{"version":"1.0.0","segments":[{"speaker":"John Simboli","startTime":0.27,"endTime":4.262,"body":"Today I'm speaking"},{"speaker":"John Simboli","startTime":0.27,"endTime":4.262,"body":"with Vlad Vitoc, founder and CEO"},{"speaker":"John Simboli","startTime":4.341,"endTime":7.864,"body":"MAIA Biotechnology,"},{"speaker":"John Simboli","startTime":4.341,"endTime":7.864,"body":"headquartered in Chicago."},{"speaker":"John Simboli","startTime":7.942,"endTime":9.9,"body":"Welcome to BioBoss, Vlad."},{"speaker":"Vlad Vitoc","startTime":10.26,"endTime":12.24,"body":"Thank you, John."},{"speaker":"Vlad Vitoc","startTime":10.26,"endTime":12.24,"body":"It's great to be here."},{"speaker":"John Simboli","startTime":12.42,"endTime":15.702,"body":"What led you to"},{"speaker":"John Simboli","startTime":12.42,"endTime":15.702,"body":"your role as founder and CEO of"},{"speaker":"John Simboli","startTime":15.772,"endTime":16.68,"body":"MAIA Biotech?"},{"speaker":"Vlad Vitoc","startTime":16.95,"endTime":20.506,"body":"I spent my entire"},{"speaker":"Vlad Vitoc","startTime":16.95,"endTime":20.506,"body":"career in oncology, in pharma"},{"speaker":"Vlad Vitoc","startTime":20.582,"endTime":24.517,"body":"and biotech. I trained as a"},{"speaker":"Vlad Vitoc","startTime":20.582,"endTime":24.517,"body":"physician, but went into"},{"speaker":"Vlad Vitoc","startTime":24.592,"endTime":29.208,"body":"business from the beginning in"},{"speaker":"Vlad Vitoc","startTime":24.592,"endTime":29.208,"body":"pharma and biotech about 50/50"},{"speaker":"Vlad Vitoc","startTime":29.284,"endTime":33.976,"body":"between medical and commercial"},{"speaker":"Vlad Vitoc","startTime":29.284,"endTime":33.976,"body":"roles, and along the way, I had"},{"speaker":"Vlad Vitoc","startTime":34.051,"endTime":38.819,"body":"the opportunity and privilege to"},{"speaker":"Vlad Vitoc","startTime":34.051,"endTime":38.819,"body":"work on and launch some of the"},{"speaker":"Vlad Vitoc","startTime":38.894,"endTime":43.359,"body":"most extraordinary anti-cancer"},{"speaker":"Vlad Vitoc","startTime":38.894,"endTime":43.359,"body":"treatments in their day. For"},{"speaker":"Vlad Vitoc","startTime":43.435,"endTime":47.748,"body":"example, at Bayer oncology, I"},{"speaker":"Vlad Vitoc","startTime":43.435,"endTime":47.748,"body":"launched Nexavar, the first"},{"speaker":"Vlad Vitoc","startTime":47.824,"endTime":52.137,"body":"tyrosine kinase inhibitor for"},{"speaker":"Vlad Vitoc","startTime":47.824,"endTime":52.137,"body":"the treatment of renal cell"},{"speaker":"Vlad Vitoc","startTime":52.213,"endTime":56.526,"body":"carcinoma and hepatocellular"},{"speaker":"Vlad Vitoc","startTime":52.213,"endTime":56.526,"body":"carcinoma, where we are also"},{"speaker":"Vlad Vitoc","startTime":56.602,"endTime":61.293,"body":"going with THIO. This was the"},{"speaker":"Vlad Vitoc","startTime":56.602,"endTime":61.293,"body":"first multikinase inhibitor drug"},{"speaker":"Vlad Vitoc","startTime":61.369,"endTime":65.682,"body":"used for the treatment of"},{"speaker":"Vlad Vitoc","startTime":61.369,"endTime":65.682,"body":"cancer, and reached more than a"},{"speaker":"Vlad Vitoc","startTime":65.758,"endTime":70.601,"body":"billion dollars in annual sales."},{"speaker":"Vlad Vitoc","startTime":65.758,"endTime":70.601,"body":"And then later on, at Astellas,"},{"speaker":"Vlad Vitoc","startTime":70.677,"endTime":74.839,"body":"I launched Tarceva for EGFR"},{"speaker":"Vlad Vitoc","startTime":70.677,"endTime":74.839,"body":"mutated non-small cell lung"},{"speaker":"Vlad Vitoc","startTime":74.914,"endTime":79.606,"body":"cancer, which reached a peak of"},{"speaker":"Vlad Vitoc","startTime":74.914,"endTime":79.606,"body":"3 billion annually. At MAIA we"},{"speaker":"Vlad Vitoc","startTime":79.682,"endTime":84.449,"body":"are studying our drug THIO, in"},{"speaker":"Vlad Vitoc","startTime":79.682,"endTime":84.449,"body":"specifically non small cell lung"},{"speaker":"Vlad Vitoc","startTime":84.525,"endTime":88.687,"body":"cancer as well. And I launched"},{"speaker":"Vlad Vitoc","startTime":84.525,"endTime":88.687,"body":"XTANDI for four types of"},{"speaker":"Vlad Vitoc","startTime":88.762,"endTime":93.303,"body":"prostate cancer. This is now"},{"speaker":"Vlad Vitoc","startTime":88.762,"endTime":93.303,"body":"over $5 billion a year, but not"},{"speaker":"Vlad Vitoc","startTime":93.378,"endTime":97.01,"body":"one of these was as"},{"speaker":"Vlad Vitoc","startTime":93.378,"endTime":97.01,"body":"extraordinary as what we are"},{"speaker":"Vlad Vitoc","startTime":97.086,"endTime":100.718,"body":"seeing here at MAIA"},{"speaker":"Vlad Vitoc","startTime":97.086,"endTime":100.718,"body":"Biotechnology, with our lead"},{"speaker":"Vlad Vitoc","startTime":100.794,"endTime":104.88,"body":"agent called THIO. So this idea"},{"speaker":"Vlad Vitoc","startTime":100.794,"endTime":104.88,"body":"of finding treatments,"},{"speaker":"Vlad Vitoc","startTime":104.956,"endTime":108.588,"body":"developing them and"},{"speaker":"Vlad Vitoc","startTime":104.956,"endTime":108.588,"body":"commercializing them for the"},{"speaker":"Vlad Vitoc","startTime":108.664,"endTime":113.356,"body":"cure of cancer is what inspired"},{"speaker":"Vlad Vitoc","startTime":108.664,"endTime":113.356,"body":"me to found MAIA Biotechnology"},{"speaker":"Vlad Vitoc","startTime":113.431,"endTime":116.61,"body":"and move it now towards commercialization."},{"speaker":"John Simboli","startTime":118.32,"endTime":121.8,"body":"Do you recall when"},{"speaker":"John Simboli","startTime":118.32,"endTime":121.8,"body":"you made that decision to make"},{"speaker":"John Simboli","startTime":121.8,"endTime":124.92,"body":"that transition from being a"},{"speaker":"John Simboli","startTime":121.8,"endTime":124.92,"body":"physician to being, you know, to"},{"speaker":"John Simboli","startTime":124.92,"endTime":127.53,"body":"starting a Biopharma company. Do"},{"speaker":"John Simboli","startTime":124.92,"endTime":127.53,"body":"you remember what it was that"},{"speaker":"John Simboli","startTime":127.53,"endTime":129.93,"body":"made you think \"It's time to do"},{"speaker":"John Simboli","startTime":127.53,"endTime":129.93,"body":"this\"?"},{"speaker":"Vlad Vitoc","startTime":130.289,"endTime":133.649,"body":"Yeah, it was right"},{"speaker":"Vlad Vitoc","startTime":130.289,"endTime":133.649,"body":"out of medical school, actually."},{"speaker":"Vlad Vitoc","startTime":133.859,"endTime":137.909,"body":"So some time ago. The decision"},{"speaker":"Vlad Vitoc","startTime":133.859,"endTime":137.909,"body":"was not a clear cut one. It was"},{"speaker":"Vlad Vitoc","startTime":137.939,"endTime":143.819,"body":"a 51 to 49 type of decision. And"},{"speaker":"Vlad Vitoc","startTime":137.939,"endTime":143.819,"body":"I had originally planned to be"},{"speaker":"Vlad Vitoc","startTime":143.849,"endTime":146.339,"body":"an oncologist, and the"},{"speaker":"Vlad Vitoc","startTime":143.849,"endTime":146.339,"body":"inspiration for that was my"},{"speaker":"Vlad Vitoc","startTime":146.339,"endTime":149.129,"body":"mother, who is a very"},{"speaker":"Vlad Vitoc","startTime":146.339,"endTime":149.129,"body":"accomplished breast cancer"},{"speaker":"Vlad Vitoc","startTime":149.159,"endTime":154.289,"body":"oncologist in my home country of"},{"speaker":"Vlad Vitoc","startTime":149.159,"endTime":154.289,"body":"Romania. And my father was the"},{"speaker":"Vlad Vitoc","startTime":154.289,"endTime":157.619,"body":"business inspiration. He's an"},{"speaker":"Vlad Vitoc","startTime":154.289,"endTime":157.619,"body":"architect, and he started an"},{"speaker":"Vlad Vitoc","startTime":157.619,"endTime":162.299,"body":"architecture business, and I"},{"speaker":"Vlad Vitoc","startTime":157.619,"endTime":162.299,"body":"worked with him in my spare time"},{"speaker":"Vlad Vitoc","startTime":162.599,"endTime":166.679,"body":"as I went through medical"},{"speaker":"Vlad Vitoc","startTime":162.599,"endTime":166.679,"body":"school, and that inspired me to"},{"speaker":"Vlad Vitoc","startTime":166.889,"endTime":171.989,"body":"explore the business side of"},{"speaker":"Vlad Vitoc","startTime":166.889,"endTime":171.989,"body":"things. Which I then did with a"},{"speaker":"Vlad Vitoc","startTime":171.989,"endTime":176.309,"body":"number of friends who were"},{"speaker":"Vlad Vitoc","startTime":171.989,"endTime":176.309,"body":"working for biotech companies in"},{"speaker":"Vlad Vitoc","startTime":176.309,"endTime":181.589,"body":"those days, and made a"},{"speaker":"Vlad Vitoc","startTime":176.309,"endTime":181.589,"body":"determination 51 to 49 to go in"},{"speaker":"Vlad Vitoc","startTime":181.619,"endTime":185.579,"body":"the business direction, and it"},{"speaker":"Vlad Vitoc","startTime":181.619,"endTime":185.579,"body":"has been business ever since."},{"speaker":"John Simboli","startTime":186.51,"endTime":188.88,"body":"To take on"},{"speaker":"John Simboli","startTime":186.51,"endTime":188.88,"body":"something substantial like this,"},{"speaker":"John Simboli","startTime":188.94,"endTime":192.39,"body":"do you have to factor in how it"},{"speaker":"John Simboli","startTime":188.94,"endTime":192.39,"body":"affects everything, including"},{"speaker":"John Simboli","startTime":192.72,"endTime":193.47,"body":"your loved ones?"},{"speaker":"Vlad Vitoc","startTime":194.16,"endTime":196.56,"body":"Absolutely, you have"},{"speaker":"Vlad Vitoc","startTime":194.16,"endTime":196.56,"body":"to. Yes, there are two things."},{"speaker":"Vlad Vitoc","startTime":196.59,"endTime":200.22,"body":"There is the financial"},{"speaker":"Vlad Vitoc","startTime":196.59,"endTime":200.22,"body":"obligation to their families and"},{"speaker":"Vlad Vitoc","startTime":200.22,"endTime":203.7,"body":"also the opportunity cost,"},{"speaker":"Vlad Vitoc","startTime":200.22,"endTime":203.7,"body":"right? So as is the case with"},{"speaker":"Vlad Vitoc","startTime":203.7,"endTime":206.82,"body":"many physicians, physicians"},{"speaker":"Vlad Vitoc","startTime":203.7,"endTime":206.82,"body":"usually calibrate their lives"},{"speaker":"Vlad Vitoc","startTime":206.82,"endTime":211.17,"body":"around an income to support"},{"speaker":"Vlad Vitoc","startTime":206.82,"endTime":211.17,"body":"their families, and also they"},{"speaker":"Vlad Vitoc","startTime":211.17,"endTime":215.49,"body":"study medicine only and not"},{"speaker":"Vlad Vitoc","startTime":211.17,"endTime":215.49,"body":"business. So they don't know how"},{"speaker":"Vlad Vitoc","startTime":215.49,"endTime":218.85,"body":"to run a business. It's not"},{"speaker":"Vlad Vitoc","startTime":215.49,"endTime":218.85,"body":"natural to them. They have to l"},{"speaker":"Vlad Vitoc","startTime":218.85,"endTime":224.01,"body":"earn it. These are, I think, the"},{"speaker":"Vlad Vitoc","startTime":218.85,"endTime":224.01,"body":"main considerations, and are the"},{"speaker":"Vlad Vitoc","startTime":224.01,"endTime":227.67,"body":"things that are preventing or"},{"speaker":"Vlad Vitoc","startTime":224.01,"endTime":227.67,"body":"making difficult for a physician"},{"speaker":"Vlad Vitoc","startTime":227.67,"endTime":232.14,"body":"to turn to business. So it's the"},{"speaker":"Vlad Vitoc","startTime":227.67,"endTime":232.14,"body":"opportunity cost of income you"},{"speaker":"Vlad Vitoc","startTime":232.14,"endTime":234.87,"body":"don't realize anymore. You know,"},{"speaker":"Vlad Vitoc","startTime":232.14,"endTime":234.87,"body":"when you start the company,"},{"speaker":"Vlad Vitoc","startTime":234.87,"endTime":239.67,"body":"oftentimes you work for free or"},{"speaker":"Vlad Vitoc","startTime":234.87,"endTime":239.67,"body":"for very little, as was the case"},{"speaker":"Vlad Vitoc","startTime":239.67,"endTime":243.51,"body":"here as well. I was able to do"},{"speaker":"Vlad Vitoc","startTime":239.67,"endTime":243.51,"body":"that because of savings from"},{"speaker":"Vlad Vitoc","startTime":243.51,"endTime":249.9,"body":"before and also because my wife"},{"speaker":"Vlad Vitoc","startTime":243.51,"endTime":249.9,"body":"is also an executive at a major"},{"speaker":"Vlad Vitoc","startTime":249.9,"endTime":254.19,"body":"company. So we were okay"},{"speaker":"Vlad Vitoc","startTime":249.9,"endTime":254.19,"body":"financially to take this chance."