body":"find the discussion is largely"},{"speaker":"John Simboli","startTime":1588.2,"endTime":1591.14,"body":"around the scientific puzzle,"},{"speaker":"John Simboli","startTime":1591.29,"endTime":1594.29,"body":"how do I unravel this? How do I"},{"speaker":"John Simboli","startTime":1591.29,"endTime":1594.29,"body":"make sense of this? How does our"},{"speaker":"John Simboli","startTime":1594.29,"endTime":1597.86,"body":"company move this forward? And"},{"speaker":"John Simboli","startTime":1594.29,"endTime":1597.86,"body":"then other times, the discussion"},{"speaker":"John Simboli","startTime":1597.98,"endTime":1602.27,"body":"will also include, if this works"},{"speaker":"John Simboli","startTime":1597.98,"endTime":1602.27,"body":"the way I think it will I can't"},{"speaker":"John Simboli","startTime":1602.27,"endTime":1604.82,"body":"wait, because I can see how this"},{"speaker":"John Simboli","startTime":1602.27,"endTime":1604.82,"body":"could have an effect on"},{"speaker":"John Simboli","startTime":1604.82,"endTime":1607.13,"body":"patients. And of course, the two"},{"speaker":"John Simboli","startTime":1604.82,"endTime":1607.13,"body":"are intertwined. You couldn't do"},{"speaker":"John Simboli","startTime":1607.13,"endTime":1610.94,"body":"one without the other. But"},{"speaker":"John Simboli","startTime":1607.13,"endTime":1610.94,"body":"there's like a shifting thing"},{"speaker":"John Simboli","startTime":1610.94,"endTime":1614.36,"body":"that happens over time in my"},{"speaker":"John Simboli","startTime":1610.94,"endTime":1614.36,"body":"experience. So where are you on"},{"speaker":"John Simboli","startTime":1614.36,"endTime":1618.89,"body":"that process? Are you, are you"},{"speaker":"John Simboli","startTime":1614.36,"endTime":1618.89,"body":"focused primarily on"},{"speaker":"John Simboli","startTime":1618.89,"endTime":1622.97,"body":"understanding how this all may"},{"speaker":"John Simboli","startTime":1618.89,"endTime":1622.97,"body":"work. Do you also allow yourself"},{"speaker":"John Simboli","startTime":1622.97,"endTime":1625.67,"body":"to think about, jeez if this"},{"speaker":"John Simboli","startTime":1622.97,"endTime":1625.67,"body":"works this is going to really do"},{"speaker":"John Simboli","startTime":1625.67,"endTime":1626.99,"body":"some good for some people."},{"speaker":"Iain Kilty","startTime":1627.62,"endTime":1629.75,"body":"Yeah, absolutely"},{"speaker":"Iain Kilty","startTime":1627.62,"endTime":1629.75,"body":"allow myself to think the"},{"speaker":"Iain Kilty","startTime":1629.75,"endTime":1631.91,"body":"latter. I think that's the thing"},{"speaker":"Iain Kilty","startTime":1629.75,"endTime":1631.91,"body":"that makes you jump out of bed"},{"speaker":"Iain Kilty","startTime":1631.91,"endTime":1634.64,"body":"in the morning. So if I didn't"},{"speaker":"Iain Kilty","startTime":1631.91,"endTime":1634.64,"body":"believe it had that potential, I"},{"speaker":"Iain Kilty","startTime":1634.64,"endTime":1639.68,"body":"wouldn't be as excited about it."},{"speaker":"Iain Kilty","startTime":1634.64,"endTime":1639.68,"body":"I think the potential here is"},{"speaker":"Iain Kilty","startTime":1639.68,"endTime":1644.3,"body":"that we can really drive a shift"},{"speaker":"Iain Kilty","startTime":1639.68,"endTime":1644.3,"body":"in immune cell phenotype from"},{"speaker":"Iain Kilty","startTime":1644.51,"endTime":1649.01,"body":"driving inflammation to more of"},{"speaker":"Iain Kilty","startTime":1644.51,"endTime":1649.01,"body":"a homeostatic or non"},{"speaker":"Iain Kilty","startTime":1649.01,"endTime":1652.31,"body":"inflammatory regulatory"},{"speaker":"Iain Kilty","startTime":1649.01,"endTime":1652.31,"body":"phenotype, and that has the"},{"speaker":"Iain Kilty","startTime":1652.31,"endTime":1655.58,"body":"potential to drive sustained"},{"speaker":"Iain Kilty","startTime":1652.31,"endTime":1655.58,"body":"remission for patients which"},{"speaker":"Iain Kilty","startTime":1655.58,"endTime":1659.9,"body":"which would be huge. Our lead"},{"speaker":"Iain Kilty","startTime":1655.58,"endTime":1659.9,"body":"program is focused on eczema,"},{"speaker":"Iain Kilty","startTime":1659.9,"endTime":1662.24,"body":"although we do think this asset"},{"speaker":"Iain Kilty","startTime":1659.9,"endTime":1662.24,"body":"could have value across"},{"speaker":"Iain Kilty","startTime":1662.27,"endTime":1666.02,"body":"additional indications, and"},{"speaker":"Iain Kilty","startTime":1662.27,"endTime":1666.02,"body":"there's clear medical need there"},{"speaker":"Iain Kilty","startTime":1666.02,"endTime":1668.33,"body":"that there's a real breakthrough"},{"speaker":"Iain Kilty","startTime":1666.02,"endTime":1668.33,"body":"a number of years ago when"},{"speaker":"Iain Kilty","startTime":1668.33,"endTime":1671.72,"body":"dupilumab dupixent was approved."