},{"speaker":"Vlad Vitoc","startTime":254.19,"endTime":258.09,"body":"But other people may not be so"},{"speaker":"Vlad Vitoc","startTime":254.19,"endTime":258.09,"body":"okay, especially if they are the"},{"speaker":"Vlad Vitoc","startTime":258.15,"endTime":261.6,"body":"only income in the house. So I"},{"speaker":"Vlad Vitoc","startTime":258.15,"endTime":261.6,"body":"was, I feel fortunate, though,"},{"speaker":"Vlad Vitoc","startTime":261.66,"endTime":262.59,"body":"of this scenario,"},{"speaker":"John Simboli","startTime":263.43,"endTime":265.83,"body":"My experience in"},{"speaker":"John Simboli","startTime":263.43,"endTime":265.83,"body":"working with physicians who have"},{"speaker":"John Simboli","startTime":265.83,"endTime":268.08,"body":"become founders of biopharma"},{"speaker":"John Simboli","startTime":265.83,"endTime":268.08,"body":"companies is they've talked to"},{"speaker":"John Simboli","startTime":268.08,"endTime":271.53,"body":"me about change in thinking"},{"speaker":"John Simboli","startTime":268.08,"endTime":271.53,"body":"between trying to help one"},{"speaker":"John Simboli","startTime":271.53,"endTime":275.91,"body":"person at a time in a big way as"},{"speaker":"John Simboli","startTime":271.53,"endTime":275.91,"body":"a physician, versus trying to"},{"speaker":"John Simboli","startTime":275.91,"endTime":278.97,"body":"help a lot of people, they hope."},{"speaker":"John Simboli","startTime":275.91,"endTime":278.97,"body":"But then maybe it'll happen."},{"speaker":"John Simboli","startTime":278.97,"endTime":282.27,"body":"Maybe it won't happen. I know"},{"speaker":"John Simboli","startTime":278.97,"endTime":282.27,"body":"your decision was early on in"},{"speaker":"John Simboli","startTime":282.27,"endTime":284.67,"body":"your career, but did you face"},{"speaker":"John Simboli","startTime":282.27,"endTime":284.67,"body":"that choice?"},{"speaker":"Vlad Vitoc","startTime":285.75,"endTime":288.72,"body":"That's a clear"},{"speaker":"Vlad Vitoc","startTime":285.75,"endTime":288.72,"body":"choice that is a very real one"},{"speaker":"Vlad Vitoc","startTime":288.75,"endTime":292.86,"body":"for even as a practicing"},{"speaker":"Vlad Vitoc","startTime":288.75,"endTime":292.86,"body":"physician, you're focused on"},{"speaker":"Vlad Vitoc","startTime":292.86,"endTime":297.66,"body":"just the person in front of you."},{"speaker":"Vlad Vitoc","startTime":292.86,"endTime":297.66,"body":"But then as a scientist"},{"speaker":"Vlad Vitoc","startTime":297.66,"endTime":302.82,"body":"physician, you now look at the"},{"speaker":"Vlad Vitoc","startTime":297.66,"endTime":302.82,"body":"patient population as a whole,"},{"speaker":"Vlad Vitoc","startTime":302.82,"endTime":306.99,"body":"and the segments in the patient"},{"speaker":"Vlad Vitoc","startTime":302.82,"endTime":306.99,"body":"population that have the"},{"speaker":"Vlad Vitoc","startTime":307.02,"endTime":310.86,"body":"specific unmet medical need you"},{"speaker":"Vlad Vitoc","startTime":307.02,"endTime":310.86,"body":"want to address. It's very"},{"speaker":"Vlad Vitoc","startTime":310.86,"endTime":313.83,"body":"different. Thinking in a"},{"speaker":"Vlad Vitoc","startTime":310.86,"endTime":313.83,"body":"statistical manner, you're"},{"speaker":"Vlad Vitoc","startTime":313.83,"endTime":321.21,"body":"helping a population, but it's"},{"speaker":"Vlad Vitoc","startTime":313.83,"endTime":321.21,"body":"no way identifiable in success."},{"speaker":"Vlad Vitoc","startTime":321.63,"endTime":325.62,"body":"You don't have the result of"},{"speaker":"Vlad Vitoc","startTime":321.63,"endTime":325.62,"body":"curing someone you know"},{"speaker":"Vlad Vitoc","startTime":325.65,"endTime":332.04,"body":"personally as a patient, or"},{"speaker":"Vlad Vitoc","startTime":325.65,"endTime":332.04,"body":"sometimes losing a patient. So"},{"speaker":"Vlad Vitoc","startTime":332.07,"endTime":337.38,"body":"these types of elements are no"},{"speaker":"Vlad Vitoc","startTime":332.07,"endTime":337.38,"body":"longer part of every day, but at"},{"speaker":"Vlad Vitoc","startTime":337.38,"endTime":341.88,"body":"the same time, the knowledge"},{"speaker":"Vlad Vitoc","startTime":337.38,"endTime":341.88,"body":"that, in aggregate, you help"},{"speaker":"Vlad Vitoc","startTime":342.69,"endTime":348.48,"body":"significant segments of"},{"speaker":"Vlad Vitoc","startTime":342.69,"endTime":348.48,"body":"humankind, is also a very"},{"speaker":"Vlad Vitoc","startTime":348.48,"endTime":354.21,"body":"powerful motivator. To me, that"},{"speaker":"Vlad Vitoc","startTime":348.48,"endTime":354.21,"body":"is the ultimate motivator. If"},{"speaker":"Vlad Vitoc","startTime":354.21,"endTime":359.28,"body":"you can make a difference at the"},{"speaker":"Vlad Vitoc","startTime":354.21,"endTime":359.28,"body":"human scale, that is the most"},{"speaker":"Vlad Vitoc","startTime":359.64,"endTime":363.69,"body":"extraordinary vision and mission"},{"speaker":"Vlad Vitoc","startTime":359.64,"endTime":363.69,"body":"in oncology."},{"speaker":"John Simboli","startTime":365.22,"endTime":368.1,"body":"My understanding"},{"speaker":"John Simboli","startTime":365.22,"endTime":368.1,"body":"is that your interest and your"},{"speaker":"John Simboli","startTime":368.1,"endTime":371.64,"body":"background has always been on"},{"speaker":"John Simboli","startTime":368.1,"endTime":371.64,"body":"the oncology side. Did I"},{"speaker":"John Simboli","startTime":371.64,"endTime":374.61,"body":"understand correctly from the"},{"speaker":"John Simboli","startTime":371.64,"endTime":374.61,"body":"research that the telomere side"},{"speaker":"John Simboli","startTime":374.61,"endTime":377.01,"body":"of it was something that came to"},{"speaker":"John Simboli","startTime":374.61,"endTime":377.01,"body":"you later on in your"},{"speaker":"John Simboli","startTime":377.01,"endTime":380.22,"body":"progression? And if that's the"},{"speaker":"John Simboli","startTime":377.01,"endTime":380.22,"body":"case, can you tell me how you"},{"speaker":"John Simboli","startTime":380.22,"endTime":383.13,"body":"made that decision? Like, that's"},{"speaker":"John Simboli","startTime":380.22,"endTime":383.13,"body":"where I want to land. That's"},{"speaker":"John Simboli","startTime":383.13,"endTime":384.06,"body":"where I want to go next."},{"speaker":"Vlad Vitoc","startTime":384.63,"endTime":388.5,"body":"Yes, like many"},{"speaker":"Vlad Vitoc","startTime":384.63,"endTime":388.5,"body":"things, it is a question of"},{"speaker":"Vlad Vitoc","startTime":388.53,"endTime":393.15,"body":"serendipity sometimes. In 2018,"},{"speaker":"Vlad Vitoc","startTime":388.53,"endTime":393.15,"body":"I was in the process of starting"},{"speaker":"Vlad Vitoc","startTime":393.18,"endTime":398.1,"body":"a biotech company and was"},{"speaker":"Vlad Vitoc","startTime":393.18,"endTime":398.1,"body":"introduced to a number of"},{"speaker":"Vlad Vitoc","startTime":398.1,"endTime":400.89,"body":"different scientists at"},{"speaker":"Vlad Vitoc","startTime":398.1,"endTime":400.89,"body":"different universities, and one"},{"speaker":"Vlad Vitoc","startTime":400.89,"endTime":404.76,"body":"of them, Jerry Shay, a professor"},{"speaker":"Vlad Vitoc","startTime":400.89,"endTime":404.76,"body":"at University of Texas, had a"},{"speaker":"Vlad Vitoc","startTime":404.76,"endTime":408.15,"body":"number of compounds in his"},{"speaker":"Vlad Vitoc","startTime":404.76,"endTime":408.15,"body":"development program in pre"},{"speaker":"Vlad Vitoc","startTime":408.15,"endTime":412.08,"body":"clinical setting, and this was"},{"speaker":"Vlad Vitoc","startTime":408.15,"endTime":412.08,"body":"one of them. And I have to"},{"speaker":"Vlad Vitoc","startTime":412.08,"endTime":416.49,"body":"admit, it was not on my radar up"},{"speaker":"Vlad Vitoc","startTime":412.08,"endTime":416.49,"body":"until that point. It was"},{"speaker":"Vlad Vitoc","startTime":416.49,"endTime":421.53,"body":"actually new science, certainly"},{"speaker":"Vlad Vitoc","startTime":416.49,"endTime":421.53,"body":"the telomeres, telomerase as"},{"speaker":"Vlad Vitoc","startTime":421.53,"endTime":427.02,"body":"they apply to the science of"},{"speaker":"Vlad Vitoc","startTime":421.53,"endTime":427.02,"body":"aging, were already well"},{"speaker":"Vlad Vitoc","startTime":427.02,"endTime":431.85,"body":"characterized in that manner,"},{"speaker":"Vlad Vitoc","startTime":427.02,"endTime":431.85,"body":"but how they applied to oncology"},{"speaker":"Vlad Vitoc","startTime":431.85,"endTime":437.55,"body":"and the treatment of cancer was"},{"speaker":"Vlad Vitoc","startTime":431.85,"endTime":437.55,"body":"entirely new science. And that's"},{"speaker":"Vlad Vitoc","startTime":437.58,"endTime":441.57,"body":"what I learned in my first"},{"speaker":"Vlad Vitoc","startTime":437.58,"endTime":441.57,"body":"interactions with Jerry at"},{"speaker":"Vlad Vitoc","startTime":441.57,"endTime":444.81,"body":"University of Texas."},{"speaker":"Vlad Vitoc","startTime":441.57,"endTime":444.81,"body":"Immediately, it piqued my"},{"speaker":"Vlad Vitoc","startTime":444.81,"endTime":449.91,"body":"interest, because it is A, a new"},{"speaker":"Vlad Vitoc","startTime":444.81,"endTime":449.91,"body":"mechanism of action that no one"},{"speaker":"Vlad Vitoc","startTime":450.42,"endTime":454.38,"body":"else has developed at all"},{"speaker":"Vlad Vitoc","startTime":450.42,"endTime":454.38,"body":"before. So it's telomere"},{"speaker":"Vlad Vitoc","startTime":454.38,"endTime":459.66,"body":"targeting, utilizing the enzyme"},{"speaker":"Vlad Vitoc","startTime":454.38,"endTime":459.66,"body":"telomerase, and later on, also"},{"speaker":"Vlad Vitoc","startTime":459.69,"endTime":464.01,"body":"immunogenic. We characterized it"},{"speaker":"Vlad Vitoc","startTime":459.69,"endTime":464.01,"body":"as an immunogenic molecule,"},{"speaker":"Vlad Vitoc","startTime":464.1,"endTime":468.27,"body":"meaning stimulating the immune"},{"speaker":"Vlad Vitoc","startTime":464.1,"endTime":468.27,"body":"system to respond to cancer. So"},{"speaker":"Vlad Vitoc","startTime":468.27,"endTime":475.38,"body":"this makes it so broadly"},{"speaker":"Vlad Vitoc","startTime":468.27,"endTime":475.38,"body":"applicable. 85% of cancer cells"},{"speaker":"Vlad Vitoc","startTime":475.41,"endTime":479.94,"body":"are telomerase positive in"},{"speaker":"Vlad Vitoc","startTime":475.41,"endTime":479.94,"body":"aggregate, and some cancer types"},{"speaker":"Vlad Vitoc","startTime":479.97,"endTime":484.26,"body":"are 100%, like small-cell lung"},{"speaker":"Vlad Vitoc","startTime":479.97,"endTime":484.26,"body":"cancer. Non small-cell is around"},{"speaker":"Vlad Vitoc","startTime":484.29,"endTime":491.25,"body":"85, 90%, colorectal around 90,"},{"speaker":"Vlad Vitoc","startTime":484.29,"endTime":491.25,"body":"HCC, around 90. On the low end,"},{"speaker":"Vlad Vitoc","startTime":491.37,"endTime":497.79,"body":"you see neuroblastoma or"},{"speaker":"Vlad Vitoc","startTime":491.37,"endTime":497.79,"body":"sarcomas with 40, 50% but big"},{"speaker":"Vlad Vitoc","startTime":497.79,"endTime":503.64,"body":"numbers. In contrast, in normal"},{"speaker":"Vlad Vitoc","startTime":497.79,"endTime":503.64,"body":"cells, less than 1% of normal"},{"speaker":"Vlad Vitoc","startTime":503.64,"endTime":508.89,"body":"cells express telomerase. So"},{"speaker":"Vlad Vitoc","startTime":503.64,"endTime":508.89,"body":"THIO needs telomerase to work."},{"speaker":"Vlad Vitoc","startTime":509.52,"endTime":514.35,"body":"Without telomerase, THIO does"},{"speaker":"Vlad Vitoc","startTime":509.52,"endTime":514.35,"body":"not work. Telomerase's role is"},{"speaker":"Vlad Vitoc","startTime":514.35,"endTime":518.46,"body":"to pick up THIO and place it in"},{"speaker":"Vlad Vitoc","startTime":514.35,"endTime":518.46,"body":"the structure of the telomere"},{"speaker":"Vlad Vitoc","startTime":518.58,"endTime":523.5,"body":"instead of a guanine base. Then"},{"speaker":"Vlad Vitoc","startTime":518.58,"endTime":523.5,"body":"the structure of the telomere"},{"speaker":"Vlad Vitoc","startTime":523.53,"endTime":527.16,"body":"becomes unstable, the telomere"},{"speaker":"Vlad Vitoc","startTime":523.53,"endTime":527.16,"body":"collapses and the cancer cell"},{"speaker":"Vlad Vitoc","startTime":527.16,"endTime":532.74,"body":"dies. So this is the main, the"},{"speaker":"Vlad Vitoc","startTime":527.16,"endTime":532.74,"body":"first telomere targeting"},{"speaker":"Vlad Vitoc","startTime":532.74,"endTime":537.51,"body":"mechanism of THIO, and it's"},{"speaker":"Vlad Vitoc","startTime":532.74,"endTime":537.51,"body":"applicable in just about any"},{"speaker":"Vlad Vitoc","startTime":537.54,"endTime":542.04,"body":"tumor type. Such an"},{"speaker":"Vlad Vitoc","startTime":537.54,"endTime":542.04,"body":"extraordinary target with such a"},{"speaker":"Vlad Vitoc","startTime":542.04,"endTime":547.38,"body":"broad applicability only comes"},{"speaker":"Vlad Vitoc","startTime":542.04,"endTime":547.38,"body":"around once in like decades."},{"speaker":"Vlad Vitoc","startTime":547.95,"endTime":554.58,"body":"Since the launch of KEYTRUDA in"},{"speaker":"Vlad Vitoc","startTime":547.95,"endTime":554.58,"body":"2014 nothing had been so widely"},{"speaker":"Vlad Vitoc","startTime":554.58,"endTime":559.41,"body":"applicable. So I really like"},{"speaker":"Vlad Vitoc","startTime":554.58,"endTime":559.41,"body":"this part of it that is so"},{"speaker":"Vlad Vitoc","startTime":559.41,"endTime":563.94,"body":"widely applicable in many tumor"},{"speaker":"Vlad Vitoc","startTime":559.41,"endTime":563.94,"body":"types, and then also very"},{"speaker":"Vlad Vitoc","startTime":564.15,"endTime":569.01,"body":"effective. This direct killing"},{"speaker":"Vlad Vitoc","startTime":564.15,"endTime":569.01,"body":"by collapsing the telomeres of"},{"speaker":"Vlad Vitoc","startTime":569.01,"endTime":575.49,"body":"the cancer cells happens in 24"},{"speaker":"Vlad Vitoc","startTime":569.01,"endTime":575.49,"body":"to 72 hours, very fast. And then"},{"speaker":"Vlad Vitoc","startTime":575.49,"endTime":581.16,"body":"it kills directly 70 to 90% of"},{"speaker":"Vlad Vitoc","startTime":575.49,"endTime":581.16,"body":"those cells, very efficient."},{"speaker":"Vlad Vitoc","startTime":581.34,"endTime":585.3,"body":"Then kicks in its immunogenic"},{"speaker":"Vlad Vitoc","startTime":581.34,"endTime":585.3,"body":"mechanism. So of the telemeric"},{"speaker":"Vlad Vitoc","startTime":585.3,"endTime":589.53,"body":"fragments, it forms micro nuclei"},{"speaker":"Vlad Vitoc","startTime":585.3,"endTime":589.53,"body":"that present these fragments to"},{"speaker":"Vlad Vitoc","startTime":589.53,"endTime":593.13,"body":"the immune cells, becoming new"},{"speaker":"Vlad Vitoc","startTime":589.53,"endTime":593.13,"body":"adjuvants in the immune"},{"speaker":"Vlad Vitoc","startTime":593.13,"endTime":597.45,"body":"pathways. They trigger an immune"},{"speaker":"Vlad Vitoc","startTime":593.13,"endTime":597.45,"body":"response that is so efficient,"},{"speaker":"Vlad Vitoc","startTime":597.75,"endTime":600.57,"body":"if you follow THIO with an"},{"speaker":"Vlad Vitoc","startTime":597.75,"endTime":600.57,"body":"immune therapy, we learned"},{"speaker":"Vlad Vitoc","startTime":600.57,"endTime":606.27,"body":"later, you get to complete"},{"speaker":"Vlad Vitoc","startTime":600.57,"endTime":606.27,"body":"response, no recurrence and anti"},{"speaker":"Vlad Vitoc","startTime":606.3,"endTime":612.39,"body":"tumor, immune memory, cure. And"},{"speaker":"Vlad Vitoc","startTime":606.3,"endTime":612.39,"body":"we have seen this in pre"},{"speaker":"Vlad Vitoc","startTime":612.39,"endTime":616.8,"body":"clinical setting, initially, in"},{"speaker":"Vlad Vitoc","startTime":612.39,"endTime":616.8,"body":"many tumor types. In lung"},{"speaker":"Vlad Vitoc","startTime":616.8,"endTime":622.68,"body":"cancer, in colorectal, in liver,"},{"speaker":"Vlad Vitoc","startTime":616.8,"endTime":622.68,"body":"small-cell lung cancer, brain"},{"speaker":"Vlad Vitoc","startTime":622.68,"endTime":630.3,"body":"cancer; the data is so strong"},{"speaker":"Vlad Vitoc","startTime":622.68,"endTime":630.3,"body":"that the FDA awarded THIO three"},{"speaker":"Vlad Vitoc","startTime":630.33,"endTime":635.52,"body":"orphan drug designations out of"},{"speaker":"Vlad Vitoc","startTime":630.33,"endTime":635.52,"body":"three applications. In liver"},{"speaker":"Vlad Vitoc","startTime":635.52,"endTime":640.5,"body":"cancer, HCC, hepatocellular"},{"speaker":"Vlad Vitoc","startTime":635.52,"endTime":640.5,"body":"carcinoma, in lung cancer,"},{"speaker":"Vlad Vitoc","startTime":640.68,"endTime":645.03,"body":"small-cell lung cancer, the"},{"speaker":"Vlad Vitoc","startTime":640.68,"endTime":645.03,"body":"deadliest form of lung cancer,"},{"speaker":"Vlad Vitoc","startTime":645.84,"endTime":652.2,"body":"and in malignant gliomas, brain"},{"speaker":"Vlad Vitoc","startTime":645.84,"endTime":652.2,"body":"cancers, including glioblastoma."},{"speaker":"Vlad Vitoc","startTime":652.65,"endTime":656.19,"body":"So this is, right there,"},{"speaker":"Vlad Vitoc","startTime":652.65,"endTime":656.19,"body":"recognition of the effectiveness"},{"speaker":"Vlad Vitoc","startTime":656.19,"endTime":659.31,"body":"of the molecule in the"},{"speaker":"Vlad Vitoc","startTime":656.19,"endTime":659.31,"body":"preclinical setting. And now we"},{"speaker":"Vlad Vitoc","startTime":659.31,"endTime":662.7,"body":"are in the clinic. And in the"},{"speaker":"Vlad Vitoc","startTime":659.31,"endTime":662.7,"body":"clinic, of course, you need to"},{"speaker":"Vlad Vitoc","startTime":662.7,"endTime":666.87,"body":"test first in as a market entry"},{"speaker":"Vlad Vitoc","startTime":662.7,"endTime":666.87,"body":"strategy, in the very sick"},{"speaker":"Vlad Vitoc","startTime":666.87,"endTime":671.4,"body":"patients in the later lines of"},{"speaker":"Vlad Vitoc","startTime":666.87,"endTime":671.4,"body":"therapy. And here, we haven't"},{"speaker":"Vlad Vitoc","startTime":671.4,"endTime":675.42,"body":"seen cures in this setting, but"},{"speaker":"Vlad Vitoc","startTime":671.4,"endTime":675.42,"body":"we have seen survival extension"},{"speaker":"Vlad Vitoc","startTime":675.96,"endTime":680.19,"body":"like nothing else in this third"},{"speaker":"Vlad Vitoc","startTime":675.96,"endTime":680.19,"body":"line of therapy. This is"},{"speaker":"Vlad Vitoc","startTime":680.22,"endTime":683.37,"body":"basically, these patients have"},{"speaker":"Vlad Vitoc","startTime":680.22,"endTime":683.37,"body":"lost hope at this point."},{"speaker":"Vlad Vitoc","startTime":684.75,"endTime":687.84,"body":"Unfortunately the median"},{"speaker":"Vlad Vitoc","startTime":684.75,"endTime":687.84,"body":"survival is under six months."},{"speaker":"Vlad Vitoc","startTime":688.65,"endTime":695.85,"body":"With THIO we have now recorded"},{"speaker":"Vlad Vitoc","startTime":688.65,"endTime":695.85,"body":"16.9 months median overall"},{"speaker":"Vlad Vitoc","startTime":695.85,"endTime":700.17,"body":"survival, 3x. This is such a"},{"speaker":"Vlad Vitoc","startTime":695.85,"endTime":700.17,"body":"tremendous progress in the"},{"speaker":"Vlad Vitoc","startTime":700.17,"endTime":704.88,"body":"setting we plan now to execute"},{"speaker":"Vlad Vitoc","startTime":700.17,"endTime":704.88,"body":"on the pivotal trials and go"},{"speaker":"Vlad Vitoc","startTime":704.88,"endTime":708.84,"body":"commercial with this, and then"},{"speaker":"Vlad Vitoc","startTime":704.88,"endTime":708.84,"body":"move it forward in the"},{"speaker":"Vlad Vitoc","startTime":708.84,"endTime":712.56,"body":"therapeutic continuum, from the"},{"speaker":"Vlad Vitoc","startTime":708.84,"endTime":712.56,"body":"third line of therapy to first"},{"speaker":"Vlad Vitoc","startTime":712.56,"endTime":717.72,"body":"line of therapy, where the"},{"speaker":"Vlad Vitoc","startTime":712.56,"endTime":717.72,"body":"chance of cure becomes real for"},{"speaker":"Vlad Vitoc","startTime":717.72,"endTime":723.33,"body":"drugs so efficient as THIO is."},{"speaker":"Vlad Vitoc","startTime":717.72,"endTime":723.33,"body":"And that's where we believe we"},{"speaker":"Vlad Vitoc","startTime":723.33,"endTime":724.02,"body":"will secure."},{"speaker":"John Simboli","startTime":724.98,"endTime":727.26,"body":"Did you have an"},{"speaker":"John Simboli","startTime":724.98,"endTime":727.26,"body":"image of yourself at any point,"},{"speaker":"John Simboli","startTime":727.41,"endTime":731.04,"body":"like early on that either was"},{"speaker":"John Simboli","startTime":727.41,"endTime":731.04,"body":"like what you turned out to do"},{"speaker":"John Simboli","startTime":731.04,"endTime":732.72,"body":"for a living, or not at all like"},{"speaker":"John Simboli","startTime":731.04,"endTime":732.72,"body":"that?"},{"speaker":"Vlad Vitoc","startTime":733.5,"endTime":738.42,"body":"Yes, of course. As"},{"speaker":"Vlad Vitoc","startTime":733.5,"endTime":738.42,"body":"you grow up, you want to be"},{"speaker":"Vlad Vitoc","startTime":739.29,"endTime":742.68,"body":"different things along the way"},{"speaker":"Vlad Vitoc","startTime":739.29,"endTime":742.68,"body":"depends on what touches you"},{"speaker":"Vlad Vitoc","startTime":742.68,"endTime":747.15,"body":"first and impresses you more. I"},{"speaker":"Vlad Vitoc","startTime":742.68,"endTime":747.15,"body":"remember a moment when I wanted"},{"speaker":"Vlad Vitoc","startTime":747.15,"endTime":753.06,"body":"to be an astronaut, maybe I was"},{"speaker":"Vlad Vitoc","startTime":747.15,"endTime":753.06,"body":"maybe seven or eight or"},{"speaker":"Vlad Vitoc","startTime":753.06,"endTime":756.75,"body":"something, and I was already"},{"speaker":"Vlad Vitoc","startTime":753.06,"endTime":756.75,"body":"wearing glasses, so the first"},{"speaker":"Vlad Vitoc","startTime":756.75,"endTime":760.77,"body":"analysis was very quick. Vision"},{"speaker":"Vlad Vitoc","startTime":756.75,"endTime":760.77,"body":"isn't good enough. So you can"},{"speaker":"Vlad Vitoc","startTime":760.77,"endTime":766.29,"body":"drop that one right away. So the"},{"speaker":"Vlad Vitoc","startTime":760.77,"endTime":766.29,"body":"idea of being an astronaut and"},{"speaker":"Vlad Vitoc","startTime":767.01,"endTime":772.05,"body":"going to places where no one has"},{"speaker":"Vlad Vitoc","startTime":767.01,"endTime":772.05,"body":"been before, discover not just"},{"speaker":"Vlad Vitoc","startTime":772.05,"endTime":775.5,"body":"new places, but new science in"},{"speaker":"Vlad Vitoc","startTime":772.05,"endTime":775.5,"body":"the process. And all this was"},{"speaker":"Vlad Vitoc","startTime":775.89,"endTime":781.95,"body":"always appealing to me, just to"},{"speaker":"Vlad Vitoc","startTime":775.89,"endTime":781.95,"body":"a very painful level, being"},{"speaker":"Vlad Vitoc","startTime":781.95,"endTime":784.8,"body":"aware that it's never going to"},{"speaker":"Vlad Vitoc","startTime":781.95,"endTime":784.8,"body":"happen because of physical"},{"speaker":"Vlad Vitoc","startTime":785.25,"endTime":791.64,"body":"issues. Vision, in this case."