},{"speaker":"Iain Kilty","startTime":1668.33,"endTime":1671.72,"body":"It's a biologic that modulates"},{"speaker":"Iain Kilty","startTime":1671.75,"endTime":1676.22,"body":"L413. But that that drug, about"},{"speaker":"Iain Kilty","startTime":1671.75,"endTime":1676.22,"body":"50% of the patients get a 75%"},{"speaker":"Iain Kilty","startTime":1676.22,"endTime":1679.58,"body":"improvement. So that's similar"},{"speaker":"Iain Kilty","startTime":1676.22,"endTime":1679.58,"body":"to an anti TNF in psoriasis. So"},{"speaker":"Iain Kilty","startTime":1679.61,"endTime":1683.0,"body":"significant, makes a huge"},{"speaker":"Iain Kilty","startTime":1679.61,"endTime":1683.0,"body":"difference to patients, but"},{"speaker":"Iain Kilty","startTime":1683.0,"endTime":1685.85,"body":"there's a lot of medical need"},{"speaker":"Iain Kilty","startTime":1683.0,"endTime":1685.85,"body":"remaining, and the next wave of"},{"speaker":"Iain Kilty","startTime":1685.85,"endTime":1688.28,"body":"compounds were Jak inhibitors. I"},{"speaker":"Iain Kilty","startTime":1685.85,"endTime":1688.28,"body":"worked on some of those when I"},{"speaker":"Iain Kilty","startTime":1688.28,"endTime":1690.65,"body":"was at Pfizer. One of those is"},{"speaker":"Iain Kilty","startTime":1688.28,"endTime":1690.65,"body":"now an approved drug, which is"},{"speaker":"Iain Kilty","startTime":1690.65,"endTime":1693.26,"body":"great, and they do give slightly"},{"speaker":"Iain Kilty","startTime":1690.65,"endTime":1693.26,"body":"more efficacy because they"},{"speaker":"Iain Kilty","startTime":1693.26,"endTime":1696.65,"body":"integrate more pathways than"},{"speaker":"Iain Kilty","startTime":1693.26,"endTime":1696.65,"body":"that 413 pathway But there are"},{"speaker":"Iain Kilty","startTime":1696.65,"endTime":1699.98,"body":"some limitations around the"},{"speaker":"Iain Kilty","startTime":1696.65,"endTime":1699.98,"body":"label and the safety of those"},{"speaker":"Iain Kilty","startTime":1699.98,"endTime":1704.36,"body":"assets. So if we could achieve"},{"speaker":"Iain Kilty","startTime":1699.98,"endTime":1704.36,"body":"efficacy similar or better, but"},{"speaker":"Iain Kilty","startTime":1704.36,"endTime":1708.02,"body":"with a much safer therapy, that"},{"speaker":"Iain Kilty","startTime":1704.36,"endTime":1708.02,"body":"for patients would be have a"},{"speaker":"Iain Kilty","startTime":1708.02,"endTime":1710.84,"body":"huge impact, and that's what"},{"speaker":"Iain Kilty","startTime":1708.02,"endTime":1710.84,"body":"makes me jump out of bed in the"},{"speaker":"Iain Kilty","startTime":1710.84,"endTime":1713.54,"body":"morning. I think we have some"},{"speaker":"Iain Kilty","startTime":1710.84,"endTime":1713.54,"body":"really nice data to say that"},{"speaker":"Iain Kilty","startTime":1713.54,"endTime":1715.64,"body":"that may well happen, but we've"},{"speaker":"Iain Kilty","startTime":1713.54,"endTime":1715.64,"body":"got to generate the clinical"},{"speaker":"Iain Kilty","startTime":1715.64,"endTime":1719.42,"body":"data to say, is that true? But I"},{"speaker":"Iain Kilty","startTime":1715.64,"endTime":1719.42,"body":"truly think that that is"},{"speaker":"Iain Kilty","startTime":1719.42,"endTime":1720.23,"body":"exciting."},{"speaker":"John Simboli","startTime":1720.44,"endTime":1723.77,"body":"Do you see that as"},{"speaker":"John Simboli","startTime":1720.44,"endTime":1723.77,"body":"a potentially incremental change"},{"speaker":"John Simboli","startTime":1723.77,"endTime":1726.26,"body":"for patients? As something"},{"speaker":"John Simboli","startTime":1723.77,"endTime":1726.26,"body":"greater than that? It's going to"},{"speaker":"John Simboli","startTime":1726.26,"endTime":1727.85,"body":"vary from patient to patient,"},{"speaker":"John Simboli","startTime":1726.26,"endTime":1727.85,"body":"but."},{"speaker":"Iain Kilty","startTime":1729.77,"endTime":1732.53,"body":"I think it has the"},{"speaker":"Iain Kilty","startTime":1729.77,"endTime":1732.53,"body":"potential to be greater than"},{"speaker":"Iain Kilty","startTime":1732.53,"endTime":1734.78,"body":"that. I think it will vary from"},{"speaker":"Iain Kilty","startTime":1732.53,"endTime":1734.78,"body":"patient to patient, which is"},{"speaker":"Iain Kilty","startTime":1734.78,"endTime":1737.27,"body":"nearly always the case. Always"},{"speaker":"Iain Kilty","startTime":1734.78,"endTime":1737.27,"body":"gets some really good responders"},{"speaker":"Iain Kilty","startTime":1737.27,"endTime":1739.64,"body":"and some people who are not"},{"speaker":"Iain Kilty","startTime":1737.27,"endTime":1739.64,"body":"responding as well to the"},{"speaker":"Iain Kilty","startTime":1739.64,"endTime":1742.82,"body":"therapy. But just because of"},{"speaker":"Iain Kilty","startTime":1739.64,"endTime":1742.82,"body":"heterogeneity within the"},{"speaker":"Iain Kilty","startTime":1742.82,"endTime":1746.27,"body":"disease, but also, there's a"},{"speaker":"Iain Kilty","startTime":1742.82,"endTime":1746.27,"body":"huge element of convenience here"},{"speaker":"Iain Kilty","startTime":1746.27,"endTime":1750.41,"body":"for patients to be able to take"},{"speaker":"Iain Kilty","startTime":1746.27,"endTime":1750.41,"body":"a pill on a day to day basis, as"},{"speaker":"Iain Kilty","startTime":1750.41,"endTime":1753.53,"body":"opposed to a two weekly"},{"speaker":"Iain Kilty","startTime":1750.41,"endTime":1753.53,"body":"injection. I think for a lot of"},{"speaker":"Iain Kilty","startTime":1753.53,"endTime":1756.68,"body":"patients it'll increase access"},{"speaker":"Iain Kilty","startTime":1753.53,"endTime":1756.68,"body":"as well. More patients will"},{"speaker":"Iain Kilty","startTime":1756.68,"endTime":1759.95,"body":"actually be able to get hold of"},{"speaker":"Iain Kilty","startTime":1756.68,"endTime":1759.95,"body":"that drug, I would hope, and"},{"speaker":"Iain Kilty","startTime":1759.98,"endTime":1761.45,"body":"therefore get that benefit."