},{"speaker":"Vlad Vitoc","startTime":785.25,"endTime":791.64,"body":"The second such moment was when"},{"speaker":"Vlad Vitoc","startTime":792.66,"endTime":797.31,"body":"I watched Formula One racing"},{"speaker":"Vlad Vitoc","startTime":792.66,"endTime":797.31,"body":"cars. Also that was at an early"},{"speaker":"Vlad Vitoc","startTime":797.31,"endTime":800.25,"body":"age. I said, Okay, I'm not going"},{"speaker":"Vlad Vitoc","startTime":797.31,"endTime":800.25,"body":"to be an astronaut. I want to be"},{"speaker":"Vlad Vitoc","startTime":800.28,"endTime":805.83,"body":"a race car driver. And there was"},{"speaker":"Vlad Vitoc","startTime":800.28,"endTime":805.83,"body":"a champion back then in Europe,"},{"speaker":"Vlad Vitoc","startTime":805.83,"endTime":810.06,"body":"from Austria, Niki Lauda, and I"},{"speaker":"Vlad Vitoc","startTime":805.83,"endTime":810.06,"body":"wanted to be like him. So I"},{"speaker":"Vlad Vitoc","startTime":810.06,"endTime":815.04,"body":"wanted to go into racing. Then,"},{"speaker":"Vlad Vitoc","startTime":810.06,"endTime":815.04,"body":"as it turns out, growing up in"},{"speaker":"Vlad Vitoc","startTime":815.04,"endTime":818.58,"body":"Romania, there is no racing to"},{"speaker":"Vlad Vitoc","startTime":815.04,"endTime":818.58,"body":"be had. So at that point in"},{"speaker":"Vlad Vitoc","startTime":818.58,"endTime":823.92,"body":"time, there was not a thing. So"},{"speaker":"Vlad Vitoc","startTime":818.58,"endTime":823.92,"body":"then I, you know, the journey is"},{"speaker":"Vlad Vitoc","startTime":823.95,"endTime":826.83,"body":"going through different things,"},{"speaker":"Vlad Vitoc","startTime":823.95,"endTime":826.83,"body":"but I think doing something"},{"speaker":"Vlad Vitoc","startTime":826.83,"endTime":829.92,"body":"extraordinary, making a"},{"speaker":"Vlad Vitoc","startTime":826.83,"endTime":829.92,"body":"difference in a big way, in a"},{"speaker":"Vlad Vitoc","startTime":829.92,"endTime":834.51,"body":"big, meaningful way, was an idea"},{"speaker":"Vlad Vitoc","startTime":829.92,"endTime":834.51,"body":"that with me started then and"},{"speaker":"Vlad Vitoc","startTime":834.51,"endTime":839.52,"body":"then along the way I learned. I"},{"speaker":"Vlad Vitoc","startTime":834.51,"endTime":839.52,"body":"learned and developed. I learned"},{"speaker":"Vlad Vitoc","startTime":839.52,"endTime":845.61,"body":"much more. I started to focus on"},{"speaker":"Vlad Vitoc","startTime":839.52,"endTime":845.61,"body":"medicine also, in high school. I"},{"speaker":"Vlad Vitoc","startTime":845.61,"endTime":847.83,"body":"started to focus on medicine,"},{"speaker":"Vlad Vitoc","startTime":845.61,"endTime":847.83,"body":"and then the business of"},{"speaker":"Vlad Vitoc","startTime":847.83,"endTime":852.93,"body":"medicine. And I think this is a"},{"speaker":"Vlad Vitoc","startTime":847.83,"endTime":852.93,"body":"journey that I'm very proud and"},{"speaker":"Vlad Vitoc","startTime":852.93,"endTime":857.07,"body":"also very thankful to other"},{"speaker":"Vlad Vitoc","startTime":852.93,"endTime":857.07,"body":"people around me, such as my"},{"speaker":"Vlad Vitoc","startTime":857.07,"endTime":862.44,"body":"parents or my wife or my"},{"speaker":"Vlad Vitoc","startTime":857.07,"endTime":862.44,"body":"children or my friends who are"},{"speaker":"Vlad Vitoc","startTime":862.47,"endTime":866.37,"body":"encouraging and supporting of"},{"speaker":"Vlad Vitoc","startTime":862.47,"endTime":866.37,"body":"these things, and it's all about"},{"speaker":"Vlad Vitoc","startTime":866.37,"endTime":870.9,"body":"making a team at the end of the"},{"speaker":"Vlad Vitoc","startTime":866.37,"endTime":870.9,"body":"day, to achieve things like"},{"speaker":"Vlad Vitoc","startTime":870.9,"endTime":876.3,"body":"this. People say it takes a"},{"speaker":"Vlad Vitoc","startTime":870.9,"endTime":876.3,"body":"village. It is. It's true. It"},{"speaker":"Vlad Vitoc","startTime":876.3,"endTime":877.47,"body":"does take a village."},{"speaker":"John Simboli","startTime":878.04,"endTime":880.28,"body":"My experience is"},{"speaker":"John Simboli","startTime":878.04,"endTime":880.28,"body":"that when trying to introduce"},{"speaker":"John Simboli","startTime":880.329,"endTime":883.056,"body":"our clients to folks and they"},{"speaker":"John Simboli","startTime":880.329,"endTime":883.056,"body":"don't know the name of the"},{"speaker":"John Simboli","startTime":883.105,"endTime":885.979,"body":"company, and that might be the"},{"speaker":"John Simboli","startTime":883.105,"endTime":885.979,"body":"case with MAIA, depending on"},{"speaker":"John Simboli","startTime":886.028,"endTime":888.95,"body":"people you're speaking with,"},{"speaker":"John Simboli","startTime":886.028,"endTime":888.95,"body":"because it's a new company. How"},{"speaker":"John Simboli","startTime":888.999,"endTime":892.019,"body":"do you describe that? Like, what"},{"speaker":"John Simboli","startTime":888.999,"endTime":892.019,"body":"do they picture you doing? Do"},{"speaker":"John Simboli","startTime":892.067,"endTime":894.941,"body":"they picture you in a lab coat?"},{"speaker":"John Simboli","startTime":892.067,"endTime":894.941,"body":"Do they picture you running"},{"speaker":"John Simboli","startTime":894.99,"endTime":898.107,"body":"analyzes? Do they picture you in"},{"speaker":"John Simboli","startTime":894.99,"endTime":898.107,"body":"meetings? How do you get across"},{"speaker":"John Simboli","startTime":898.156,"endTime":899.91,"body":"what you actually do during the day?"},{"speaker":"Vlad Vitoc","startTime":900.6,"endTime":905.64,"body":"In a small startup"},{"speaker":"Vlad Vitoc","startTime":900.6,"endTime":905.64,"body":"company, you have to do a lot of"},{"speaker":"Vlad Vitoc","startTime":905.64,"endTime":912.06,"body":"things. My days are long and"},{"speaker":"Vlad Vitoc","startTime":905.64,"endTime":912.06,"body":"very eventful. It's like there's"},{"speaker":"Vlad Vitoc","startTime":912.09,"endTime":916.17,"body":"one thing after another. And"},{"speaker":"Vlad Vitoc","startTime":912.09,"endTime":916.17,"body":"also, this doesn't stop when I"},{"speaker":"Vlad Vitoc","startTime":916.17,"endTime":921.99,"body":"travel or even when I take"},{"speaker":"Vlad Vitoc","startTime":916.17,"endTime":921.99,"body":"vacation days. Everything goes"},{"speaker":"Vlad Vitoc","startTime":921.99,"endTime":927.54,"body":"with so I never stop. I begin"},{"speaker":"Vlad Vitoc","startTime":921.99,"endTime":927.54,"body":"early in the morning, as soon as"},{"speaker":"Vlad Vitoc","startTime":927.54,"endTime":931.53,"body":"I wake up, I'm on it. I try to"},{"speaker":"Vlad Vitoc","startTime":927.54,"endTime":931.53,"body":"fit in some exercising in there."},{"speaker":"Vlad Vitoc","startTime":931.95,"endTime":935.58,"body":"But what I do, it's really"},{"speaker":"Vlad Vitoc","startTime":931.95,"endTime":935.58,"body":"touching every aspect of the"},{"speaker":"Vlad Vitoc","startTime":935.58,"endTime":939.54,"body":"business. It is managing every"},{"speaker":"Vlad Vitoc","startTime":935.58,"endTime":939.54,"body":"aspect of the business, from"},{"speaker":"Vlad Vitoc","startTime":939.63,"endTime":944.34,"body":"things like preclinical testing"},{"speaker":"Vlad Vitoc","startTime":939.63,"endTime":944.34,"body":"to clinical development, to"},{"speaker":"Vlad Vitoc","startTime":944.76,"endTime":949.71,"body":"manufacturing, to financing,"},{"speaker":"Vlad Vitoc","startTime":944.76,"endTime":949.71,"body":"that takes a lot of time. But of"},{"speaker":"Vlad Vitoc","startTime":949.71,"endTime":952.38,"body":"course, there you need to, I"},{"speaker":"Vlad Vitoc","startTime":949.71,"endTime":952.38,"body":"surround myself with very"},{"speaker":"Vlad Vitoc","startTime":952.38,"endTime":956.7,"body":"capable people, true leaders in"},{"speaker":"Vlad Vitoc","startTime":952.38,"endTime":956.7,"body":"the field. So I don't need to do"},{"speaker":"Vlad Vitoc","startTime":956.73,"endTime":962.1,"body":"all of this hands on every day,"},{"speaker":"Vlad Vitoc","startTime":956.73,"endTime":962.1,"body":"because it is simply impossible."},{"speaker":"Vlad Vitoc","startTime":962.1,"endTime":966.54,"body":"It's not scalable. But what do I"},{"speaker":"Vlad Vitoc","startTime":962.1,"endTime":966.54,"body":"do every day? I move every part"},{"speaker":"Vlad Vitoc","startTime":966.54,"endTime":967.41,"body":"of the organization."},{"speaker":"John Simboli","startTime":967.92,"endTime":970.17,"body":"If someone were to"},{"speaker":"John Simboli","startTime":967.92,"endTime":970.17,"body":"ask you, what's your management"},{"speaker":"John Simboli","startTime":970.2,"endTime":973.98,"body":"approach? How do you make"},{"speaker":"John Simboli","startTime":970.2,"endTime":973.98,"body":"decisions? How do you lead? How"},{"speaker":"John Simboli","startTime":973.98,"endTime":975.39,"body":"would you describe it for"},{"speaker":"John Simboli","startTime":973.98,"endTime":975.39,"body":"yourself?"},{"speaker":"Vlad Vitoc","startTime":975.6,"endTime":978.66,"body":"My management"},{"speaker":"Vlad Vitoc","startTime":975.6,"endTime":978.66,"body":"approach, it has to be very"},{"speaker":"Vlad Vitoc","startTime":978.66,"endTime":981.9,"body":"nimble. And there is, I know, I"},{"speaker":"Vlad Vitoc","startTime":978.66,"endTime":981.9,"body":"know there's a lot of science"},{"speaker":"Vlad Vitoc","startTime":981.93,"endTime":986.1,"body":"developed around styles of"},{"speaker":"Vlad Vitoc","startTime":981.93,"endTime":986.1,"body":"management. I studied many"},{"speaker":"Vlad Vitoc","startTime":986.1,"endTime":990.09,"body":"styles of management along the"},{"speaker":"Vlad Vitoc","startTime":986.1,"endTime":990.09,"body":"way, as I progressed in my"},{"speaker":"Vlad Vitoc","startTime":990.09,"endTime":995.13,"body":"career. But, I think at the end"},{"speaker":"Vlad Vitoc","startTime":990.09,"endTime":995.13,"body":"of the day, it is more than"},{"speaker":"Vlad Vitoc","startTime":995.13,"endTime":999.99,"body":"anything, a situational"},{"speaker":"Vlad Vitoc","startTime":995.13,"endTime":999.99,"body":"leadership scenario in which you"},{"speaker":"Vlad Vitoc","startTime":999.99,"endTime":1006.35,"body":"have to work with each situation"},{"speaker":"Vlad Vitoc","startTime":999.99,"endTime":1006.35,"body":"in its own manner. And you know,"},{"speaker":"Vlad Vitoc","startTime":1006.56,"endTime":1009.44,"body":"just make sure that you put the"},{"speaker":"Vlad Vitoc","startTime":1006.56,"endTime":1009.44,"body":"right leadership in play,"},{"speaker":"Vlad Vitoc","startTime":1010.01,"endTime":1013.07,"body":"whether it's yours or somebody"},{"speaker":"Vlad Vitoc","startTime":1010.01,"endTime":1013.07,"body":"else's, which is often the case"},{"speaker":"Vlad Vitoc","startTime":1013.07,"endTime":1019.55,"body":"as well for each of the"},{"speaker":"Vlad Vitoc","startTime":1013.07,"endTime":1019.55,"body":"scenarios. So I made a very"},{"speaker":"Vlad Vitoc","startTime":1019.55,"endTime":1023.0,"body":"important effort to build a"},{"speaker":"Vlad Vitoc","startTime":1019.55,"endTime":1023.0,"body":"really good team. We have a very"},{"speaker":"Vlad Vitoc","startTime":1023.0,"endTime":1029.03,"body":"good team right now. It's a team"},{"speaker":"Vlad Vitoc","startTime":1023.0,"endTime":1029.03,"body":"in which most of them can easily"},{"speaker":"Vlad Vitoc","startTime":1029.12,"endTime":1034.73,"body":"take leadership in their field."},{"speaker":"Vlad Vitoc","startTime":1029.12,"endTime":1034.73,"body":"So this makes it very productive"},{"speaker":"Vlad Vitoc","startTime":1034.76,"endTime":1038.69,"body":"and efficient, and at the end of"},{"speaker":"Vlad Vitoc","startTime":1034.76,"endTime":1038.69,"body":"the day, that's what matters the"},{"speaker":"Vlad Vitoc","startTime":1038.69,"endTime":1039.05,"body":"most."},{"speaker":"John Simboli","startTime":1039.859,"endTime":1042.554,"body":"When people ask"},{"speaker":"John Simboli","startTime":1039.859,"endTime":1042.554,"body":"you for that really tight, terse"},{"speaker":"John Simboli","startTime":1042.611,"endTime":1046.205,"body":"description when they say, What"},{"speaker":"John Simboli","startTime":1042.611,"endTime":1046.205,"body":"is MAIA? What's the short answer"},{"speaker":"John Simboli","startTime":1046.261,"endTime":1047.329,"body":"you give to people?"},{"speaker":"Vlad Vitoc","startTime":1047.9,"endTime":1051.428,"body":"MAIA is a biotech"},{"speaker":"Vlad Vitoc","startTime":1047.9,"endTime":1051.428,"body":"company that develops new agents"},{"speaker":"Vlad Vitoc","startTime":1051.499,"endTime":1055.945,"body":"for the treatment of cancer, and"},{"speaker":"Vlad Vitoc","startTime":1051.499,"endTime":1055.945,"body":"we have the telomere targeting"},{"speaker":"Vlad Vitoc","startTime":1056.016,"endTime":1060.321,"body":"franchise with THIO as a leading"},{"speaker":"Vlad Vitoc","startTime":1056.016,"endTime":1060.321,"body":"agent, and we're going after"},{"speaker":"Vlad Vitoc","startTime":1060.391,"endTime":1064.273,"body":"multiple cancers with non"},{"speaker":"Vlad Vitoc","startTime":1060.391,"endTime":1064.273,"body":"small-cell lung cancer as the"},{"speaker":"Vlad Vitoc","startTime":1064.343,"endTime":1068.154,"body":"first one, then colorectal,"},{"speaker":"Vlad Vitoc","startTime":1064.343,"endTime":1068.154,"body":"liver and others. So we're"},{"speaker":"Vlad Vitoc","startTime":1068.225,"endTime":1072.318,"body":"developing a franchise that we"},{"speaker":"Vlad Vitoc","startTime":1068.225,"endTime":1072.318,"body":"have the next generation of"},{"speaker":"Vlad Vitoc","startTime":1072.389,"endTime":1076.412,"body":"telomere targeting agents in"},{"speaker":"Vlad Vitoc","startTime":1072.389,"endTime":1076.412,"body":"play as well, and we are now"},{"speaker":"Vlad Vitoc","startTime":1076.482,"endTime":1080.576,"body":"pivotal trials ready. We're"},{"speaker":"Vlad Vitoc","startTime":1076.482,"endTime":1080.576,"body":"about to begin them, and we're"},{"speaker":"Vlad Vitoc","startTime":1080.646,"endTime":1084.74,"body":"looking to commercialize in two"},{"speaker":"Vlad Vitoc","startTime":1080.646,"endTime":1084.74,"body":"to three years from today."},{"speaker":"John Simboli","startTime":1085.64,"endTime":1088.25,"body":"Being the leader"},{"speaker":"John Simboli","startTime":1085.64,"endTime":1088.25,"body":"in a field sometimes begs the"},{"speaker":"John Simboli","startTime":1088.25,"endTime":1092.66,"body":"question of, in relation to"},{"speaker":"John Simboli","startTime":1088.25,"endTime":1092.66,"body":"what? People want to position a"},{"speaker":"John Simboli","startTime":1092.66,"endTime":1094.97,"body":"company in relation to other"},{"speaker":"John Simboli","startTime":1092.66,"endTime":1094.97,"body":"companies. Is there a way to"},{"speaker":"John Simboli","startTime":1094.97,"endTime":1099.29,"body":"explain that you're different,"},{"speaker":"John Simboli","startTime":1094.97,"endTime":1099.29,"body":"but you're located within some"},{"speaker":"John Simboli","startTime":1099.29,"endTime":1099.95,"body":"sector?"},{"speaker":"Vlad Vitoc","startTime":1101.18,"endTime":1104.36,"body":"Well, yes, the"},{"speaker":"Vlad Vitoc","startTime":1101.18,"endTime":1104.36,"body":"sector is oncology. We are an"},{"speaker":"Vlad Vitoc","startTime":1104.36,"endTime":1108.11,"body":"anti-cancer company. Within"},{"speaker":"Vlad Vitoc","startTime":1104.36,"endTime":1108.11,"body":"oncology, you can say it's a sub"},{"speaker":"Vlad Vitoc","startTime":1108.11,"endTime":1111.98,"body":"sector of therapeutics."},{"speaker":"Vlad Vitoc","startTime":1108.11,"endTime":1111.98,"body":"Therapeutics versus supportive"},{"speaker":"Vlad Vitoc","startTime":1111.98,"endTime":1115.49,"body":"care. And then within"},{"speaker":"Vlad Vitoc","startTime":1111.98,"endTime":1115.49,"body":"therapeutics, you can say we're"},{"speaker":"Vlad Vitoc","startTime":1115.49,"endTime":1119.75,"body":"developing small molecules, and"},{"speaker":"Vlad Vitoc","startTime":1115.49,"endTime":1119.75,"body":"you can say that they are"},{"speaker":"Vlad Vitoc","startTime":1120.14,"endTime":1125.9,"body":"telomere targeting agents and"},{"speaker":"Vlad Vitoc","startTime":1120.14,"endTime":1125.9,"body":"immunogenic agents. So it's a"},{"speaker":"Vlad Vitoc","startTime":1125.9,"endTime":1132.53,"body":"targeted therapy, but it's also"},{"speaker":"Vlad Vitoc","startTime":1125.9,"endTime":1132.53,"body":"an immune therapy as well. Which"},{"speaker":"Vlad Vitoc","startTime":1132.95,"endTime":1139.16,"body":"is, it's a new segment, and"},{"speaker":"Vlad Vitoc","startTime":1132.95,"endTime":1139.16,"body":"within this telomere targeting,"},{"speaker":"Vlad Vitoc","startTime":1139.16,"endTime":1144.47,"body":"we are pioneers here. So this is"},{"speaker":"Vlad Vitoc","startTime":1139.16,"endTime":1144.47,"body":"definitely the first in this"},{"speaker":"Vlad Vitoc","startTime":1144.47,"endTime":1145.61,"body":"mechanism of action."},{"speaker":"John Simboli","startTime":1146.72,"endTime":1149.435,"body":"When people, after"},{"speaker":"John Simboli","startTime":1146.72,"endTime":1149.435,"body":"hearing the story about MAIA,"},{"speaker":"John Simboli","startTime":1149.492,"endTime":1152.66,"body":"when people misunderstand and"},{"speaker":"John Simboli","startTime":1149.492,"endTime":1152.66,"body":"misperceive it, is there a"},{"speaker":"John Simboli","startTime":1152.716,"endTime":1156.224,"body":"pattern? And then what is that"},{"speaker":"John Simboli","startTime":1152.716,"endTime":1156.224,"body":"pattern? And if so, what do you"},{"speaker":"John Simboli","startTime":1156.281,"endTime":1159.11,"body":"do to get them back on track to"},{"speaker":"John Simboli","startTime":1156.281,"endTime":1159.11,"body":"what it really is,"},{"speaker":"Vlad Vitoc","startTime":1160.79,"endTime":1163.64,"body":"One common"},{"speaker":"Vlad Vitoc","startTime":1160.79,"endTime":1163.64,"body":"misperception that we needed to"},{"speaker":"Vlad Vitoc","startTime":1163.64,"endTime":1168.56,"body":"explain was about telomerase"},{"speaker":"Vlad Vitoc","startTime":1163.64,"endTime":1168.56,"body":"targeting. This is because"},{"speaker":"Vlad Vitoc","startTime":1168.56,"endTime":1172.61,"body":"telomerase has been as an"},{"speaker":"Vlad Vitoc","startTime":1168.56,"endTime":1172.61,"body":"enzyme, has been a target for"},{"speaker":"Vlad Vitoc","startTime":1172.64,"endTime":1177.08,"body":"oncology for some time, and"},{"speaker":"Vlad Vitoc","startTime":1172.64,"endTime":1177.08,"body":"several companies attempted to"},{"speaker":"Vlad Vitoc","startTime":1177.08,"endTime":1182.06,"body":"develop telomerase inhibitors."},{"speaker":"Vlad Vitoc","startTime":1177.08,"endTime":1182.06,"body":"One of them succeeded. Geron"},{"speaker":"Vlad Vitoc","startTime":1182.06,"endTime":1186.11,"body":"Corporation has imetelstat now"},{"speaker":"Vlad Vitoc","startTime":1182.06,"endTime":1186.11,"body":"commercially approved for"},{"speaker":"Vlad Vitoc","startTime":1186.11,"endTime":1193.04,"body":"myelofibrosis. So telomerase is"},{"speaker":"Vlad Vitoc","startTime":1186.11,"endTime":1193.04,"body":"the enzyme that is very"},{"speaker":"Vlad Vitoc","startTime":1193.04,"endTime":1197.87,"body":"prevalent in many cancer cells."},{"speaker":"Vlad Vitoc","startTime":1193.04,"endTime":1197.87,"body":"That's not what we target. We"},{"speaker":"Vlad Vitoc","startTime":1197.87,"endTime":1202.97,"body":"target the telomeres and we use"},{"speaker":"Vlad Vitoc","startTime":1197.87,"endTime":1202.97,"body":"the enzyme telomerase. So"},{"speaker":"Vlad Vitoc","startTime":1202.97,"endTime":1206.24,"body":"without telomerase, our drug"},{"speaker":"Vlad Vitoc","startTime":1202.97,"endTime":1206.24,"body":"would do absolutely nothing. It"},{"speaker":"Vlad Vitoc","startTime":1206.24,"endTime":1210.35,"body":"would be inert. With telomerase,"},{"speaker":"Vlad Vitoc","startTime":1206.24,"endTime":1210.35,"body":"it becomes hugely active."},{"speaker":"Vlad Vitoc","startTime":1210.8,"endTime":1214.67,"body":"Imetelstat in contrast"},{"speaker":"Vlad Vitoc","startTime":1210.8,"endTime":1214.67,"body":"eliminates telomerase. So there"},{"speaker":"Vlad Vitoc","startTime":1214.67,"endTime":1218.15,"body":"will be something like the ying"},{"speaker":"Vlad Vitoc","startTime":1214.67,"endTime":1218.15,"body":"and the yang, or the exact"},{"speaker":"Vlad Vitoc","startTime":1218.15,"endTime":1225.26,"body":"opposites in the same spectrum."},{"speaker":"Vlad Vitoc","startTime":1218.15,"endTime":1225.26,"body":"So that's a common question that"},{"speaker":"Vlad Vitoc","startTime":1225.26,"endTime":1229.4,"body":"came from investors, especially"},{"speaker":"Vlad Vitoc","startTime":1225.26,"endTime":1229.4,"body":"investors who have already been"},{"speaker":"Vlad Vitoc","startTime":1229.4,"endTime":1233.48,"body":"exposed to telomerase inhibitors"},{"speaker":"Vlad Vitoc","startTime":1229.4,"endTime":1233.48,"body":"in the past."},{"speaker":"John Simboli","startTime":1235.28,"endTime":1237.41,"body":"With that"},{"speaker":"John Simboli","startTime":1235.28,"endTime":1237.41,"body":"distinction in mind, how do you"},{"speaker":"John Simboli","startTime":1237.41,"endTime":1240.68,"body":"explain to people what it would"},{"speaker":"John Simboli","startTime":1237.41,"endTime":1240.68,"body":"mean for patients if you were to"},{"speaker":"John Simboli","startTime":1240.68,"endTime":1241.31,"body":"succeed?"