},{"speaker":"John Simboli","startTime":1761.99,"endTime":1764.66,"body":"When you tell the"},{"speaker":"John Simboli","startTime":1761.99,"endTime":1764.66,"body":"story about Sitryx and people"},{"speaker":"John Simboli","startTime":1765.29,"endTime":1768.38,"body":"get it wrong, do you ever see a"},{"speaker":"John Simboli","startTime":1765.29,"endTime":1768.38,"body":"pattern about why they're"},{"speaker":"John Simboli","startTime":1768.38,"endTime":1770.12,"body":"getting it wrong, even though"},{"speaker":"John Simboli","startTime":1768.38,"endTime":1770.12,"body":"you said it a different way,"},{"speaker":"John Simboli","startTime":1770.12,"endTime":1771.86,"body":"they heard it a different way,"},{"speaker":"John Simboli","startTime":1770.12,"endTime":1771.86,"body":"and then you can help them to"},{"speaker":"John Simboli","startTime":1771.86,"endTime":1775.01,"body":"get back on track. Another way"},{"speaker":"John Simboli","startTime":1771.86,"endTime":1775.01,"body":"of saying this, how might people"},{"speaker":"John Simboli","startTime":1775.01,"endTime":1777.5,"body":"misperceive what Sitryx is"},{"speaker":"John Simboli","startTime":1775.01,"endTime":1777.5,"body":"about?"},{"speaker":"Iain Kilty","startTime":1779.06,"endTime":1783.59,"body":"Yeah. So I think the"},{"speaker":"Iain Kilty","startTime":1779.06,"endTime":1783.59,"body":"biggest misperception we see is"},{"speaker":"Iain Kilty","startTime":1783.65,"endTime":1787.25,"body":"actually more on the safety side"},{"speaker":"Iain Kilty","startTime":1783.65,"endTime":1787.25,"body":"of things, if you're interfering"},{"speaker":"Iain Kilty","startTime":1787.25,"endTime":1790.58,"body":"with metabolism. So getting"},{"speaker":"Iain Kilty","startTime":1787.25,"endTime":1790.58,"body":"people comfortable that we're"},{"speaker":"Iain Kilty","startTime":1790.58,"endTime":1795.17,"body":"not interfering with fundamental"},{"speaker":"Iain Kilty","startTime":1790.58,"endTime":1795.17,"body":"electron transport, chain type"},{"speaker":"Iain Kilty","startTime":1795.17,"endTime":1799.1,"body":"metabolism. What we're focusing"},{"speaker":"Iain Kilty","startTime":1795.17,"endTime":1799.1,"body":"on are those metabolic changes"},{"speaker":"Iain Kilty","startTime":1799.1,"endTime":1802.61,"body":"we're seeing at inflammatory"},{"speaker":"Iain Kilty","startTime":1799.1,"endTime":1802.61,"body":"sites, those cysts, those"},{"speaker":"Iain Kilty","startTime":1802.64,"endTime":1807.11,"body":"pathways which upregulated to"},{"speaker":"Iain Kilty","startTime":1802.64,"endTime":1807.11,"body":"make a TH17 cell more active or"},{"speaker":"Iain Kilty","startTime":1807.47,"endTime":1812.0,"body":"or a macrophage produce more"},{"speaker":"Iain Kilty","startTime":1807.47,"endTime":1812.0,"body":"cytokines and so on, and to"},{"speaker":"Iain Kilty","startTime":1812.0,"endTime":1815.3,"body":"really helping people to"},{"speaker":"Iain Kilty","startTime":1812.0,"endTime":1815.3,"body":"understand that by targeting"},{"speaker":"Iain Kilty","startTime":1815.3,"endTime":1818.99,"body":"specific enzymes which"},{"speaker":"Iain Kilty","startTime":1815.3,"endTime":1818.99,"body":"upregulated at those sites, but"},{"speaker":"Iain Kilty","startTime":1819.02,"endTime":1822.35,"body":"also the importance of cellular"},{"speaker":"Iain Kilty","startTime":1819.02,"endTime":1822.35,"body":"context that we talked about"},{"speaker":"Iain Kilty","startTime":1822.38,"endTime":1826.52,"body":"earlier will drive a very"},{"speaker":"Iain Kilty","startTime":1822.38,"endTime":1826.52,"body":"focused pharmacological effect."},{"speaker":"Iain Kilty","startTime":1826.52,"endTime":1829.43,"body":"So it's not a broad effect that"},{"speaker":"Iain Kilty","startTime":1826.52,"endTime":1829.43,"body":"you'll see across all tissues,"},{"speaker":"Iain Kilty","startTime":1829.7,"endTime":1834.62,"body":"and that tends to be a place"},{"speaker":"Iain Kilty","startTime":1829.7,"endTime":1834.62,"body":"where people can, yeah, they"},{"speaker":"Iain Kilty","startTime":1834.62,"endTime":1837.71,"body":"come in, possibly with a bias"},{"speaker":"Iain Kilty","startTime":1834.62,"endTime":1837.71,"body":"that I can't see how you could"},{"speaker":"Iain Kilty","startTime":1837.71,"endTime":1842.96,"body":"do this in a safe manner. Now,"},{"speaker":"Iain Kilty","startTime":1837.71,"endTime":1842.96,"body":"the nice thing we can do now is"},{"speaker":"Iain Kilty","startTime":1842.96,"endTime":1847.91,"body":"that we have a program that Lily"},{"speaker":"Iain Kilty","startTime":1842.96,"endTime":1847.91,"body":"opted into at IND last year. So"},{"speaker":"Iain Kilty","startTime":1847.91,"endTime":1851.48,"body":"we show that we can generate"},{"speaker":"Iain Kilty","startTime":1847.91,"endTime":1851.48,"body":"good margins through GLP talks,"},{"speaker":"Iain Kilty","startTime":1851.48,"endTime":1854.51,"body":"which gives you some confidence"},{"speaker":"Iain Kilty","startTime":1851.48,"endTime":1854.51,"body":"that this isn't a type of"},{"speaker":"Iain Kilty","startTime":1854.51,"endTime":1858.02,"body":"approach which can never be"},{"speaker":"Iain Kilty","startTime":1854.51,"endTime":1858.02,"body":"safe. And now our lead program"},{"speaker":"Iain Kilty","startTime":1858.02,"endTime":1861.38,"body":"is at a similar stage within"},{"speaker":"Iain Kilty","startTime":1858.02,"endTime":1861.38,"body":"Sitryx, our wholly owned"},{"speaker":"Iain Kilty","startTime":1861.38,"endTime":1864.53,"body":"program, as well, where, again,"},{"speaker":"Iain Kilty","startTime":1861.38,"endTime":1864.53,"body":"we've shown good margins through"},{"speaker":"Iain Kilty","startTime":1864.53,"endTime":1868.61,"body":"GLP talk studies. Which so I"},{"speaker":"Iain Kilty","startTime":1864.53,"endTime":1868.61,"body":"think as we build that data set,"},{"speaker":"Iain Kilty","startTime":1868.61,"endTime":1870.86,"body":"people will get more comfortable"},{"speaker":"Iain Kilty","startTime":1868.61,"endTime":1870.86,"body":"with that. But conceptually,"},{"speaker":"Iain Kilty","startTime":1870.86,"endTime":1872.21,"body":"that can be a challenge early"},{"speaker":"Iain Kilty","startTime":1870.86,"endTime":1872.21,"body":"on."