},{"speaker":"Vlad Vitoc","startTime":1242.51,"endTime":1246.23,"body":"So I think it will"},{"speaker":"Vlad Vitoc","startTime":1242.51,"endTime":1246.23,"body":"be very much transformative in"},{"speaker":"Vlad Vitoc","startTime":1246.23,"endTime":1249.74,"body":"our first indication. This is in"},{"speaker":"Vlad Vitoc","startTime":1246.23,"endTime":1249.74,"body":"non small-cell lung cancer. In"},{"speaker":"Vlad Vitoc","startTime":1249.74,"endTime":1254.18,"body":"third line of therapy, on the"},{"speaker":"Vlad Vitoc","startTime":1249.74,"endTime":1254.18,"body":"average, we're seeing survival"},{"speaker":"Vlad Vitoc","startTime":1254.18,"endTime":1258.86,"body":"three times longer. And on a"},{"speaker":"Vlad Vitoc","startTime":1254.18,"endTime":1258.86,"body":"specific patient basis, we have"},{"speaker":"Vlad Vitoc","startTime":1258.86,"endTime":1262.07,"body":"patients who have been on"},{"speaker":"Vlad Vitoc","startTime":1258.86,"endTime":1262.07,"body":"therapy now close to two years"},{"speaker":"Vlad Vitoc","startTime":1262.1,"endTime":1268.94,"body":"and doing still well. These"},{"speaker":"Vlad Vitoc","startTime":1262.1,"endTime":1268.94,"body":"patients without THIO and the"},{"speaker":"Vlad Vitoc","startTime":1268.94,"endTime":1272.54,"body":"checkpoint inhibitor in the mix"},{"speaker":"Vlad Vitoc","startTime":1268.94,"endTime":1272.54,"body":"here, most likely would have"},{"speaker":"Vlad Vitoc","startTime":1272.54,"endTime":1278.18,"body":"been dead a long time ago. And"},{"speaker":"Vlad Vitoc","startTime":1272.54,"endTime":1278.18,"body":"they may very well live much"},{"speaker":"Vlad Vitoc","startTime":1278.18,"endTime":1281.12,"body":"longer from here on. I think"},{"speaker":"Vlad Vitoc","startTime":1278.18,"endTime":1281.12,"body":"when we go to first line of"},{"speaker":"Vlad Vitoc","startTime":1281.12,"endTime":1285.71,"body":"therapy, we will see real cures."},{"speaker":"Vlad Vitoc","startTime":1281.12,"endTime":1285.71,"body":"And that's going to be what we"},{"speaker":"Vlad Vitoc","startTime":1285.71,"endTime":1289.46,"body":"actually strive for all along."},{"speaker":"Vlad Vitoc","startTime":1285.71,"endTime":1289.46,"body":"We want to go there and show"},{"speaker":"Vlad Vitoc","startTime":1289.52,"endTime":1294.98,"body":"curative effect. Certainly, the"},{"speaker":"Vlad Vitoc","startTime":1289.52,"endTime":1294.98,"body":"first line clinical development"},{"speaker":"Vlad Vitoc","startTime":1294.98,"endTime":1298.64,"body":"is more expensive. The trials"},{"speaker":"Vlad Vitoc","startTime":1294.98,"endTime":1298.64,"body":"are bigger, they're longer. You"},{"speaker":"Vlad Vitoc","startTime":1298.64,"endTime":1302.81,"body":"need more patients. You need to"},{"speaker":"Vlad Vitoc","startTime":1298.64,"endTime":1302.81,"body":"provide competitor, expensive"},{"speaker":"Vlad Vitoc","startTime":1302.81,"endTime":1307.31,"body":"treatments. So those are"},{"speaker":"Vlad Vitoc","startTime":1302.81,"endTime":1307.31,"body":"different budgets, are much,"},{"speaker":"Vlad Vitoc","startTime":1307.31,"endTime":1311.15,"body":"much greater budgets, and"},{"speaker":"Vlad Vitoc","startTime":1307.31,"endTime":1311.15,"body":"usually not even big companies"},{"speaker":"Vlad Vitoc","startTime":1311.15,"endTime":1315.32,"body":"undertake them, unless the drug"},{"speaker":"Vlad Vitoc","startTime":1311.15,"endTime":1315.32,"body":"is already commercially"},{"speaker":"Vlad Vitoc","startTime":1315.32,"endTime":1319.43,"body":"available in a third line,"},{"speaker":"Vlad Vitoc","startTime":1315.32,"endTime":1319.43,"body":"second line, third line, fourth"},{"speaker":"Vlad Vitoc","startTime":1319.43,"endTime":1323.54,"body":"line, setting somewhere, and"},{"speaker":"Vlad Vitoc","startTime":1319.43,"endTime":1323.54,"body":"then invest this type of money,"},{"speaker":"Vlad Vitoc","startTime":1323.54,"endTime":1328.52,"body":"as we're talking about serious"},{"speaker":"Vlad Vitoc","startTime":1323.54,"endTime":1328.52,"body":"10s, hundreds of millions of"},{"speaker":"Vlad Vitoc","startTime":1328.52,"endTime":1332.45,"body":"dollars. Some programs like"},{"speaker":"Vlad Vitoc","startTime":1328.52,"endTime":1332.45,"body":"Tarceva, for instance, ended up"},{"speaker":"Vlad Vitoc","startTime":1332.45,"endTime":1336.77,"body":"investing more than $1 billion"},{"speaker":"Vlad Vitoc","startTime":1332.45,"endTime":1336.77,"body":"in clinical development projects"},{"speaker":"Vlad Vitoc","startTime":1338.12,"endTime":1340.82,"body":"along the way. So that's a"},{"speaker":"Vlad Vitoc","startTime":1338.12,"endTime":1340.82,"body":"number one investment"},{"speaker":"Vlad Vitoc","startTime":1340.94,"endTime":1344.66,"body":"pharmaceutical companies make"},{"speaker":"Vlad Vitoc","startTime":1340.94,"endTime":1344.66,"body":"ultimately, but they want to"},{"speaker":"Vlad Vitoc","startTime":1344.72,"endTime":1349.1,"body":"approach it in risk"},{"speaker":"Vlad Vitoc","startTime":1344.72,"endTime":1349.1,"body":"conscientious fashion, so they"},{"speaker":"Vlad Vitoc","startTime":1349.46,"endTime":1353.75,"body":"eliminate development risk by"},{"speaker":"Vlad Vitoc","startTime":1349.46,"endTime":1353.75,"body":"getting the drug first on the"},{"speaker":"Vlad Vitoc","startTime":1353.75,"endTime":1354.32,"body":"market."},{"speaker":"John Simboli","startTime":1355.34,"endTime":1358.79,"body":"How does your"},{"speaker":"John Simboli","startTime":1355.34,"endTime":1358.79,"body":"vision for the pipeline, what"},{"speaker":"John Simboli","startTime":1358.79,"endTime":1362.45,"body":"are the pieces of it, and how do"},{"speaker":"John Simboli","startTime":1358.79,"endTime":1362.45,"body":"they come together to realize"},{"speaker":"John Simboli","startTime":1362.45,"endTime":1364.55,"body":"your vision for what the company"},{"speaker":"John Simboli","startTime":1362.45,"endTime":1364.55,"body":"is trying to do?"},{"speaker":"Vlad Vitoc","startTime":1365.09,"endTime":1369.02,"body":"So the pipeline, we"},{"speaker":"Vlad Vitoc","startTime":1365.09,"endTime":1369.02,"body":"have started this project about"},{"speaker":"Vlad Vitoc","startTime":1369.05,"endTime":1375.29,"body":"two years ago, and we have"},{"speaker":"Vlad Vitoc","startTime":1369.05,"endTime":1375.29,"body":"developed 84 new molecules. Some"},{"speaker":"Vlad Vitoc","startTime":1375.29,"endTime":1378.71,"body":"of them are a structural"},{"speaker":"Vlad Vitoc","startTime":1375.29,"endTime":1378.71,"body":"evolution of the original"},{"speaker":"Vlad Vitoc","startTime":1378.71,"endTime":1384.74,"body":"molecule, and others are new"},{"speaker":"Vlad Vitoc","startTime":1378.71,"endTime":1384.74,"body":"structures entirely. They all"},{"speaker":"Vlad Vitoc","startTime":1384.8,"endTime":1388.82,"body":"work in the same way, telomere"},{"speaker":"Vlad Vitoc","startTime":1384.8,"endTime":1388.82,"body":"targeting with immunogenic"},{"speaker":"Vlad Vitoc","startTime":1388.82,"endTime":1394.22,"body":"capabilities. And we tested them"},{"speaker":"Vlad Vitoc","startTime":1388.82,"endTime":1394.22,"body":"all preclinically, in vitro, in"},{"speaker":"Vlad Vitoc","startTime":1394.25,"endTime":1399.44,"body":"cell cultures, first, then in"},{"speaker":"Vlad Vitoc","startTime":1394.25,"endTime":1399.44,"body":"vivo, in animal models. And"},{"speaker":"Vlad Vitoc","startTime":1399.5,"endTime":1404.66,"body":"seven of them proved to be very"},{"speaker":"Vlad Vitoc","startTime":1399.5,"endTime":1404.66,"body":"much more effective than the"},{"speaker":"Vlad Vitoc","startTime":1404.66,"endTime":1409.88,"body":"original molecule in certain"},{"speaker":"Vlad Vitoc","startTime":1404.66,"endTime":1409.88,"body":"tumor types. So we patented"},{"speaker":"Vlad Vitoc","startTime":1409.88,"endTime":1413.87,"body":"them, and we started the first"},{"speaker":"Vlad Vitoc","startTime":1409.88,"endTime":1413.87,"body":"two into the pre clinical"},{"speaker":"Vlad Vitoc","startTime":1413.87,"endTime":1418.31,"body":"development in animal models."},{"speaker":"Vlad Vitoc","startTime":1413.87,"endTime":1418.31,"body":"And now we are, we are almost"},{"speaker":"Vlad Vitoc","startTime":1418.34,"endTime":1422.6,"body":"ready with this pre-IND testing"},{"speaker":"Vlad Vitoc","startTime":1418.34,"endTime":1422.6,"body":"for the first two, and we hope"},{"speaker":"Vlad Vitoc","startTime":1422.6,"endTime":1426.77,"body":"to get them to the clinic maybe"},{"speaker":"Vlad Vitoc","startTime":1422.6,"endTime":1426.77,"body":"this year or next year. And then"},{"speaker":"Vlad Vitoc","startTime":1426.8,"endTime":1430.1,"body":"there's a third one that's ready"},{"speaker":"Vlad Vitoc","startTime":1426.8,"endTime":1430.1,"body":"to start as well, and we keep"},{"speaker":"Vlad Vitoc","startTime":1430.1,"endTime":1435.23,"body":"four more in reserve. So the"},{"speaker":"Vlad Vitoc","startTime":1430.1,"endTime":1435.23,"body":"plan is to bring them forward in"},{"speaker":"Vlad Vitoc","startTime":1435.23,"endTime":1439.64,"body":"a staggered manner as budget"},{"speaker":"Vlad Vitoc","startTime":1435.23,"endTime":1439.64,"body":"forms to support the development"},{"speaker":"Vlad Vitoc","startTime":1439.64,"endTime":1443.99,"body":"plans, with a priority, of"},{"speaker":"Vlad Vitoc","startTime":1439.64,"endTime":1443.99,"body":"course, at the moment on THIO"},{"speaker":"Vlad Vitoc","startTime":1444.02,"endTime":1447.89,"body":"because this is the closest,"},{"speaker":"Vlad Vitoc","startTime":1444.02,"endTime":1447.89,"body":"most real deal for"},{"speaker":"Vlad Vitoc","startTime":1447.89,"endTime":1452.15,"body":"commercialization. And once we"},{"speaker":"Vlad Vitoc","startTime":1447.89,"endTime":1452.15,"body":"have revenues coming from THIO,"},{"speaker":"Vlad Vitoc","startTime":1452.15,"endTime":1456.41,"body":"then we can go all out in 20"},{"speaker":"Vlad Vitoc","startTime":1452.15,"endTime":1456.41,"body":"different tumor types with seven"},{"speaker":"Vlad Vitoc","startTime":1456.41,"endTime":1460.13,"body":"different agents. And we"},{"speaker":"Vlad Vitoc","startTime":1456.41,"endTime":1460.13,"body":"certainly will find a lot of"},{"speaker":"Vlad Vitoc","startTime":1460.13,"endTime":1461.54,"body":"cures for a lot of cancers."},{"speaker":"John Simboli","startTime":1462.35,"endTime":1464.39,"body":"What kind of"},{"speaker":"John Simboli","startTime":1462.35,"endTime":1464.39,"body":"partner is a good partner for"},{"speaker":"John Simboli","startTime":1464.39,"endTime":1464.66,"body":"you?"},{"speaker":"Vlad Vitoc","startTime":1465.05,"endTime":1469.52,"body":"These drugs, THIO in"},{"speaker":"Vlad Vitoc","startTime":1465.05,"endTime":1469.52,"body":"this case, has such a broad"},{"speaker":"Vlad Vitoc","startTime":1469.52,"endTime":1472.52,"body":"applicability, it can go after"},{"speaker":"Vlad Vitoc","startTime":1469.52,"endTime":1472.52,"body":"many tumor types. But this"},{"speaker":"Vlad Vitoc","startTime":1472.52,"endTime":1477.8,"body":"requires a budget, and with what"},{"speaker":"Vlad Vitoc","startTime":1472.52,"endTime":1477.8,"body":"we can raise in the market,"},{"speaker":"Vlad Vitoc","startTime":1477.8,"endTime":1483.68,"body":"we're limited to how fast we can"},{"speaker":"Vlad Vitoc","startTime":1477.8,"endTime":1483.68,"body":"go. So we're looking for a"},{"speaker":"Vlad Vitoc","startTime":1483.68,"endTime":1487.97,"body":"partner that would engage with"},{"speaker":"Vlad Vitoc","startTime":1483.68,"endTime":1487.97,"body":"us in a co development agreement"},{"speaker":"Vlad Vitoc","startTime":1488.57,"endTime":1494.9,"body":"under which we co develop the"},{"speaker":"Vlad Vitoc","startTime":1488.57,"endTime":1494.9,"body":"drug. For instance, they give us"},{"speaker":"Vlad Vitoc","startTime":1494.96,"endTime":1499.85,"body":"their drug for a trial we do in,"},{"speaker":"Vlad Vitoc","startTime":1494.96,"endTime":1499.85,"body":"let's say non small-cell lung"},{"speaker":"Vlad Vitoc","startTime":1499.85,"endTime":1504.53,"body":"cancer in third line, we give"},{"speaker":"Vlad Vitoc","startTime":1499.85,"endTime":1504.53,"body":"them our drug for them to do the"},{"speaker":"Vlad Vitoc","startTime":1504.53,"endTime":1509.45,"body":"trial on their own in the first"},{"speaker":"Vlad Vitoc","startTime":1504.53,"endTime":1509.45,"body":"line of therapy. In other cases,"},{"speaker":"Vlad Vitoc","startTime":1509.45,"endTime":1514.37,"body":"we