},{"speaker":"John Simboli","startTime":1872.99,"endTime":1875.87,"body":"For the people who"},{"speaker":"John Simboli","startTime":1872.99,"endTime":1875.87,"body":"like the devil's advocate"},{"speaker":"John Simboli","startTime":1875.87,"endTime":1879.23,"body":"approach, sometimes the question"},{"speaker":"John Simboli","startTime":1875.87,"endTime":1879.23,"body":"for the CEO becomes, well,"},{"speaker":"John Simboli","startTime":1879.23,"endTime":1881.42,"body":"that's a great idea, but if it's"},{"speaker":"John Simboli","startTime":1879.23,"endTime":1881.42,"body":"such a great idea, how come"},{"speaker":"John Simboli","startTime":1881.42,"endTime":1884.51,"body":"nobody else did it? So I'm sure"},{"speaker":"John Simboli","startTime":1881.42,"endTime":1884.51,"body":"you get variations on that from"},{"speaker":"John Simboli","startTime":1884.51,"endTime":1886.79,"body":"time to time. What's the best"},{"speaker":"John Simboli","startTime":1884.51,"endTime":1886.79,"body":"answer for that?"},{"speaker":"Iain Kilty","startTime":1887.35,"endTime":1889.18,"body":"Well, I think the"},{"speaker":"Iain Kilty","startTime":1887.35,"endTime":1889.18,"body":"science is evolving all of the"},{"speaker":"Iain Kilty","startTime":1889.18,"endTime":1892.66,"body":"time, and people actually have"},{"speaker":"Iain Kilty","startTime":1889.18,"endTime":1892.66,"body":"focused on immuno metabolism in"},{"speaker":"Iain Kilty","startTime":1892.66,"endTime":1895.63,"body":"cancer in the past, which"},{"speaker":"Iain Kilty","startTime":1892.66,"endTime":1895.63,"body":"actually has been a good source"},{"speaker":"Iain Kilty","startTime":1895.63,"endTime":1898.57,"body":"of targets and certainly tool"},{"speaker":"Iain Kilty","startTime":1895.63,"endTime":1898.57,"body":"compounds for us to validate"},{"speaker":"Iain Kilty","startTime":1898.57,"endTime":1901.72,"body":"mechanisms and pathways, and it"},{"speaker":"Iain Kilty","startTime":1898.57,"endTime":1901.72,"body":"hasn't necessarily been the most"},{"speaker":"Iain Kilty","startTime":1901.72,"endTime":1904.09,"body":"efficacious therapy in cancer,"},{"speaker":"Iain Kilty","startTime":1901.72,"endTime":1904.09,"body":"but you're trying to do"},{"speaker":"Iain Kilty","startTime":1904.09,"endTime":1906.28,"body":"something very different in"},{"speaker":"Iain Kilty","startTime":1904.09,"endTime":1906.28,"body":"cancer. In cancer, you're trying"},{"speaker":"Iain Kilty","startTime":1906.28,"endTime":1909.64,"body":"to block a pathway to kill a"},{"speaker":"Iain Kilty","startTime":1906.28,"endTime":1909.64,"body":"cell. What we're doing is"},{"speaker":"Iain Kilty","startTime":1909.64,"endTime":1913.21,"body":"blocking a pathway to drive"},{"speaker":"Iain Kilty","startTime":1909.64,"endTime":1913.21,"body":"rewiring of the pathway to"},{"speaker":"Iain Kilty","startTime":1913.21,"endTime":1916.09,"body":"different metabolic pathways"},{"speaker":"Iain Kilty","startTime":1913.21,"endTime":1916.09,"body":"within the cell and changing the"},{"speaker":"Iain Kilty","startTime":1916.09,"endTime":1919.06,"body":"phenotype of the cell. And"},{"speaker":"Iain Kilty","startTime":1916.09,"endTime":1919.06,"body":"that's actually what was seen in"},{"speaker":"Iain Kilty","startTime":1919.06,"endTime":1921.67,"body":"some of some of the oncology"},{"speaker":"Iain Kilty","startTime":1919.06,"endTime":1921.67,"body":"studies. So we've learned from"},{"speaker":"Iain Kilty","startTime":1921.67,"endTime":1925.12,"body":"the oncology studies, and then"},{"speaker":"Iain Kilty","startTime":1921.67,"endTime":1925.12,"body":"applied that to immunology. So I"},{"speaker":"Iain Kilty","startTime":1925.12,"endTime":1928.33,"body":"think it's actually reflective"},{"speaker":"Iain Kilty","startTime":1925.12,"endTime":1928.33,"body":"of the evolving science, and"},{"speaker":"Iain Kilty","startTime":1928.33,"endTime":1931.54,"body":"that we're part of the first"},{"speaker":"Iain Kilty","startTime":1928.33,"endTime":1931.54,"body":"wave there. And then I'd go back"},{"speaker":"Iain Kilty","startTime":1931.54,"endTime":1934.48,"body":"to again, that we just have"},{"speaker":"Iain Kilty","startTime":1931.54,"endTime":1934.48,"body":"great founders who are a number"},{"speaker":"Iain Kilty","startTime":1934.48,"endTime":1936.91,"body":"of the leaders in the field that"},{"speaker":"Iain Kilty","startTime":1934.48,"endTime":1936.91,"body":"have helped us move at speed."},{"speaker":"Iain Kilty","startTime":1937.21,"endTime":1940.51,"body":"And we continue to work really"},{"speaker":"Iain Kilty","startTime":1937.21,"endTime":1940.51,"body":"closely with particularly Luke"},{"speaker":"Iain Kilty","startTime":1940.51,"endTime":1943.42,"body":"O'Neill and Mike Rosenblum for"},{"speaker":"Iain Kilty","startTime":1940.51,"endTime":1943.42,"body":"completely different things,"},{"speaker":"Iain Kilty","startTime":1943.42,"endTime":1947.23,"body":"actually, but work closely with"},{"speaker":"Iain Kilty","startTime":1943.42,"endTime":1947.23,"body":"those guys as we drive forward"},{"speaker":"Iain Kilty","startTime":1947.23,"endTime":1948.16,"body":"our portfolio."},{"speaker":"John Simboli","startTime":1949.09,"endTime":1951.55,"body":"Who makes a good"},{"speaker":"John Simboli","startTime":1949.09,"endTime":1951.55,"body":"partner to Sitryx therapeutics?"