can do 50/50 cost sharing,"},{"speaker":"Vlad Vitoc","startTime":1509.45,"endTime":1514.37,"body":"and this would go a much longer"},{"speaker":"Vlad Vitoc","startTime":1514.37,"endTime":1519.95,"body":"way compared to just financing"},{"speaker":"Vlad Vitoc","startTime":1514.37,"endTime":1519.95,"body":"on your own in the markets. So"},{"speaker":"Vlad Vitoc","startTime":1519.95,"endTime":1525.86,"body":"that's co development and then"},{"speaker":"Vlad Vitoc","startTime":1519.95,"endTime":1525.86,"body":"two, commercialization. So I've"},{"speaker":"Vlad Vitoc","startTime":1525.86,"endTime":1529.37,"body":"been in many commercialization"},{"speaker":"Vlad Vitoc","startTime":1525.86,"endTime":1529.37,"body":"teams along the way. So in"},{"speaker":"Vlad Vitoc","startTime":1529.37,"endTime":1532.82,"body":"oncology, in the US, it's very"},{"speaker":"Vlad Vitoc","startTime":1529.37,"endTime":1532.82,"body":"straightforward, from my"},{"speaker":"Vlad Vitoc","startTime":1532.82,"endTime":1536.09,"body":"perspective, how we're going to"},{"speaker":"Vlad Vitoc","startTime":1532.82,"endTime":1536.09,"body":"build a commercial organization"},{"speaker":"Vlad Vitoc","startTime":1536.09,"endTime":1541.07,"body":"and run it. Ex US, on the other"},{"speaker":"Vlad Vitoc","startTime":1536.09,"endTime":1541.07,"body":"hand, is more complex because"},{"speaker":"Vlad Vitoc","startTime":1541.07,"endTime":1545.0,"body":"you have different regulators,"},{"speaker":"Vlad Vitoc","startTime":1541.07,"endTime":1545.0,"body":"you have languages, marketing is"},{"speaker":"Vlad Vitoc","startTime":1545.0,"endTime":1547.88,"body":"different, distributors are"},{"speaker":"Vlad Vitoc","startTime":1545.0,"endTime":1547.88,"body":"different, so it becomes way"},{"speaker":"Vlad Vitoc","startTime":1547.88,"endTime":1551.93,"body":"much more complex, and that's"},{"speaker":"Vlad Vitoc","startTime":1547.88,"endTime":1551.93,"body":"where I would prefer to have a"},{"speaker":"Vlad Vitoc","startTime":1552.29,"endTime":1555.56,"body":"pharmaceutical company with an"},{"speaker":"Vlad Vitoc","startTime":1552.29,"endTime":1555.56,"body":"established global presence that"},{"speaker":"Vlad Vitoc","startTime":1555.56,"endTime":1561.98,"body":"can take Ex US on and we can"},{"speaker":"Vlad Vitoc","startTime":1555.56,"endTime":1561.98,"body":"keep the US commercialization."},{"speaker":"Vlad Vitoc","startTime":1562.73,"endTime":1567.26,"body":"Or as a variation, it can be co"},{"speaker":"Vlad Vitoc","startTime":1562.73,"endTime":1567.26,"body":"commercialization in the US as"},{"speaker":"Vlad Vitoc","startTime":1567.26,"endTime":1572.51,"body":"well. So sometimes that's the"},{"speaker":"Vlad Vitoc","startTime":1567.26,"endTime":1572.51,"body":"model that is more adequate for"},{"speaker":"Vlad Vitoc","startTime":1572.51,"endTime":1576.26,"body":"United States as well. So that"},{"speaker":"Vlad Vitoc","startTime":1572.51,"endTime":1576.26,"body":"would be a co development to"},{"speaker":"Vlad Vitoc","startTime":1576.26,"endTime":1578.42,"body":"commercialization alliance."},{"speaker":"John Simboli","startTime":1578.99,"endTime":1581.038,"body":"How did it come to"},{"speaker":"John Simboli","startTime":1578.99,"endTime":1581.038,"body":"be that MAIA was headquartered"},{"speaker":"John Simboli","startTime":1581.08,"endTime":1581.54,"body":"in Chicago?"},{"speaker":"Vlad Vitoc","startTime":1582.02,"endTime":1586.64,"body":"It's simply because"},{"speaker":"Vlad Vitoc","startTime":1582.02,"endTime":1586.64,"body":"I live in Chicago, and I think"},{"speaker":"Vlad Vitoc","startTime":1586.64,"endTime":1590.33,"body":"that's probably the case with"},{"speaker":"Vlad Vitoc","startTime":1586.64,"endTime":1590.33,"body":"the vast majority of the founder"},{"speaker":"Vlad Vitoc","startTime":1590.33,"endTime":1593.69,"body":"entrepreneurs is they start"},{"speaker":"Vlad Vitoc","startTime":1590.33,"endTime":1593.69,"body":"where they are; in their own"},{"speaker":"Vlad Vitoc","startTime":1593.69,"endTime":1597.89,"body":"garage or in their own attic or"},{"speaker":"Vlad Vitoc","startTime":1593.69,"endTime":1597.89,"body":"something. Well, I happen to"},{"speaker":"Vlad Vitoc","startTime":1597.89,"endTime":1601.46,"body":"love Chicago. We have moved to"},{"speaker":"Vlad Vitoc","startTime":1597.89,"endTime":1601.46,"body":"Chicago with a role with"},{"speaker":"Vlad Vitoc","startTime":1601.46,"endTime":1605.18,"body":"Astellas oncology, which was"},{"speaker":"Vlad Vitoc","startTime":1601.46,"endTime":1605.18,"body":"based here in the northern"},{"speaker":"Vlad Vitoc","startTime":1605.18,"endTime":1612.05,"body":"suburbs, and I come to a Chicago"},{"speaker":"Vlad Vitoc","startTime":1605.18,"endTime":1612.05,"body":"that had recently transformed to"},{"speaker":"Vlad Vitoc","startTime":1612.05,"endTime":1616.94,"body":"an extraordinary, modern city"},{"speaker":"Vlad Vitoc","startTime":1612.05,"endTime":1616.94,"body":"and accessible too. You know, it"},{"speaker":"Vlad Vitoc","startTime":1616.94,"endTime":1620.36,"body":"doesn't have the prices you see"},{"speaker":"Vlad Vitoc","startTime":1616.94,"endTime":1620.36,"body":"in Boston, in New York or in San"},{"speaker":"Vlad Vitoc","startTime":1620.36,"endTime":1624.26,"body":"Francisco, where your typical"},{"speaker":"Vlad Vitoc","startTime":1620.36,"endTime":1624.26,"body":"San Francisco, Boston, San"},{"speaker":"Vlad Vitoc","startTime":1624.26,"endTime":1628.07,"body":"Diego, were more typical biotech"},{"speaker":"Vlad Vitoc","startTime":1624.26,"endTime":1628.07,"body":"hubs, right? So for me, it was"},{"speaker":"Vlad Vitoc","startTime":1628.1,"endTime":1631.52,"body":"that role that drew me to"},{"speaker":"Vlad Vitoc","startTime":1628.1,"endTime":1631.52,"body":"Chicago. And then I met my wife,"},{"speaker":"Vlad Vitoc","startTime":1631.52,"endTime":1636.08,"body":"Charlotte, who was with a role"},{"speaker":"Vlad Vitoc","startTime":1631.52,"endTime":1636.08,"body":"in banking, also in Chicago. So"},{"speaker":"Vlad Vitoc","startTime":1636.53,"endTime":1640.58,"body":"we both continued in Chicago."},{"speaker":"Vlad Vitoc","startTime":1636.53,"endTime":1640.58,"body":"And so it's a great place to be"},{"speaker":"Vlad Vitoc","startTime":1640.61,"endTime":1644.6,"body":"for us. And to, you know, I know"},{"speaker":"Vlad Vitoc","startTime":1640.61,"endTime":1644.6,"body":"people think that the best place"},{"speaker":"Vlad Vitoc","startTime":1644.6,"endTime":1648.08,"body":"to raise a family is in the"},{"speaker":"Vlad Vitoc","startTime":1644.6,"endTime":1648.08,"body":"suburbs. And yes, the suburbs"},{"speaker":"Vlad Vitoc","startTime":1648.08,"endTime":1651.56,"body":"have many merits, for sure, but"},{"speaker":"Vlad Vitoc","startTime":1648.08,"endTime":1651.56,"body":"also the cities do. Now, back"},{"speaker":"Vlad Vitoc","startTime":1651.56,"endTime":1655.79,"body":"to, how do you manage a biotech"},{"speaker":"Vlad Vitoc","startTime":1651.56,"endTime":1655.79,"body":"company? You know, I learned in"},{"speaker":"Vlad Vitoc","startTime":1655.82,"endTime":1659.57,"body":"in my different roles with other"},{"speaker":"Vlad Vitoc","startTime":1655.82,"endTime":1659.57,"body":"companies, where I commuted, I"},{"speaker":"Vlad Vitoc","startTime":1659.57,"endTime":1664.1,"body":"lived in other places is I would"},{"speaker":"Vlad Vitoc","startTime":1659.57,"endTime":1664.1,"body":"just go to the office and then"},{"speaker":"Vlad Vitoc","startTime":1664.1,"endTime":1670.49,"body":"be on a bat phone for most of"},{"speaker":"Vlad Vitoc","startTime":1664.1,"endTime":1670.49,"body":"the time, and the meetings were"},{"speaker":"Vlad Vitoc","startTime":1670.49,"endTime":1674.72,"body":"hybrid or they were just calls."},{"speaker":"Vlad Vitoc","startTime":1670.49,"endTime":1674.72,"body":"So my idea from the get go is"},{"speaker":"Vlad Vitoc","startTime":1674.75,"endTime":1678.2,"body":"this, I'm not going to move"},{"speaker":"Vlad Vitoc","startTime":1674.75,"endTime":1678.2,"body":"anybody. Talent is where talent"},{"speaker":"Vlad Vitoc","startTime":1678.2,"endTime":1682.25,"body":"is. Don't try to relocate"},{"speaker":"Vlad Vitoc","startTime":1678.2,"endTime":1682.25,"body":"talent. Instead work with them"},{"speaker":"Vlad Vitoc","startTime":1682.25,"endTime":1686.78,"body":"where they are. So I started out"},{"speaker":"Vlad Vitoc","startTime":1682.25,"endTime":1686.78,"body":"with the notion of virtual"},{"speaker":"Vlad Vitoc","startTime":1686.81,"endTime":1692.12,"body":"organization in this manner so"},{"speaker":"Vlad Vitoc","startTime":1686.81,"endTime":1692.12,"body":"that we have a head office, who"},{"speaker":"Vlad Vitoc","startTime":1692.12,"endTime":1696.32,"body":"is in Chicago, or wants to be in"},{"speaker":"Vlad Vitoc","startTime":1692.12,"endTime":1696.32,"body":"Chicago, can be. But I'm not"},{"speaker":"Vlad Vitoc","startTime":1696.32,"endTime":1700.1,"body":"going to move people from Boston"},{"speaker":"Vlad Vitoc","startTime":1696.32,"endTime":1700.1,"body":"to Chicago or from San Francisco"},{"speaker":"Vlad Vitoc","startTime":1700.1,"endTime":1705.44,"body":"to Chicago. It's like if we have"},{"speaker":"Vlad Vitoc","startTime":1700.1,"endTime":1705.44,"body":"now, our people are everywhere."},{"speaker":"Vlad Vitoc","startTime":1705.53,"endTime":1709.67,"body":"In Chicago, just three of us,"},{"speaker":"Vlad Vitoc","startTime":1705.53,"endTime":1709.67,"body":"but there are others on the West"},{"speaker":"Vlad Vitoc","startTime":1709.67,"endTime":1713.54,"body":"Coast, others in the San"},{"speaker":"Vlad Vitoc","startTime":1709.67,"endTime":1713.54,"body":"Francisco area. Others are in,"},{"speaker":"Vlad Vitoc","startTime":1714.17,"endTime":1717.38,"body":"our consultants are everywhere"},{"speaker":"Vlad Vitoc","startTime":1714.17,"endTime":1717.38,"body":"in the world, really. We have"},{"speaker":"Vlad Vitoc","startTime":1717.38,"endTime":1721.43,"body":"even someone in Argentina,"},{"speaker":"Vlad Vitoc","startTime":1717.38,"endTime":1721.43,"body":"someone in Romania. Some are"},{"speaker":"Vlad Vitoc","startTime":1721.64,"endTime":1726.44,"body":"people in Asia, in Europe, in"},{"speaker":"Vlad Vitoc","startTime":1721.64,"endTime":1726.44,"body":"other countries, in Canada, it's"},{"speaker":"Vlad Vitoc","startTime":1726.44,"endTime":1734.96,"body":"a global organization in no"},{"speaker":"Vlad Vitoc","startTime":1726.44,"endTime":1734.96,"body":"time. And I think this became a"},{"speaker":"Vlad Vitoc","startTime":1734.99,"endTime":1737.99,"body":"working model for other"},{"speaker":"Vlad Vitoc","startTime":1734.99,"endTime":1737.99,"body":"companies as well. In especially"},{"speaker":"Vlad Vitoc","startTime":1737.99,"endTime":1742.28,"body":"since the COVID episode, people"},{"speaker":"Vlad Vitoc","startTime":1737.99,"endTime":1742.28,"body":"were forced into this model in"},{"speaker":"Vlad Vitoc","startTime":1742.28,"endTime":1746.54,"body":"some cases. For us, it works"},{"speaker":"Vlad Vitoc","startTime":1742.28,"endTime":1746.54,"body":"very, very well. The cost of"},{"speaker":"Vlad Vitoc","startTime":1746.54,"endTime":1750.83,"body":"operating is so much more"},{"speaker":"Vlad Vitoc","startTime":1746.54,"endTime":1750.83,"body":"streamlined, and people are so"},{"speaker":"Vlad Vitoc","startTime":1750.83,"endTime":1754.73,"body":"much more happy to just not have"},{"speaker":"Vlad Vitoc","startTime":1750.83,"endTime":1754.73,"body":"to commute. I used to