},{"speaker":"Iain Kilty","startTime":1952.24,"endTime":1954.07,"body":"We're really lucky,"},{"speaker":"Iain Kilty","startTime":1952.24,"endTime":1954.07,"body":"actually. We have some fantastic"},{"speaker":"Iain Kilty","startTime":1954.07,"endTime":1957.34,"body":"partners at different levels. So"},{"speaker":"Iain Kilty","startTime":1954.07,"endTime":1957.34,"body":"going to some of our founders,"},{"speaker":"Iain Kilty","startTime":1957.34,"endTime":1960.43,"body":"academic partners, I've"},{"speaker":"Iain Kilty","startTime":1957.34,"endTime":1960.43,"body":"mentioned Professor Luke O'Neill"},{"speaker":"Iain Kilty","startTime":1960.43,"endTime":1963.31,"body":"a couple of times from Trinity"},{"speaker":"Iain Kilty","startTime":1960.43,"endTime":1963.31,"body":"College, we have a postdoc in"},{"speaker":"Iain Kilty","startTime":1963.31,"endTime":1966.97,"body":"his lab, but we have joint lab"},{"speaker":"Iain Kilty","startTime":1963.31,"endTime":1966.97,"body":"meetings with with Luke, and a"},{"speaker":"Iain Kilty","startTime":1966.97,"endTime":1969.7,"body":"really open dialog. And I think"},{"speaker":"Iain Kilty","startTime":1966.97,"endTime":1969.7,"body":"that really helps us, because"},{"speaker":"Iain Kilty","startTime":1969.7,"endTime":1972.85,"body":"that keeps us at the cutting"},{"speaker":"Iain Kilty","startTime":1969.7,"endTime":1972.85,"body":"edge of the academic science in"},{"speaker":"Iain Kilty","startTime":1972.85,"endTime":1976.84,"body":"this space, and also helps, from"},{"speaker":"Iain Kilty","startTime":1972.85,"endTime":1976.84,"body":"his side, he learns more about"},{"speaker":"Iain Kilty","startTime":1976.84,"endTime":1978.94,"body":"the pharmacology, and we're"},{"speaker":"Iain Kilty","startTime":1976.84,"endTime":1978.94,"body":"getting great tools, which he"},{"speaker":"Iain Kilty","startTime":1978.94,"endTime":1982.99,"body":"can then use in his science. So"},{"speaker":"Iain Kilty","startTime":1978.94,"endTime":1982.99,"body":"there's joint benefit there. But"},{"speaker":"Iain Kilty","startTime":1982.99,"endTime":1986.26,"body":"the other really good"},{"speaker":"Iain Kilty","startTime":1982.99,"endTime":1986.26,"body":"partnership we have is with Eli"},{"speaker":"Iain Kilty","startTime":1986.26,"endTime":1989.2,"body":"Lilly. So we signed that deal,"},{"speaker":"Iain Kilty","startTime":1986.26,"endTime":1989.2,"body":"actually just before I joined"},{"speaker":"Iain Kilty","startTime":1989.23,"endTime":1993.37,"body":"Sitryx, and they've worked with"},{"speaker":"Iain Kilty","startTime":1989.23,"endTime":1993.37,"body":"us on a number of programs. They"},{"speaker":"Iain Kilty","startTime":1993.4,"endTime":1996.88,"body":"opted into one of our programs"},{"speaker":"Iain Kilty","startTime":1993.4,"endTime":1996.88,"body":"last year that was IMD, which"},{"speaker":"Iain Kilty","startTime":1996.88,"endTime":2000.66,"body":"they now fully run, and it's in"},{"speaker":"Iain Kilty","startTime":1996.88,"endTime":2000.66,"body":"phase one development. And we"},{"speaker":"Iain Kilty","startTime":2000.66,"endTime":2003.12,"body":"have a second program we're"},{"speaker":"Iain Kilty","startTime":2000.66,"endTime":2003.12,"body":"working on with those guys. And"},{"speaker":"Iain Kilty","startTime":2003.12,"endTime":2005.94,"body":"the way that works so well,"},{"speaker":"Iain Kilty","startTime":2003.12,"endTime":2005.94,"body":"actually, is that we just,"},{"speaker":"Iain Kilty","startTime":2005.94,"endTime":2008.58,"body":"again, we have joint project"},{"speaker":"Iain Kilty","startTime":2005.94,"endTime":2008.58,"body":"teams. It's really open between"},{"speaker":"Iain Kilty","startTime":2008.58,"endTime":2013.29,"body":"the two companies, and we bring"},{"speaker":"Iain Kilty","startTime":2008.58,"endTime":2013.29,"body":"different skills to the table."},{"speaker":"Iain Kilty","startTime":2013.29,"endTime":2017.13,"body":"So we own the strategy at"},{"speaker":"Iain Kilty","startTime":2013.29,"endTime":2017.13,"body":"Sitryx, but it's hugely helpful"},{"speaker":"Iain Kilty","startTime":2017.13,"endTime":2020.34,"body":"to be able to pull on the"},{"speaker":"Iain Kilty","startTime":2017.13,"endTime":2020.34,"body":"knowledge of the Lilly team and"},{"speaker":"Iain Kilty","startTime":2020.37,"endTime":2022.98,"body":"ensure that we're fully aligned"},{"speaker":"Iain Kilty","startTime":2020.37,"endTime":2022.98,"body":"as we're moving things forward."},{"speaker":"Iain Kilty","startTime":2022.98,"endTime":2025.08,"body":"The last thing we want to do is"},{"speaker":"Iain Kilty","startTime":2022.98,"endTime":2025.08,"body":"provide a package that doesn't"},{"speaker":"Iain Kilty","startTime":2025.08,"endTime":2027.81,"body":"align with their needs. And"},{"speaker":"Iain Kilty","startTime":2025.08,"endTime":2027.81,"body":"they're very good as well."},{"speaker":"Iain Kilty","startTime":2027.81,"endTime":2030.45,"body":"They're not, certainly not"},{"speaker":"Iain Kilty","startTime":2027.81,"endTime":2030.45,"body":"obliged to, but they do help"},{"speaker":"Iain Kilty","startTime":2030.45,"endTime":2033.66,"body":"generate various data from"},{"speaker":"Iain Kilty","startTime":2030.45,"endTime":2033.66,"body":"databases they can access that"},{"speaker":"Iain Kilty","startTime":2033.66,"endTime":2036.15,"body":"we can't, that help us move"},{"speaker":"Iain Kilty","startTime":2033.66,"endTime":2036.15,"body":"forward more efficiently. So I"},{"speaker":"Iain Kilty","startTime":2036.15,"endTime":2039.78,"body":"think the similarity in both"},{"speaker":"Iain Kilty","startTime":2036.15,"endTime":2039.78,"body":"cases is that openness. I'm"},{"speaker":"Iain Kilty","startTime":2039.78,"endTime":2042.87,"body":"really trying to work as one"},{"speaker":"Iain Kilty","startTime":2039.78,"endTime":2042.87,"body":"team with a common goal. The"},{"speaker":"Iain Kilty","startTime":2042.87,"endTime":2045.24,"body":"science has to be good. If a"},{"speaker":"Iain Kilty","startTime":2042.87,"endTime":2045.24,"body":"science