commute"},{"speaker":"Vlad Vitoc","startTime":1755.15,"endTime":1760.19,"body":"from, for instance, in Chicago,"},{"speaker":"Vlad Vitoc","startTime":1755.15,"endTime":1760.19,"body":"from here to the northern"},{"speaker":"Vlad Vitoc","startTime":1760.19,"endTime":1764.45,"body":"suburbs, to Astellas, it was"},{"speaker":"Vlad Vitoc","startTime":1760.19,"endTime":1764.45,"body":"three hours every day going and"},{"speaker":"Vlad Vitoc","startTime":1764.45,"endTime":1767.72,"body":"coming. I mean, yeah, okay, so"},{"speaker":"Vlad Vitoc","startTime":1764.45,"endTime":1767.72,"body":"I'm taking some calls on this"},{"speaker":"Vlad Vitoc","startTime":1767.72,"endTime":1771.41,"body":"time and doing some other"},{"speaker":"Vlad Vitoc","startTime":1767.72,"endTime":1771.41,"body":"things. But it's tiring, it's"},{"speaker":"Vlad Vitoc","startTime":1771.41,"endTime":1776.6,"body":"costly, it's brutal on so many"},{"speaker":"Vlad Vitoc","startTime":1771.41,"endTime":1776.6,"body":"directions. Then I commuted from"},{"speaker":"Vlad Vitoc","startTime":1776.6,"endTime":1781.64,"body":"Chicago to San Francisco, even"},{"speaker":"Vlad Vitoc","startTime":1776.6,"endTime":1781.64,"body":"more crazy. So now you go on a"},{"speaker":"Vlad Vitoc","startTime":1781.64,"endTime":1786.05,"body":"plane and work from the San"},{"speaker":"Vlad Vitoc","startTime":1781.64,"endTime":1786.05,"body":"Francisco office for four days"},{"speaker":"Vlad Vitoc","startTime":1786.05,"endTime":1790.43,"body":"or five days a week, and then"},{"speaker":"Vlad Vitoc","startTime":1786.05,"endTime":1790.43,"body":"fly back. And why? Because it's"},{"speaker":"Vlad Vitoc","startTime":1790.43,"endTime":1794.3,"body":"still a hybrid meeting. Most"},{"speaker":"Vlad Vitoc","startTime":1790.43,"endTime":1794.3,"body":"people are on the phone anyway."},{"speaker":"John Simboli","startTime":1794.87,"endTime":1797.63,"body":"I'm in New Haven,"},{"speaker":"John Simboli","startTime":1794.87,"endTime":1797.63,"body":"and the city has been trying to"},{"speaker":"John Simboli","startTime":1797.63,"endTime":1801.23,"body":"build lab space, because that's"},{"speaker":"John Simboli","startTime":1797.63,"endTime":1801.23,"body":"part of the deal. Does Chicago"},{"speaker":"John Simboli","startTime":1801.23,"endTime":1803.87,"body":"provide that for you? Do you"},{"speaker":"John Simboli","startTime":1801.23,"endTime":1803.87,"body":"need that at this stage?"},{"speaker":"Vlad Vitoc","startTime":1804.5,"endTime":1807.59,"body":"Yes, Chicago has it."},{"speaker":"Vlad Vitoc","startTime":1804.5,"endTime":1807.59,"body":"They want to provide it. They"},{"speaker":"Vlad Vitoc","startTime":1807.59,"endTime":1812.72,"body":"want to sell it to me every day,"},{"speaker":"Vlad Vitoc","startTime":1807.59,"endTime":1812.72,"body":"but we don't need it. So that's"},{"speaker":"Vlad Vitoc","startTime":1812.72,"endTime":1815.84,"body":"for a different type of"},{"speaker":"Vlad Vitoc","startTime":1812.72,"endTime":1815.84,"body":"organization. So pre clinical,"},{"speaker":"Vlad Vitoc","startTime":1816.53,"endTime":1820.19,"body":"we use contract research"},{"speaker":"Vlad Vitoc","startTime":1816.53,"endTime":1820.19,"body":"organizations to do the testing,"},{"speaker":"Vlad Vitoc","startTime":1820.22,"endTime":1824.57,"body":"and we use our scientists more"},{"speaker":"Vlad Vitoc","startTime":1820.22,"endTime":1824.57,"body":"or less in the function of"},{"speaker":"Vlad Vitoc","startTime":1824.57,"endTime":1828.71,"body":"leaders and project managers. So"},{"speaker":"Vlad Vitoc","startTime":1824.57,"endTime":1828.71,"body":"they do design the molecules,"},{"speaker":"Vlad Vitoc","startTime":1828.74,"endTime":1834.8,"body":"they guide the the other company"},{"speaker":"Vlad Vitoc","startTime":1828.74,"endTime":1834.8,"body":"to deliver. But you know, to"},{"speaker":"Vlad Vitoc","startTime":1834.8,"endTime":1839.66,"body":"have wet labs is costly, and"},{"speaker":"Vlad Vitoc","startTime":1834.8,"endTime":1839.66,"body":"unless you have serious activity"},{"speaker":"Vlad Vitoc","startTime":1839.66,"endTime":1842.87,"body":"going on there, you're never"},{"speaker":"Vlad Vitoc","startTime":1839.66,"endTime":1842.87,"body":"going to recover costs like"},{"speaker":"Vlad Vitoc","startTime":1842.87,"endTime":1847.16,"body":"that. So we're now in the clinic"},{"speaker":"Vlad Vitoc","startTime":1842.87,"endTime":1847.16,"body":"anyway, with the majority of our"},{"speaker":"Vlad Vitoc","startTime":1847.16,"endTime":1851.03,"body":"activity. We also have the"},{"speaker":"Vlad Vitoc","startTime":1847.16,"endTime":1851.03,"body":"preclinical testing, yes, but we"},{"speaker":"Vlad Vitoc","startTime":1851.03,"endTime":1852.35,"body":"don't need the labs."},{"speaker":"John Simboli","startTime":1852.95,"endTime":1854.84,"body":"Have you staked"},{"speaker":"John Simboli","startTime":1852.95,"endTime":1854.84,"body":"out territory that you want to"},{"speaker":"John Simboli","startTime":1854.84,"endTime":1857.51,"body":"pursue? You know, that's"},{"speaker":"John Simboli","startTime":1854.84,"endTime":1857.51,"body":"specific that you could say,"},{"speaker":"John Simboli","startTime":1857.51,"endTime":1859.55,"body":"Yeah, I'm particularly"},{"speaker":"John Simboli","startTime":1857.51,"endTime":1859.55,"body":"interested in?"},{"speaker":"Vlad Vitoc","startTime":1860.3,"endTime":1863.39,"body":"Yeah, I'm"},{"speaker":"Vlad Vitoc","startTime":1860.3,"endTime":1863.39,"body":"particularly interested in"},{"speaker":"Vlad Vitoc","startTime":1863.9,"endTime":1868.01,"body":"treatments for cancer, and I"},{"speaker":"Vlad Vitoc","startTime":1863.9,"endTime":1868.01,"body":"think that cancer is a major"},{"speaker":"Vlad Vitoc","startTime":1868.01,"endTime":1873.95,"body":"problem of humankind. That is,"},{"speaker":"Vlad Vitoc","startTime":1868.01,"endTime":1873.95,"body":"we've made progress as humans in"},{"speaker":"Vlad Vitoc","startTime":1873.95,"endTime":1877.64,"body":"finding therapies and"},{"speaker":"Vlad Vitoc","startTime":1873.95,"endTime":1877.64,"body":"occasionally cures, but it's"},{"speaker":"Vlad Vitoc","startTime":1877.64,"endTime":1881.06,"body":"still growing instead of going"},{"speaker":"Vlad Vitoc","startTime":1877.64,"endTime":1881.06,"body":"away, because, simply because"},{"speaker":"Vlad Vitoc","startTime":1881.06,"endTime":1886.28,"body":"it's a factor of aging. The"},{"speaker":"Vlad Vitoc","startTime":1881.06,"endTime":1886.28,"body":"number one factor is aging, and"},{"speaker":"Vlad Vitoc","startTime":1886.28,"endTime":1889.76,"body":"as I described with aging"},{"speaker":"Vlad Vitoc","startTime":1886.28,"endTime":1889.76,"body":"process with the telomeres and"},{"speaker":"Vlad Vitoc","startTime":1889.76,"endTime":1894.5,"body":"telomerase, these telomeres"},{"speaker":"Vlad Vitoc","startTime":1889.76,"endTime":1894.5,"body":"become so short so fast when you"},{"speaker":"Vlad Vitoc","startTime":1894.5,"endTime":1899.33,"body":"pass a certain age, 70, 80. Then"},{"speaker":"Vlad Vitoc","startTime":1894.5,"endTime":1899.33,"body":"mutations appear, and now you"},{"speaker":"Vlad Vitoc","startTime":1899.33,"endTime":1902.24,"body":"have to deal with this cancer"},{"speaker":"Vlad Vitoc","startTime":1899.33,"endTime":1902.24,"body":"and that cancer and other"},{"speaker":"Vlad Vitoc","startTime":1902.24,"endTime":1907.37,"body":"diseases. By certain statistics"},{"speaker":"Vlad Vitoc","startTime":1902.24,"endTime":1907.37,"body":"you know, once you cross 80, the"},{"speaker":"Vlad Vitoc","startTime":1907.37,"endTime":1911.03,"body":"probability of having a cancer"},{"speaker":"Vlad Vitoc","startTime":1907.37,"endTime":1911.03,"body":"is very high, and by you get to"},{"speaker":"Vlad Vitoc","startTime":1911.03,"endTime":1914.66,"body":"90, the probability of being"},{"speaker":"Vlad Vitoc","startTime":1911.03,"endTime":1914.66,"body":"diagnosed in your lifetime with"},{"speaker":"Vlad Vitoc","startTime":1914.69,"endTime":1919.7,"body":"a type of cancer is 40% and to"},{"speaker":"Vlad Vitoc","startTime":1914.69,"endTime":1919.7,"body":"die of it is 20%. I've seen"},{"speaker":"Vlad Vitoc","startTime":1919.73,"endTime":1923.9,"body":"around me people have, almost"},{"speaker":"Vlad Vitoc","startTime":1919.73,"endTime":1923.9,"body":"everyone has cancer a type of"},{"speaker":"Vlad Vitoc","startTime":1923.9,"endTime":1928.64,"body":"cancer after age 70, 80. My"},{"speaker":"Vlad Vitoc","startTime":1923.9,"endTime":1928.64,"body":"parents, both of them. It's"},{"speaker":"Vlad Vitoc","startTime":1929.63,"endTime":1933.17,"body":"certainly not deadly, but they"},{"speaker":"Vlad Vitoc","startTime":1929.63,"endTime":1933.17,"body":"have to deal with it. Skin"},{"speaker":"Vlad Vitoc","startTime":1933.17,"endTime":1937.22,"body":"cancer is very common, right? So"},{"speaker":"Vlad Vitoc","startTime":1933.17,"endTime":1937.22,"body":"you got prostate cancer for men,"},{"speaker":"Vlad Vitoc","startTime":1937.25,"endTime":1941.45,"body":"breast cancer for women. It is a"},{"speaker":"Vlad Vitoc","startTime":1937.25,"endTime":1941.45,"body":"problem that will continue to be"},{"speaker":"Vlad Vitoc","startTime":1941.45,"endTime":1945.86,"body":"a problem, even more prevalent"},{"speaker":"Vlad Vitoc","startTime":1941.45,"endTime":1945.86,"body":"as people grow older. We now"},{"speaker":"Vlad Vitoc","startTime":1945.89,"endTime":1952.25,"body":"have 25 countries have their"},{"speaker":"Vlad Vitoc","startTime":1945.89,"endTime":1952.25,"body":"life expectancy over 80 already,"},{"speaker":"Vlad Vitoc","startTime":1953.03,"endTime":1957.29,"body":"and you have in the lead with"},{"speaker":"Vlad Vitoc","startTime":1953.03,"endTime":1957.29,"body":"85, 86 years life expectancy you"},{"speaker":"Vlad Vitoc","startTime":1957.29,"endTime":1960.92,"body":"have places like Hong Kong and"},{"speaker":"Vlad Vitoc","startTime":1957.29,"endTime":1960.92,"body":"Japan and Korea and the United"},{"speaker":"Vlad Vitoc","startTime":1960.92,"endTime":1964.55,"body":"States is part of this leading"},{"speaker":"Vlad Vitoc","startTime":1960.92,"endTime":1964.55,"body":"group, but it's just crossing 80"},{"speaker":"Vlad Vitoc","startTime":1964.55,"endTime":1970.13,"body":"now, and people live beyond 80."},{"speaker":"Vlad Vitoc","startTime":1964.55,"endTime":1970.13,"body":"I think our generation will be"},{"speaker":"Vlad Vitoc","startTime":1970.13,"endTime":1975.74,"body":"confronted with a new set of"},{"speaker":"Vlad Vitoc","startTime":1970.13,"endTime":1975.74,"body":"dilemmas of how to manage aging."},{"speaker":"Vlad Vitoc","startTime":1975.77,"endTime":1980.45,"body":"You cannot prevent it, but maybe"},{"speaker":"Vlad Vitoc","startTime":1975.77,"endTime":1980.45,"body":"perhaps you can age better. And"},{"speaker":"Vlad Vitoc","startTime":1980.45,"endTime":1983.36,"body":"one thing, one key thing, is"},{"speaker":"Vlad Vitoc","startTime":1980.45,"endTime":1983.36,"body":"make sure you don't die,"},{"speaker":"Vlad Vitoc","startTime":1983.84,"endTime":1985.79,"body":"especially of something stupid"},{"speaker":"Vlad Vitoc","startTime":1983.84,"endTime":1985.79,"body":"like cancer."},{"speaker":"John Simboli","startTime":1986.39,"endTime":1988.4,"body":"Vlad, thanks for"},{"speaker":"John Simboli","startTime":1986.39,"endTime":1988.4,"body":"speaking with me today."},{"speaker":"Vlad Vitoc","startTime":1989.21,"endTime":1990.23,"body":"Thank you for having"},{"speaker":"Vlad Vitoc","startTime":1989.21,"endTime":1990.23,"body":"me."}]}