isn't good, then doesn't"},{"speaker":"Iain Kilty","startTime":2045.24,"endTime":2046.95,"body":"matter if you put the best team"},{"speaker":"Iain Kilty","startTime":2045.24,"endTime":2046.95,"body":"in the world in it, you won't"},{"speaker":"Iain Kilty","startTime":2046.95,"endTime":2049.92,"body":"deliver drugs. But you can have"},{"speaker":"Iain Kilty","startTime":2046.95,"endTime":2049.92,"body":"great science with a team that's"},{"speaker":"Iain Kilty","startTime":2049.92,"endTime":2052.71,"body":"not functional, and you're not"},{"speaker":"Iain Kilty","startTime":2049.92,"endTime":2052.71,"body":"going to get there either. And I"},{"speaker":"Iain Kilty","startTime":2052.71,"endTime":2056.43,"body":"think the culture that's been"},{"speaker":"Iain Kilty","startTime":2052.71,"endTime":2056.43,"body":"built at Sitryx has really"},{"speaker":"Iain Kilty","startTime":2056.43,"endTime":2060.48,"body":"enabled the company to move"},{"speaker":"Iain Kilty","startTime":2056.43,"endTime":2060.48,"body":"rapidly to the point we are"},{"speaker":"Iain Kilty","startTime":2060.48,"endTime":2064.44,"body":"today, and it's just a fun place"},{"speaker":"Iain Kilty","startTime":2060.48,"endTime":2064.44,"body":"to work for those reasons. And I"},{"speaker":"Iain Kilty","startTime":2064.44,"endTime":2068.52,"body":"think, as well, has facilitated"},{"speaker":"Iain Kilty","startTime":2064.44,"endTime":2068.52,"body":"this close collaboration, with a"},{"speaker":"Iain Kilty","startTime":2068.52,"endTime":2071.55,"body":"couple of examples I was giving"},{"speaker":"Iain Kilty","startTime":2068.52,"endTime":2071.55,"body":"you earlier, around the academic"},{"speaker":"Iain Kilty","startTime":2071.55,"endTime":2074.01,"body":"collaborations and the"},{"speaker":"Iain Kilty","startTime":2071.55,"endTime":2074.01,"body":"industrial collaborations."},{"speaker":"John Simboli","startTime":2074.61,"endTime":2076.95,"body":"If I were to ask"},{"speaker":"John Simboli","startTime":2074.61,"endTime":2076.95,"body":"people on your immediate team,"},{"speaker":"John Simboli","startTime":2076.95,"endTime":2079.62,"body":"you know, what's Iain's"},{"speaker":"John Simboli","startTime":2076.95,"endTime":2079.62,"body":"management approach, how do you"},{"speaker":"John Simboli","startTime":2079.62,"endTime":2080.82,"body":"think they would answer there?"},{"speaker":"Iain Kilty","startTime":2081.12,"endTime":2083.22,"body":"Yeah so, I think"},{"speaker":"Iain Kilty","startTime":2081.12,"endTime":2083.22,"body":"they would answer that I'm"},{"speaker":"Iain Kilty","startTime":2083.91,"endTime":2087.03,"body":"approachable and very calm. I've"},{"speaker":"Iain Kilty","startTime":2083.91,"endTime":2087.03,"body":"always been told I'm a very calm"},{"speaker":"Iain Kilty","startTime":2087.27,"endTime":2091.08,"body":"person, which is great. Like to"},{"speaker":"Iain Kilty","startTime":2087.27,"endTime":2091.08,"body":"listen to everybody's views, but"},{"speaker":"Iain Kilty","startTime":2091.08,"endTime":2093.96,"body":"I really do like to have a"},{"speaker":"Iain Kilty","startTime":2091.08,"endTime":2093.96,"body":"decision made. It doesn't always"},{"speaker":"Iain Kilty","startTime":2093.96,"endTime":2096.0,"body":"have to be my decision. I just"},{"speaker":"Iain Kilty","startTime":2093.96,"endTime":2096.0,"body":"don't like leaving a room"},{"speaker":"Iain Kilty","startTime":2096.0,"endTime":2099.24,"body":"without a clear plan. And I"},{"speaker":"Iain Kilty","startTime":2096.0,"endTime":2099.24,"body":"think they would probably"},{"speaker":"Iain Kilty","startTime":2099.24,"endTime":2103.14,"body":"reflect that ss well in their"},{"speaker":"Iain Kilty","startTime":2099.24,"endTime":2103.14,"body":"feedback. And I'd certainly"},{"speaker":"Iain Kilty","startTime":2103.14,"endTime":2106.11,"body":"hope, as I said, that they would"},{"speaker":"Iain Kilty","startTime":2103.14,"endTime":2106.11,"body":"feel that I'm accessible and"},{"speaker":"Iain Kilty","startTime":2106.11,"endTime":2109.38,"body":"they can chat to me. And there's"},{"speaker":"Iain Kilty","startTime":2106.11,"endTime":2109.38,"body":"certainly elements of evidence"},{"speaker":"Iain Kilty","startTime":2109.38,"endTime":2112.59,"body":"for that that I take comfort"},{"speaker":"Iain Kilty","startTime":2109.38,"endTime":2112.59,"body":"from, that that's true. You get"},{"speaker":"Iain Kilty","startTime":2112.59,"endTime":2115.62,"body":"bits of feedback, but as we went"},{"speaker":"Iain Kilty","startTime":2112.59,"endTime":2115.62,"body":"through the transition, a number"},{"speaker":"Iain Kilty","startTime":2115.62,"endTime":2117.54,"body":"of those quite junior team"},{"speaker":"Iain Kilty","startTime":2115.62,"endTime":2117.54,"body":"members would come and chat to"},{"speaker":"Iain Kilty","startTime":2117.54,"endTime":2121.14,"body":"me about, oh, if in this new"},{"speaker":"Iain Kilty","startTime":2117.54,"endTime":2121.14,"body":"role, will I still have chance"},{"speaker":"Iain Kilty","startTime":2121.14,"endTime":2123.81,"body":"to ask you about this, and can I"},{"speaker":"Iain Kilty","startTime":2121.14,"endTime":2123.81,"body":"share these thoughts or whatever"},{"speaker":"Iain Kilty","startTime":2123.81,"endTime":2126.75,"body":"it might be? And I was really"},{"speaker":"Iain Kilty","startTime":2123.81,"endTime":2126.75,"body":"pleased that people were willing"},{"speaker":"Iain Kilty","startTime":2126.75,"endTime":2130.8,"body":"to come and take some time with"},{"speaker":"Iain Kilty","startTime":2126.75,"endTime":2130.8,"body":"me to talk about any concerns"},{"speaker":"Iain Kilty","startTime":2130.8,"endTime":2132.81,"body":"they had about any changes"},{"speaker":"Iain Kilty","startTime":2130.8,"endTime":2132.81,"body":"within the company."},{"speaker":"John Simboli","startTime":2133.23,"endTime":2135.84,"body":"How do you know"},{"speaker":"John Simboli","startTime":2133.23,"endTime":2135.84,"body":"when it's time to make a"},{"speaker":"John Simboli","startTime":2135.84,"endTime":2138.51,"body":"decision versus when it's time"},{"speaker":"John Simboli","startTime":2135.84,"endTime":2138.51,"body":"to look for more information?"},{"speaker":"Iain Kilty","startTime":2139.23,"endTime":2141.66,"body":"Yeah, it's a great"},{"speaker":"Iain Kilty","startTime":2139.23,"endTime":2141.66,"body":"question, especially in"},{"speaker":"Iain Kilty","startTime":2141.66,"endTime":2144.33,"body":"research, because I don't think"},{"speaker":"Iain Kilty","startTime":2141.66,"endTime":2144.33,"body":"you ever really know, are you at"},{"speaker":"Iain Kilty","startTime":2144.54,"endTime":2148.74,"body":"60% of the information? Have I"},{"speaker":"Iain Kilty","startTime":2144.54,"endTime":2148.74,"body":"got 90 or actually 20? How far"},{"speaker":"Iain Kilty","startTime":2148.74,"endTime":2151.26,"body":"do I need to go? So a lot of"},{"speaker":"Iain Kilty","startTime":2148.74,"endTime":2151.26,"body":"this, I think, comes from some"},{"speaker":"Iain Kilty","startTime":2151.26,"endTime":2155.4,"body":"experience, and also just the"},{"speaker":"Iain Kilty","startTime":2151.26,"endTime":2155.4,"body":"importance of the decision and"},{"speaker":"Iain Kilty","startTime":2155.4,"endTime":2160.14,"body":"the impact of the decision. So"},{"speaker":"Iain Kilty","startTime":2155.4,"endTime":2160.14,"body":"if this is a relatively small"},{"speaker":"Iain Kilty","startTime":2160.14,"endTime":2164.64,"body":"decision, it's $5,000 to be"},{"speaker":"Iain Kilty","startTime":2160.14,"endTime":2164.64,"body":"spent on study x, or whatever it"},{"speaker":"Iain Kilty","startTime":2164.64,"endTime":2167.7,"body":"might be, then I think you can"},{"speaker":"Iain Kilty","startTime":2164.64,"endTime":2167.7,"body":"be pretty comfortable making"},{"speaker":"Iain Kilty","startTime":2167.7,"endTime":2171.96,"body":"those decisions with relatively"},{"speaker":"Iain Kilty","startTime":2167.7,"endTime":2171.96,"body":"small amounts of information. If"},{"speaker":"Iain Kilty","startTime":2171.96,"endTime":2176.82,"body":"the decision really could impact"},{"speaker":"Iain Kilty","startTime":2171.96,"endTime":2176.82,"body":"the future of the company and"},{"speaker":"Iain Kilty","startTime":2176.82,"endTime":2179.58,"body":"the direction you're going to"},{"speaker":"Iain Kilty","startTime":2176.82,"endTime":2179.58,"body":"go, and maybe something you"},{"speaker":"Iain Kilty","startTime":2179.58,"endTime":2181.98,"body":"couldn't easily undo, then you"},{"speaker":"Iain Kilty","startTime":2179.58,"endTime":2181.98,"body":"really need to make sure you've"},{"speaker":"Iain Kilty","startTime":2181.98,"endTime":2186.15,"body":"done as much diligence as you"},{"speaker":"Iain Kilty","startTime":2181.98,"endTime":2186.15,"body":"can. But I do think one of the"},{"speaker":"Iain Kilty","startTime":2186.15,"endTime":2189.21,"body":"things from my experience in"},{"speaker":"Iain Kilty","startTime":2186.15,"endTime":2189.21,"body":"both big pharma and biotech,"},{"speaker":"Iain Kilty","startTime":2189.21,"endTime":2192.63,"body":"that if you get into a place"},{"speaker":"Iain Kilty","startTime":2189.21,"endTime":2192.63,"body":"where you can't make a decision,"},{"speaker":"Iain Kilty","startTime":2193.14,"endTime":2196.2,"body":"then you're in trouble, because"},{"speaker":"Iain Kilty","startTime":2193.14,"endTime":2196.2,"body":"you've almost made a decision by"},{"speaker":"Iain Kilty","startTime":2196.2,"endTime":2198.69,"body":"not making it, you're just"},{"speaker":"Iain Kilty","startTime":2196.2,"endTime":2198.69,"body":"static, and if you're not moving"},{"speaker":"Iain Kilty","startTime":2198.69,"endTime":2201.6,"body":"forward, you're moving"},{"speaker":"Iain Kilty","startTime":2198.69,"endTime":2201.6,"body":"backwards. So I think you've"},{"speaker":"Iain Kilty","startTime":2201.6,"endTime":2205.65,"body":"obviously got to be careful."},{"speaker":"Iain Kilty","startTime":2201.6,"endTime":2205.65,"body":"You're not ready fire aim. You"},{"speaker":"Iain Kilty","startTime":2205.65,"endTime":2208.8,"body":"need to give yourself chance to"},{"speaker":"Iain Kilty","startTime":2205.65,"endTime":2208.8,"body":"have really thought things"},{"speaker":"Iain Kilty","startTime":2208.8,"endTime":2212.07,"body":"through and had the appropriate"},{"speaker":"Iain Kilty","startTime":2208.8,"endTime":2212.07,"body":"diligence around a decision that"},{"speaker":"Iain Kilty","startTime":2212.07,"endTime":2214.8,"body":"you make. But it can be"},{"speaker":"Iain Kilty","startTime":2212.07,"endTime":2214.8,"body":"comfortable sometimes,"},{"speaker":"Iain Kilty","startTime":2214.83,"endTime":2216.51,"body":"especially for the more"},{"speaker":"Iain Kilty","startTime":2214.83,"endTime":2216.51,"body":"difficult decisions to say,"},{"speaker":"Iain Kilty","startTime":2216.78,"endTime":2219.42,"body":"okay, let's get back together in"},{"speaker":"Iain Kilty","startTime":2216.78,"endTime":2219.42,"body":"two more weeks, and we'll do"},{"speaker":"Iain Kilty","startTime":2219.42,"endTime":2222.75,"body":"research X and come back to this"},{"speaker":"Iain Kilty","startTime":2219.42,"endTime":2222.75,"body":"decision. So I just think, you"},{"speaker":"Iain Kilty","startTime":2222.75,"endTime":2224.85,"body":"know, you have to be careful,"},{"speaker":"Iain Kilty","startTime":2222.75,"endTime":2224.85,"body":"because you've, you've actually"},{"speaker":"Iain Kilty","startTime":2224.85,"endTime":2226.23,"body":"made a default decision there."},{"speaker":"John Simboli","startTime":2226.41,"endTime":2230.55,"body":"Is anything about"},{"speaker":"John Simboli","startTime":2226.41,"endTime":2230.55,"body":"the origin story and the"},{"speaker":"John Simboli","startTime":2230.55,"endTime":2235.53,"body":"community that is there in"},{"speaker":"John Simboli","startTime":2230.55,"endTime":2235.53,"body":"Oxford and in UK in general,"},{"speaker":"John Simboli","startTime":2235.53,"endTime":2238.53,"body":"that would be interesting for"},{"speaker":"John Simboli","startTime":2235.53,"endTime":2238.53,"body":"you, in your opinion, to talk"},{"speaker":"John Simboli","startTime":2238.53,"endTime":2238.89,"body":"about?"},{"speaker":"Iain Kilty","startTime":2239.29,"endTime":2241.33,"body":"Well actually I was"},{"speaker":"Iain Kilty","startTime":2239.29,"endTime":2241.33,"body":"in Cambridge, Mass for 10 years"},{"speaker":"Iain Kilty","startTime":2241.81,"endTime":2243.85,"body":"before I took this job, so that"},{"speaker":"Iain Kilty","startTime":2241.81,"endTime":2243.85,"body":"was quite a different"},{"speaker":"Iain Kilty","startTime":2244.27,"endTime":2248.53,"body":"environment. So first I can"},{"speaker":"Iain Kilty","startTime":2244.27,"endTime":2248.53,"body":"comment on that. So I originally"},{"speaker":"Iain Kilty","startTime":2248.53,"endTime":2251.26,"body":"was in biotech, working with"},{"speaker":"Iain Kilty","startTime":2248.53,"endTime":2251.26,"body":"Atlas venture in tech square in"},{"speaker":"Iain Kilty","startTime":2251.32,"endTime":2254.53,"body":"Cambridge, and it's a hugely"},{"speaker":"Iain Kilty","startTime":2251.32,"endTime":2254.53,"body":"vibrant atmosphere there. It was"},{"speaker":"Iain Kilty","startTime":2254.53,"endTime":2258.55,"body":"a fantastic place to first be"},{"speaker":"Iain Kilty","startTime":2254.53,"endTime":2258.55,"body":"involved in biotech, and I"},{"speaker":"Iain Kilty","startTime":2258.55,"endTime":2261.19,"body":"worked with Bruce Booth. He was"},{"speaker":"Iain Kilty","startTime":2258.55,"endTime":2261.19,"body":"the chairman of our board, and"},{"speaker":"Iain Kilty","startTime":2261.19,"endTime":2264.13,"body":"again, another great mentor. So"},{"speaker":"Iain Kilty","startTime":2261.19,"endTime":2264.13,"body":"again, as I say, luckily,"},{"speaker":"Iain Kilty","startTime":2264.13,"endTime":2267.1,"body":"through my career with people"},{"speaker":"Iain Kilty","startTime":2264.13,"endTime":2267.1,"body":"I've interacted with in that"},{"speaker":"Iain Kilty","startTime":2267.1,"endTime":2270.64,"body":"way. The Oxford ecosystem offers"},{"speaker":"Iain Kilty","startTime":2267.1,"endTime":2270.64,"body":"something slightly different."},{"speaker":"Iain Kilty","startTime":2270.64,"endTime":2273.76,"body":"It's not as developed as the"},{"speaker":"Iain Kilty","startTime":2270.64,"endTime":2273.76,"body":"Cambridge mass ecosystem, and"},{"speaker":"Iain Kilty","startTime":2273.76,"endTime":2275.92,"body":"we're more spread out. We're not"},{"speaker":"Iain Kilty","startTime":2273.76,"endTime":2275.92,"body":"all in tech square. We're at a"},{"speaker":"Iain Kilty","startTime":2275.92,"endTime":2278.98,"body":"science park, but there's an"},{"speaker":"Iain Kilty","startTime":2275.92,"endTime":2278.98,"body":"incredible amount of high"},{"speaker":"Iain Kilty","startTime":2278.98,"endTime":2283.36,"body":"quality science in the UK and"},{"speaker":"Iain Kilty","startTime":2278.98,"endTime":2283.36,"body":"excellent scientists, which"},{"speaker":"Iain Kilty","startTime":2283.45,"endTime":2287.26,"body":"offer a great opportunity to"},{"speaker":"Iain Kilty","startTime":2283.45,"endTime":2287.26,"body":"think about new approaches to"},{"speaker":"Iain Kilty","startTime":2287.29,"endTime":2290.32,"body":"developing new drugs for"},{"speaker":"Iain Kilty","startTime":2287.29,"endTime":2290.32,"body":"patients, whether that's for"},{"speaker":"Iain Kilty","startTime":2290.32,"endTime":2293.14,"body":"Sitryx, specifically within"},{"speaker":"Iain Kilty","startTime":2290.32,"endTime":2293.14,"body":"immuno metabolism, or beyond"},{"speaker":"Iain Kilty","startTime":2293.14,"endTime":2297.01,"body":"that, in my venture partner role"},{"speaker":"Iain Kilty","startTime":2293.14,"endTime":2297.01,"body":"with SV health investors. So I"},{"speaker":"Iain Kilty","startTime":2297.01,"endTime":2301.42,"body":"really enjoyed becoming part of"},{"speaker":"Iain Kilty","startTime":2297.01,"endTime":2301.42,"body":"that UK ecosystem and starting"},{"speaker":"Iain Kilty","startTime":2301.42,"endTime":2304.27,"body":"to think, how can I bring some"},{"speaker":"Iain Kilty","startTime":2301.42,"endTime":2304.27,"body":"of the experience that I have"},{"speaker":"Iain Kilty","startTime":2304.27,"endTime":2308.77,"body":"from the US into the UK to help"},{"speaker":"Iain Kilty","startTime":2304.27,"endTime":2308.77,"body":"us, you know, make more from"},{"speaker":"Iain Kilty","startTime":2308.77,"endTime":2311.44,"body":"from the really good quality"},{"speaker":"Iain Kilty","startTime":2308.77,"endTime":2311.44,"body":"substrate that we have."},{"speaker":"John Simboli","startTime":2312.04,"endTime":2313.96,"body":"Thanks for"},{"speaker":"John Simboli","startTime":2312.04,"endTime":2313.96,"body":"speaking with me today, Iain."},{"speaker":"Iain Kilty","startTime":2314.8,"endTime":2316.9,"body":"Thanks, John. I"},{"speaker":"Iain Kilty","startTime":2314.8,"endTime":2316.9,"body":"really enjoyed the conversation."}]}